Gene: ENSG00000039650 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000039650
Transcript Identifier
ENST00000596014
Gene Type
Coding gene
Location
19 : 49861248-49867204 : negative

Family Information

Homologous gene family
HOM02SEM005935
(14 genes in 14 species)
specific family

Descriptions

gene_descr
polynucleotide kinase 3'-phosphatase

Identifiers

Type Value
pidENSP00000472300
HGNC9154
UniprotQ96T60
EMBLAC018766
EMBLAF120499
EMBLAF125807
EMBLAF126486
EMBLAF354258
EMBLAY133033
EMBLBC002519
EMBLBC033822

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1904355
IMP
Genome Projectpositive regulation of telomere capping
GO:1904355
IMP
Gene Ontologypositive regulation of telomere capping1
GO:0098506
IEA
Genome Projectpolynucleotide 3' dephosphorylation
GO:0098504
IBA
Genome ProjectDNA 3' dephosphorylation involved in DNA repair
GO:0090305
IEA
Genome Projectnucleic acid phosphodiester bond hydrolysis
GO:0051973
IMP
Genome Projectpositive regulation of telomerase activity
GO:0051973
IMP
Gene Ontologypositive regulation of telomerase activity1
GO:0046939
IDA
Genome Projectnucleotide phosphorylation
GO:0046939
IDA
Gene Ontologynucleotide phosphorylation2
GO:0042769
IDA
NAS
Genome ProjectDNA damage response, detection of DNA damage
GO:0042769
IDA
NAS
Gene OntologyDNA damage response, detection of DNA damage2 3
GO:0032212
IMP
Genome Projectpositive regulation of telomere maintenance via telomerase
GO:0032212
IMP
Gene Ontologypositive regulation of telomere maintenance via telomerase1
GO:0016311
IDA
Genome Projectdephosphorylation
GO:0016311
IDA
Gene Ontologydephosphorylation2
GO:0009314
TAS, NAS
Genome Projectresponse to radiation
GO:0009314
TAS, NAS
Gene Ontologyresponse to radiation2 3
GO:0006979
IDA
Genome Projectresponse to oxidative stress
GO:0006979
IDA
Gene Ontologyresponse to oxidative stress3
GO:0006281
IGI
Genome ProjectDNA repair
GO:0006281
IGI
Gene OntologyDNA repair3
GO:0006261
NAS
Genome ProjectDNA-dependent DNA replication
GO:0006261
NAS
Gene OntologyDNA-dependent DNA replication3
GO:0000718
NAS
Genome Projectnucleotide-excision repair, DNA damage removal
GO:0000718
NAS
Gene Ontologynucleotide-excision repair, DNA damage removal2
GO:0010836
IMP
Gene Ontologynegative regulation of protein ADP-ribosylation4
GO:0006302
IEA
PLAZA Integrative Orthologydouble-strand break repair YMR156C
GO:0006304
IEA
PLAZA Integrative OrthologyDNA modification AT3G14890
GO:0070988
IEA
PLAZA Integrative Orthologydemethylation AT3G14890
GO:0035510
IEA
PLAZA Integrative OrthologyDNA dealkylation AT3G14890
GO:0080111
IEA
PLAZA Integrative OrthologyDNA demethylation AT3G14890
GO:0006284
IEA
PLAZA Integrative Orthologybase-excision repair SPAC23C11.04c
GO:0044728
IEA
PLAZA Integrative OrthologyDNA methylation or demethylation AT3G14890
GO:0000012
IEA
PLAZA Integrative Orthologysingle strand break repair SPAC23C11.04c

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0046404
IDA
Genome ProjectATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO:0046404
IDA
Gene OntologyATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity2
GO:0046403
IDA
TAS
Genome Projectpolynucleotide 3'-phosphatase activity
GO:0046403
IDA
TAS
Gene Ontologypolynucleotide 3'-phosphatase activity2 3
GO:0017076
NAS
Genome Projectpurine nucleotide binding
GO:0017076
NAS
Gene Ontologypurine nucleotide binding2
GO:0005524
NAS
Genome ProjectATP binding
GO:0005524
NAS
Gene OntologyATP binding3
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding5 6 7 8 9 10
GO:0004519
NAS
Genome Projectendonuclease activity
GO:0004519
NAS
Gene Ontologyendonuclease activity3
GO:0003690
TAS
Genome Projectdouble-stranded DNA binding
GO:0003690
TAS
Gene Ontologydouble-stranded DNA binding2
GO:0003684
NAS
Genome Projectdamaged DNA binding
GO:0003684
NAS
Gene Ontologydamaged DNA binding2
GO:0050145
IDA
Gene Ontologynucleoside monophosphate kinase activity2 3

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016020
IDA
Genome Projectmembrane
GO:0016020
Gene Ontologymembrane11
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005730
IDA
Genome Projectnucleolus
GO:0005730
IDA
Gene Ontologynucleolus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus2

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR006549HAD-superfamily hydrolase,subfamily IIIA
IPR006550Polynucleotide kinase 3-phosphatase, metazoan
IPR006551Polynucleotide 3'-phosphatase
IPR008984SMAD/FHA domain superfamily
IPR013954Polynucleotide kinase 3 phosphatase
IPR023214HAD superfamily
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.
KeggID Description
K08073PNKP; bifunctional polynucleotide phosphatase/kinase
No chloroplast target sequence found.