InterPro domain: IPR003750

This family has a TIM barrel-like fold with a deep C-terminal trefoil knot. The arrangement of its hydrophilic and hydrophobic surfaces are opposite to that of the classic TIM barrel proteins. It is likely to bind RNA [ 1 ], and may function as a methyltransferase [ 2 , 3 ].

1. Deep trefoil knot implicated in RNA binding found in an archaebacterial protein. Proteins 50, 177-83
2. Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases. BMC Bioinformatics 8, 73
3. RNomics and Modomics in the halophilic archaea Haloferax volcanii: identification of RNA modification genes. BMC Genomics 9, 470