InterPro domain: IPR024925

Malonyl CoA-acyl carrier protein transacylases transfer the malonyl moiety from coenzyme A to acyl-carrier protein. These include proteins involved in fatty acid biosynthesis (FabD), antibiotic biosynthesis (PksC) and the McdH subunit of malonate decarboxylase [ 1 , 2 , 3 ].

1. Cloning, nucleotide sequence, and expression of the Escherichia coli fabD gene, encoding malonyl coenzyme A-acyl carrier protein transacylase. J. Bacteriol. 174, 2851-7
2. Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. Proc. Natl. Acad. Sci. U.S.A. 103, 8977-82
3. Formation of catalytically active acetyl-S-malonate decarboxylase requires malonyl-coenzyme A:acyl carrier protein transacylase as auxiliary enzyme [corrected] Eur. J. Biochem. 259, 181-7