Gene: ENSG00000002330 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000002330
Transcript Identifier
ENST00000309032
Gene Type
Coding gene
Location
11 : 64270209-64284368 : negative

Family Information

Homologous gene family
HOM02SEM084358
(orphan gene)
specific family

Descriptions

gene_descr
BCL2-associated agonist of cell death

Identifiers

Type Value
pidENSP00000309103
HGNC936
UniprotQ92934
UniprotA0A024R562
RefSeq_mRNANM_032989.2
EMBLCH471076

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001244
TAS
Genome Projectpositive regulation of intrinsic apoptotic signaling pathway
GO:2001244
TAS
Gene Ontologypositive regulation of intrinsic apoptotic signaling pathway
GO:2000078
ISS
Genome Projectpositive regulation of type B pancreatic cell development
GO:2000078
ISS
Gene Ontologypositive regulation of type B pancreatic cell development
GO:1902220
IEA
Genome Projectpositive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1901216
IEA
Genome Projectpositive regulation of neuron death
GO:1900740
TAS
Genome Projectpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900740
TAS
Gene Ontologypositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0097202
IDA
Genome Projectactivation of cysteine-type endopeptidase activity
GO:0097202
IDA
Gene Ontologyactivation of cysteine-type endopeptidase activity1
GO:0097193
IMP
Genome Projectintrinsic apoptotic signaling pathway
GO:0097193
IMP
Gene Ontologyintrinsic apoptotic signaling pathway2
GO:0097192
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:0097191
IMP
Genome Projectextrinsic apoptotic signaling pathway
GO:0097191
IMP
Gene Ontologyextrinsic apoptotic signaling pathway3
GO:0090200
IMP
Genome Projectpositive regulation of release of cytochrome c from mitochondria
GO:0090200
IMP
Gene Ontologypositive regulation of release of cytochrome c from mitochondria4
GO:0071456
IEP
Genome Projectcellular response to hypoxia
GO:0071456
IEP
Gene Ontologycellular response to hypoxia5
GO:0071396
IEA
Genome Projectcellular response to lipid
GO:0071316
IDA
Genome Projectcellular response to nicotine
GO:0071316
IDA
Gene Ontologycellular response to nicotine2
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0071260
IEP
Gene Ontologycellular response to mechanical stimulus6
GO:0071247
IEA
Genome Projectcellular response to chromate
GO:0060154
IEA
Genome Projectcellular process regulating host cell cycle in response to virus
GO:0060139
IEA
Genome Projectpositive regulation of apoptotic process by virus
GO:0051592
IEA
Genome Projectresponse to calcium ion
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0050679
IMP
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050679
IMP
Gene Ontologypositive regulation of epithelial cell proliferation6
GO:0046931
IDA
Genome Projectpore complex assembly
GO:0046931
IDA
Gene Ontologypore complex assembly7 8
GO:0046902
IMP
Genome Projectregulation of mitochondrial membrane permeability
GO:0046902
IMP
Gene Ontologyregulation of mitochondrial membrane permeability9
GO:0046034
ISS
Genome ProjectATP metabolic process
GO:0046034
ISS
Gene OntologyATP metabolic process
GO:0046031
ISS
Genome ProjectADP metabolic process
GO:0046031
ISS
Gene OntologyADP metabolic process
GO:0045918
IMP
Genome Projectnegative regulation of cytolysis
GO:0045862
IDA
Genome Projectpositive regulation of proteolysis
GO:0045862
IDA
Gene Ontologypositive regulation of proteolysis1
GO:0045582
IEA
Genome Projectpositive regulation of T cell differentiation
GO:0045579
IEA
Genome Projectpositive regulation of B cell differentiation
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0044342
ISS
Genome Projecttype B pancreatic cell proliferation
GO:0044342
ISS
Gene Ontologytype B pancreatic cell proliferation
GO:0043280
IDA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280
IDA
Gene Ontologypositive regulation of cysteine-type endopeptidase activity involved in apoptotic process10
GO:0043200
IEA
Genome Projectresponse to amino acid
GO:0043065
IDA, IMP
TAS
Genome Projectpositive regulation of apoptotic process
GO:0043065
IDA, IMP
Gene Ontologypositive regulation of apoptotic process4 11
GO:0042593
ISS
Genome Projectglucose homeostasis
GO:0042593
ISS
Gene Ontologyglucose homeostasis
GO:0042542
IEA
Genome Projectresponse to hydrogen peroxide
GO:0042493
IEA
Genome Projectresponse to drug
GO:0035774
IEA
Genome Projectpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0034201
IEA
Genome Projectresponse to oleic acid
GO:0033574
IEA
Genome Projectresponse to testosterone
GO:0033133
ISS
Genome Projectpositive regulation of glucokinase activity
GO:0033133
ISS
Gene Ontologypositive regulation of glucokinase activity
GO:0032570
IEA
Genome Projectresponse to progesterone
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0032024
ISS
Genome Projectpositive regulation of insulin secretion
GO:0032024
ISS
Gene Ontologypositive regulation of insulin secretion
GO:0021987
IEA
Genome Projectcerebral cortex development
GO:0019221
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0019050
IEA
Genome Projectsuppression by virus of host apoptotic process
GO:0010918
ISS
Genome Projectpositive regulation of mitochondrial membrane potential
GO:0010918
ISS
Gene Ontologypositive regulation of mitochondrial membrane potential
GO:0010508
TAS
Genome Projectpositive regulation of autophagy
GO:0010508
TAS
Gene Ontologypositive regulation of autophagy12
GO:0009749
IEA
Genome Projectresponse to glucose
GO:0008630
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0008625
IEA
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0007283
IEA
Genome Projectspermatogenesis
GO:0006919
ISS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
ISS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915
IDA
TAS
Genome Projectapoptotic process
GO:0006915
IDA
TAS
Gene Ontologyapoptotic process7 13
GO:0006007
IEA
Genome Projectglucose catabolic process
GO:0001844
TAS
Genome Projectprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001844
TAS
Gene Ontologyprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001836
IEA
Genome Projectrelease of cytochrome c from mitochondria

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0071889
IEA
Genome Project14-3-3 protein binding
GO:0046982
IEA
Genome Projectprotein heterodimerization activity
GO:0043422
IEA
Genome Projectprotein kinase B binding
GO:0030346
IEA
Genome Projectprotein phosphatase 2B binding
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0019901
IPI
Gene Ontologyprotein kinase binding14
GO:0008656
IDA
Genome Projectcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008656
IDA
Gene Ontologycysteine-type endopeptidase activator activity involved in apoptotic process10
GO:0008289
IDA
Genome Projectlipid binding
GO:0008289
IDA
Gene Ontologylipid binding7
GO:0005543
IMP
Genome Projectphospholipid binding
GO:0005543
IMP
Gene Ontologyphospholipid binding8
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding7 8 11 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol9
GO:0005741
IDA
TAS
Genome Projectmitochondrial outer membrane
GO:0005741
IDA
TAS
Gene Ontologymitochondrial outer membrane9
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005739
IDA
Gene Ontologymitochondrion

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR018868Bcl2-associated agonist of cell death

No MapMan annotations defined for this gene.
KeggID Description
K02158BAD; Bcl-2-antagonist of cell death
No chloroplast target sequence found.