InterPro domain: IPR037382

There are two forms of the RSC remodelling complex in yeast, differing only in whether they contain the Rsc1 or Rsc2 subunits [ 1 ]. Rsc1 and Rsc2 have similar structures including two bromodomains and a BAH (Bromo-adjacent homology) domain [ 2 ].

There is only a single orthologue of Rsc1/Rsc2 in human cells, a protein designated BAF180 (or Polybromo), which appears to be a fusion protein of Rsc1, Rsc2 and a third RSC protein, Rsc4. BAF180 contains six bromodomains, followed by two BAH domains and an HMG domain close to the C terminus [ 2 ]. BAF180 is a subunit of the PBAF (or SWI/SNF-B) remodelling complex, which affects the transcription of many genes [ 3 , 4 ]. Many human cancers have mutations in the gene encoding BAF180 [ 5 , 6 ].

1. Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains. Mol. Cell 4, 715-23
2. The BAH domain, polybromo and the RSC chromatin remodelling complex. Gene 268, 1-7
3. Composition and functional specificity of SWI2/SNF2 class chromatin remodeling complexes. Biochim. Biophys. Acta 1681, 59-73
4. Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Proc. Natl. Acad. Sci. U.S.A. 107, 14280-5
5. BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer. Cancer Res. 68, 1667-74
6. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469, 539-42