Gene: AT5G48000 (Arabidopsis thaliana)

Overview

Gene Identifier
AT5G48000
Transcript Identifier
AT5G48000.1
Gene Type
Coding gene
Location
5 : 19444313-19447790 : negative

Family

Gene family
HOM03D000054
(839 genes in 16 species)
specific family

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Descriptions

Description
cytochrome P450, family 708, subfamily A, polypeptide 2
Curated Summary
Encodes a member of the CYP708A family of cytochrome P450 enzymes. THAH appears to add a hydroxyl group to the triterpene thalianol. thah1 mutants have an elevated accumulation of thalianol. thah1-1 mutants have longer roots than wild type plants. Thalian-diol and desaturated thalian-diol are lost from the root extracts of thah1-1 mutants. Overexpression of the sequence from At5g48000.1 rescues the thah1-1 mutant phenotype (Field 2008); it is unknown whether the shorter sequences associated with other gene models would provide functional complementation.
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Identifiers

Identifier Name
aliasTHALIANOL HYDROXYLASE
aliasCYP708 A2
aliasTHALIANOL HYDROXYLASE 1
aliasTHAH1
aliasCYP708A2
aliasCYTOCHROME P450, FAMILY 708, SUBFAMILY A, POLYPEPTIDE 2
aliasTHAH
alias'cytochrome P450, family 708, subfamily A, polypeptide 2'
uniprotQ8L7D5

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0048364IMP, RCAGene Ontologyroot development1 2
GO:0080003IMPGene Ontologythalianol metabolic process1
GO:0006826RCAGene Ontologyiron ion transport1
GO:0009653RCAGene Ontologyanatomical structure morphogenesis1
GO:0010106RCAGene Ontologycellular response to iron ion starvation1
GO:0010167RCAGene Ontologyresponse to nitrate1
GO:0015706RCAGene Ontologynitrate transport1
GO:0048527RCAGene Ontologylateral root development1
GO:0048589RCAGene Ontologydevelopmental growth1
GO:0048765RCAGene Ontologyroot hair cell differentiation1
GO:0048869RCAGene Ontologycellular developmental process1
GO:0055114IEAInterProoxidation-reduction process
GO:0044699IEAPLAZA Homologysingle-organism processHOM03D000064
GO:0044710IEAPLAZA Homologysingle-organism metabolic processHOM03D000064
GO:0008152IEAPLAZA Homologymetabolic processHOM03D000064

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0019825ISSGene Ontologyoxygen binding
GO:0080014IMPGene Ontologythalianol hydroxylase activity1
GO:0004497IEAUniProtmonooxygenase activity1 2 3 4
GO:0005506IEAUniProtiron ion binding1 2 3 4
GO:0016705IEAUniProtoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen1 2 3 4
GO:0020037IEAUniProtheme binding1 2 3 4
GO:0043169IEAPLAZA Homologycation bindingHOM03D000064
GO:0043167IEAPLAZA Homologyion bindingHOM03D000064
GO:0046914IEAPLAZA Homologytransition metal ion bindingHOM03D000064
GO:0003824IEAPLAZA Homologycatalytic activityHOM03D000064
GO:0046906IEAPLAZA Homologytetrapyrrole bindingHOM03D000064
GO:0046872IEAPLAZA Homologymetal ion bindingHOM03D000064
GO:1901363IEAPLAZA Homologyheterocyclic compound bindingHOM03D000064
GO:0005488IEAPLAZA HomologybindingHOM03D000064
GO:0016491IEAPLAZA Homologyoxidoreductase activityHOM03D000064
GO:0097159IEAPLAZA Homologyorganic cyclic compound bindingHOM03D000064

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0009507ISMGene Ontologychloroplast
GO:0005783IDAGene Ontologyendoplasmic reticulum1
GO:0016021IEAUniProtintegral to membrane1 2 3 4

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Computational Reviewed Evidence
Electronic Evidence
Experimental Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001128Cytochrome P450
IPR002403Cytochrome P450, E-class, group IV
IPR017972Cytochrome P450, conserved site
Mapman id Description
26.10misc.cytochrome P450
No SignalP domains detected for this gene.