PLAZA Gymnosperms gene overview : AT1G08370

Gene: AT1G08370 (Arabidopsis thaliana)

Loading...please wait

Curated Summary: Encodes DCP1 involved in mRNA decapping. DCP1 forms a mRNA decapping complex with DCP2 (At5g13570) and VCS (VARICOSE) (At3g13300). However, unlike DCP2, DCP1 itself does not have mRNA decapping activity in vitro. DCP1, DCP2 and VCS colocalize in cytoplasmic loci, which are putative Arabidopsis mRNA processing bodies. Null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. These mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology. The protein was shown by immunoprecipitation not to interact with DCP2.

GO term	Evidence(s)	Provider	Description	Source
GO:0031087	IDA	UniProt	deadenylation-independent decapping of nuclear-transcribed mRNA	1 2 3 4 5
GO:0000278	RCA	Gene Ontology	mitotic cell cycle	1
GO:0006396	RCA	Gene Ontology	RNA processing	1
GO:0006397	IEA	UniProt	mRNA processing	1 2 3 4

GO term	Evidence(s)	Provider	Description	Source
GO:0005515	IPI	Gene Ontology	protein binding	1
GO:0042803	IPI	Gene Ontology	protein homodimerization activity	1
GO:0050072	IDA	Gene Ontology	m7G(5')pppN diphosphatase activity	1
GO:0016787	IEA	UniProt	hydrolase activity	1 2 3 4

GO term	Evidence(s)	Provider	Description	Source
GO:0005634	ISM	Gene Ontology	nucleus
GO:0000932	IDA, NAS,	UniProt	cytoplasmic mRNA processing body	1 2 3 4 5 6
GO:0005737	IDA	Gene Ontology	cytoplasm	1

Computational Reviewed Evidence

Electronic Evidence

Experimental Evidence

InterPro	Description
IPR010334	Dcp1-like decapping
IPR011993	Pleckstrin homology-like domain

Mapman id	Description
27.1	RNA.processing

No SignalP domains detected for this gene.