InterPro domain: IPR030296
General Information
- Identifier IPR030296
- Description Probable ABC transporter ATP-binding protein MlaF/Mkl
- Number of genes 1
- Gene duplication stats Loading...
Abstract
Intermembrane phospholipid transport system ATP-binding protein MlaF is part of the ABC transporter complex MlaFEDB that maintains lipid asymmetry in the Gram-negative outer membrane [ 1 ]. MlaF is predicted to be nucleotide-binding domain of the complex [ 2 ]. This entry also includes Mkl from Mycobacterium [ 3 ], and Rhodococcus jostii RHA1 protein, ro02744 (UniProt: Q0SD37 ), which is an ATPase orthologous to mceG, the Mlk ATPase gene of M. tuberculosis. It may function in the RHA1 Mce4 system, which has a role in steroid uptake [ 4 ].
1. An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane. Proc. Natl. Acad. Sci. U.S.A. 106, 8009-14
2. Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry. Elife 5, 60
3. A phylogenomic analysis of the Actinomycetales mce operons. BMC Genomics 8
4. The actinobacterial mce4 locus encodes a steroid transporter. J. Biol. Chem. 283, 35368-74