Gene: ENSG00000035928 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000035928
Transcript Identifier
ENST00000381897
Gene Type
Coding gene
Location
4 : 39288761-39366241 : negative

Family Information

Homologous gene family
HOM02SEM001874
(33 genes in 25 species)
specific family

Descriptions

gene_descr
replication factor C (activator 1) 1, 145kDa

Identifiers

Type Value
pidENSP00000371321
HGNC9969
UniprotP35251
RefSeq_mRNANM_001204747.1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070987
TAS
Genome Projecterror-free translesion synthesis
GO:0070987
TAS
Gene Ontologyerror-free translesion synthesis
GO:0045893
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0043085
IEA
Genome Projectpositive regulation of catalytic activity
GO:0042769
TAS
Genome ProjectDNA damage response, detection of DNA damage
GO:0042769
TAS
Gene OntologyDNA damage response, detection of DNA damage
GO:0042276
TAS
Genome Projecterror-prone translesion synthesis
GO:0042276
TAS
Gene Ontologyerror-prone translesion synthesis
GO:0033683
TAS
Genome Projectnucleotide-excision repair, DNA incision
GO:0033683
TAS
Gene Ontologynucleotide-excision repair, DNA incision
GO:0019985
TAS
Genome Projecttranslesion synthesis
GO:0019985
TAS
Gene Ontologytranslesion synthesis
GO:0007004
TAS
Genome Projecttelomere maintenance via telomerase
GO:0007004
TAS
Gene Ontologytelomere maintenance via telomerase1
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006297
TAS
Genome Projectnucleotide-excision repair, DNA gap filling
GO:0006297
TAS
Gene Ontologynucleotide-excision repair, DNA gap filling
GO:0006296
TAS
Genome Projectnucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006296
TAS
Gene Ontologynucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006283
TAS
Genome Projecttranscription-coupled nucleotide-excision repair
GO:0006283
TAS
Gene Ontologytranscription-coupled nucleotide-excision repair
GO:0006261
TAS
Genome ProjectDNA-dependent DNA replication
GO:0006261
TAS
Gene OntologyDNA-dependent DNA replication2
GO:0000722
TAS
Genome Projecttelomere maintenance via recombination
GO:0000122
IEA
Genome Projectnegative regulation of transcription by RNA polymerase II
GO:0090618
IMP
Gene OntologyDNA clamp unloading3
GO:0032201
TAS
Gene Ontologytelomere maintenance via semi-conservative replication
GO:0018205
IEA
PLAZA Integrative Orthologypeptidyl-lysine modification AT5G22010
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0004913
GO:0046331
IEA
PLAZA Integrative Orthologylateral inhibition FBgn0004913
GO:0009737
IEA
PLAZA Integrative Orthologyresponse to abscisic acid AT5G22010
GO:0001101
IEA
PLAZA Integrative Orthologyresponse to acid chemical AT5G22010
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0004913
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction AT5G22010
GO:0006479
IEA
PLAZA Integrative Orthologyprotein methylation AT5G22010
GO:0048468
IEA
PLAZA Integrative Orthologycell development FBgn0004913
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process AT5G22010
GO:0044267
IEA
PLAZA Integrative Orthologycellular protein metabolic process AT5G22010
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process FBgn0004913
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process FBgn0004913
GO:0097549
IEA
PLAZA Integrative Orthologychromatin organization involved in negative regulation of transcription AT5G22010
GO:0071478
IEA
PLAZA Integrative Orthologycellular response to radiation SPBC23E6.07c
GO:0097305
IEA
PLAZA Integrative Orthologyresponse to alcohol AT5G22010
GO:0034401
IEA
PLAZA Integrative Orthologychromatin organization involved in regulation of transcription AT5G22010
GO:0034644
IEA
PLAZA Integrative Orthologycellular response to UV SPBC23E6.07c
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis FBgn0004913
GO:0031935
IEA
PLAZA Integrative Orthologyregulation of chromatin silencing AT5G22010
GO:0048858
IEA
PLAZA Integrative Orthologycell projection morphogenesis FBgn0004913
GO:0048699
IEA
PLAZA Integrative Orthologygeneration of neurons FBgn0004913
GO:0006342
IEA
PLAZA Integrative Orthologychromatin silencing AT5G22010
GO:1901564
IEA
PLAZA Integrative Orthologyorganonitrogen compound metabolic process AT5G22010
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development FBgn0004913
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0004913
GO:0006464
IEA
PLAZA Integrative Orthologycellular protein modification process AT5G22010
GO:0033043
IEA
PLAZA Integrative Orthologyregulation of organelle organization AT5G22010
GO:0032990
IEA
PLAZA Integrative Orthologycell part morphogenesis FBgn0004913
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development FBgn0004913
GO:0007154
IEA
PLAZA Integrative Orthologycell communication FBgn0004913
GO:0033044
IEA
PLAZA Integrative Orthologyregulation of chromosome organization AT5G22010
GO:0019538
IEA
PLAZA Integrative Orthologyprotein metabolic process AT5G22010
GO:0104004
IEA
PLAZA Integrative Orthologycellular response to environmental stimulus SPBC23E6.07c
GO:0051570
IEA
PLAZA Integrative Orthologyregulation of histone H3-K9 methylation AT5G22010
GO:0048731
IEA
PLAZA Integrative Orthologysystem development FBgn0004913
GO:0042221
IEA
PLAZA Integrative Orthologyresponse to chemical AT5G22010
GO:0061647
IEA
PLAZA Integrative Orthologyhistone H3-K9 modification AT5G22010
GO:0030182
IEA
PLAZA Integrative Orthologyneuron differentiation FBgn0004913
GO:0070914
IEA
PLAZA Integrative OrthologyUV-damage excision repair SPBC23E6.07c
GO:0051567
IEA
PLAZA Integrative Orthologyhistone H3-K9 methylation AT5G22010
GO:0098813
IEA
PLAZA Integrative Orthologynuclear chromosome segregation AT5G22010
GO:0071214
IEA
PLAZA Integrative Orthologycellular response to abiotic stimulus SPBC23E6.07c
GO:0031399
IEA
PLAZA Integrative Orthologyregulation of protein modification process AT5G22010
GO:0016571
IEA
PLAZA Integrative Orthologyhistone methylation AT5G22010
GO:0016570
IEA
PLAZA Integrative Orthologyhistone modification AT5G22010
GO:0018193
IEA
PLAZA Integrative Orthologypeptidyl-amino acid modification AT5G22010
GO:0051321
IEA
PLAZA Integrative Orthologymeiotic cell cycle AT5G22010
GO:0048285
IEA
PLAZA Integrative Orthologyorganelle fission AT5G22010
GO:0009628
IEA
PLAZA Integrative Orthologyresponse to abiotic stimulus SPBC23E6.07c
GO:1901700
IEA
PLAZA Integrative Orthologyresponse to oxygen-containing compound AT5G22010
GO:0060968
IEA
PLAZA Integrative Orthologyregulation of gene silencing AT5G22010
GO:0045168
IEA
PLAZA Integrative Orthologycell-cell signaling involved in cell fate commitment FBgn0004913
GO:0007059
IEA
PLAZA Integrative Orthologychromosome segregation AT5G22010
GO:1903046
IEA
PLAZA Integrative Orthologymeiotic cell cycle process AT5G22010
GO:0120039
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection morphogenesis FBgn0004913
GO:0120036
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection organization FBgn0004913
GO:0036211
IEA
PLAZA Integrative Orthologyprotein modification process AT5G22010
GO:0016569
IEA
PLAZA Integrative Orthologycovalent chromatin modification AT5G22010
GO:0032259
IEA
PLAZA Integrative Orthologymethylation AT5G22010
GO:0045165
IEA
PLAZA Integrative Orthologycell fate commitment FBgn0004913
GO:0043414
IEA
PLAZA Integrative Orthologymacromolecule methylation AT5G22010
GO:0007127
IEA
PLAZA Integrative Orthologymeiosis I AT5G22010
GO:0040029
IEA
PLAZA Integrative Orthologyregulation of gene expression, epigenetic AT5G22010
GO:0043412
IEA
PLAZA Integrative Orthologymacromolecule modification AT5G22010
GO:0048666
IEA
PLAZA Integrative Orthologyneuron development FBgn0004913
GO:0048667
IEA
PLAZA Integrative Orthologycell morphogenesis involved in neuron differentiation FBgn0004913
GO:0008213
IEA
PLAZA Integrative Orthologyprotein alkylation AT5G22010
GO:0006272
IEA
PLAZA Integrative Orthologyleading strand elongation YOR217W
GO:0006271
IEA
PLAZA Integrative OrthologyDNA strand elongation involved in DNA replication SPBC23E6.07c
GO:0031175
IEA
PLAZA Integrative Orthologyneuron projection development FBgn0004913
GO:0022616
IEA
PLAZA Integrative OrthologyDNA strand elongation SPBC23E6.07c
GO:0061982
IEA
PLAZA Integrative Orthologymeiosis I cell cycle process AT5G22010
GO:0016458
IEA
PLAZA Integrative Orthologygene silencing AT5G22010
GO:0016358
IEA
PLAZA Integrative Orthologydendrite development FBgn0004913
GO:0140013
IEA
PLAZA Integrative Orthologymeiotic nuclear division AT5G22010
GO:0051304
IEA
PLAZA Integrative Orthologychromosome separation AT5G22010
GO:0031056
IEA
PLAZA Integrative Orthologyregulation of histone modification AT5G22010
GO:0033993
IEA
PLAZA Integrative Orthologyresponse to lipid AT5G22010
GO:0051307
IEA
PLAZA Integrative Orthologymeiotic chromosome separation AT5G22010
GO:0032268
IEA
PLAZA Integrative Orthologyregulation of cellular protein metabolic process AT5G22010
GO:0000280
IEA
PLAZA Integrative Orthologynuclear division AT5G22010
GO:0034968
IEA
PLAZA Integrative Orthologyhistone lysine methylation AT5G22010
GO:0048813
IEA
PLAZA Integrative Orthologydendrite morphogenesis FBgn0004913
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle YOR217W
GO:0009416
IEA
PLAZA Integrative Orthologyresponse to light stimulus SPBC23E6.07c
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis FBgn0004913
GO:0009411
IEA
PLAZA Integrative Orthologyresponse to UV SPBC23E6.07c
GO:0000712
IEA
PLAZA Integrative Orthologyresolution of meiotic recombination intermediates AT5G22010
GO:0048812
IEA
PLAZA Integrative Orthologyneuron projection morphogenesis FBgn0004913
GO:0031060
IEA
PLAZA Integrative Orthologyregulation of histone methylation AT5G22010
GO:0035825
IEA
PLAZA Integrative Orthologyhomologous recombination AT5G22010
GO:0023052
IEA
PLAZA Integrative Orthologysignaling FBgn0004913
GO:0009719
IEA
PLAZA Integrative Orthologyresponse to endogenous stimulus AT5G22010
GO:0018022
IEA
PLAZA Integrative Orthologypeptidyl-lysine methylation AT5G22010
GO:0071482
IEA
PLAZA Integrative Orthologycellular response to light stimulus SPBC23E6.07c
GO:0009725
IEA
PLAZA Integrative Orthologyresponse to hormone AT5G22010
GO:0006298
IEA
PLAZA Integrative Orthologymismatch repair YOR217W
GO:0007267
IEA
PLAZA Integrative Orthologycell-cell signaling FBgn0004913
GO:0000902
IEA
PLAZA Integrative Orthologycell morphogenesis FBgn0004913
GO:0000904
IEA
PLAZA Integrative Orthologycell morphogenesis involved in differentiation FBgn0004913
GO:0010033
IEA
PLAZA Integrative Orthologyresponse to organic substance AT5G22010
GO:0045814
IEA
PLAZA Integrative Orthologynegative regulation of gene expression, epigenetic AT5G22010
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization AT5G22010
GO:0045132
IEA
PLAZA Integrative Orthologymeiotic chromosome segregation AT5G22010
GO:0051246
IEA
PLAZA Integrative Orthologyregulation of protein metabolic process AT5G22010
GO:0006325
IEA
PLAZA Integrative Orthologychromatin organization AT5G22010
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0004913
GO:0009314
IEA
PLAZA Integrative Orthologyresponse to radiation SPBC23E6.07c
GO:0030030
IEA
PLAZA Integrative Orthologycell projection organization FBgn0004913
GO:1902275
IEA
PLAZA Integrative Orthologyregulation of chromatin organization AT5G22010
GO:0007131
IEA
PLAZA Integrative Orthologyreciprocal meiotic recombination AT5G22010

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043565
IEA
Genome Projectsequence-specific DNA binding
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0008047
TAS
Genome Projectenzyme activator activity
GO:0008047
TAS
Gene Ontologyenzyme activator activity1
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding4 5 6
GO:0003690
IEA
Genome Projectdouble-stranded DNA binding
GO:0003689
IEA
Genome ProjectDNA clamp loader activity
GO:0003677
IBA
Genome ProjectDNA binding
GO:0061860
IMP
Gene OntologyDNA clamp unloader activity3
GO:0003682
IEA
PLAZA Integrative Orthologychromatin binding SPBC23E6.07c

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome7
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005730
IEA
Genome Projectnucleolus
GO:0005663
IDA
Genome ProjectDNA replication factor C complex
GO:0005663
IDA
Gene OntologyDNA replication factor C complex4
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
IBA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus
GO:0031391
IDA
Gene OntologyElg1 RFC-like complex3
GO:0044430
IEA
PLAZA Integrative Orthologycytoskeletal part FBgn0004913
GO:0000790
IEA
PLAZA Integrative Orthologynuclear chromatin SPBC23E6.07c
GO:0000785
IEA
PLAZA Integrative Orthologychromatin SPBC23E6.07c
GO:0015630
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton FBgn0004913
GO:0005856
IEA
PLAZA Integrative Orthologycytoskeleton FBgn0004913
GO:0044454
IEA
PLAZA Integrative Orthologynuclear chromosome part SPBC23E6.07c
GO:0000228
IEA
PLAZA Integrative Orthologynuclear chromosome SPBC23E6.07c
GO:0043596
IEA
PLAZA Integrative Orthologynuclear replication fork SPBC23E6.07c
GO:0005875
IEA
PLAZA Integrative Orthologymicrotubule associated complex FBgn0004913

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001357BRCT domain
IPR003593AAA+ ATPase domain
IPR003959ATPase, AAA-type, core
IPR008921DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
IPR012178Replication factor C subunit 1
IPR013725DNA replication factor RFC1, C-terminal
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.
KeggID Description
K10754RFC1; replication factor C subunit 1
No chloroplast target sequence found.