Gene: AT5G63920 (Arabidopsis thaliana)

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Gene Identifier
AT5G63920
Transcript Identifier
AT5G63920.1
Gene Type
Coding gene
Location
5 : 25574533-25581230 : positive

Family Information

Homologous gene family
HOM02SEM000849
(54 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM000955
(51 genes in 26 species)
specific family

Descriptions

Description
topoisomerase 3alpha
Curated Summary
Encodes topoisomerase 3alpha. Suppresses somatic crossovers. Essential for resolution of meiotic recombination intermediates.
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Identifiers

Type Value
aliasAtTOP3alpha
aliasTOP3A

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006265
ISS
Gene OntologyDNA topological change1
GO:0006265
IEA
InterProDNA topological change
GO:0051321
IMP
Gene Ontologymeiotic cell cycle2 3
GO:0007059
IMP
Gene Ontologychromosome segregation2 3
GO:0006281
IMP
Gene OntologyDNA repair2 3
GO:0000712
IMP
Gene Ontologyresolution of meiotic recombination intermediates2 3
GO:0000278
IMP
Gene Ontologymitotic cell cycle2 3
GO:0006268
ISS
Gene OntologyDNA unwinding involved in DNA replication1
GO:0031323
IEA
PLAZA Integrative Orthologyregulation of cellular metabolic process YLR234W
GO:0050789
IEA
PLAZA Integrative Orthologyregulation of biological process YLR234W
GO:0080090
IEA
PLAZA Integrative Orthologyregulation of primary metabolic process YLR234W
GO:0010646
IEA
PLAZA Integrative Orthologyregulation of cell communication ENSG00000177302
GO:0044271
IEA
PLAZA Integrative Orthologycellular nitrogen compound biosynthetic process YLR234W
GO:0000002
IEA
PLAZA Integrative Orthologymitochondrial genome maintenance FBgn0040268
GO:0007005
IEA
PLAZA Integrative Orthologymitochondrion organization FBgn0040268
GO:0042246
IEA
PLAZA Integrative Orthologytissue regeneration FBgn0040268
GO:0048589
IEA
PLAZA Integrative Orthologydevelopmental growth FBgn0040268
GO:0044786
IEA
PLAZA Integrative Orthologycell cycle DNA replication SPBC16G5.12c
GO:0006278
IEA
PLAZA Integrative OrthologyRNA-dependent DNA biosynthetic process YLR234W
GO:0000723
IEA
PLAZA Integrative Orthologytelomere maintenance YLR234W
GO:0007004
IEA
PLAZA Integrative Orthologytelomere maintenance via telomerase YLR234W
GO:0000724
IEA
PLAZA Integrative Orthologydouble-strand break repair via homologous recombination FBgn0040268
GO:0000725
IEA
PLAZA Integrative Orthologyrecombinational repair FBgn0040268
GO:0007165
IEA
PLAZA Integrative Orthologysignal transduction ENSG00000177302
GO:0060255
IEA
PLAZA Integrative Orthologyregulation of macromolecule metabolic process YLR234W
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process FBgn0040268
GO:0031099
IEA
PLAZA Integrative Orthologyregeneration FBgn0040268
GO:0010833
IEA
PLAZA Integrative Orthologytelomere maintenance via telomere lengthening YLR234W
GO:0019222
IEA
PLAZA Integrative Orthologyregulation of metabolic process YLR234W
GO:0140014
IEA
PLAZA Integrative Orthologymitotic nuclear division YLR234W
GO:0018130
IEA
PLAZA Integrative Orthologyheterocycle biosynthetic process YLR234W
GO:0043570
IEA
PLAZA Integrative Orthologymaintenance of DNA repeat elements SPBC16G5.12c
GO:1902969
IEA
PLAZA Integrative Orthologymitotic DNA replication SPBC16G5.12c
GO:0048583
IEA
PLAZA Integrative Orthologyregulation of response to stimulus ENSG00000177302
GO:0006302
IEA
PLAZA Integrative Orthologydouble-strand break repair FBgn0040268
GO:0043007
IEA
PLAZA Integrative Orthologymaintenance of rDNA SPBC16G5.12c
GO:0006301
IEA
PLAZA Integrative Orthologypostreplication repair SPBC16G5.12c
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development FBgn0040268
GO:0009611
IEA
PLAZA Integrative Orthologyresponse to wounding FBgn0040268
GO:1902531
IEA
PLAZA Integrative Orthologyregulation of intracellular signal transduction ENSG00000177302
GO:0007154
IEA
PLAZA Integrative Orthologycell communication ENSG00000177302
GO:1901362
IEA
PLAZA Integrative Orthologyorganic cyclic compound biosynthetic process YLR234W
GO:0019219
IEA
PLAZA Integrative Orthologyregulation of nucleobase-containing compound metabolic process YLR234W
GO:0019438
IEA
PLAZA Integrative Orthologyaromatic compound biosynthetic process YLR234W
GO:0034654
IEA
PLAZA Integrative Orthologynucleobase-containing compound biosynthetic process YLR234W
GO:0000070
IEA
PLAZA Integrative Orthologymitotic sister chromatid segregation YLR234W
GO:0072331
IEA
PLAZA Integrative Orthologysignal transduction by p53 class mediator ENSG00000177302
GO:0023052
IEA
PLAZA Integrative Orthologysignaling ENSG00000177302
GO:0042592
IEA
PLAZA Integrative Orthologyhomeostatic process YLR234W
GO:0023051
IEA
PLAZA Integrative Orthologyregulation of signaling ENSG00000177302
GO:0009888
IEA
PLAZA Integrative Orthologytissue development FBgn0040268
GO:0040007
IEA
PLAZA Integrative Orthologygrowth FBgn0040268
GO:0009966
IEA
PLAZA Integrative Orthologyregulation of signal transduction ENSG00000177302
GO:1901796
IEA
PLAZA Integrative Orthologyregulation of signal transduction by p53 class mediator ENSG00000177302
GO:0007064
IEA
PLAZA Integrative Orthologymitotic sister chromatid cohesion YLR234W
GO:0007062
IEA
PLAZA Integrative Orthologysister chromatid cohesion YLR234W
GO:0065008
IEA
PLAZA Integrative Orthologyregulation of biological quality YLR234W
GO:0065007
IEA
PLAZA Integrative Orthologybiological regulation YLR234W
GO:0035556
IEA
PLAZA Integrative Orthologyintracellular signal transduction ENSG00000177302
GO:0032200
IEA
PLAZA Integrative Orthologytelomere organization YLR234W
GO:0071897
IEA
PLAZA Integrative OrthologyDNA biosynthetic process YLR234W
GO:0050794
IEA
PLAZA Integrative Orthologyregulation of cellular process YLR234W
GO:0042060
IEA
PLAZA Integrative Orthologywound healing FBgn0040268
GO:0060249
IEA
PLAZA Integrative Orthologyanatomical structure homeostasis YLR234W
GO:0000731
IEA
PLAZA Integrative OrthologyDNA synthesis involved in DNA repair ENSG00000177302
GO:0000732
IEA
PLAZA Integrative Orthologystrand displacement ENSG00000177302
GO:0051171
IEA
PLAZA Integrative Orthologyregulation of nitrogen compound metabolic process YLR234W
GO:0000018
IEA
PLAZA Integrative Orthologyregulation of DNA recombination YLR234W
GO:0051052
IEA
PLAZA Integrative Orthologyregulation of DNA metabolic process YLR234W
GO:1903047
IEA
PLAZA Integrative Orthologymitotic cell cycle process SPBC16G5.12c
GO:0000819
IEA
PLAZA Integrative Orthologysister chromatid segregation YLR234W
GO:0033260
IEA
PLAZA Integrative Orthologynuclear DNA replication SPBC16G5.12c

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003677
ISS
Gene OntologyDNA binding1
GO:0003677
IEA
InterProDNA binding
GO:0003916
ISS
Gene OntologyDNA topoisomerase activity1
GO:0003916
IEA
InterProDNA topoisomerase activity
GO:0003676
IEA
InterPronucleic acid binding
GO:0008270
IEA
InterProzinc ion binding
GO:0003917
IEA
InterProDNA topoisomerase type I activity
GO:0005515
IEA
PLAZA Integrative Orthologyprotein binding SPBC16G5.12c

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005694
IEA
InterProchromosome
GO:0005634
ISM
Gene Ontologynucleus4
GO:0005739
IEA
PLAZA Integrative Orthologymitochondrion SPBC16G5.12c
GO:0070013
IEA
PLAZA Integrative Orthologyintracellular organelle lumen ENSG00000177302
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm SPBC16G5.12c
GO:0044427
IEA
PLAZA Integrative Orthologychromosomal part SPBC16G5.12c
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part SPBC16G5.12c
GO:0044428
IEA
PLAZA Integrative Orthologynuclear part ENSG00000177302
GO:0031974
IEA
PLAZA Integrative Orthologymembrane-enclosed lumen ENSG00000177302
GO:0005654
IEA
PLAZA Integrative Orthologynucleoplasm ENSG00000177302
GO:0035861
IEA
PLAZA Integrative Orthologysite of double-strand break SPBC16G5.12c
GO:0031422
IEA
PLAZA Integrative OrthologyRecQ helicase-Topo III complex SPBC16G5.12c
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex SPBC16G5.12c
GO:0031981
IEA
PLAZA Integrative Orthologynuclear lumen ENSG00000177302
GO:0044451
IEA
PLAZA Integrative Orthologynucleoplasm part ENSG00000177302
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part SPBC16G5.12c
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part SPBC16G5.12c
GO:0043233
IEA
PLAZA Integrative Orthologyorganelle lumen ENSG00000177302
GO:0016605
IEA
PLAZA Integrative OrthologyPML body ENSG00000177302
GO:0016604
IEA
PLAZA Integrative Orthologynuclear body ENSG00000177302
GO:0090734
IEA
PLAZA Integrative Orthologysite of DNA damage SPBC16G5.12c

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR013497DNA topoisomerase, type IA, central
IPR006171TOPRIM domain
IPR001878Zinc finger, CCHC-type
IPR013824DNA topoisomerase, type IA, central region, subdomain 1
IPR013826DNA topoisomerase, type IA, central region, subdomain 3
IPR000380DNA topoisomerase, type IA
IPR010666Zinc finger, GRF-type
IPR013498DNA topoisomerase, type IA, zn finger
IPR023406DNA topoisomerase, type IA, active site
IPR003601DNA topoisomerase, type IA, domain 2
IPR003602DNA topoisomerase, type IA, DNA-binding domain
IPR023405DNA topoisomerase, type IA, core domain

No MapMan annotations defined for this gene.
KeggID Description
K03165TOP3; DNA topoisomerase III [EC:5.6.2.1]
No chloroplast target sequence found.