Gene: ENSG00000015475 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000015475
Transcript Identifier
ENST00000317361
Gene Type
Coding gene
Location
22 : 17735580-17773689 : negative

Family Information

Homologous gene family
HOM02SEM107639
(orphan gene)
specific family

Descriptions

gene_descr
BH3 interacting domain death agonist

Identifiers

Type Value
pidENSP00000318822
HGNC1050
UniprotP55957
RefSeq_mRNANM_197966.2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001244
TAS
Genome Projectpositive regulation of intrinsic apoptotic signaling pathway
GO:2001244
IMP
TAS
Gene Ontologypositive regulation of intrinsic apoptotic signaling pathway1
GO:2001238
IMP
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway
GO:2001238
IMP
Gene Ontologypositive regulation of extrinsic apoptotic signaling pathway2
GO:2000271
IEA
Genome Projectpositive regulation of fibroblast apoptotic process
GO:2000045
IEA
Genome Projectregulation of G1/S transition of mitotic cell cycle
GO:1902230
IEA
Genome Projectnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1901030
TAS
Genome Projectpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030
TAS
Gene Ontologypositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1900740
TAS
Genome Projectpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900740
TAS
Gene Ontologypositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0097345
IEA
Genome Projectmitochondrial outer membrane permeabilization
GO:0097284
IEA
Genome Projecthepatocyte apoptotic process
GO:0090200
IMP, IGI
Genome Projectpositive regulation of release of cytochrome c from mitochondria
GO:0090200
IMP, IGI
Gene Ontologypositive regulation of release of cytochrome c from mitochondria1 3 4
GO:0090150
IDA
Genome Projectestablishment of protein localization to membrane
GO:0090150
IDA
Gene Ontologyestablishment of protein localization to membrane4
GO:0051402
TAS
Genome Projectneuron apoptotic process
GO:0051402
TAS
Gene Ontologyneuron apoptotic process5
GO:0051260
IEA
Genome Projectprotein homooligomerization
GO:0043065
IMP
Genome Projectpositive regulation of apoptotic process
GO:0043065
IMP
Gene Ontologypositive regulation of apoptotic process3 6
GO:0042981
TAS
Genome Projectregulation of apoptotic process
GO:0042981
TAS
Gene Ontologyregulation of apoptotic process
GO:0042775
IEA
Genome Projectmitochondrial ATP synthesis coupled electron transport
GO:0042770
TAS
Genome Projectsignal transduction in response to DNA damage
GO:0042770
TAS
Gene Ontologysignal transduction in response to DNA damage7
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0034349
IEA
Genome Projectglial cell apoptotic process
GO:0032464
IDA
Genome Projectpositive regulation of protein homooligomerization
GO:0032464
IDA
Gene Ontologypositive regulation of protein homooligomerization4
GO:0032461
IDA
Genome Projectpositive regulation of protein oligomerization
GO:0032461
IDA
Gene Ontologypositive regulation of protein oligomerization8
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0010918
IEA
Genome Projectpositive regulation of mitochondrial membrane potential
GO:0008637
TAS
Genome Projectapoptotic mitochondrial changes
GO:0008637
TAS
Gene Ontologyapoptotic mitochondrial changes9
GO:0008625
TAS
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0008625
TAS
Gene Ontologyextrinsic apoptotic signaling pathway via death domain receptors10
GO:0007420
IEA
Genome Projectbrain development
GO:0006919
IEA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006626
IEA
Genome Projectprotein targeting to mitochondrion
GO:0001836
IDA
Genome Projectrelease of cytochrome c from mitochondria
GO:0001836
IDA
Gene Ontologyrelease of cytochrome c from mitochondria11
GO:0043066
TAS
Gene Ontologynegative regulation of apoptotic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0046982
IEA
Genome Projectprotein heterodimerization activity
GO:0031625
IEA
Genome Projectubiquitin protein ligase binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 8 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
GO:0005123
TAS
Genome Projectdeath receptor binding
GO:0005123
TAS
Gene Ontologydeath receptor binding30

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0032592
IEA
Genome Projectintegral component of mitochondrial membrane
GO:0016020
TAS
Genome Projectmembrane
GO:0016020
TAS
Gene Ontologymembrane30
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol
GO:0005741
TAS
Genome Projectmitochondrial outer membrane
GO:0005741
IDA
TAS
Gene Ontologymitochondrial outer membrane29
GO:0005739
TAS
Genome Projectmitochondrion
GO:0005739
TAS
Gene Ontologymitochondrion10

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR010479BH3-interacting domain death agonist
IPR020728Apoptosis regulator, Bcl-2, BH3 motif, conserved site
IPR026298Blc2 family

No MapMan annotations defined for this gene.
KeggID Description
K04726BID; BH3 interacting domain death agonist
No chloroplast target sequence found.