Gene: AT2G41500 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT2G41500
Transcript Identifier
AT2G41500.1
Gene Type
Coding gene
Location
2 : 17304319-17306855 : negative

Family Information

Homologous gene family
HOM02SEM002698
(27 genes in 23 species)
specific family
Orthologous gene family
ORTHO02SEM003047
(26 genes in 23 species)
specific family

Descriptions

Description
WD-40 repeat family protein / small nuclear ribonucleoprotein Prp4p-related
Curated Summary
Encodes LACHESIS (LIS), a protein with seven WD40 repeats. LIS is homologous to the yeast splicing factor PRP4 which is associated with the U4/U6 complex of the spliceosome. LIS is involved in a mechanism that prevents accessory cells from adopting gametic cell fate: lis mutant forms supernumerary egg cells.
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Identifiers

Type Value
uniprotO22212
aliasLACHESIS
aliasLIS
aliasEMB2776

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0009553
IMP
Gene Ontologyembryo sac development1 2
GO:0007267
IMP
Gene Ontologycell-cell signaling1 2
GO:0009560
IMP
Gene Ontologyembryo sac egg cell differentiation3 4
GO:0001709
IMP
Gene Ontologycell fate determination3 4
GO:0000398
ISS
Gene OntologymRNA splicing, via spliceosome3 4
GO:0034247
IEA
PLAZA Integrative OrthologysnoRNA splicing YPR178W
GO:0016074
IEA
PLAZA Integrative OrthologysnoRNA metabolic process YPR178W
GO:0043144
IEA
PLAZA Integrative OrthologysnoRNA processing YPR178W
GO:0034660
IEA
PLAZA Integrative OrthologyncRNA metabolic process YPR178W
GO:0034470
IEA
PLAZA Integrative OrthologyncRNA processing YPR178W

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IEA
InterProprotein binding
GO:0000166
ISS
Gene Ontologynucleotide binding5
GO:0030621
IEA
PLAZA Integrative OrthologyU4 snRNA binding FBgn0036733
GO:0017069
IEA
PLAZA Integrative OrthologysnRNA binding FBgn0036733
GO:0003723
IEA
PLAZA Integrative OrthologyRNA binding FBgn0036733
GO:0017070
IEA
PLAZA Integrative OrthologyU6 snRNA binding FBgn0036733
GO:0003676
IEA
PLAZA Integrative Orthologynucleic acid binding FBgn0036733

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016607
IDA
Gene Ontologynuclear speck6 7
GO:0080008
ISS
Gene OntologyCul4-RING E3 ubiquitin ligase complex8 9
GO:0005681
ISS
Gene Ontologyspliceosomal complex3 4
GO:0005634
ISM
Gene Ontologynucleus10
GO:0030532
IEA
PLAZA Integrative Orthologysmall nuclear ribonucleoprotein complex SPAC227.12
GO:0071005
IEA
PLAZA Integrative OrthologyU2-type precatalytic spliceosome ENSG00000136875
GO:0005829
IEA
PLAZA Integrative Orthologycytosol SPAC227.12
GO:0097525
IEA
PLAZA Integrative Orthologyspliceosomal snRNP complex SPAC227.12
GO:0097526
IEA
PLAZA Integrative Orthologyspliceosomal tri-snRNP complex SPAC227.12
GO:0071001
IEA
PLAZA Integrative OrthologyU4/U6 snRNP ENSG00000136875
GO:0046540
IEA
PLAZA Integrative OrthologyU4/U6 x U5 tri-snRNP complex SPAC227.12
GO:0071011
IEA
PLAZA Integrative Orthologyprecatalytic spliceosome ENSG00000136875
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm SPAC227.12
GO:0071013
IEA
PLAZA Integrative Orthologycatalytic step 2 spliceosome FBgn0036733
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part SPAC227.12
GO:0005684
IEA
PLAZA Integrative OrthologyU2-type spliceosomal complex ENSG00000136875
GO:0015030
IEA
PLAZA Integrative OrthologyCajal body ENSG00000136875
GO:0120114
IEA
PLAZA Integrative OrthologySm-like protein family complex SPAC227.12

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR015943WD40/YVTN repeat-like-containing domain superfamily
IPR027106U4/U6 small nuclear ribonucleoprotein Prp4
IPR001680WD40 repeat
IPR014906Pre-mRNA processing factor 4 (PRP4)-like
IPR020472G-protein beta WD-40 repeat
IPR019775WD40 repeat, conserved site
IPR017986WD40-repeat-containing domain

No MapMan annotations defined for this gene.
KeggID Description
K12662PRPF4, PRP4; U4/U6 small nuclear ribonucleoprotein PRP4
No chloroplast target sequence found.