InterPro domain: IPR013946

NCA2 (Nuclear Control of ATPase), is one of the two nuclear genes involved in the control of mitochondrial expression of subunits 6 and 8 of the Fo-F1 ATP synthase in Saccharomyces cerevisiae. Mutations in either NCA2 or NCA3 ( IPR005556 ) dramatically lower the level of the co-transcript encoding subunits 6 and 8 [ 1 , 2 ].

This entry also includes DGS1 from Arabidopsis. DGS1 is a mitochondrial outer membrane protein involved in galactoglycerolipid biosynthesis [ 3 ].

1. NCA2, a second nuclear gene required for the control of mitochondrial synthesis of subunits 6 and 8 of ATP synthase in Saccharomyces cerevisiae. J. Mol. Biol. 247, 588-96
2. NCA3, a nuclear gene involved in the mitochondrial expression of subunits 6 and 8 of the Fo-F1 ATP synthase of S. cerevisiae. Curr. Genet. 27, 409-16
3. Phosphate regulation of lipid biosynthesis in Arabidopsis is independent of the mitochondrial outer membrane DGS1 complex. Plant Physiol. 152, 1951-9