InterPro domain: IPR007245
General Information
- Identifier IPR007245
- Description GPI transamidase component PIG-T
- Number of genes 157
- Gene duplication stats Loading...
- Associated GO terms GO:0016255 GO:0042765
Abstract
Phosphatidylinositol-glycan biosynthesis class T protein (PIG-T, also known as Gpi16 in budding yeasts) is a component of the glycosylphosphatidylinositol (GPI) trans-amidase complex that adds GPIs to newly synthesized proteins [ 1 ]. Mammalian GPI transamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for its function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U. The exact function of PIG-S is unclear [ 2 ].
1. The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p. Mol. Biol. Cell 12, 3295-306
2. A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase. J. Biol. Chem. 279, 6540-5