InterPro domain: IPR024491

This entry represents an eukaryotic family of selenoproteins. It includes SelK, which seems to play an important role in protecting cells from endoplasmic reticulum stress-induced apoptosis [ 1 ]. It is required for Ca2+ flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration [ 2 ]. SelK is also required for palmitoylation of some proteins which regulates its stability and function [ 3 , 4 ]. SelG, which may be involved in regulating the redox state of the cell [ 5 ].

1. SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. Arch. Biochem. Biophys. 502, 137-43
2. Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. J. Immunol. 186, 2127-37
3. Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis. J. Leukoc. Biol. 93, 771-80
4. Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. Proc. Natl. Acad. Sci. U.S.A. 111, 16478-83
5. Selenium metabolism in Drosophila: selenoproteins, selenoprotein mRNA expression, fertility, and mortality. J. Biol. Chem. 276, 29798-804