Gene: ENSG00000001084 (Homo sapiens)

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Gene Identifier
ENSG00000001084
Transcript Identifier
ENST00000229416
Gene Type
Coding gene
Location
6 : 53498756-53544645 : negative

Family Information

Homologous gene family
HOM02SEM001508
(38 genes in 24 species)
specific family
Orthologous gene family
ORTHO02SEM001553
(38 genes in 24 species)
specific family

Descriptions

gene_descr
glutamate-cysteine ligase, catalytic subunit

Identifiers

Type Value
pidENSP00000229416
HGNC4311
UniprotP48506
UniprotQ14TF0
RefSeq_mRNANM_001498.3
EMBLCHEMBL4055
EMBLAB262176
EMBLAF118846
EMBLAK313480
EMBLAL033397
EMBLAY780794
EMBLBC022487
EMBLBC039894
EMBLCH471081
EMBLL39773
EMBLM90656

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001237
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway
GO:2000490
IEA
Genome Projectnegative regulation of hepatic stellate cell activation
GO:0097069
IEA
Genome Projectcellular response to thyroxine stimulus
GO:0071372
IEA
Genome Projectcellular response to follicle-stimulating hormone stimulus
GO:0071333
IEA
Genome Projectcellular response to glucose stimulus
GO:0071260
IEA
Genome Projectcellular response to mechanical stimulus
GO:0070555
IEA
Genome Projectresponse to interleukin-1
GO:0051900
IEA
Genome Projectregulation of mitochondrial depolarization
GO:0051409
IEA
Genome Projectresponse to nitrosative stress
GO:0050880
IMP
Genome Projectregulation of blood vessel size
GO:0050880
IMP
Gene Ontologyregulation of blood vessel size1
GO:0046686
IEA
Genome Projectresponse to cadmium ion
GO:0046685
IEA
Genome Projectresponse to arsenic-containing substance
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045892
IDA
Gene Ontologynegative regulation of transcription, DNA-templated2
GO:0045454
IDA
Genome Projectcell redox homeostasis
GO:0045454
IDA
Gene Ontologycell redox homeostasis2
GO:0044752
IEA
Genome Projectresponse to human chorionic gonadotropin
GO:0044344
IEA
Genome Projectcellular response to fibroblast growth factor stimulus
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043066
IDA
Gene Ontologynegative regulation of apoptotic process2
GO:0035729
IEA
Genome Projectcellular response to hepatocyte growth factor stimulus
GO:0032869
IEA
Genome Projectcellular response to insulin stimulus
GO:0032436
IEA
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031397
IEA
Genome Projectnegative regulation of protein ubiquitination
GO:0019852
IEA
Genome ProjectL-ascorbic acid metabolic process
GO:0014823
IEA
Genome Projectresponse to activity
GO:0009725
IDA
Genome Projectresponse to hormone
GO:0009725
IDA
Gene Ontologyresponse to hormone3
GO:0009410
IEA
Genome Projectresponse to xenobiotic stimulus
GO:0009408
IDA
Genome Projectresponse to heat
GO:0009408
IDA
Gene Ontologyresponse to heat3
GO:0008637
IEA
Genome Projectapoptotic mitochondrial changes
GO:0007584
IEA
Genome Projectresponse to nutrient
GO:0007568
IEA
Genome Projectaging
GO:0006979
IDA
Genome Projectresponse to oxidative stress
GO:0006979
IDA
Gene Ontologyresponse to oxidative stress4 5
GO:0006750
IDA, IMP
TAS, IEA
Genome Projectglutathione biosynthetic process
GO:0006750
IDA, IMP
Gene Ontologyglutathione biosynthetic process3 4 6
GO:0006536
IDA
Genome Projectglutamate metabolic process
GO:0006536
IDA
Gene Ontologyglutamate metabolic process6 7
GO:0006534
IDA
Genome Projectcysteine metabolic process
GO:0006534
IDA
Gene Ontologycysteine metabolic process7
GO:0034635
IEA
PLAZA Integrative Orthologyglutathione transport SPAC22F3.10c
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0040319
GO:0044550
IEA
PLAZA Integrative Orthologysecondary metabolite biosynthetic process SPAC22F3.10c
GO:0071585
IEA
PLAZA Integrative Orthologydetoxification of cadmium ion SPAC22F3.10c
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization SPAC22F3.10c
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0040319
GO:0042886
IEA
PLAZA Integrative Orthologyamide transport SPAC22F3.10c
GO:0048468
IEA
PLAZA Integrative Orthologycell development FBgn0040319
GO:0007444
IEA
PLAZA Integrative Orthologyimaginal disc development FBgn0040319
GO:0046688
IEA
PLAZA Integrative Orthologyresponse to copper ion FBgn0040319
GO:0035295
IEA
PLAZA Integrative Orthologytube development FBgn0040319
GO:0007560
IEA
PLAZA Integrative Orthologyimaginal disc morphogenesis FBgn0040319
GO:1990748
IEA
PLAZA Integrative Orthologycellular detoxification SPAC22F3.10c
GO:0033554
IEA
PLAZA Integrative Orthologycellular response to stress FBgn0040319
GO:0098754
IEA
PLAZA Integrative Orthologydetoxification SPAC22F3.10c
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis FBgn0040319
GO:0006857
IEA
PLAZA Integrative Orthologyoligopeptide transport SPAC22F3.10c
GO:0048736
IEA
PLAZA Integrative Orthologyappendage development FBgn0040319
GO:0048737
IEA
PLAZA Integrative Orthologyimaginal disc-derived appendage development FBgn0040319
GO:0048858
IEA
PLAZA Integrative Orthologycell projection morphogenesis FBgn0040319
GO:0007552
IEA
PLAZA Integrative Orthologymetamorphosis FBgn0040319
GO:0048699
IEA
PLAZA Integrative Orthologygeneration of neurons FBgn0040319
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development FBgn0040319
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0040319
GO:0046677
IEA
PLAZA Integrative Orthologyresponse to antibiotic YJL101C
GO:0032990
IEA
PLAZA Integrative Orthologycell part morphogenesis FBgn0040319
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development FBgn0040319
GO:0035220
IEA
PLAZA Integrative Orthologywing disc development FBgn0040319
GO:0035107
IEA
PLAZA Integrative Orthologyappendage morphogenesis FBgn0040319
GO:0048731
IEA
PLAZA Integrative Orthologysystem development FBgn0040319
GO:0051179
IEA
PLAZA Integrative Orthologylocalization SPAC22F3.10c
GO:0009887
IEA
PLAZA Integrative Orthologyanimal organ morphogenesis FBgn0040319
GO:0009888
IEA
PLAZA Integrative Orthologytissue development FBgn0040319
GO:0006810
IEA
PLAZA Integrative Orthologytransport SPAC22F3.10c
GO:0000302
IEA
PLAZA Integrative Orthologyresponse to reactive oxygen species YJL101C
GO:0000303
IEA
PLAZA Integrative Orthologyresponse to superoxide WBGene00001527
GO:0051181
IEA
PLAZA Integrative Orthologycofactor transport SPAC22F3.10c
GO:0048569
IEA
PLAZA Integrative Orthologypost-embryonic animal organ development FBgn0040319
GO:0000305
IEA
PLAZA Integrative Orthologyresponse to oxygen radical WBGene00001527
GO:0009886
IEA
PLAZA Integrative Orthologypost-embryonic animal morphogenesis FBgn0040319
GO:0030182
IEA
PLAZA Integrative Orthologyneuron differentiation FBgn0040319
GO:0048729
IEA
PLAZA Integrative Orthologytissue morphogenesis FBgn0040319
GO:0035114
IEA
PLAZA Integrative Orthologyimaginal disc-derived appendage morphogenesis FBgn0040319
GO:0035239
IEA
PLAZA Integrative Orthologytube morphogenesis FBgn0040319
GO:0048563
IEA
PLAZA Integrative Orthologypost-embryonic animal organ morphogenesis FBgn0040319
GO:0009636
IEA
PLAZA Integrative Orthologyresponse to toxic substance SPAC22F3.10c
GO:0002165
IEA
PLAZA Integrative Orthologyinstar larval or pupal development FBgn0040319
GO:1990170
IEA
PLAZA Integrative Orthologystress response to cadmium ion SPAC22F3.10c
GO:0035120
IEA
PLAZA Integrative Orthologypost-embryonic appendage morphogenesis FBgn0040319
GO:0120039
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection morphogenesis FBgn0040319
GO:0046937
IEA
PLAZA Integrative Orthologyphytochelatin metabolic process SPAC22F3.10c
GO:0120036
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection organization FBgn0040319
GO:0060562
IEA
PLAZA Integrative Orthologyepithelial tube morphogenesis FBgn0040319
GO:0046938
IEA
PLAZA Integrative Orthologyphytochelatin biosynthetic process SPAC22F3.10c
GO:0071702
IEA
PLAZA Integrative Orthologyorganic substance transport SPAC22F3.10c
GO:0098849
IEA
PLAZA Integrative Orthologycellular detoxification of cadmium ion SPAC22F3.10c
GO:0097237
IEA
PLAZA Integrative Orthologycellular response to toxic substance SPAC22F3.10c
GO:0048666
IEA
PLAZA Integrative Orthologyneuron development FBgn0040319
GO:0048667
IEA
PLAZA Integrative Orthologycell morphogenesis involved in neuron differentiation FBgn0040319
GO:0031175
IEA
PLAZA Integrative Orthologyneuron projection development FBgn0040319
GO:0048707
IEA
PLAZA Integrative Orthologyinstar larval or pupal morphogenesis FBgn0040319
GO:0071705
IEA
PLAZA Integrative Orthologynitrogen compound transport SPAC22F3.10c
GO:0097501
IEA
PLAZA Integrative Orthologystress response to metal ion SPAC22F3.10c
GO:0071276
IEA
PLAZA Integrative Orthologycellular response to cadmium ion SPAC22F3.10c
GO:0006811
IEA
PLAZA Integrative Orthologyion transport SPAC22F3.10c
GO:0006820
IEA
PLAZA Integrative Orthologyanion transport SPAC22F3.10c
GO:0060429
IEA
PLAZA Integrative Orthologyepithelium development FBgn0040319
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis FBgn0040319
GO:0007476
IEA
PLAZA Integrative Orthologyimaginal disc-derived wing morphogenesis FBgn0040319
GO:0048812
IEA
PLAZA Integrative Orthologyneuron projection morphogenesis FBgn0040319
GO:0007472
IEA
PLAZA Integrative Orthologywing disc morphogenesis FBgn0040319
GO:0015711
IEA
PLAZA Integrative Orthologyorganic anion transport SPAC22F3.10c
GO:0015833
IEA
PLAZA Integrative Orthologypeptide transport SPAC22F3.10c
GO:0072337
IEA
PLAZA Integrative Orthologymodified amino acid transport SPAC22F3.10c
GO:0071248
IEA
PLAZA Integrative Orthologycellular response to metal ion SPAC22F3.10c
GO:0002009
IEA
PLAZA Integrative Orthologymorphogenesis of an epithelium FBgn0040319
GO:0071241
IEA
PLAZA Integrative Orthologycellular response to inorganic substance SPAC22F3.10c
GO:0006974
IEA
PLAZA Integrative Orthologycellular response to DNA damage stimulus FBgn0040319
GO:0061687
IEA
PLAZA Integrative Orthologydetoxification of inorganic compound SPAC22F3.10c
GO:0042542
IEA
PLAZA Integrative Orthologyresponse to hydrogen peroxide YJL101C
GO:0000902
IEA
PLAZA Integrative Orthologycell morphogenesis FBgn0040319
GO:0000904
IEA
PLAZA Integrative Orthologycell morphogenesis involved in differentiation FBgn0040319
GO:0061564
IEA
PLAZA Integrative Orthologyaxon development FBgn0040319
GO:0019748
IEA
PLAZA Integrative Orthologysecondary metabolic process SPAC22F3.10c
GO:0072348
IEA
PLAZA Integrative Orthologysulfur compound transport SPAC22F3.10c
GO:0007409
IEA
PLAZA Integrative Orthologyaxonogenesis FBgn0040319
GO:0048513
IEA
PLAZA Integrative Orthologyanimal organ development FBgn0040319
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0040319
GO:0009791
IEA
PLAZA Integrative Orthologypost-embryonic development FBgn0040319
GO:0030030
IEA
PLAZA Integrative Orthologycell projection organization FBgn0040319
GO:0042939
IEA
PLAZA Integrative Orthologytripeptide transport SPAC22F3.10c

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0050662
IPI
Genome Projectcoenzyme binding
GO:0050662
IPI
Gene Ontologycoenzyme binding8 9
GO:0046982
IEA
Genome Projectprotein heterodimerization activity
GO:0043531
IDA
Genome ProjectADP binding
GO:0043531
IDA
Gene OntologyADP binding10
GO:0016595
IDA
Genome Projectglutamate binding
GO:0016595
IDA
Gene Ontologyglutamate binding9
GO:0005524
IEA
Genome ProjectATP binding
GO:0004357
IDA, IMP
Genome Projectglutamate-cysteine ligase activity
GO:0004357
IDA, IMP
Gene Ontologyglutamate-cysteine ligase activity3 5 11
GO:0000287
IDA
Genome Projectmagnesium ion binding
GO:0000287
IDA
Gene Ontologymagnesium ion binding10
GO:0046911
IEA
PLAZA Integrative Orthologymetal chelating activity SPAC22F3.10c

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0017109
IEA
Genome Projectglutamate-cysteine ligase complex
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0048471
IEA
PLAZA Integrative Orthologyperinuclear region of cytoplasm FBgn0040319
GO:0005634
IEA
PLAZA Integrative Orthologynucleus SPAC22F3.10c
GO:0043231
IEA
PLAZA Integrative Orthologyintracellular membrane-bounded organelle SPAC22F3.10c
GO:0043227
IEA
PLAZA Integrative Orthologymembrane-bounded organelle SPAC22F3.10c
GO:0043226
IEA
PLAZA Integrative Orthologyorganelle SPAC22F3.10c
GO:0043229
IEA
PLAZA Integrative Orthologyintracellular organelle SPAC22F3.10c

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR004308Glutamate-cysteine ligase catalytic subunit

No MapMan annotations defined for this gene.
KeggID Description
K11204GCLC; glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]
No chloroplast target sequence found.