Gene: AT4G34640 (Arabidopsis thaliana)

Overview

Gene Identifier
AT4G34640
Transcript Identifier
AT4G34640.1
Gene Type
Coding gene
Location
4 : 16538489-16541655 : positive

Family

Gene family
HOM03D004286
(30 genes in 16 species)
specific family
Subfamily
ORTHO03D002131
(20 genes in 16 species)
specific family

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Descriptions

Description
squalene synthase 1
Curated Summary
Encodes squalene synthase, which converts two molecules of farnesyl diphosphate (FPP) into squalene via an intermediate: presqualene diphosphate (PSPP). It is generally thought to be one of the key enzymes of sterol biosynthesis, since it catalyzes the first pathway-specific reaction of the sterol branch of the isoprenoid pathway.
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Identifiers

Identifier Name
aliasERG9
aliasSQS1
aliassqualene synthase 1
uniprotP53799

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006084RCAGene Ontologyacetyl-CoA metabolic process1
GO:0006598RCAGene Ontologypolyamine catabolic process1
GO:0009698RCAGene Ontologyphenylpropanoid metabolic process1
GO:0016126TAS, RCAUniProtsterol biosynthetic process1 2 3 4 5 6
GO:0016132RCAGene Ontologybrassinosteroid biosynthetic process1
GO:0042398RCAGene Ontologycellular modified amino acid biosynthetic process1
GO:0008610IEAInterProlipid biosynthetic process
GO:0009058IEAInterProbiosynthetic process
GO:0008299IEAUniProtisoprenoid biosynthetic process1 2 3 4

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004310IDA, ISSIEA, UniProtfarnesyl-diphosphate farnesyltransferase activity1 2 3 4 5
GO:0016765IEAInterProtransferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0016740IEAInterProtransferase activity
GO:0016491IEAUniProtoxidoreductase activity1 2 3 4
GO:0051996IEAUniProtsqualene synthase activity1 2 3 4

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005783IDAGene Ontologyendoplasmic reticulum1
GO:0005886IDAUniProtplasma membrane1 2 3 4 5
GO:0005789TASUniProtendoplasmic reticulum membrane1 2 3 4 5
GO:0016021IEAUniProtintegral to membrane1 2 3 4

Color Legend

Computational Reviewed Evidence
Electronic Evidence
Experimental Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR008949Terpenoid synthase
IPR019845Squalene/phytoene synthase, conserved site
IPR002060Squalene/phytoene synthase
IPR006449Farnesyl-diphosphate farnesyltransferase
Mapman id Description
11.8.8lipid metabolism.exotics (steroids, squalene etc).squalene synthase
No SignalP domains detected for this gene.