InterPro domain: IPR001925
General Information
- Identifier IPR001925
- Description Porin, eukaryotic type
- Number of genes 891
- Gene duplication stats Loading...
- Associated GO terms GO:0008308 GO:0098656 GO:0005741
Abstract
Eukaryotic mitochondrial porins are voltage-dependent anion-selective channels (VDAC) that behave as general diffusion pores for small hydrophilic molecules [ 1 , 2 , 3 , 4 ]. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV.
The proteins are composed of between 12 to 16 beta-strands that span the mitochondrial outer membrane. Yeast contains two members of this family (genes POR1 and POR2); vertebrates have at least three members (genes VDAC1, VDAC2 and VDAC3) [ 5 , 6 ].
1. Permeation of hydrophilic solutes through mitochondrial outer membranes: review on mitochondrial porins. Biochim. Biophys. Acta 1197, 167-96
2. The 'ins' and 'outs' of mitochondrial membrane channels. Trends Biochem. Sci. 17, 315-20
3. The biogenesis and function of eukaryotic porins. Experientia 46, 146-53
4. Molecular genetics of the VDAC ion channel: structural model and sequence analysis. J. Bioenerg. Biomembr. 19, 341-50
5. A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8. Genomics 36, 192-6
6. VDAC isoforms in mammals. Biochim. Biophys. Acta 1818, 1466-76