protein_id NCBI protein ID NCBI locus tag Manual annotation GO ID Sacer ID Sacer STD ID Sacer function UniProt description PAS_157c00000 CAY67126.1 PAS_c159_0001 hypothetical protein PAS_157c00005 CAY67128.1 PAS_c157_0001 alcohol dehydrogenase GO:0008270;GO:0016491 NADP-dependent alcohol dehydrogenase C 1 PAS_157c00010 CAY67130.1 PAS_c157_0002 methionine sulfoxide reductase GO:0016671;GO:0019538 Probable peptide methionine sulfoxide reductase PAS_1g00000 PAS_1g00005 CAY67059.1 PAS_chr1-3_0003 Hypothetical protein PAS_1g00010 CAY67060.1 PAS_chr1-3_0004 Hexose transporter with moderate affinity for glucose Sugar transporter STL1 PAS_1g00015 CAY67061.1 PAS_chr1-3_0005 Hypothetical protein PAS_1g00020 PAS_1g00025 PAS_1g00030 CAY67062.1 PAS_chr1-3_0008 Hypothetical protein PAS_1g00035 PAS_1g00040 PAS_1g00045 CAY67063.1 PAS_chr1-3_0010 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 PAS_1g00050 CAY67064.1 PAS_chr1-3_0011 "Putative transporter, member of the sugar porter family" High-affinity glucose transporter PAS_1g00055 PAS_1g00060 CAY67065.1 PAS_chr1-3_0013 Hypothetical protein GO:0003824;GO:0008152 Uncharacterized isochorismatase family protein yddQ PAS_1g00065 CAY67066.1 PAS_chr1-3_0014 "Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane" GO:0016491;GO:0050660 Thiol-specific monooxygenase PAS_1g00070 CAY67067.1 PAS_chr1-3_0015 Hypothetical protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 PAS_1g00075 CAY67068.1 PAS_chr1-3_0016 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway GO:0008152;GO:0016491 3-oxoacyl-[acyl-carrier-protein] reductase PAS_1g00080 CAY67069.1 PAS_chr1-3_0017 High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters YLL055W YCT1 High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene Uncharacterized transporter PB1C11.03 PAS_1g00085 CAY67070.1 PAS_chr1-3_0018 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 Uncharacterized transcriptional regulatory protein C16G5.17 PAS_1g00090 PAS_1g00095 CAY67071.1 PAS_chr1-3_0020 Hypothetical protein PAS_1g00100 CAY67072.1 PAS_chr1-3_0290 hypothetical protein PAS_1g00105 CAY67073.1 PAS_chr1-3_0021 Putative protein of unknown function identified by fungal homology comparisons and RT-PCR Uncharacterized protein YLR154C-H/YLR156C-A/YLR157C-C/YLR159C-A PAS_1g00110 CAY67074.1 PAS_chr1-3_0022 "Transportin, cytosolic karyopherin beta 2" GO:0005488 YBR017C KAP104 Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis Importin subunit beta-2 PAS_1g00115 CAY67075.1 PAS_chr1-3_0023 "Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation" GO:0016810 YIR027C DAL1 "Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression" Allantoinase PAS_1g00120 CAY67076.1 PAS_chr1-3_0024 Succinate semialdehyde dehydrogenase GO:0016620 YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm Succinate-semialdehyde dehydrogenase [NADP+] PAS_1g00125 CAY67077.1 PAS_chr1-3_0025 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA GO:0003677;GO:0005524;GO:0006259;GO:0008094 YDR004W RAD57 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p DNA repair protein RAD57 PAS_1g00130 CAY67078.1 PAS_chr1-3_0026 Negative regulator of RNA polymerase III YDR005C MAF1 Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB Repressor of RNA polymerase III transcription MAF1 PAS_1g00135 CAY67079.1 PAS_chr1-3_0027 "Protein of unknown function, expression is regulated by phosphate levels" GO:0016020 YOL084W PHM7 "Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole" Uncharacterized membrane protein C24H6.13 PAS_1g00140 CAY67080.1 PAS_chr1-3_0028 Cytoplasmic inorganic pyrophosphatase (PPase) GO:0000287;GO:0004427;GO:0005737;GO:0006796 YBR011C IPP1 "Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase" Inorganic pyrophosphatase PAS_1g00145 CAY67081.1 PAS_chr1-3_0029 Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis GO:0003824;GO:0008152 YDR007W TRP1 "Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)" N-(5'-phosphoribosyl)anthranilate isomerase PAS_1g00150 CAY67082.1 PAS_chr1-3_0030 Subunit of heteropentameric Replication factor C (RF-C) GO:0003689;GO:0005524;GO:0005663;GO:0006260 YOL094C RFC4 "Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon" Replication factor C subunit 4 PAS_1g00155 CAY67083.1 PAS_chr1-3_0031 Component of the GARP (Golgi-associated retrograde protein) complex YDR484W VPS52 "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin" Vacuolar protein sorting-associated protein 52 PAS_1g00160 CAY67084.1 PAS_chr1-3_0032 EH domain-containing protein GO:0005509 YJL083W TAX4 "EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS" Increased rDNA silencing protein 4 PAS_1g00165 CAY67085.1 PAS_chr1-3_0033 Nuclear SAM-dependent mono-and asymmetric arginine dimethylating methyltransferase GO:0005737;GO:0006479;GO:0008276 YBR034C HMT1 "Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; also methylates ribosomal protein Rps2p" HNRNP arginine N-methyltransferase PAS_1g00170 CAY67086.1 PAS_chr1-3_0034 "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap" YDR012W RPL4B "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins" 60S ribosomal protein L4-A PAS_1g00175 YEL011W GLC3 "Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern" "1,4-alpha-glucan-branching enzyme " PAS_1g00180 CAY67087.1 PAS_chr1-3_0036 Putative protein of unknown function GO:0004871;GO:0007165 Uncharacterized transcriptional regulatory protein YBR239C PAS_1g00185 CAY67088.1 PAS_chr1-3_0037 Defining member of the SET3 histone deacetylase complex GO:0008270 YKR029C SET3 Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains SET domain-containing protein 3 PAS_1g00190 CAY67089.1 PAS_chr1-3_0038 Constituent of the mitochondrial import motor associated with the presequence translocase YJL104W PAM16 Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain Mitochondrial import inner membrane translocase subunit TIM16 PAS_1g00195 CAY67090.1 PAS_chr1-3_0039 Hypothetical protein GO:0003676;GO:0008270 Zinc finger CCCH domain-containing protein 3 PAS_1g00200 CAY67091.1 PAS_chr1-3_0040 Putative protein of unknown function GO:0005634;GO:0008270;GO:0030528;GO:0045449 YKR023W YKR023W "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Uncharacterized protein YKR023W PAS_1g00205 CAY67092.1 PAS_chr1-3_0041 Serine/threonine protein kinase involved in activation of meiosis YJL106W IME2 "Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p" Meiosis induction protein kinase IME2/SME1 PAS_1g00210 PAS_1g00215 CAY67093.1 PAS_chr1-3_0043 "Pheromone-regulated protein, predicted to have 5 transmembrane segments" Uncharacterized protein C7D4.12c PAS_1g00220 CAY67094.1 PAS_chr1-3_0044 "Pheromone-regulated protein, predicted to have 5 transmembrane segments" YJL108C PRM10 "Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation" Pheromone-regulated membrane protein 10 PAS_1g00225 CAY67095.1 PAS_chr1-3_0045 Essential RNA-binding G protein effector of mating response pathway GO:0003723 YJL080C SCP160 "Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins" Protein SCP160 PAS_1g00230 CAY67096.1 PAS_chr1-3_0046 Putative protein of unknown function YFR016C YFR016C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene Uncharacterized protein YFR016C PAS_1g00235 CAY67097.1 PAS_chr1-3_0047 Hypothetical protein PAS_1g00240 CAY67098.1 PAS_chr1-3_0048 Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex GO:0019787;GO:0043687;GO:0051246 YDR054C CDC34 "Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation" Ubiquitin-conjugating enzyme E2-34 kDa PAS_1g00245 CAY67099.1 PAS_chr1-3_0049 Hypothetical protein PAS_1g00250 CAY67100.1 PAS_chr1-3_0050 Regulatory subunit of Cdc7p-Dbf4p kinase complex GO:0003676;GO:0008270 YDR052C DBF4 "Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated" Protein DBF4 PAS_1g00255 CAY67101.1 PAS_chr1-3_0051 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 YCR106W RDS1 Zinc cluster transcription factor involved in conferring resistance to cycloheximide Uncharacterized transcriptional regulatory protein C15D4.02 PAS_1g00260 CAY67102.1 PAS_chr1-3_0052 "Biotin synthase, catalyzes the conversion of dethiobiotin to biotin" GO:0004076;GO:0009102 YGR286C BIO2 "Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant" "Biotin synthase, mitochondrial " PAS_1g00265 CAY67103.1 PAS_chr1-3_0053 Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins YPL096W PNG1 "Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation, localizes to the cytoplasm and nucleus, interacts with the DNA repair protein Rad23p" Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase PAS_1g00270 CAY67104.1 PAS_chr1-3_0291 hypothetical protein YER149C PEA2 "Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth" Protein PEA2 PAS_1g00275 CAY67105.1 PAS_chr1-3_0292 hypothetical protein Molybdopterin synthase sulfur carrier subunit PAS_1g00280 CAY67106.1 PAS_chr1-3_0054 Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex GO:0003824;GO:0005992 YDR074W TPS2 "Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway" Trehalose-phosphatase PAS_1g00285 CAY67107.1 PAS_chr1-3_0055 Class II abasic (AP) endonuclease involved in repair of DNA damage YBL019W APN2 Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII DNA-(apurinic or apyrimidinic site) lyase 2 PAS_1g00290 CAY67108.1 PAS_chr1-3_0056 Hypothetical protein YGL029W CGR1 Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress rRNA-processing protein CGR1 PAS_1g00295 CAY67109.1 PAS_chr1-3_0057 Component of both the Nup84 nuclear pore sub-complex and of the COPII complex YLR208W SEC13 "Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesicles" Protein transport protein SEC13 PAS_1g00300 CAY67110.1 PAS_chr1-3_0058 Hypothetical protein PAS_1g00305 CAY67111.1 PAS_chr1-3_0059 "Uracil permease, localized to the plasma membrane" GO:0015205;GO:0015931;GO:0016020 Allantoin permease PAS_1g00310 CAY67112.1 PAS_chr1-3_0293 hypothetical protein YIL067C YIL067C Uncharacterized protein of unknown function Uncharacterized protein YIL067C PAS_1g00315 CAY67113.1 PAS_chr1-3_0061 Phosphotyrosine-specific protein phosphatase GO:0004725;GO:0006470 Tyrosine-protein phosphatase Lar-like PAS_1g00320 CAY67114.1 PAS_chr1-3_0062 Integral membrane protein required for ER to Golgi transport YER074W-A YOS1 "Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p" Protein transport protein yos1 PAS_1g00325 CAY67115.1 PAS_chr1-3_0063 Molecular chaperone of the endoplasmic reticulum lumen YKL073W LHS1 "Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway" Heat shock protein 70 homolog LHS1 PAS_1g00330 CAY67116.1 PAS_chr1-3_0064 Hypothetical protein GO:0000166 Splicing factor U2AF 59 kDa subunit PAS_1g00335 CAY67117.1 PAS_chr1-3_0065 "Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex" GO:0005097;GO:0005622;GO:0032313 YMR055C BUB2 "Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage" Mitotic check point protein BUB2 PAS_1g00340 CAY67118.1 PAS_chr1-3_0066 "Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p)" GO:0015992;GO:0016020 "V-type proton ATPase subunit a, vacuolar isoform " PAS_1g00345 CAY67119.1 PAS_chr1-3_0067 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6 YDR137W RGP1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p PAS_1g00350 CAY67120.1 PAS_chr1-3_0068 "Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e" GO:0005622;GO:0042254 YLR340W RPP0 "Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302" 60S acidic ribosomal protein P0 PAS_1g00355 CAY67121.1 PAS_chr1-3_0069 Membrane protein of unknown function GO:0016020 YMR266W RSN1 Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane Uncharacterized protein RSN1 PAS_1g00360 CAY67122.1 PAS_chr1-3_0070 Mitochondrial inorganic pyrophosphatase GO:0000287;GO:0004427;GO:0005737;GO:0006796 "Inorganic pyrophosphatase, mitochondrial " PAS_1g00365 CAY67123.1 PAS_chr1-3_0071 Subunit of the nuclear pore complex (NPC) YML103C NUP188 "Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p" Nucleoporin NUP188 PAS_1g00370 CAY67124.1 PAS_chr1-3_0072 Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling GO:0000166 YMR268C PRP24 Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling U4/U6 snRNA-associated-splicing factor PRP24 PAS_1g00375 CAY67125.1 PAS_chr1-3_0073 Nucleolar protein of unknown function implicated in ribosome biogenesis YMR269W TMA23 Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes Protein TMA23 PAS_1g00380 CAY67127.1 PAS_chr1-3_0074 Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family YOR046C DBP5 Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination ATP-dependent RNA helicase DBP5 PAS_1g00385 CAY67129.1 PAS_chr1-3_0075 Hypothetical protein GO:0016021 YDR276C PMP3 "Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential" Plasma membrane proteolipid 3 homolog PAS_1g00390 CAY67131.1 PAS_chr1-3_0076 Hypothetical protein YOR045W TOM6 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex Mitochondrial import receptor subunit TOM6 PAS_1g00395 CAY67132.1 PAS_chr1-3_0077 Nuclear protein of unknown function GO:0006464 YOR052C YOR052C "Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid" AN1-type zinc finger protein YOR052C PAS_1g00400 CAY67133.1 PAS_chr1-3_0294 hypothetical protein GO:0008152;GO:0016787 YKR070W YKR070W "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Uncharacterized protein YKR070W PAS_1g00405 CAY67134.1 PAS_chr1-3_0078 S-adenosyl-L-methionine uroporphyrinogen III transmethylase GO:0006779 YKR069W MET1 "S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis" Uroporphyrinogen-III C-methyltransferase PAS_1g00410 CAY67135.1 PAS_chr1-3_0079 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae YOR051C YOR051C "Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts" Uncharacterized protein YOR051C PAS_1g00415 CAY67136.1 PAS_chr1-3_0080 Hydrophilic protein that acts in conjunction with SNARE proteins YKR068C BET3 Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex Transport protein particle 22 kDa subunit PAS_1g00420 CAY67137.1 PAS_chr1-3_0081 Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase GO:0008152;GO:0008415 YKR067W GPT2 Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis Glycerol-3-phosphate O-acyltransferase 1 PAS_1g00425 CAY67138.1 PAS_chr1-3_0082 Integral membrane protein YNL263C YIF1 "Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles" Protein transport protein yif1 PAS_1g00430 CAY67139.1 PAS_chr1-3_0083 Catalytic subunit of DNA polymerase (II) epsilon GO:0000166;GO:0003677;GO:0003887;GO:0006260 YNL262W POL2 "Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p" DNA polymerase epsilon catalytic subunit A PAS_1g00435 CAY67140.1 PAS_chr1-3_0084 Subunit of the origin recognition complex YNL261W ORC5 "Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing" Origin recognition complex subunit 5 PAS_1g00440 CAY67141.1 PAS_chr1-3_0295 hypothetical protein YNL260C YNL260C Putative protein of unknown function with similarity to a human protein overexpressed in oral cancers; essential gene with defects in anaerobic and filamentous growth; localizes to the nucleus and cytoplasm PAS_1g00445 CAY67142.1 PAS_chr1-3_0085 Hypothetical protein YHR156C LIN1 "Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication" Protein LIN1 PAS_1g00450 CAY67143.1 PAS_chr1-3_0086 Hypothetical protein PAS_1g00455 CAY67144.1 PAS_chr1-3_0087 Hypothetical protein GO:0030001;GO:0046872 YNL259C ATX1 "Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake" Metal homeostasis factor ATX1 PAS_1g00460 CAY67145.1 PAS_chr1-3_0088 Hypothetical protein YNL258C DSL1 Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p PAS_1g00465 CAY67146.1 PAS_chr1-3_0089 Protein chaperone involved in regulation of the HSP90 and HSP70 functions GO:0006457;GO:0031072;GO:0051082 DnaJ homolog subfamily B member 4 PAS_1g00470 CAY67147.1 PAS_chr1-3_0090 "Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p)" YHR013C ARD1 "Subunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells" N-terminal acetyltransferase A complex catalytic subunit ARD1 PAS_1g00475 CAY67148.1 PAS_chr1-3_0091 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi YDR472W TRS31 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic Transport protein particle subunit trs31 PAS_1g00480 CAY67149.1 PAS_chr1-3_0296 hypothetical protein GO:0005622;GO:0008270 YOR023C AHC1 "Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex" Protein AHC1 PAS_1g00485 CAY67150.1 PAS_chr1-3_0092 Putative protein of unknown function YOR021C YOR021C Putative protein of unknown function; YOR021C is not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism Uncharacterized protein YOR021C PAS_1g00490 CAY67151.1 PAS_chr1-3_0093 Protein with similarity to bovine phospholipase A1 GO:0003824 YOR022C YOR022C "Protein with similarity to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" "Probable phospholipase C20G8.02, mitochondrial " PAS_1g00495 CAY67152.1 PAS_chr1-3_0297 hypothetical protein YML030W AIM31 Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; may interact with respiratory chain complexes III or IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss HIG1 domain-containing protein YML030W PAS_1g00500 CAY67153.1 PAS_chr1-3_0094 "Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase" YDR148C KGD2 "Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated" "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial " PAS_1g00505 CAY67154.1 PAS_chr1-3_0095 Hypothetical protein PAS_1g00510 CAY67155.1 PAS_chr1-3_0096 Hypothetical protein YHR132W-A YHR132W-A Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance is decreased upon intracellular iron depletion Protein IGO2 PAS_1g00515 CAY67156.1 PAS_chr1-3_0097 Hypothetical protein YHR133C NSG1 "Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins" Protein NSG1 PAS_1g00520 CAY67157.1 PAS_chr1-3_0098 "DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator" Transcription factor MBP1 PAS_1g00525 PAS_1g00530 CAY67158.1 PAS_chr1-3_0298 hypothetical protein PAS_1g00535 CAY67159.1 PAS_chr1-3_0099 Transcription factor that activates transcription of genes GO:0003676 YDR146C SWI5 Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase Transcriptional factor SWI5 PAS_1g00540 CAY67160.1 PAS_chr1-3_0100 Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway YLR305C STT4 "Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization" Phosphatidylinositol 4-kinase STT4 PAS_1g00545 CAY67161.1 PAS_chr1-3_0101 "Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6" GO:0042256;GO:0043022 YPR016C TIF6 "Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits" Eukaryotic translation initiation factor 6 PAS_1g00550 CAY67162.1 PAS_chr1-3_0102 Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) GO:0005515;GO:0019538 YLL026W HSP104 "Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation" Heat shock protein 104 PAS_1g00555 PAS_1g00560 CAY67163.1 PAS_chr1-3_0104 "Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitoc" GO:0008152 YLR304C ACO1 "Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy" "Aconitate hydratase, mitochondrial " PAS_1g00565 CAY67164.1 PAS_chr1-3_0299 hypothetical protein GO:0000166 YHL024W RIM4 Putative RNA-binding protein required for the expression of early and middle sporulation genes Meiotic activator RIM4 PAS_1g00570 CAY67165.1 PAS_chr1-3_0105 Catalytic subunit of the COP9 signalosome (CSN) complex GO:0000166 YDL216C RRI1 Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling COP9 signalosome complex subunit 5 PAS_1g00575 CAY67166.1 PAS_chr1-3_0106 Protein kinase YNL183C NPR1 Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation Nitrogen permease reactivator protein PAS_1g00580 CAY67167.1 PAS_chr1-3_0107 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YNL185C MRPL19 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L19, mitochondrial " PAS_1g00585 CAY67168.1 PAS_chr1-3_0108 Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties GO:0004221;GO:0006511 YNL186W UBP10 Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus Ubiquitin carboxyl-terminal hydrolase 10 PAS_1g00590 CAY67169.1 PAS_chr1-3_0109 Putative oxidoreductase GO:0008152;GO:0016491 YNL181W YNL181W Putative oxidoreductase; required for cell viability Uncharacterized oxidoreductase C19A8.06 PAS_1g00595 CAY67170.1 PAS_chr1-3_0110 "Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p)" YNL182C IPI3 "Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles" Pre-rRNA-processing protein IPI3 PAS_1g00600 CAY67171.1 PAS_chr1-3_0111 Hypothetical protein U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein PAS_1g00605 CAY67172.1 PAS_chr1-3_0112 Putative RNA-binding protein implicated in ribosome biogenesis GO:0000166 YDL213C NOP6 Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes Nucleolar protein 6 PAS_1g00610 CAY67173.1 PAS_chr1-3_0113 "Small rho-like GTPase, essential for establishment and maintenance of cell polarity" GO:0005525;GO:0005622;GO:0007264 Ras-related C3 botulinum toxin substrate 1 PAS_1g00615 CAY67174.1 PAS_chr1-3_0114 "Protein required for beta-1,6 glucan biosynthesis" GO:0003980;GO:0006486 UDP-glucose:glycoprotein glucosyltransferase PAS_1g00620 CAY67175.1 PAS_chr1-3_0115 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0006412;GO:0015935 YNL178W RPS3 "Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins" 40S ribosomal protein S3 PAS_1g00625 CAY67176.1 PAS_chr1-3_0116 Endoplasmic reticulum packaging chaperone GO:0006605;GO:0006886;GO:0016020 YDL212W SHR3 "Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface" Secretory component protein SHR3 PAS_1g00630 CAY67177.1 PAS_chr1-3_0117 Hypothetical protein NADH-ubiquinone oxidoreductase 9.5 kDa subunit PAS_1g00635 CAY67178.1 PAS_chr1-3_0118 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0006412;GO:0015934 YNL177C MRPL22 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L22, mitochondrial " PAS_1g00640 CAY67179.1 PAS_chr1-3_0119 "Protein of unknown function, has homology to kinase Snf7p" Protein yippee-like MOH1 PAS_1g00645 CAY67180.1 PAS_chr1-3_0120 Hypothetical protein PAS_1g00650 CAY67181.1 PAS_chr1-3_0121 "Protein of unknown function, localizes to the nucleolus and nucleoplasm" GO:0000166 YNL175C NOP13 Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM) Nucleolar protein 13 PAS_1g00655 CAY67182.1 PAS_chr1-3_0122 "UDP-glucose pyrophosphorylase (UGPase), catalyses the reversible formation of UDP-Glc" YKL035W UGP1 "UDP-glucose pyrophosphorylase (UGPase), catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p" UTP--glucose-1-phosphate uridylyltransferase PAS_1g00660 CAY67183.1 PAS_chr1-3_0123 Putative protein of unknown function YOR287C YOR287C Putative protein of unknown function; may play a role in the ribosome and rRNA biosynthesis based on expression profiles and mutant phenotype UPF0399 protein YOR287C PAS_1g00665 CAY67184.1 PAS_chr1-3_0124 Mitochondrial ribosomal protein of the large subunit YMR225C MRPL44 Mitochondrial ribosomal protein of the large subunit "60S ribosomal protein L44, mitochondrial " PAS_1g00670 CAY67185.1 PAS_chr1-3_0125 Member of the protein disulfide isomerase (PDI) family GO:0003700;GO:0005622;GO:0006355;GO:0043565 YOR288C MPD1 Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation Protein disulfide-isomerase MPD1 PAS_1g00675 CAY67186.1 PAS_chr1-3_0126 Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR) GO:0003700;GO:0005634;GO:0006355;GO:0008270;GO:0043565 YER040W GLN3 "Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source" Nitrogen regulatory protein GLN3 PAS_1g00680 CAY67187.1 PAS_chr1-3_0127 Hypothetical protein GO:0003723;GO:0003743;GO:0005737;GO:0006413 Eukaryotic translation initiation factor 4E PAS_1g00685 CAY67188.1 PAS_chr1-3_0128 Probable di-and tri-peptidase GO:0016787;GO:0046983 YFR044C DUG1 Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) Cys-Gly metallodipeptidase DUG1 PAS_1g00690 CAY67189.1 PAS_chr1-3_0129 Hypothetical protein GO:0000166 Peptidyl-prolyl cis-trans isomerase-like 4 PAS_1g00695 CAY67190.1 PAS_chr1-3_0130 Pyrimidine nucleotidase YGL224C SDT1 "Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives" Protein SSM1 PAS_1g00700 CAY67191.1 PAS_chr1-3_0131 Hypothetical protein PAS_1g00705 CAY67192.1 PAS_chr1-3_0132 Hypothetical protein GO:0004129;GO:0006118 "Cytochrome c oxidase polypeptide 5B, mitochondrial " PAS_1g00710 CAY67193.1 PAS_chr1-3_0133 Hypothetical protein "Beta-1,6-glucan synthesis-associated protein KEG1 " PAS_1g00715 CAY67194.1 PAS_chr1-3_0134 Type I membrane protein with a J domain is required to preserve the folding capacity of the ER GO:0031072 YFR041C ERJ5 Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response ER-localized J domain-containing protein 5 PAS_1g00720 CAY67195.1 PAS_chr1-3_0135 Protein that forms a complex with the Sit4p protein phosphatase SIT4-associating protein SAP155 PAS_1g00725 CAY67196.1 PAS_chr1-3_0136 Hypothetical protein YGL228W SHE10 Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest Glutamic acid-rich protein PAS_1g00730 CAY67197.1 PAS_chr1-3_0137 Molecular chaperone GO:0005739;GO:0006461 YNL315C ATP11 "Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase" "Protein ATP11, mitochondrial " PAS_1g00735 CAY67198.1 PAS_chr1-3_0138 "Alpha-1,2-mannosyltransferase involved in O-and N-linked protein glycosylation" GO:0004377;GO:0006486;GO:0016020 Probable mannosyltransferase MNT3 PAS_1g00740 CAY67199.1 PAS_chr1-3_0140 Small subunit of the clathrin-associated adaptor complex AP-1 GO:0006810 YLR170C APS1 "Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex" AP-1 complex subunit sigma-1 PAS_1g00745 CAY67200.1 PAS_chr1-3_0141 Protein with a role in cellular adhesion and filamentous growth GO:0016021 YER113C TMN3 Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation Transmembrane 9 superfamily member 3 PAS_1g00750 CAY67201.1 PAS_chr1-3_0142 Lsm (Like Sm) protein GO:0016071;GO:0030529 YER112W LSM4 "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA" U6 snRNA-associated Sm-like protein LSm4 PAS_1g00755 CAY67202.1 PAS_chr1-3_0143 Protein kinase primarily involved in telomere length regulation YBL088C TEL1 Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene Serine/threonine-protein kinase TEL1 PAS_1g00760 CAY67203.1 PAS_chr1-3_0300 hypothetical protein GO:0003735;GO:0005622;GO:0005840;GO:0006412 YBL087C RPL23A "Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins" 60S ribosomal protein L23 PAS_1g00765 CAY67204.1 PAS_chr1-3_0144 Hypothetical protein YER116C SLX8 Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8 PAS_1g00770 CAY67205.1 PAS_chr1-3_0145 Hypothetical protein PAS_1g00775 CAY67206.1 PAS_chr1-3_0146 Hypothetical protein PAS_1g00780 CAY67207.1 PAS_chr1-3_0147 "Protein implicated in polar growth, functionally redundant with Boi1p" YER114C BOI2 "Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain" Protein BOI2 PAS_1g00785 CAY67208.1 PAS_chr1-3_0148 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) YBL084C CDC27 "Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition" Anaphase-promoting complex subunit CDC27 PAS_1g00790 CAY67209.1 PAS_chr1-3_0149 Transmembrane osmosensor YER118C SHO1 "Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway" Protein SSU81 PAS_1g00795 CAY67210.1 PAS_chr1-3_0150 Ubiquitin-protein ligase (E3) GO:0004842;GO:0006512;GO:0008270 YGR184C UBR1 "E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)" E3 ubiquitin-protein ligase UBR1 PAS_1g00800 CAY67211.1 PAS_chr1-3_0151 Nucleolar protein required for normal metabolism of the rRNA primary transcript YJR041C URB2 "Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis" PAS_1g00805 CAY67212.1 PAS_chr1-3_0152 Hypothetical protein ULP1-interacting protein 4 PAS_1g00810 CAY67213.1 PAS_chr1-3_0153 Plasma membrane pyridoxine (vitamin B6) transporter GO:0015205;GO:0015931;GO:0016020 YGL186C TPN1 "Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p" Vitamin B6 transporter TPN1 PAS_1g00815 CAY67214.1 PAS_chr1-3_0154 Hypothetical protein Aromatic amino acid aminotransferase 1 PAS_1g00820 CAY67215.1 PAS_chr1-3_0155 Putative RNA binding protein GO:0000166 YPL184C MRN1 "RNA-binding protein proposed to be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES)" Uncharacterized RNA-binding protein YPL184C PAS_1g00825 CAY67216.1 PAS_chr1-3_0301 hypothetical protein PAS_1g00830 CAY67217.1 PAS_chr1-3_0156 1-acyl-sn-gylcerol-3-phosphate acyltransferase GO:0003841;GO:0008654;GO:0016020 YDL052C SLC1 "1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes" Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase PAS_1g00835 CAY67218.1 PAS_chr1-3_0157 Subunit of the Dcp1p-Dcp2p decapping enzyme complex YOL149W DCP1 "Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p" mRNA-decapping enzyme subunit 1 PAS_1g00840 CAY67219.1 PAS_chr1-3_0158 Hypothetical protein identified by homology YDR379C-A YDR379C-A Putative protein of unknown function; identified by homology with other fungi; GFP-fusion protein localized to the mitochondrion "Succinate dehydrogenase assembly factor 1 homolog, mitochondrial " PAS_1g00845 CAY67220.1 PAS_chr1-3_0159 GTPase-activating protein for the polarity-establishment protein Cdc42p GO:0005622;GO:0007165 YOR127W RGA1 "GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth" Rho-type GTPase-activating protein 1 PAS_1g00850 CAY67221.1 PAS_chr1-3_0160 Putative protein of unknown function YPL222W FMP40 "Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" UPF0061 protein C20G4.05c PAS_1g00855 CAY67222.1 PAS_chr1-3_0161 Type II membrane protein required for vesicular transport YIL004C BET1 Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins Protein transport protein BET1 PAS_1g00860 CAY67223.1 PAS_chr1-3_0162 "Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm" GO:0008270;GO:0016887;GO:0019538;GO:0046983 YIL003W CFD1 "Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol" Cytosolic Fe-S cluster assembly factor CFD1 PAS_1g00865 CAY67224.1 PAS_chr1-3_0302 hypothetical protein PAS_1g00870 CAY67225.1 PAS_chr1-3_0163 Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter GO:0005338;GO:0015780;GO:0016021 YEL004W YEA4 Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER UDP-N-acetylglucosamine transporter slc35b4 PAS_1g00875 CAY67226.1 PAS_chr1-3_0164 Putative protein of unknown function YMR010W YMR010W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 Uncharacterized membrane protein YMR010W PAS_1g00880 CAY67227.1 PAS_chr1-3_0165 Putative protein of unknown function YEL007W YEL007W Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) Gluconate transport inducer 1 PAS_1g00885 CAY67228.1 PAS_chr1-3_0166 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0043565;GO:0046983 AP-1-like transcription factor PAS_1g00890 CAY67229.1 PAS_chr1-3_0167 Protein with a role in 5'-end processing of mitochondrial RNAs YOR017W PET127 "Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane" Putative mitochondrial translation system component PET127 PAS_1g00895 CAY67230.1 PAS_chr1-3_0168 Peripheral membrane protein required for vesicle formation YNL242W ATG2 "Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria" Autophagy-related protein 2 PAS_1g00900 CAY67231.1 PAS_chr1-3_0169 Hypothetical protein PAS_1g00905 CAY67232.1 PAS_chr1-3_0170 Zinc-finger DNA-binding protein GO:0003676;GO:0005622;GO:0008270 YDR253C MET32 "Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met31p" Transcriptional regulator MET32 PAS_1g00910 CAY67233.1 PAS_chr1-3_0171 Hypothetical protein PAS_1g00915 CAY67234.1 PAS_chr1-3_0172 Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting YPL037C EGD1 "Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b" Nascent polypeptide-associated complex subunit beta PAS_1g00920 CAY67235.1 PAS_chr1-3_0303 hypothetical protein PAS_1g00925 CAY67236.1 PAS_chr1-3_0173 "Protein of unknown function, mutant phenotype suggests a potential role in vacuolar function" GO:0016491 YDR251W PAM1 "Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype" Styryl dye vacuolar localization protein 3 PAS_1g00930 CAY67237.1 PAS_chr1-3_0174 "One of several homologs of bacterial chaperone DnaJ, located in the ER lumen" GO:0006457;GO:0031072;GO:0051082 YMR214W SCJ1 "One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins" DnaJ-related protein SCJ1 PAS_1g00935 CAY67238.1 PAS_chr1-3_0175 Essential protein involved in mtDNA inheritance GO:0043234;GO:0051258 YMR211W DML1 "Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family" Protein DML1 PAS_1g00940 CAY67239.1 PAS_chr1-3_0176 Hypothetical protein PAS_1g00945 CAY67240.1 PAS_chr1-3_0177 Hypothetical protein PAS_1g00950 CAY67241.1 PAS_chr1-3_0178 Protein of unknown function that associates with ribosomes YOR252W TMA16 Protein of unknown function that associates with ribosomes Translation machinery-associated protein 16 PAS_1g00955 CAY67242.1 PAS_chr1-3_0179 Hypothetical protein YOR276W CAF20 "Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E" Cap-associated protein CAF20 PAS_1g00960 CAY67243.1 PAS_chr1-3_0180 Non-essential protein of unknown function YMR212C EFR3 "Non-essential protein of unknown function; exhibits synthetic lethal genetic interactions with PHO85; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies and is phosphorylated" Protein EFR3 PAS_1g00965 CAY67244.1 PAS_chr1-3_0181 Protein of unknown function GO:0007242 YJR138W IML1 "Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane" Vacuolar membrane-associated protein IML1 PAS_1g00970 CAY67245.1 PAS_chr1-3_0182 Essential splicing factor YMR213W CEF1 "Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p" Pre-mRNA-splicing factor CEF1 PAS_1g00975 CAY67246.1 PAS_chr1-3_0183 RNA-binding subunit of the mRNA cleavage and polyadenylation factor GO:0003676;GO:0005634 YDR301W CFT1 "RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF" Protein CFT1 PAS_1g00980 CAY67247.1 PAS_chr1-3_0184 Protein involved in proteolytic activation of Rim101p in response to alkaline pH YOR275C RIM20 Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation pH-response regulator protein palA/RIM20 PAS_1g00985 CAY67248.1 PAS_chr1-3_0185 Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase GO:0004811;GO:0005524;GO:0008033 YOR274W MOD5 "Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms" "tRNA dimethylallyltransferase, mitochondrial " PAS_1g00990 CAY67249.1 PAS_chr1-3_0186 "Putative protein, predicted to be an alpha-isopropylmalate carrier" GO:0006812;GO:0008324;GO:0016020 YOR271C FSF1 "Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis" Probable mitochondrial transport protein FSF1 PAS_1g00995 CAY67250.1 PAS_chr1-3_0187 "Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol" YMR208W ERG12 "Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate" Putative mevalonate kinase PAS_1g01000 CAY67251.1 PAS_chr1-3_0188 "Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit" YOR272W YTM1 "Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats" Ribosome biogenesis protein YTM1 PAS_1g01005 CAY67252.1 PAS_chr1-3_0189 Putative protein of unknown function YMR209C YMR209C Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene Uncharacterized protein YMR209C PAS_1g01010 CAY67253.1 PAS_chr1-3_0190 Hypothetical protein GO:0000287;GO:0006633;GO:0008897 YPL148C PPT2 "Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation" PAS_1g01015 CAY67254.1 PAS_chr1-3_0191 "GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from IMP" GO:0003824;GO:0009058 YMR217W GUA1 "GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation" GMP synthase [glutamine-hydrolyzing] PAS_1g01020 CAY67255.1 PAS_chr1-3_0192 Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase YKL019W RAM2 Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha PAS_1g01025 CAY67256.1 PAS_chr1-3_0193 Protein phosphatase YIR026C YVH1 "Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases" Tyrosine-protein phosphatase YVH1 PAS_1g01030 CAY67257.1 PAS_chr1-3_0304 hypothetical protein PAS_1g01035 CAY67258.1 PAS_chr1-3_0194 Heme A:farnesyltransferase GO:0004659;GO:0016021 YPL172C COX10 "Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders" "Protoheme IX farnesyltransferase, mitochondrial " PAS_1g01040 CAY67259.1 PAS_chr1-3_0195 "Essential, non-ATPase regulatory subunit of the 26S proteasome" YOR261C RPN8 "Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p" 26S proteasome regulatory subunit rpn-8 PAS_1g01045 YOR265W RBL2 "Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A" Tubulin-specific chaperone A PAS_1g01050 CAY67260.1 PAS_chr1-3_0197 Protein of unknown function required for establishment of sister chromatid cohesion GO:0000166 YOR262W YOR262W Protein of unknown function required for establishment of sister chromatid cohesion; contains an ATP/GTP binding site motif; similar to YLR243W and is highly conserved across species and homologous to human gene GPN2/ATPBD1B GPN-loop GTPase 2 homolog PAS_1g01055 CAY67261.1 PAS_chr1-3_0198 Hypothetical protein YFL023W BUD27 "Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by TOR kinase; diploid mutants show a random budding pattern rather than the wild-type bipolar pattern; plays a role in regulating Ty1 transposition" Bud site selection protein 27 PAS_1g01060 CAY67262.1 PAS_chr1-3_0199 Hypothetical protein GO:0005524 UPF0329 protein ECU05_1680/ECU11_0050 PAS_1g01065 CAY67263.1 PAS_chr1-3_0200 Hypothetical protein PAS_1g01070 CAY67264.1 PAS_chr1-3_0201 Hypothetical protein GO:0003676;GO:0008168;GO:0032259 PAS_1g01075 CAY67265.1 PAS_chr1-3_0202 "Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p)" GO:0009306;GO:0015450;GO:0016020;n/a YLR378C SEC61 "Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER" Protein transport protein SEC61 subunit alpha PAS_1g01080 CAY67266.1 PAS_chr1-3_0305 hypothetical protein YDL177C YDL177C Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene Protein IMPACT PAS_1g01085 CAY67267.1 PAS_chr1-3_0203 Hypothetical protein "Adenylate cyclase, terminal-differentiation specific " PAS_1g01090 YNL040W YNL040W Putative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene Alanyl-tRNA editing protein Aarsd1 PAS_1g01095 CAY67269.1 PAS_chr1-3_0205 Hypothetical protein YBR138C YBR138C "Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene" Uncharacterized protein YBR138C PAS_1g01100 CAY67270.1 PAS_chr1-3_0206 Permease of basic amino acids in the vacuolar membrane YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane Multidrug resistance protein fnx1 PAS_1g01105 CAY67271.1 PAS_chr1-3_0207 Essential protein involved in assembly of cytosolic and nuclear iron-sulfur proteins YDR267C CIA1 WD40 repeat protein involved in assembly of cytosolic and nuclear iron-sulfur proteins; similar to the human Ciao1 protein; YDR267C is an essential gene Probable cytosolic iron-sulfur protein assembly protein 1 PAS_1g01110 CAY67272.1 PAS_chr1-3_0208 Mitochondrial peripheral inner membrane protein YOR037W CYC2 "Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)" Cytochrome c mitochondrial import factor CYC2 PAS_1g01115 CAY67273.1 PAS_chr1-3_0209 Target membrane receptor (t-SNARE) GO:0005484;GO:0006886;GO:0016020 YOR036W PEP12 "Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin" Syntaxin PEP12 PAS_1g01120 CAY67274.1 PAS_chr1-3_0210 Hypothetical protein GO:0006118;GO:0008137;GO:0009055;GO:0016020 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 PAS_1g01125 CAY67275.1 PAS_chr1-3_0211 "Deoxyhypusine synthase, catalyzes formation of deoxyhypusine" GO:0008612 YHR068W DYS1 "Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric" Deoxyhypusine synthase PAS_1g01130 CAY67276.1 PAS_chr1-3_0212 Lanosterol 14-alpha-demethylase GO:0004497;GO:0005506;GO:0006118;GO:0020037 Probable cytochrome P450 311a1 PAS_1g01135 CAY67277.1 PAS_chr1-3_0213 Protein kinase GO:0004674;GO:0006468 Serine/threonine-protein kinase oca2 PAS_1g01140 PAS_1g01145 CAY67278.1 PAS_chr1-3_0215 Polyamine transport protein specific for spermine Uncharacterized MFS-type transporter C409.08 PAS_1g01150 CAY67279.1 PAS_chr1-3_0216 Non-essential protein of unknown function YBL101C ECM21 Protein involved in regulating the endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements Transcription factor CSR2 PAS_1g01155 CAY67280.1 PAS_chr1-3_0217 Protein involved in assembly of mitochondrial respiratory complexes YBR185C MBA1 Protein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane "Protein MBA1, mitochondrial " PAS_1g01160 CAY67281.1 PAS_chr1-3_0218 Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase YPL057C SUR1 "Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p" Mannosyl phosphorylinositol ceramide synthase SUR1 PAS_1g01165 CAY67282.1 PAS_chr1-3_0219 Cis-golgi GTPase-activating protein (GAP) GO:0005097;GO:0005622;GO:0032313 YOR070C GYP1 "Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion" GTPase-activating protein gyp1 PAS_1g01170 CAY67283.1 PAS_chr1-3_0220 "NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase" GO:0003824;GO:0009396 YKR080W MTD1 "NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline" Methylenetetrahydrofolate dehydrogenase [NAD+] PAS_1g01175 CAY67284.1 PAS_chr1-3_0221 "Nuclear pore-associated protein, forms a complex with Thp1p" YDR159W SAC3 "Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus" Nuclear mRNA export protein SAC3 PAS_1g01180 CAY67285.1 PAS_chr1-3_0222 Putative protein of unknown function YDR128W MTC5 Protein of unknown function; mtc5 is synthetically sick with cdc13-1 WD repeat-containing protein YDR128W PAS_1g01185 PAS_1g01190 YGL116W CDC20 "Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate" APC/C activator protein CDC20 PAS_1g01195 CAY67286.1 PAS_chr1-3_0225 "Catalytic subunit of 1,3-beta-D-glucan synthase" GO:0000148;GO:0003843;GO:0006075;GO:0016020 "1,3-beta-glucan synthase component FKS1 " PAS_1g01200 CAY67287.1 PAS_chr1-3_0226 "Beta-1,3-glucanosyltransferase, required for cell wall assembly" YMR307W GAS1 "Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery" "1,3-beta-glucanosyltransferase GAS1 " PAS_1g01205 CAY67288.1 PAS_chr1-3_0227 "Beta-1,3-glucanosyltransferase, required for cell wall assembly" GO:0003824;GO:0005975;GO:0043169 Protein EPD1 PAS_1g01210 CAY67289.1 PAS_chr1-3_0228 Essential protein involved in rRNA and snoRNA maturation GO:0003676;GO:0005622 YGR280C PXR1 "Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain" Protein PXR1 PAS_1g01215 CAY67290.1 PAS_chr1-3_0229 Cell wall protein with similarity to glucanases GO:0004553;GO:0005975 YGR279C SCW4 Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating Probable family 17 glucosidase SCW10 PAS_1g01220 CAY67291.1 PAS_chr1-3_0230 ER membrane protein that interacts with exocyst subunit Sec6p and with Yip3p GO:0005783 YDR233C RTN1 "ER membrane protein that interacts with Sey1p to maintain ER morphology; interacts with exocyst subunit Sec6p, with Yip3p, and with Sbh1p; null mutant has an altered ER morphology; member of the RTNLA (reticulon-like A) subfamily" Cell lysis protein cwl1 PAS_1g01225 CAY67292.1 PAS_chr1-3_0231 Hypothetical protein PAS_1g01230 CAY67293.1 PAS_chr1-3_0306 hypothetical protein GO:0005488 YMR231W PEP5 Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p Vacuolar membrane protein PEP5 PAS_1g01235 CAY67294.1 PAS_chr1-3_0232 Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors GO:0005488 YLR113W HOG1 Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p Mitogen-activated protein kinase HOG1 PAS_1g01240 CAY67295.1 PAS_chr1-3_0233 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 YKL038W RGT1 Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor Uncharacterized transcriptional regulatory protein C320.03 PAS_1g01245 CAY67296.1 PAS_chr1-3_0234 Hypothetical protein YPL070W MUK1 Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation PAS_1g01250 CAY67297.1 PAS_chr1-3_0235 "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretio" YOL065C INP54 "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins" "Inositol-1,4,5-trisphosphate 5-phosphatase 4 " PAS_1g01255 CAY67298.1 PAS_chr1-3_0236 "Protein involved in retention of membrane proteins, including Sec12p, in the ER" GO:0016021 YCL001W RER1 "Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER" Protein RER1 PAS_1g01260 CAY67299.1 PAS_chr1-3_0237 Karyopherin/importin that interacts with the nuclear pore complex GO:0005488 YMR308C PSE1 "Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p" Importin subunit beta-3 PAS_1g01265 CAY67300.1 PAS_chr1-3_0238 "Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate" GO:0003824;GO:0008152 YCL004W PGS1 "Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis" CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PAS_1g01270 CAY67301.1 PAS_chr1-3_0239 "DRAP deaminase, catalyzes the third step of the riboflavin biosynthesis pathway" GO:0001522;GO:0003723;GO:0009982 YOL066C RIB2 Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs Bifunctional protein RIB2 PAS_1g01275 CAY67302.1 PAS_chr1-3_0240 Flavin adenine dinucleotide (FAD) synthetase GO:0008152;GO:0016740 YDL045C FAD1 "Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin" Probable FAD synthase PAS_1g01280 CAY67303.1 PAS_chr1-3_0241 Hypothetical protein GO:0005622;GO:0008270 YDL043C PRP11 "Subunit of the SF3a splicing factor complex, required for spliceosome assembly" CWF complex protein sap62 PAS_1g01285 CAY67304.1 PAS_chr1-3_0242 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex GO:0000775;GO:0007067 YOL069W NUF2 "Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering" Probable kinetochore protein NUF2 PAS_1g01290 CAY67305.1 PAS_chr1-3_0243 "Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA" GO:0004518;GO:0005622;GO:0006281 YBR228W SLX1 "Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p" Structure-specific endonuclease subunit SLX1 PAS_1g01295 CAY67306.1 PAS_chr1-3_0244 Cytoplasmic and mitochondrial histidine tRNA synthetase GO:0000166;GO:0004821;GO:0005524;GO:0005737;GO:0006412;GO:0006427 YPR033C HTS1 Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence "Histidyl-tRNA synthetase, mitochondrial " PAS_1g01300 CAY67307.1 PAS_chr1-3_0307 hypothetical protein GO:0005515;GO:0008270 YJL157C FAR1 "Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate" PAS_1g01305 CAY67308.1 PAS_chr1-3_0308 hypothetical protein PAS_1g01310 CAY67309.1 PAS_chr1-3_0245 Hypothetical protein PAS_1g01315 CAY67310.1 PAS_chr1-3_0246 Essential protein associated with the U1 snRNP complex YDL087C LUC7 Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA Protein LUC7 PAS_1g01320 CAY67311.1 PAS_chr1-3_0247 Catalytic subunit of the mitochondrial inner membrane peptidase complex GO:0008236;GO:0009003;GO:0016021 YMR150C IMP1 "Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p" Mitochondrial inner membrane protease subunit 1 PAS_1g01325 CAY67312.1 PAS_chr1-3_0248 Hypothetical protein GO:0004579;GO:0005789;GO:0008250;GO:0018279 YMR149W SWP1 "Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum" Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1 PAS_1g01330 CAY67313.1 PAS_chr1-3_0249 Hypothetical protein PAS_1g01335 CAY67314.1 PAS_chr1-3_0250 Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix GO:0005488;GO:0005743;GO:0006810 YHR002W LEU5 "Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized" Mitochondrial carrier protein LEU5 PAS_1g01340 CAY67315.1 PAS_chr1-3_0251 Mannosyltransferase of the cis-Golgi apparatus YGL038C OCH1 "Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins" Putative glycosyltransferase HOC1 PAS_1g01345 CAY67316.1 PAS_chr1-3_0252 DNA-binding protein involved in either activation or repression of transcription GO:0005622 YNL216W RAP1 "DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure" DNA-binding protein RAP1 PAS_1g01350 CAY67317.1 PAS_chr1-3_0253 Hypothetical protein GO:0016787 YNL217W YNL217W Hypothetical protein Putative metallophosphoesterase YNL217W PAS_1g01355 CAY67318.1 PAS_chr1-3_0254 GTPase-activating protein for yeast Rab family members GO:0005097;GO:0005622;GO:0032313 YDL234C GYP7 "GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking" GTPase-activating protein GYP7 PAS_1g01360 CAY67319.1 PAS_chr1-3_0255 Polyamine acetyltransferase YDR071C PAA1 "Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication" Polyamine N-acetyltransferase 1 PAS_1g01365 CAY67320.1 PAS_chr1-3_0256 Hypothetical protein GO:0016071;GO:0030529;n/a YER146W LSM5 "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA" U6 snRNA-associated Sm-like protein LSm5 PAS_1g01370 CAY67321.1 PAS_chr1-3_0257 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents GO:0003824;GO:0006281 YER142C MAG1 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired DNA-3-methyladenine glycosylase PAS_1g01375 CAY67322.1 PAS_chr1-3_0258 "DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain" YER143W DDI1 "DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control" DNA damage-inducible protein 1 PAS_1g01380 CAY67323.1 PAS_chr1-3_0259 Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae YDR067C OCA6 "Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT" Putative tyrosine-protein phosphatase OCA6 PAS_1g01385 CAY67324.1 PAS_chr1-3_0260 Hypothetical protein PAS_1g01390 CAY67325.1 PAS_chr1-3_0261 Ubiquitin isopeptidase GO:0004221;GO:0006511 YDR069C DOA4 "Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole" Ubiquitin carboxyl-terminal hydrolase 4 PAS_1g01395 CAY67326.1 PAS_chr1-3_0262 Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes YLR139C SLS1 Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery "Sigma-like sequence protein 1, mitochondrial " PAS_1g01400 PAS_1g01405 CAY67327.1 PAS_chr1-3_0264 Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) GO:0003755;GO:0006457 YDR155C CPR1 "Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A" Peptidyl-prolyl cis-trans isomerase PAS_1g01410 CAY67328.1 PAS_chr1-3_0309 hypothetical protein YDR153C ENT5 "Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin" ENTH domain-containing protein C794.11c PAS_1g01415 CAY67329.1 PAS_chr1-3_0265 Highly-acidic cytoplasmic RWD domain-containing protein of unknown function YDR152W GIR2 Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein Protein GIR2 PAS_1g01420 CAY67330.1 PAS_chr1-3_0266 Putative protein of unknown function YDR161W YDR161W Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD) UPF0661 TPR repeat-containing protein YDR161W PAS_1g01425 CAY67331.1 PAS_chr1-3_0267 Protein involved in the HOG (high osmolarity glycerol) pathway YDR162C NBP2 "Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p" NAP1-binding protein 2 PAS_1g01430 CAY67332.1 PAS_chr1-3_0268 Hypothetical protein GO:0000398;GO:0005681 Pre-mRNA-splicing factor CWC15 PAS_1g01435 CAY67333.1 PAS_chr1-3_0269 "Proline oxidase, nuclear-encoded mitochondrial protein" YLR142W PUT1 "Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source" "Proline dehydrogenase, mitochondrial " PAS_1g01440 PAS_1g01445 CAY67334.1 PAS_chr1-3_0310 hypothetical protein YGL164C YRB30 "RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes" Ran-specific GTPase-activating protein 30 PAS_1g01450 CAY67335.1 PAS_chr1-3_0271 Non-essential tRNA:pseudouridine synthase GO:0000049;GO:0001522;GO:0008033;GO:0016439 YFL001W DEG1 "tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability" tRNA pseudouridine synthase 3 PAS_1g01455 CAY67336.1 PAS_chr1-3_0311 hypothetical protein PAS_1g01460 CAY67337.1 PAS_chr1-3_0272 "Putative ATP-dependent RNA helicase, nucleolar protein" YFL002C SPB4 "Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients" ATP-dependent rRNA helicase SPB4 PAS_1g01465 CAY67338.1 PAS_chr1-3_0273 "Putative cysteine synthase, localized to the mitochondrial outer membrane" GO:0003824;GO:0008152;GO:0030170 YGR012W YGR012W "Putative cysteine synthase, localized to the mitochondrial outer membrane" Putative cysteine synthase PAS_1g01470 CAY67339.1 PAS_chr1-3_0274 Hypothetical protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 Cutinase transcription factor 1 alpha PAS_1g01475 CAY67340.1 PAS_chr1-3_0275 Hypothetical protein YGR013W SNU71 "Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart" U1 small nuclear ribonucleoprotein component SNU71 PAS_1g01480 CAY67341.1 PAS_chr1-3_0276 Mucin family member Protein MSB2 PAS_1g01485 CAY67342.1 PAS_chr1-3_0277 Hypothetical protein YLL033W IRC19 Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci Sporulation protein YLL033W PAS_1g01490 CAY67343.1 PAS_chr1-3_0278 Hypothetical protein PAS_1g01495 CAY67344.1 PAS_chr1-3_0279 Hypothetical protein PAS_1g01500 CAY67345.1 PAS_chr1-3_0280 Hypothetical protein PAS_1g01505 CAY67346.1 PAS_chr1-3_0312 hypothetical protein SERF-like protein YDL085C-A PAS_1g01510 CAY67347.1 PAS_chr1-3_0281 Subunit of the core complex of translation initiation factor (eIF3) YMR146C TIF34 "eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation" Eukaryotic translation initiation factor 3 subunit I PAS_1g01515 PAS_1g01520 PAS_1g01525 PAS_1g01530 CAY67348.1 PAS_chr1-3_0285 Hypothetical protein PAS_1g01535 YAR042W SWH1 Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction Oxysterol-binding protein homolog 1 PAS_1g01540 CAY67349.1 PAS_chr1-3_0287 Hypothetical protein YBR272C HSM3 Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b DNA mismatch repair protein HSM3 PAS_1g01545 CAY67350.1 PAS_chr1-3_0288 Hypothetical protein GO:0015031 YJL049W YJL049W Putative protein of unknown function; YJL049W is a non-essential gene Charged multivesicular body protein 7 PAS_1g01550 CAY67351.1 PAS_chr1-3_0289 Hypothetical protein YBR273C UBX7 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p UBX domain-containing protein 7 PAS_1g01555 CAY67352.1 PAS_chr1-1_0002 "Plasma membrane H+-ATPase, pumps protons out of the cell" GO:0015992;GO:0016021;GO:0016887;n/a YGL008C PMA1 "Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases" Plasma membrane ATPase PAS_1g01560 CAY67353.1 PAS_chr1-1_0003 Probable transporter Probable transporter SEO1 PAS_1g01565 CAY67354.1 PAS_chr1-1_0459 Dolichol-phosphate mannosyltransferase YPR183W DPM1 "Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation" Dolichol-phosphate mannosyltransferase PAS_1g01570 CAY67355.1 PAS_chr1-1_0461 hypothetical protein PAS_1g01575 PAS_1g01580 CAY67356.1 PAS_chr1-1_0460 hypothetical protein YDL077C VAM6 Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p PAS_1g01585 CAY67357.1 PAS_chr1-1_0004 U3 small nucleolar RNA-associated protein YLR409C UTP21 Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma U3 small nucleolar RNA-associated protein 21 PAS_1g01590 CAY67358.1 PAS_chr1-1_0005 Inositol hexakisphosphate and inositol heptakisphosphate kinase GO:0003993 YLR410W VIP1 "Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of IP7 by Vip1p is important for phosphate signaling; likely involved in cortical actin cytoskeleton function, by analogy with S. pombe ortholog asp1" Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase PAS_1g01595 CAY67359.1 PAS_chr1-1_0006 Ribose-phosphate pyrophosphokinase GO:0000287;GO:0004749;GO:0009156;GO:0044249 YKL181W PRS1 "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes" Ribose-phosphate pyrophosphokinase 1 PAS_1g01600 CAY67360.1 PAS_chr1-1_0007 SRR1 domain-containing protein YLR412W BER1 "Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene" PAS_1g01605 CAY67361.1 PAS_chr1-1_0008 Beta subunit of fatty acid synthetase; catalyzes the synthesis of long-chain saturated fatty acids YKL182W FAS1 "Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities" Fatty acid synthase subunit beta PAS_1g01610 CAY67362.1 PAS_chr1-1_0009 Serine esterase that deacylates exogenous lysophospholipids GO:0006629 YML059C NTE1 "Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes" Lysophospholipase NTE1 PAS_1g01615 CAY67363.1 PAS_chr1-1_0010 Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins GO:0006508;GO:0008234 YIL031W ULP2 "Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate" Ubiquitin-like-specific protease 2 PAS_1g01620 CAY67364.1 PAS_chr1-1_0011 Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum GO:0005515;GO:0005789;GO:0006467;GO:0009055;GO:0016671;GO:0050660 YML130C ERO1 Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum Endoplasmic oxidoreductin-1 PAS_1g01625 CAY67365.1 PAS_chr1-1_0012 "TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation" GO:0003677 YML098W TAF13 "TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors" Transcription initiation factor TFIID subunit 13 PAS_1g01630 CAY67366.1 PAS_chr1-1_0013 Hypothetical protein GO:0020037;GO:0046914 Fatty acid desaturase 3 PAS_1g01635 CAY67367.1 PAS_chr1-1_0014 Lsm (Like Sm) protein GO:0016071;GO:0030529 YLR438C-A LSM3 "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA" Probable U6 snRNA-associated Sm-like protein LSm3 PAS_1g01640 CAY67368.1 PAS_chr1-1_0015 Putative endoribonuclease GO:0016787 YLR277C YSH1 "Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs" Endoribonuclease YSH1 PAS_1g01645 CAY67369.1 PAS_chr1-1_0016 transcription factor GO:0003700;GO:0005634;GO:0006355;GO:0008270 PAS_1g01650 CAY67370.1 PAS_chr1-1_0017 Hypothetical protein PAS_1g01655 CAY67371.1 PAS_chr1-1_0018 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) GO:0003677;GO:0005634 YML069W POB3 "Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p)" FACT complex subunit POB3 PAS_1g01660 CAY67372.1 PAS_chr1-1_0019 Component of the TREX complex required for nuclear mRNA export YDL084W SUB2 Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56 ATP-dependent RNA helicase SUB2 PAS_1g01665 CAY67373.1 PAS_chr1-1_0020 Actin-like protein GO:0005515 YLR085C ARP6 "Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A" Actin-like protein ARP6 PAS_1g01670 CAY67374.1 PAS_chr1-1_0462 hypothetical protein YDR089W YDR089W Protein of unknown function; deletion confers resistance to Nickel Uncharacterized protein YDR089W PAS_1g01675 CAY67375.1 PAS_chr1-1_0021 Hypothetical protein YDR088C SLU7 "RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain" Pre-mRNA-splicing factor SLU7 PAS_1g01680 CAY67376.1 PAS_chr1-1_0022 Essential conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits GO:0006364;GO:0030688 YDR087C RRP1 "Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles" Ribosomal RNA-processing protein 1 homolog PAS_1g01685 CAY67377.1 PAS_chr1-1_0023 Hypothetical protein GO:0006605;GO:0006886;GO:0016020 YDR086C SSS1 "Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p" Protein transport protein SSS1 PAS_1g01690 CAY67378.1 PAS_chr1-1_0024 Hypothetical protein Protein SPT2 PAS_1g01695 CAY67379.1 PAS_chr1-1_0025 DNA repair protein GO:0003684;GO:0005634;GO:0006289 YER162C RAD4 Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein DNA repair protein RAD4 PAS_1g01700 CAY67380.1 PAS_chr1-1_0026 Hypothetical protein GO:0006605;GO:0006886;GO:0016020 PAS_1g01705 CAY67381.1 PAS_chr1-1_0027 Putative protein of unknown function YDR090C YDR090C Putative protein of unknown function Uncharacterized membrane protein YDR090C PAS_1g01710 CAY67382.1 PAS_chr1-1_0028 "Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation" YDR536W STL1 "Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock" Sugar transporter STL1 PAS_1g01715 YDR411C DFM1 ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxes Derlin-2 PAS_1g01720 CAY67383.1 PAS_chr1-1_0029 Putative protein of unknown function YER163C YER163C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle; weak similarity to bacterial cation transport protein Cation transport regulator-like protein PAS_1g01725 CAY67384.1 PAS_chr1-1_0030 General amino acid permease GO:0006810;GO:0016020 YKR039W GAP1 General amino acid permease; localization to the plasma membrane is regulated by nitrogen source General amino-acid permease GAP1 PAS_1g01730 CAY67385.1 PAS_chr1-1_0464 hypothetical protein PAS_1g01735 CAY67386.1 PAS_chr1-1_0465 hypothetical protein GO:0003824 YCR068W ATG15 Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Putative lipase ATG15 PAS_1g01740 CAY67387.1 PAS_chr1-1_0031 Cytoplasmic pre-60S factor GO:0003676;GO:0005622;GO:0008270 YBR267W REI1 "Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network" Pre-60S factor REI1 PAS_1g01745 CAY67388.1 PAS_chr1-1_0466 hypothetical protein PAS_1g01750 CAY67389.1 PAS_chr1-1_0032 Component of the mitochondrial Tim54p-Tim22p complex YJL054W TIM54 Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane Mitochondrial import inner membrane translocase subunit TIM54 PAS_1g01755 CAY67390.1 PAS_chr1-1_0467 hypothetical protein YDR165W TRM82 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA tRNA (guanine-N(7)-)-methyltransferase subunit TRM82 PAS_1g01760 CAY67391.1 PAS_chr1-1_0033 Hypothetical protein YHL020C OPI1 Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance Transcriptional repressor OPI1 PAS_1g01765 CAY67392.1 PAS_chr1-1_0034 vacuolar sorting protein GO:0015031 YKL041W VPS24 One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway Vacuolar protein-sorting-associated protein 24 PAS_1g01770 CAY67393.1 PAS_chr1-1_0035 "Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles" GO:0006810 YFR051C RET2 "Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER" Coatomer subunit delta PAS_1g01775 CAY67394.1 PAS_chr1-1_0036 Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex YHR064C SSZ1 Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP Ribosome-associated complex subunit SSZ1 PAS_1g01780 CAY67395.1 PAS_chr1-1_0037 Hypothetical protein GO:0016491 PAS_1g01785 CAY67396.1 PAS_chr1-1_0038 Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p GO:0005488 YOR080W DIA2 "Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth" PAS_1g01790 CAY67397.1 PAS_chr1-1_0039 Myb-related transcription factor YKR099W BAS1 Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Myb-like DNA-binding protein BAS1 PAS_1g01795 CAY67398.1 PAS_chr1-1_0040 Ubiquitin carboxyl-terminal hydrolase GO:0004221;GO:0006511 YIL156W UBP7 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions Ubiquitin carboxyl-terminal hydrolase 11 PAS_1g01800 CAY67399.1 PAS_chr1-1_0041 Hypothetical protein GO:0008270 PHD and RING finger domain-containing protein C126.07c PAS_1g01805 CAY67400.1 PAS_chr1-1_0042 Multistep regulator of cAMP-PKA signaling YAL056W GPB2 "Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p" PAS_1g01810 CAY67401.1 PAS_chr1-1_0043 Hypothetical protein PAS_1g01815 CAY67402.1 PAS_chr1-1_0044 "ER membrane protein,N-acetylglucosaminyl phosphatidylinositol de-N-acetylase" YMR281W GPI12 "ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp" Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase PAS_1g01820 CAY67403.1 PAS_chr1-1_0045 Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC) YAL001C TFC3 Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding Transcription factor tau subunit sfc3 PAS_1g01825 CAY67404.1 PAS_chr1-1_0046 "Component of the SSU processome, which is required for pre-18S rRNA processing" YNL075W IMP4 "Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs" U3 small nucleolar ribonucleoprotein protein IMP4 PAS_1g01830 CAY67405.1 PAS_chr1-1_0047 Mitochondrial lysine-tRNA synthetase GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YNL073W MSK1 "Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)" "Lysyl-tRNA synthetase, mitochondrial " PAS_1g01835 CAY67406.1 PAS_chr1-1_0048 GTPase-activating protein YPR181C SEC23 "GTPase-activating protein; component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; stimulates the GDP-bound form of Sar1p" Protein transport protein SEC23 PAS_1g01840 CAY67407.1 PAS_chr1-1_0049 "Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis" GO:0003676 YNL072W RNH201 "Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; homolog of RNAse HI (the S. cerevisiae homolog of mammalian RNAse HII is RNH1); related to human AGS4 that causes Aicardi-Goutieres syndrome" Ribonuclease H2 subunit A PAS_1g01845 CAY67408.1 PAS_chr1-1_0050 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex YNL071W LAT1 "Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA" "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial " PAS_1g01850 CAY67409.1 PAS_chr1-1_0051 Nonessential putative protein kinase of unknown cellular role GO:0004674;GO:0006468 YLL019C KNS1 "Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues" Dual specificity protein kinase KNS1 PAS_1g01855 CAY67410.1 PAS_chr1-1_0052 Hypothetical protein PAS_1g01860 CAY67411.1 PAS_chr1-1_0053 "Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F)" GO:0005515;GO:0016070 YGL049C TIF4632 "Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p" Eukaryotic initiation factor 4F subunit p150 PAS_1g01865 CAY67412.1 PAS_chr1-1_0054 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation GO:0005634;GO:0005737;GO:0016787;GO:0030163 YGL048C RPT6 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle 26S protease regulatory subunit 8 homolog PAS_1g01870 CAY67413.1 PAS_chr1-1_0055 "Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins" GO:0006511 Zinc finger protein 567 PAS_1g01875 CAY67414.1 PAS_chr1-1_0056 "Zinc-regulated transcription factor, binds to zinc-responsive promoter elements" GO:0003676 YJL056C ZAP1 "Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains" Zinc finger protein 287 PAS_1g01880 CAY67415.1 PAS_chr1-1_0057 Putative protein serine/threonine kinase expressed at the end of meiosis Serine/threonine-protein kinase MST4 PAS_1g01885 CAY67416.1 PAS_chr1-1_0058 "GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits" YER006W NUG1 "GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus" Nuclear GTP-binding protein NUG1 PAS_1g01890 CAY67417.1 PAS_chr1-1_0059 "Transcription factor TFIIB, a general transcription factor" GO:0003700;GO:0005634;GO:0006355;GO:0008270;GO:0043565 YPR086W SUA7 "Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II" Transcription initiation factor IIB PAS_1g01895 CAY67418.1 PAS_chr1-1_0060 Hypothetical protein GO:0000166 Pre-mRNA branch site p14-like protein PAS_1g01900 CAY67419.1 PAS_chr1-1_0061 ATP-dependent RNA helicase YMR290C HAS1 ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles ATP-dependent RNA helicase HAS1 PAS_1g01905 CAY67420.1 PAS_chr1-1_0062 "GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway" GO:0003934;GO:0005737;GO:0019438 YGR267C FOL2 "GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway" GTP cyclohydrolase 1 PAS_1g01910 CAY67421.1 PAS_chr1-1_0063 Apyrase with wide substrate specificity GO:0016787 YER005W YND1 "Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p" Golgi apyrase PAS_1g01915 CAY67422.1 PAS_chr1-1_0064 Protein of unknown function that associates with ribosomes and has a putative RNA binding domain YER007C-A TMA20 Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1 Translation machinery-associated protein 20 PAS_1g01920 CAY67423.1 PAS_chr1-1_0468 hypothetical protein GO:0000166 YIR005W IST3 "Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing" "RNA-binding motif protein, X-linked 2 " PAS_1g01925 CAY67424.1 PAS_chr1-1_0065 Component of the U2 snRNP GO:0000166 YGR128C UTP8 Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA U3 small nucleolar RNA-associated protein 8 PAS_1g01930 CAY67425.1 PAS_chr1-1_0066 Putative X-Pro aminopeptidase GO:0006508;GO:0008235 YFR006W YFR006W Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene Uncharacterized peptidase YFR006W PAS_1g01935 CAY67426.1 PAS_chr1-1_0067 Essential N-acetylglucosamine-phosphate mutase GO:0005975;GO:0016868 YEL058W PCM1 "Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors" Phosphoacetylglucosamine mutase PAS_1g01940 CAY67427.1 PAS_chr1-1_0068 "Putative protein of unknown function, has homology to Staphylococcus aureus nuclease" GO:0003676 YGL085W YGL085W "Putative protein of unknown function, has homology to Staphylococcus aureus nuclease; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS" Probable endonuclease YGL085W PAS_1g01945 CAY67428.1 PAS_chr1-1_0069 Plasma membrane protein involved in remodeling GPI anchors YGL084C GUP1 Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Glycerol uptake protein 1 PAS_1g01950 CAY67429.1 PAS_chr1-1_0469 hypothetical protein PAS_1g01955 CAY67430.1 PAS_chr1-1_0070 "Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p)" Probable lipase C16A3.12c PAS_1g01960 CAY67431.1 PAS_chr1-1_0071 Hypothetical protein PAS_1g01965 CAY67432.1 PAS_chr1-1_0072 "Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis" GO:0004332;GO:0006096;n/a YKL060C FBA1 "Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress" Fructose-bisphosphate aldolase PAS_1g01970 CAY67433.1 PAS_chr1-1_0470 hypothetical protein Putative mediator of RNA polymerase II transcription subunit 26 PAS_1g01975 YPR052C NHP6A "High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters" Non-histone chromosomal protein 6 PAS_1g01980 CAY67434.1 PAS_chr1-1_0074 "Essential protein of the inner mitochondrial membrane, peripherally localized" GO:0006626;GO:0042719;GO:0045039 YBR091C TIM12 "Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins" Mitochondrial import inner membrane translocase subunit tim10 PAS_1g01985 Inhibitor of Bruton tyrosine kinase PAS_1g01990 CAY67435.1 PAS_chr1-1_0076 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 40S ribosomal protein S22 PAS_1g01995 CAY67436.1 PAS_chr1-1_0077 Putative protein of unknown function GO:0005488 YKL033W TTI1 Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies TEL2-interacting protein 1 PAS_1g02000 CAY67437.1 PAS_chr1-1_0078 Regulatory subunit of type 1 protein phosphatase Glc7p YDR028C REG1 "Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes" Protein HEX2 PAS_1g02005 CAY67438.1 PAS_chr1-1_0079 Non-ATPase regulatory subunit of the 26S proteasome YDR427W RPN9 "Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects" 26S proteasome regulatory subunit RPN9 PAS_1g02010 CAY67439.1 PAS_chr1-1_0080 "Protein of unknown function, deletion causes multi-budding phenotype" GO:0031177 YMR100W MUB1 Protein that interacts with E2 and E3 enzymes Ubr2p and Rad6p and is required for ubiquitylation and degradation of Rpn4p; contains a MYND domain (residues 512 to 555); has a short half-life; has similarity to Aspergillus nidulans samB gene MYND-type zinc finger protein MUB1 PAS_1g02015 CAY67440.1 PAS_chr1-1_0081 "Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate" GO:0005215;GO:0005743;GO:0006810 YKL120W OAC1 "Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family" Mitochondrial oxaloacetate transport protein PAS_1g02020 CAY67441.1 PAS_chr1-1_0471 hypothetical protein YMR102C YMR102C Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene WD repeat-containing protein YKL121W PAS_1g02025 CAY67442.1 PAS_chr1-1_0082 RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm GO:0000166 YDR432W NPL3 "RNA-binding protein that promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm" Nucleolar protein 3 PAS_1g02030 CAY67443.1 PAS_chr1-1_0083 Kinesin-related motor protein involved in mitotic spindle positioning GO:0003777;GO:0005524;GO:0005875;GO:0007018 Kinesin-related protein 1 PAS_1g02035 CAY67444.1 PAS_chr1-1_0084 Protein involved in ER-associated protein degradation YML013W UBX2 Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain UBX domain-containing protein 3 PAS_1g02040 CAY67445.1 PAS_chr1-1_0085 Hypothetical protein YDL218W YDL218W Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin Uncharacterized membrane protein YGR131W PAS_1g02045 CAY67446.1 PAS_chr1-1_0086 "Co-chaperone for Hsp40p, anchored in the ER membrane" GO:0006457;GO:0031072;GO:0051082 YMR161W HLJ1 "Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ" Uncharacterized J domain-containing protein C17A3.05c PAS_1g02050 CAY67447.1 PAS_chr1-1_0087 "ATPase that forms a large complex, containing actin and several actin-related proteins" GO:0003677;GO:0005524 YGL150C INO80 "ATPase, subunit of a complex containing actin and several actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription" Putative DNA helicase ino80 PAS_1g02055 CAY67448.1 PAS_chr1-1_0088 Essential protein that binds ribosomal protein L11 GO:0005634;GO:0042254 YOR294W RRS1 Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice Regulator of ribosome biosynthesis PAS_1g02060 CAY67449.1 PAS_chr1-1_0089 Hypothetical protein GO:0005634 PAS_1g02065 CAY67450.1 PAS_chr1-1_0090 Putative protein of unknown function YOR296W YOR296W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene Uncharacterized protein YOR296W PAS_1g02070 CAY67451.1 PAS_chr1-1_0091 Protein involved in programmed cell death GRAM domain-containing protein YSP2 PAS_1g02075 CAY67452.1 PAS_chr1-1_0092 Hypothetical protein GO:0016020;GO:0030001;GO:0046873 Magnesium transport protein corA PAS_1g02080 CAY67453.1 PAS_chr1-1_0093 Hypothetical protein YGR053C YGR053C Putative protein of unknown function PAS_1g02085 CAY67454.1 PAS_chr1-1_0094 Hypothetical protein PAS_1g02090 CAY67455.1 PAS_chr1-1_0472 hypothetical protein PAS_1g02095 CAY67456.1 PAS_chr1-1_0095 Subunit (60 kDa) of TFIID and SAGA complexes GO:0005634;GO:0006352;GO:0016986 YGL112C TAF6 "Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4" Transcription initiation factor TFIID subunit 6 PAS_1g02100 CAY67457.1 PAS_chr1-1_0473 hypothetical protein YBR238C YBR238C Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span "Protein RMD9, mitochondrial " PAS_1g02105 CAY67458.1 PAS_chr1-1_0096 GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors GO:0004871;GO:0005525;GO:0007186 YHR005C GPA1 GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome Guanine nucleotide-binding protein alpha-1 subunit PAS_1g02110 CAY67459.1 PAS_chr1-1_0097 "Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcript" YHR071W PCL5 "Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity" PHO85 cyclin-5 PAS_1g02115 CAY67460.1 PAS_chr1-1_0098 "Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YJR113C RSM7 "Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein" "37S ribosomal protein S7, mitochondrial " PAS_1g02120 CAY67461.1 PAS_chr1-1_0099 Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex) GO:0003824;GO:0046872 YBL045C COR1 "Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain" "Cytochrome b-c1 complex subunit 1, mitochondrial " PAS_1g02125 CAY67462.1 PAS_chr1-1_0100 Mitochondrial ribosomal protein of the small subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YPR166C MRP2 Mitochondrial ribosomal protein of the small subunit "40S ribosomal protein MRP2, mitochondrial " PAS_1g02130 CAY67463.1 PAS_chr1-1_0101 Hypothetical protein YLR392C ART10 Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene PAS_1g02135 CAY67464.1 PAS_chr1-1_0102 Histone methyltransferase with a role in transcriptional elongation "Histone-lysine N-methyltransferase, H3 lysine-36 specific " PAS_1g02140 CAY67465.1 PAS_chr1-1_0103 "Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component" GO:0005975;GO:0016810 YLR308W CDA2 "Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall" Chitin deacetylase 2 PAS_1g02145 CAY67466.1 PAS_chr1-1_0104 Putative protein proposed to be involved in the metabolism of purine and pyrimidine base analogues YJL055W YJL055W "Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU" LOG family protein YJL055W PAS_1g02150 CAY67467.1 PAS_chr1-1_0105 MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway YJL128C PBS2 "MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; plays a role in regulating Ty1 transposition" MAP kinase kinase PBS2 PAS_1g02155 CAY67468.1 PAS_chr1-1_0106 Subunit of the RNA polymerase II mediator complex YNL236W SIN4 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription Mediator of RNA polymerase II transcription subunit 16 PAS_1g02160 CAY67469.1 PAS_chr1-1_0107 NADP(+)-dependent glutamate dehydrogenase GO:0006520;GO:0016491 YAL062W GDH3 "NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources" NADP-specific glutamate dehydrogenase PAS_1g02165 CAY67470.1 PAS_chr1-1_0108 Hypothetical protein GO:0008152;GO:0016491 Oleate-induced peroxisomal protein POX18 PAS_1g02170 CAY67471.1 PAS_chr1-1_0109 Hypothetical protein GO:0006801;GO:0046872 PAS_1g02175 CAY67472.1 PAS_chr1-1_0110 Mitochondrial matrix protein involved in biogenesis of iron-sulfur (Fe/S) cluster of Fe/S proteins GO:0005198;GO:0016226;GO:0051536 YLL027W ISA1 "Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources" Iron-sulfur assembly protein 1 PAS_1g02180 CAY67473.1 PAS_chr1-1_0111 Protein involved in negative regulation of transcription of iron regulon GO:0006508;GO:0008235 YLL029W FRA1 "Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation" Uncharacterized peptidase C22G7.01c PAS_1g02185 CAY67474.1 PAS_chr1-1_0112 "Karyopherin beta, responsible for the import of the Toa1p-Toa2p complex into the nucleus" GO:0005488 YGL016W KAP122 "Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance" Pleiotropic drug resistance regulatory protein 6 PAS_1g02190 CAY67475.1 PAS_chr1-1_0113 Subunit of heterotrimeric Replication Protein A (RPA) YAR007C RFA1 "Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination" Replication factor A protein 1 PAS_1g02195 CAY67476.1 PAS_chr1-1_0114 Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome YGL004C RPN14 Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p 26S proteasome regulatory subunit RPN14 PAS_1g02200 CAY67477.1 PAS_chr1-1_0116 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) YGL005C COG7 "Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" Conserved oligomeric Golgi complex subunit 7 PAS_1g02205 CAY67478.1 PAS_chr1-1_0117 Calcium-transporting ATPase GO:0006812;GO:0015662;GO:0016020 YGL006W PMC1 Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a Calcium-transporting ATPase 2 PAS_1g02210 CAY67479.1 PAS_chr1-1_0118 Hypothetical protein Mitochondrial outer membrane protein OM45 PAS_1g02215 CAY67480.1 PAS_chr1-1_0474 hypothetical protein YDR279W RNH202 "Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome" PAS_1g02220 CAY67481.1 PAS_chr1-1_0119 Zinc finger protein YDR049W YDR049W Zinc finger protein; putative transcription factor that may interact with proteins involved in histone acetylation or deacetylation; may be involved in altering acetylation on histone lysines Zinc finger protein YDR049W PAS_1g02225 CAY67482.1 PAS_chr1-1_0120 "Lipid-binding protein, localized to the bud via specific mRNA transport" YML072C TCB3 "Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact" Tricalbin-3 PAS_1g02230 CAY67483.1 PAS_chr1-1_0475 hypothetical protein GO:0044262;GO:0046912 YNR001C CIT1 "Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein" "Citrate synthase, mitochondrial " PAS_1g02235 PAS_1g02240 CAY67484.1 PAS_chr1-1_0122 Hypothetical protein GO:0005634;GO:0030528;GO:0045449 Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007 PAS_1g02245 CAY67485.1 PAS_chr1-1_0123 Putative sensor/transporter protein involved in cell wall biogenesis YCR017C CWH43 Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion Protein CWH43 PAS_1g02250 CAY67486.1 PAS_chr1-1_0124 Hypothetical protein "NADH-ubiquinone oxidoreductase 12 kDa subunit, mitochondrial " PAS_1g02255 PAS_1g02260 CAY67487.1 PAS_chr1-1_0126 Hypothetical protein YCR015C YCR015C Putative protein of unknown function; YCR015C is not an essential gene PAS_1g02265 CAY67488.1 PAS_chr1-1_0127 Hypothetical protein GO:0016787;GO:0046983 Peptidase M20 domain-containing protein C757.05c PAS_1g02270 CAY67489.1 PAS_chr1-1_0476 hypothetical protein YCR016W YCR016W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis DNA ligase 1 PAS_1g02275 CAY67490.1 PAS_chr1-1_0128 Hypothetical protein Cullin-associated NEDD8-dissociated protein 1 PAS_1g02280 CAY67491.1 PAS_chr1-1_0477 hypothetical protein GO:0003824;GO:0008152 PAS_1g02285 CAY67492.1 PAS_chr1-1_0129 Putative protein of unknown function GO:0006118;GO:0016491 Trimethyllysine dioxygenase PAS_1g02290 CAY67493.1 PAS_chr1-1_0478 hypothetical protein PAS_1g02295 CAY67494.1 PAS_chr1-1_0130 "Daughter cell-specific secreted protein with similarity to glucanases, endo-1,3-beta-glucanase" YNR067C DSE4 "Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother" "Endo-1,3(4)-beta-glucanase 1 " PAS_1g02300 CAY67495.1 PAS_chr1-1_0131 "General transcriptional co-repressor, acts together with Tup1p" General transcriptional corepressor trfA PAS_1g02305 CAY67496.1 PAS_chr1-1_0132 "Purine nucleoside phosphorylase, specifically metabolizes inosine & guanosine nucleosides" GO:0004731;GO:0006139 YLR209C PNP1 "Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway" Purine nucleoside phosphorylase PAS_1g02310 CAY67497.1 PAS_chr1-1_0133 Hypothetical protein PAS_1g02315 CAY67498.1 PAS_chr1-1_0134 Putative protein of unknown function YKL077W YKL077W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Uncharacterized protein YKL077W PAS_1g02320 CAY67499.1 PAS_chr1-1_0135 Hypothetical protein Spore coat protein SP96 PAS_1g02325 CAY67500.1 PAS_chr1-1_0136 "Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)" YMR126C DLT1 "Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)" PAS_1g02330 CAY67501.1 PAS_chr1-1_0137 Hypothetical protein YMR059W SEN15 "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p" tRNA-splicing endonuclease subunit SEN15 PAS_1g02335 CAY67502.1 PAS_chr1-1_0138 Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex YMR060C SAM37 "Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability" PAS_1g02340 CAY67503.1 PAS_chr1-1_0139 Protein required for accurate chromosome segregation YGL093W SPC105 Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components Spindle pole body component SPC105 PAS_1g02345 CAY67504.1 PAS_chr1-1_0140 Hypothetical protein SNF1 protein kinase subunit beta-2 PAS_1g02350 CAY67505.1 PAS_chr1-1_0141 Non-essential protein of unknown function YBL029W YBL029W Non-essential protein of unknown function Uncharacterized protein YBL029W PAS_1g02355 CAY67506.1 PAS_chr1-1_0142 Putative protein of unknown function YKL047W YKL047W "Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" Uncharacterized protein YKL047W PAS_1g02360 CAY67507.1 PAS_chr1-1_0143 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease comple YGL094C PAN2 "Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes" PAB-dependent poly(A)-specific ribonuclease subunit PAN2 PAS_1g02365 CAY67508.1 PAS_chr1-1_0144 Homolog of the prokaryotic ribosomal protein L36 GO:0003735;GO:0005622;GO:0005840;GO:0006412 YPL183W-A RTC6 "Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome; null mutation suppresses cdc13-1 temperature sensitivity" "54S ribosomal protein YPL183W-A, mitochondrial " PAS_1g02370 CAY67509.1 PAS_chr1-1_0145 Cytoplasmic protein with a role in regulation of Ty1 transposition YPL183C RTT10 Cytoplasmic protein with a role in regulation of Ty1 transposition Uncharacterized WD repeat-containing protein YPL183C PAS_1g02375 CAY67510.1 PAS_chr1-1_0146 Putative protein of unknown function GO:0003824;GO:0008152 YMR130W YMR130W Putative protein of unknown function; YMR130W is not an essential gene Uncharacterized protein YMR130W PAS_1g02380 CAY67511.1 PAS_chr1-1_0147 "Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein" YMR238W DFG5 "Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p" "Mannan endo-1,6-alpha-mannosidase DFG5 " PAS_1g02385 CAY67512.1 PAS_chr1-1_0148 Hypothetical protein YPL180W TCO89 "Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin" Target of rapamycin complex 1 subunit TCO89 PAS_1g02390 CAY67513.1 PAS_chr1-1_0149 Hypothetical protein YMR172W HOT1 Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p High-osmolarity-induced transcription protein 1 PAS_1g02395 CAY67514.1 PAS_chr1-1_0150 "Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting" GO:0006904;GO:0016192 YGL095C VPS45 "Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment" Vacuolar protein sorting-associated protein 45 PAS_1g02400 CAY67515.1 PAS_chr1-1_0151 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor GO:0008270 YPL181W CTI6 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain Histone deacetylase complex subunit CTI6 PAS_1g02405 CAY67516.1 PAS_chr1-1_0152 "Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p)" YHR109W CTM1 "Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth" Cytochrome c lysine N-methyltransferase 1 PAS_1g02410 CAY67517.1 PAS_chr1-1_0153 "Serine/threonine protein phosphatase Z, isoform of Ppz2p" GO:0016787 Serine/threonine-protein phosphatase PP-Z1 PAS_1g02415 CAY67518.1 PAS_chr1-1_0154 Small subunit of the heterodimeric cap binding complex that also contains Sto1p GO:0000166 YPL178W CBC2 "Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif" Nuclear cap-binding protein subunit 2 PAS_1g02420 CAY67519.1 PAS_chr1-1_0155 "Nuclear thiol peroxidase, functions as an alkyl-hydroperoxide reductase during post-diauxic growth" YIL010W DOT5 Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth Peroxiredoxin DOT5 PAS_1g02425 CAY67520.1 PAS_chr1-1_0156 Hypothetical protein YBR275C RIF1 Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation PAS_1g02430 CAY67521.1 PAS_chr1-1_0157 "Protein of unknown function, expression is sensitive to nitrogen catabolite repression" YIR030C DCG1 "Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain" Protein DCG1 PAS_1g02435 CAY67522.1 PAS_chr1-1_0158 "Putative transmembrane protein involved in export of ammonia, a starvation signal" GO:0016020 YNR002C ATO2 "Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p" Accumulation of dyads protein 2 PAS_1g02440 CAY67523.1 PAS_chr1-1_0479 hypothetical protein Cell wall protein DAN4 PAS_1g02445 CAY67524.1 PAS_chr1-1_0159 "Protein of unknown function, required for normal localization of actin patches" YBR151W APD1 "Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus" Actin patches distal protein 1 PAS_1g02450 CAY67525.1 PAS_chr1-1_0160 "Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen" GO:0005783 Protein disulfide-isomerase erp38 PAS_1g02455 CAY67526.1 PAS_chr1-1_0161 N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding YLR084C RAX2 N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p Bud site selection protein RAX2 PAS_1g02460 CAY67527.1 PAS_chr1-1_0162 Hypothetical protein PAS_1g02465 CAY67528.1 PAS_chr1-1_0163 Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis YHR144C DCD1 Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated Deoxycytidylate deaminase PAS_1g02470 CAY67529.1 PAS_chr1-1_0164 Putative protein of fumarylacetoacetate hydrolase family protein GO:0003824;GO:0008152 YNL168C FMP41 "Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Uncharacterized hydrolase C21C3.09c PAS_1g02475 CAY67530.1 PAS_chr1-1_0165 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0043565;GO:0046983 YNL167C SKO1 "Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses" Transcription factor atf1 PAS_1g02480 CAY67531.1 PAS_chr1-1_0166 "RNA polymerase subunit, found in RNA polymerase complexes I, II, and III" GO:0003677;GO:0003899;GO:0006350 YHR143W-A RPC10 "RNA polymerase subunit, found in RNA polymerase complexes I, II, and III" "DNA-directed RNA polymerases I, II, and III subunit RPABC4 " PAS_1g02485 CAY67532.1 PAS_chr1-1_0167 "Peripheral mitochondrial inner membrane protein, located on the matrix face of the membrane" YPL005W AEP3 "Peripheral mitochondrial inner membrane protein, located on the matrix face of the membrane; stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex" ATPase expression protein 3 PAS_1g02490 CAY67533.1 PAS_chr1-1_0168 Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway GO:0016021 YPL006W NCR1 "Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein" Niemann-Pick C1 protein PAS_1g02495 CAY67534.1 PAS_chr1-1_0169 Protein required for the ubiquinone (Coenzyme Q) biosynthesis GO:0006744;GO:0019538 YOR125C CAT5 Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation Catabolite repression protein CAT5 PAS_1g02500 CAY67535.1 PAS_chr1-1_0170 N-myristoylated calcium-binding protein that may have a role in intracellular signaling GO:0005509 YDR373W FRQ1 N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily Calcium-binding protein NCS-1 PAS_1g02505 CAY67536.1 PAS_chr1-1_0171 Negative regulator of the glucose-sensing signal transduction pathway YDR277C MTH1 "Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation" Protein MTH1 PAS_1g02510 CAY67537.1 PAS_chr1-1_0172 Hypothetical protein GO:0003954;GO:0005739;GO:0006118;GO:0008137 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 PAS_1g02515 CAY67538.1 PAS_chr1-1_0173 Hypothetical protein PAS_1g02520 CAY67539.1 PAS_chr1-1_0174 ATP-dependent Lon protease involved in degradation of misfolded proteins in mitochondria GO:0004176;GO:0004252;GO:0006508 "Lon protease homolog 2, peroxisomal " PAS_1g02525 CAY67540.1 PAS_chr1-1_0175 Hypothetical protein GO:0008152;GO:0016829 Dihydrodipicolinate synthase PAS_1g02530 CAY67541.1 PAS_chr1-1_0176 Putative FAD transporter YGL139W FLC3 "Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER" Flavin carrier protein 2 PAS_1g02535 CAY67542.1 PAS_chr1-1_0177 Hypothetical protein YGL138C YGL138C Putative protein of unknown function; has no significant sequence similarity to any known protein PAS_1g02540 CAY67543.1 PAS_chr1-1_0178 Hypothetical protein Cyclin-U2-1 PAS_1g02545 CAY67544.1 PAS_chr1-1_0179 Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits YPL217C BMS1 "GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p" Ribosome biogenesis protein BMS1 PAS_1g02550 CAY67545.1 PAS_chr1-1_0180 "GTPase; GTP-binding protein of the ARF family, component of COPII coat of vesicles" GO:0005525 YPL218W SAR1 "GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport" Small COPII coat GTPase SAR1 PAS_1g02555 CAY67546.1 PAS_chr1-1_0181 "Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport" YGL137W SEC27 "Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP" Coatomer subunit beta' PAS_1g02560 CAY67547.1 PAS_chr1-1_0182 "Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA" YGL136C MRM2 "Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ" "Ribosomal RNA methyltransferase MRM2, mitochondrial " PAS_1g02565 CAY67548.1 PAS_chr1-1_0183 N-terminally acetylated protein component of the large (60S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YGL135W RPL1B "N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal" 60S ribosomal protein L1 PAS_1g02570 CAY67549.1 PAS_chr1-1_0480 hypothetical protein GO:0005634;GO:0006281;GO:0008081 YBR223C TDP1 "Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI" Probable tyrosyl-DNA phosphodiesterase PAS_1g02575 CAY67550.1 PAS_chr1-1_0184 Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis GO:0004357;GO:0006750 YJL101C GSH1 "Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury" Glutamate--cysteine ligase PAS_1g02580 CAY67551.1 PAS_chr1-1_0185 Hypothetical protein PAS_1g02585 CAY67552.1 PAS_chr1-1_0186 Putative GTPase involved in 60S ribosomal subunit biogenesis GO:0005525;GO:0005622 YGL099W LSG1 Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Large subunit GTPase 1 PAS_1g02590 CAY67553.1 PAS_chr1-1_0481 hypothetical protein YGL098W USE1 "Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p" PAS_1g02595 CAY67554.1 PAS_chr1-1_0187 "Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex" GO:0005524;GO:0005622;GO:0006355;GO:0008134 YLR106C MDN1 "Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm" Midasin PAS_1g02600 PAS_1g02605 CAY67555.1 PAS_chr1-1_0189 "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YDR418W RPL12B "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins" 60S ribosomal protein L12 PAS_1g02610 CAY67556.1 PAS_chr1-1_0190 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type YEL053C MAK10 "Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible" "N-alpha-acetyltransferase, 35 NatC auxiliary subunit homolog " PAS_1g02615 CAY67557.1 PAS_chr1-1_0191 Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase GO:0015986;GO:0016469;GO:0046933;GO:0046961 YDR298C ATP5 "Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated" "ATP synthase subunit 5, mitochondrial " PAS_1g02620 CAY67558.1 PAS_chr1-1_0192 "Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein" GO:0003723;GO:0003735;GO:0006412;GO:0015934;GO:0016740 YEL050C RML2 "Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor" "54S ribosomal protein RML2, mitochondrial " PAS_1g02625 CAY67559.1 PAS_chr1-1_0193 Hypothetical protein PAS_1g02630 CAY67560.1 PAS_chr1-1_0194 Putative protein of unknown function GO:0006508;GO:0008233 YDR415C YDR415C Putative protein of unknown function Probable aminopeptidase YDR415C PAS_1g02635 CAY67561.1 PAS_chr1-1_0195 Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) GO:0016469;GO:0042626;GO:0046961 YEL051W VMA8 "Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis" V-type proton ATPase subunit D PAS_1g02640 CAY67562.1 PAS_chr1-1_0196 Component of the spliceosome complex involved in pre-mRNA splicing GO:0005488 YDR416W SYF1 "Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans" Pre-mRNA-splicing factor syf1 PAS_1g02645 CAY67563.1 PAS_chr1-1_0197 Conserved protein that may act as a chaperone in the degradation of cytochrome c oxidase subunits YEL052W AFG1 Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain Protein AFG1 PAS_1g02650 CAY67564.1 PAS_chr1-1_0198 Hypothetical protein PAS_1g02655 CAY67565.1 PAS_chr1-1_0199 "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA" YDR324C UTP4 Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript U3 small nucleolar RNA-associated protein 4 PAS_1g02660 CAY67566.1 PAS_chr1-1_0482 hypothetical protein YMR087W YMR087W Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain PAS_1g02665 CAY67567.1 PAS_chr1-1_0200 Cytosolic aspartate aminotransferase; involved in nitrogen metabolism GO:0003824;GO:0030170 "Aspartate aminotransferase, mitochondrial " PAS_1g02670 CAY67568.1 PAS_chr1-1_0201 "G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway" YOR212W STE4 "G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats" Guanine nucleotide-binding protein subunit beta PAS_1g02675 CAY67569.1 PAS_chr1-1_0483 hypothetical protein YCR081W SRB8 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression Mediator of RNA polymerase II transcription subunit 12 PAS_1g02680 CAY67570.1 PAS_chr1-1_0202 Subunit of the RNA polymerase II mediator complex GO:0005524 "[Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial " PAS_1g02685 CAY67571.1 PAS_chr1-1_0203 General amino acid permease GO:0006810;GO:0016020 General amino-acid permease GAP1 PAS_1g02690 CAY67572.1 PAS_chr1-1_0204 Hypothetical protein GO:0000166 Transformer-2 protein homolog alpha PAS_1g02695 CAY67573.1 PAS_chr1-1_0205 Hypothetical protein Uncharacterized protein YIL156W-B PAS_1g02700 CAY67574.1 PAS_chr1-1_0206 "Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4" YKL018W SWD2 "Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination" COMPASS component SWD2 PAS_1g02705 CAY67575.1 PAS_chr1-1_0207 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis GO:0003677;GO:0004003;GO:0005524;GO:0006281;n/a YKL017C HCS1 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities DNA polymerase alpha-associated DNA helicase A PAS_1g02710 CAY67576.1 PAS_chr1-1_0484 hypothetical protein GO:0015986;GO:0016469;GO:0046933;GO:0046961 YKL016C ATP7 "Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis" "ATP synthase subunit d, mitochondrial " PAS_1g02715 CAY67577.1 PAS_chr1-1_0208 Hypothetical protein Uncharacterized protein YLR154C-H/YLR156C-A/YLR157C-C/YLR159C-A PAS_1g02720 CAY67578.1 PAS_chr1-1_0209 Hypothetical protein PAS_1g02725 CAY67579.1 PAS_chr1-1_0210 Hypothetical protein PAS_1g02730 CAY67580.1 PAS_chr1-1_0211 Putative vacuolar protein sorting-associated protein vps13 GO:0008104 YLL040C VPS13 "Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention" Vacuolar protein sorting-associated protein 13 PAS_1g02735 CAY67581.1 PAS_chr1-1_0212 "Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria" GO:0009058;GO:0016742 YBL013W FMT1 "Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate" "Methionyl-tRNA formyltransferase, mitochondrial " PAS_1g02740 CAY67582.1 PAS_chr1-1_0213 Putative protein of unknown function YMR155W YMR155W Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Probable transporter MCH1 PAS_1g02745 CAY67583.1 PAS_chr1-1_0214 Hypothetical protein PAS_1g02750 CAY67584.1 PAS_chr1-1_0485 hypothetical protein Ras-interacting protein RIP3 PAS_1g02755 CAY67585.1 PAS_chr1-1_0215 "Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein" GO:0003824 YGL027C CWH41 "Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress" Mannosyl-oligosaccharide glucosidase PAS_1g02760 CAY67586.1 PAS_chr1-1_0216 "Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap" GO:0030529;GO:0042254 60S ribosomal protein L8-A PAS_1g02765 CAY67587.1 PAS_chr1-1_0217 Hypothetical protein GO:0006122;GO:0008121 YFR033C QCR6 "Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1" Cytochrome b-c1 complex subunit 6 PAS_1g02770 CAY67588.1 PAS_chr1-1_0218 Hypothetical protein GO:0000166 Single-stranded TG1-3 DNA-binding protein PAS_1g02775 CAY67589.1 PAS_chr1-1_0219 "Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp" GO:0003735;GO:0005622;GO:0005840;GO:0006412 60S ribosomal protein L2 PAS_1g02780 CAY67590.1 PAS_chr1-1_0220 Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport GO:0005524;GO:0006810;GO:0016021;GO:0042626 YLL048C YBT1 Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters ATP-dependent bile acid permease PAS_1g02785 CAY67591.1 PAS_chr1-1_0221 "Low affinity methionine permease, similar to Mup1p" GO:0006810;GO:0016020 YHL036W MUP3 "Low affinity methionine permease, similar to Mup1p" Low-affinity methionine permease PAS_1g02790 PAS_1g02795 CAY67592.1 PAS_chr1-1_0223 Hypothetical protein PAS_1g02800 CAY67593.1 PAS_chr1-1_0224 Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex YGL100W SEH1 "Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p" Nucleoporin SEH1 PAS_1g02805 CAY67594.1 PAS_chr1-1_0225 Hypothetical protein Uncharacterized protein DDB_G0271670 PAS_1g02810 CAY67595.1 PAS_chr1-1_0226 "Vacuolar proteinase B (yscB), a serine protease of the subtilisin family" YEL060C PRB1 "Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation" Cerevisin PAS_1g02815 CAY67596.1 PAS_chr1-1_0227 "Nuclear pore-associated protein, forms a complex with Sac3p" YOL072W THP1 "Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding" Nuclear mRNA export protein THP1 PAS_1g02820 CAY67597.1 PAS_chr1-1_0228 Hypothetical protein Protein PXR1 PAS_1g02825 CAY67598.1 PAS_chr1-1_0229 Hypothetical protein PAS_1g02830 CAY67599.1 PAS_chr1-1_0230 "tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs" YOL093W TRM10 "tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs" tRNA (guanine-N(1)-)-methyltransferase PAS_1g02835 CAY67600.1 PAS_chr1-1_0231 Putative protein of unknown function YBR147W RTC2 Protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; detected in highly purified mitochondria; null mutant suppresses cdc13-1; similar to a G-protein coupled receptor from S. pombe Uncharacterized membrane protein YOL092W PAS_1g02840 CAY67601.1 PAS_chr1-1_0232 Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore YMR047C NUP116 Subunit of the Nup82 subcomplex of the nuclear pore complex; localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p Nucleoporin nup189 PAS_1g02845 CAY67602.1 PAS_chr1-1_0233 "Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate" GO:0004450 YDL066W IDP1 "Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes" "Isocitrate dehydrogenase [NADP], mitochondrial " PAS_1g02850 CAY67603.1 PAS_chr1-1_0234 Hypothetical protein PAS_1g02855 CAY67604.1 PAS_chr1-1_0235 Protein binding phosphatidylinositol 3-phosphate GO:0008270 YGL023C PIB2 "Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27" Phosphatidylinositol-3-phosphate-binding protein 2 PAS_1g02860 CAY67605.1 PAS_chr1-1_0236 "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap" GO:0003735;GO:0005622;GO:0005840;GO:0006412 60S ribosomal protein L9-B PAS_1g02865 CAY67606.1 PAS_chr1-1_0237 Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p GO:0005783 YOL031C SIL1 "Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein" Nucleotide exchange factor SIL1 PAS_1g02870 CAY67607.1 PAS_chr1-1_0238 "Protein whose overexpression affects chromosome stability, potential Cdc28p substrate" GO:0003677;GO:0005524 Uncharacterized ATP-dependent helicase FUN30 PAS_1g02875 CAY67608.1 PAS_chr1-1_0239 "Protein required, with Elongator complex, Kti11p & Kti12p, for modification of wobble nucleosides in" YAL020C ATS1 "Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle" RCC1 repeat-containing protein C10F6.04 PAS_1g02880 CAY67609.1 PAS_chr1-1_0486 hypothetical protein YOL032W OPI10 "Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline" Protein OPI10 PAS_1g02885 CAY67610.1 PAS_chr1-1_0240 Hypothetical protein PAS_1g02890 CAY67611.1 PAS_chr1-1_0241 "Mitochondrial glutamyl-tRNA synthetase, encoded by a nuclear gene" GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412 YOL033W MSE1 "Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated" "Glutamyl-tRNA synthetase, mitochondrial " PAS_1g02895 CAY67612.1 PAS_chr1-1_0242 "DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p" GO:0003676;GO:0006304 YLR234W TOP3 "DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination" DNA topoisomerase 3 PAS_1g02900 CAY67613.1 PAS_chr1-1_0243 "Lipoyl ligase, involved in the modification of mitochondrial enzymes" GO:0003824;GO:0006464 YLR239C LIP2 "Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups" "Putative lipoyltransferase 2, mitochondrial " PAS_1g02905 CAY67614.1 PAS_chr1-1_0244 "Protein of unknown function, component of the SWR1 complex" YAL011W SWC3 "Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae" SWR1-complex protein 3 PAS_1g02910 CAY67615.1 PAS_chr1-1_0245 Structural maintenance of chromosomes (SMC) protein GO:0005524;GO:0005694;GO:0006259 YOL034W SMC5 Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair Structural maintenance of chromosomes protein 5 PAS_1g02915 CAY67616.1 PAS_chr1-1_0246 Hypothetical protein YAL014C SYN8 Endosomal SNARE related to mammalian syntaxin 8 Syntaxin-6 PAS_1g02920 CAY67617.1 PAS_chr1-1_0247 Subunit of both the Mdm10-Mdm12-Mmm1 complex and the mitochondrial sorting and assembly machinery YAL010C MDM10 "Subunit of both the ERMES complex that links the ER to mitochondria, and of the mitochondrial sorting and assembly machinery (SAM complex) that functions in import and assembly of outer membrane beta-barrel proteins" Mitochondrial distribution and morphology protein 10 PAS_1g02925 CAY67618.1 PAS_chr1-1_0248 Regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme YAL009W SPO7 "Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation" Sporulation-specific protein SPO7 PAS_1g02930 CAY67619.1 PAS_chr1-1_0249 "Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers" YPR107C YTH1 "Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation" mRNA 3'-end-processing protein YTH1 PAS_1g02935 CAY67620.1 PAS_chr1-1_0250 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) YPR105C COG4 "Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" Conserved oligomeric Golgi complex subunit 4 PAS_1g02940 CAY67621.1 PAS_chr1-1_0251 Hypothetical protein PAS_1g02945 CAY67622.1 PAS_chr1-1_0252 Hypothetical protein PAS_1g02950 CAY67623.1 PAS_chr1-1_0253 Member of the DRG family of GTP-binding proteins GO:0005525;GO:0005622 YAL036C RBG1 "Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid" GTP-binding protein RBG1 PAS_1g02955 CAY67624.1 PAS_chr1-1_0254 GTPase YAL035W FUN12 "GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2" Eukaryotic translation initiation factor 5B PAS_1g02960 CAY67625.1 PAS_chr1-1_0255 Subunit of the THO complex GO:0031177 YNL139C THO2 "Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids" THO complex subunit 2 PAS_1g02965 CAY67626.1 PAS_chr1-1_0256 Hypothetical protein YNL138W-A YSF3 "Component of the SF3b subcomplex of the U2 snRNP, essential protein required for for splicing and for assembly of SF3b" Splicing factor 3B subunit 5 PAS_1g02970 CAY67627.1 PAS_chr1-1_0257 Hypothetical protein PAS_1g02975 CAY67628.1 PAS_chr1-1_0258 Essential protein that associates with the contractile actomyosin ring YNL152W INN1 "Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function" Uncharacterized protein YNL152W PAS_1g02980 CAY67629.1 PAS_chr1-1_0259 Hypothetical protein GO:0004867 YNL151C RPC31 RNA polymerase III subunit C31; contains HMG-like C-terminal domain DNA-directed RNA polymerase III subunit RPC7 PAS_1g02985 CAY67630.1 PAS_chr1-1_0260 Hypothetical protein YNL149C PGA2 Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect Uncharacterized protein YNL149C PAS_1g02990 CAY67631.1 PAS_chr1-1_0261 "Alpha-tubulin folding protein, similar to mammalian cofactor B" YNL148C ALF1 "Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance" Tubulin-folding cofactor B PAS_1g02995 CAY67632.1 PAS_chr1-1_0487 hypothetical protein YNL147W LSM7 "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA" U6 snRNA-associated Sm-like protein LSm7 PAS_1g03000 CAY67633.1 PAS_chr1-1_0262 "Uracil phosphoribosyltransferase, synthesizes UMP from uracil" GO:0016071;GO:0030529 YHR128W FUR1 "Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway" Uracil phosphoribosyltransferase PAS_1g03005 CAY67634.1 PAS_chr1-1_0263 Actin-related protein of the dynactin complex GO:0005515 Beta-centractin PAS_1g03010 CAY67635.1 PAS_chr1-1_0264 Hypothetical protein GO:0005488 PAS_1g03015 CAY67636.1 PAS_chr1-1_0265 Hypothetical protein GO:0005634;GO:0030528;GO:0045449 YFR034C PHO4 Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability Uncharacterized protein DDB_G0271670 PAS_1g03020 CAY67637.1 PAS_chr1-1_0266 Putative protein of unknown function YGR125W YGR125W Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Uncharacterized vacuolar membrane protein YGR125W PAS_1g03025 CAY67638.1 PAS_chr1-1_0267 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum GO:0003755;GO:0006457 YDR304C CPR5 "Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER" Peptidyl-prolyl cis-trans isomerase B PAS_1g03030 CAY67639.1 PAS_chr1-1_0268 Hypothetical protein YMR294W JNM1 "Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B" PAS_1g03035 CAY67640.1 PAS_chr1-1_0269 "Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs" YGR271W SLH1 "Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses" Antiviral helicase SLH1 PAS_1g03040 CAY67641.1 PAS_chr1-1_0270 Protein of unknown function YGR271C-A EFG1 Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus rRNA-processing protein EFG1 PAS_1g03045 CAY67642.1 PAS_chr1-1_0271 Evolutionarily conserved non-essential protein present in early Golgi cisternae GO:0016192 YMR292W GOT1 "Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2p" Protein transport protein GOT1 PAS_1g03050 YGR268C HUA1 Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly Proline-rich protein HUA1 PAS_1g03055 CAY67643.1 PAS_chr1-1_0273 Protein tyrosine phosphatase involved in cell cycle control GO:0000087;GO:0004725;GO:0005622;GO:0006470 YMR036C MIH1 Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25 M-phase inducer phosphatase PAS_1g03060 CAY67644.1 PAS_chr1-1_0274 Catalytic subunit of the mitochondrial inner membrane peptidase complex GO:0008236;GO:0009003;GO:0016021 YMR035W IMP2 "Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p" Mitochondrial inner membrane protease subunit 2 PAS_1g03065 CAY67645.1 PAS_chr1-1_0275 "Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection" GO:0006801;GO:0046872 YMR038C CCS1 "Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation" Superoxide dismutase 1 copper chaperone PAS_1g03070 CAY67646.1 PAS_chr1-1_0488 hypothetical protein PAS_1g03075 CAY67647.1 PAS_chr1-1_0276 Endoplasmic reticulum transmembrane protein GO:0005783;GO:0006886;GO:0006915;GO:0016021;n/a YKL065C YET1 "Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein" Endoplasmic reticulum transmembrane protein 1 PAS_1g03080 CAY67648.1 PAS_chr1-1_0489 hypothetical protein PAS_1g03085 CAY67649.1 PAS_chr1-1_0277 Protein with a possible role in tRNA export GO:0006098;GO:0017057 YNR034W SOL1 "Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p" 6-phosphogluconolactonase-like protein 1 PAS_1g03090 CAY67650.1 PAS_chr1-1_0278 Hypothetical protein LIMR family protein C622.11 PAS_1g03095 CAY67651.1 PAS_chr1-1_0279 Mitochondrial protein phosphatase of type 2C with similarity to mammalian PP1Ks YCR079W PTC6 Mitochondrial protein phosphatase of type 2C with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase Protein phosphatase 2C homolog 6 PAS_1g03100 CAY67652.1 PAS_chr1-1_0490 hypothetical protein GO:0008270;GO:0016491 YJR159W SOR1 Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose Sorbitol dehydrogenase 1 PAS_1g03105 CAY67653.1 PAS_chr1-1_0491 hypothetical protein GO:0005787;GO:0005792;GO:0006465;GO:0009003;GO:0016021 Probable signal peptidase complex subunit 1 PAS_1g03110 CAY67654.1 PAS_chr1-1_0280 "Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP" GO:0005787;GO:0005792;GO:0006465;GO:0009003;GO:0016021 YGR194C XKS1 "Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains" Probable D-xylulose kinase A PAS_1g03115 CAY67655.1 PAS_chr1-1_0281 "Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds" GO:0006814;GO:0008508;GO:0016020 YPR201W ARR3 "Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite" Arsenical-resistance protein ACR3 PAS_1g03120 CAY67656.1 PAS_chr1-1_0282 One of two large regulatory subunits of ribonucleotide-diphosphate reductase GO:0004748;GO:0005515;GO:0005971;GO:0006260 YER070W RNR1 "One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits" Ribonucleoside-diphosphate reductase large chain 2 PAS_1g03125 CAY67657.1 PAS_chr1-1_0283 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 40S ribosomal protein S27 PAS_1g03130 CAY67658.1 PAS_chr1-1_0284 Putative plasma membrane permease proposed to be involved in carboxylic acid uptake YLR004C THI73 Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs Thiamine pathway transporter THI73 PAS_1g03135 CAY67659.1 PAS_chr1-1_0492 hypothetical protein PAS_1g03140 CAY67660.1 PAS_chr1-1_0285 F-box protein of unknown function YDR306C YDR306C F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain F-box protein YDR306C PAS_1g03145 CAY67661.1 PAS_chr1-1_0286 "Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose" GO:0016020 Dolichyl-phosphate-mannose--protein mannosyltransferase 1 PAS_1g03150 CAY67662.1 PAS_chr1-1_0287 Allantoin permease YJR152W DAL5 "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" Uncharacterized transporter C417.10 PAS_1g03155 CAY67663.1 PAS_chr1-1_0288 Subunit of the RNA polymerase II mediator complex GO:0005634 YDR308C SRB7 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p Mediator of RNA polymerase II transcription subunit 21 PAS_1g03160 CAY67664.1 PAS_chr1-1_0493 hypothetical protein YHR060W VMA22 "Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)" Centromere protein F PAS_1g03165 CAY67665.1 PAS_chr1-1_0289 Hypothetical protein PAS_1g03170 CAY67666.1 PAS_chr1-1_0290 RING-type ubiquitin ligase of the endosomal and vacuolar membranes GO:0008270 YDR313C PIB1 "RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain" E3 ubiquitin-protein ligase PIB1 PAS_1g03175 CAY67667.1 PAS_chr1-1_0291 "Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p" YDR312W SSF2 "Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family" Brix domain-containing protein C1B9.03c PAS_1g03180 CAY67668.1 PAS_chr1-1_0292 Protein involved in rRNA processing YHR065C RRP3 "Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity" ATP-dependent rRNA helicase RRP3 PAS_1g03185 CAY67669.1 PAS_chr1-1_0293 Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan GO:0004553;GO:0005975 YEL040W UTR2 Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck Probable glycosidase crf2 PAS_1g03190 CAY67670.1 PAS_chr1-1_0294 Alpha subunit of COPI vesicle coatomer complex GO:0005198;GO:0005515;GO:0006461;GO:0006886;GO:0008565;GO:0016192;GO:0030126 YDL145C COP1 "Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway" Coatomer subunit alpha PAS_1g03195 CAY67671.1 PAS_chr1-1_0295 JmjC domain family histone demethylase specific for H3-K36 GO:0008270 YER051W JHD1 "JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe" JmjC domain-containing histone demethylation protein 1 PAS_1g03200 CAY67672.1 PAS_chr1-1_0296 Mitochondrial ribosomal protein of the small subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YER050C RSM18 "Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein" "37S ribosomal protein RSM18, mitochondrial " PAS_1g03205 CAY67673.1 PAS_chr1-1_0297 Mitochondrial protein kinase GO:0016310;GO:0016772 YIL042C PKP1 Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p "[Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial " PAS_1g03210 CAY67674.1 PAS_chr1-1_0298 Protein of unknown function YDL146W LDB17 "Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck" Protein LDB17 PAS_1g03215 CAY67675.1 PAS_chr1-1_0495 hypothetical protein PAS_1g03220 CAY67676.1 PAS_chr1-1_0299 "Essential, non-ATPase regulatory subunit of the 26S proteasome lid" YDL147W RPN5 "Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p" 26S proteasome regulatory subunit RPN5 PAS_1g03225 CAY67677.1 PAS_chr1-1_0300 Plasma membrane glucose sensor that regulates glucose transport YDL194W SNF3 Plasma membrane low glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; similar to Rgt2p High-affinity glucose transporter SNF3 PAS_1g03230 CAY67678.1 PAS_chr1-1_0301 "Prenyltransferase, required for cell viability" GO:0008152;GO:0016740 YDL193W NUS1 "Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY" Probable undecaprenyl pyrophosphate synthase PAS_1g03235 CAY67679.1 PAS_chr1-1_0302 "Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YDL136W RPL35B "Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein" 60S ribosomal protein L35 PAS_1g03240 CAY67680.1 PAS_chr1-1_0303 Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1) YDL190C UFD2 "Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3" E4 ubiquitin-protein ligase UFD2 PAS_1g03245 CAY67681.1 PAS_chr1-1_0304 "Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations" GO:0003676 YDL189W RBS1 "Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain" RNA-binding suppressor of PAS kinase protein 1 PAS_1g03250 CAY67682.1 PAS_chr1-1_0305 Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p GO:0005094;GO:0005737 YDL135C RDI1 Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p Rho GDP-dissociation inhibitor PAS_1g03255 CAY67683.1 PAS_chr1-1_0306 Hypothetical protein Probable allantoinase 1 PAS_1g03260 CAY67684.1 PAS_chr1-1_0307 "Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p" GO:0016787 YDL134C PPH21 "Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis" Serine/threonine-protein phosphatase PP2A-2 catalytic subunit PAS_1g03265 CAY67685.1 PAS_chr1-1_0308 Hypothetical protein PAS_1g03270 CAY67686.1 PAS_chr1-1_0309 Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites GO:0003735;GO:0005840;GO:0006412 YDL185W TFP1 "Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease" V-type proton ATPase catalytic subunit A PAS_1g03275 CAY67687.1 PAS_chr1-1_0310 Putative protein of unknown function YDL183C YDL183C Putative protein of unknown function; YDL183C is not an essential gene Uncharacterized protein YDL183C PAS_1g03280 CAY67688.1 PAS_chr1-1_0311 Putative protein of unknown function YDL133W YDL133W Putative protein of unknown function Uncharacterized membrane protein YDL133W PAS_1g03285 CAY67689.1 PAS_chr1-1_0312 "Cullin, structural protein of SCF complexes, involved in ubiquination" YDL132W CDC53 "Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation" Cell division control protein 53 PAS_1g03290 CAY67690.1 PAS_chr1-1_0313 "Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate" GO:0019752;GO:0046912 YDL131W LYS21 "Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p" "Homocitrate synthase, mitochondrial " PAS_1g03295 CAY67691.1 PAS_chr1-1_0314 Component of the GARP (Golgi-associated retrograde protein) complex GO:0005515;GO:0042147 YDR027C VPS54 "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p" Vacuolar protein sorting-associated protein 54 PAS_1g03300 CAY67692.1 PAS_chr1-1_0315 Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase GO:0004857;GO:0005739;GO:0045980 YDL181W INH1 Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro "ATPase inhibitor, mitochondrial " PAS_1g03305 PAS_1g03310 CAY67693.1 PAS_chr1-1_0317 Hypothetical protein GO:0004190;GO:0006508 U5 small nuclear ribonucleoprotein 40 kDa protein PAS_1g03315 CAY67694.1 PAS_chr1-1_0318 Hypothetical protein GO:0003677;GO:0005524 DNA repair protein RAD5 PAS_1g03320 CAY67695.1 PAS_chr1-1_0319 "Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis" GO:0004332;GO:0006096 Fructose-bisphosphate aldolase PAS_1g03325 CAY67696.1 PAS_chr1-1_0320 Putative protein of unknown function YNL144C YNL144C "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene" PH domain-containing protein YHR131C PAS_1g03330 Uncharacterized protein YLR154C-H/YLR156C-A/YLR157C-C/YLR159C-A PAS_1g03335 CAY67697.1 PAS_chr1-1_0322 Subunit 7 of the ubiquinol cytochrome-c reductase complex GO:0006118;GO:0006122;GO:0008121 YDR529C QCR7 "Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly" Cytochrome b-c1 complex subunit 7 PAS_1g03340 CAY67698.1 PAS_chr1-1_0323 "Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase)" GO:0003877;GO:0005524 YDR530C APA2 "Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p" "5',5'''-P-1,P-4-tetraphosphate phosphorylase 2 " PAS_1g03345 CAY67699.1 PAS_chr1-1_0324 "Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33)" GO:0004594;GO:0005524;GO:0015937 YDR531W CAB1 "Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA)" Pantothenate kinase PAS_1g03350 CAY67700.1 PAS_chr1-1_0325 Hypothetical protein Seryl-tRNA synthetase PAS_1g03355 CAY67701.1 PAS_chr1-1_0326 Hypothetical protein PAS_1g03360 CAY67702.1 PAS_chr1-1_0327 "Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria" GO:0006508;GO:0008237;GO:0008270 YCL057W PRD1 "Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins" Saccharolysin PAS_1g03365 CAY67703.1 PAS_chr1-1_0496 hypothetical protein Probable serine/threonine-protein kinase roco8 PAS_1g03370 CAY67704.1 PAS_chr1-1_0328 Hypothetical protein Uncharacterized protein DDB_G0271670 PAS_1g03375 CAY67705.1 PAS_chr1-1_0329 Hypothetical protein YCL061C MRC1 "S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres" Mediator of replication checkpoint protein 1 PAS_1g03380 CAY67706.1 PAS_chr1-1_0330 Putative protein of unknown function YCL057C-A YCL057C-A "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" UPF0327 protein AFR743W PAS_1g03385 CAY67707.1 PAS_chr1-1_0497 hypothetical protein PAS_1g03390 CAY67708.1 PAS_chr1-1_0331 Essential nucleolar protein required for the synthesis of 18S rRNA GO:0003723 YCL059C KRR1 Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit Ribosomal RNA assembly protein KRR1 PAS_1g03395 CAY67709.1 PAS_chr1-1_0332 Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating YNL279W PRM1 Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p Plasma membrane fusion protein PRM1 PAS_1g03400 CAY67710.1 PAS_chr1-1_0333 Hypothetical protein PAS_1g03405 CAY67711.1 PAS_chr1-1_0334 Hypothetical protein PAS_1g03410 CAY67712.1 PAS_chr1-1_0335 Member of the alpha/beta knot fold methyltransferase superfamily GO:0005634 YLR186W EMG1 Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers Essential for mitotic growth 1 PAS_1g03415 CAY67713.1 PAS_chr1-1_0336 Hypothetical protein YDR499W LCD1 Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP DNA damage checkpoint protein LCD1 PAS_1g03420 CAY67714.1 PAS_chr1-1_0337 "Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YLR185W RPL37A "Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein" 60S ribosomal protein L37-A PAS_1g03425 CAY67715.1 PAS_chr1-1_0338 Protein required for partitioning of the 2-micron plasmid YDR501W PLM2 Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; similar to TOS4 Protein PLM2 PAS_1g03430 CAY67716.1 PAS_chr1-1_0339 Putative protein of unknown function YLR177W YLR177W Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene Uncharacterized protein PB7E8.02 PAS_1g03435 CAY67717.1 PAS_chr1-1_0498 hypothetical protein GO:0003824;GO:0016020 Probable diacylglycerol pyrophosphate phosphatase 1 PAS_1g03440 CAY67718.1 PAS_chr1-1_0340 Protein kinase involved in bud growth and assembly of the septin ring GO:0004672;GO:0005524;GO:0006468 YDR507C GIN4 "Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p" Probable serine/threonine-protein kinase KCC4 PAS_1g03445 CAY67719.1 PAS_chr1-1_0341 Lysine permease GO:0006810;GO:0016020 Lysine-specific permease PAS_1g03450 CAY67720.1 PAS_chr1-1_0342 Hypothetical protein PAS_1g03455 PAS_1g03460 CAY67721.1 PAS_chr1-1_0345 Protein component of the large (60S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YPL131W RPL5 Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly 60S ribosomal protein L5 PAS_1g03465 CAY67722.1 PAS_chr1-1_0346 Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus GO:0005515 YPL137C GIP3 "Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments" Uncharacterized protein YOR227W PAS_1g03470 CAY67723.1 PAS_chr1-1_0347 Hypothetical protein PAS_1g03475 CAY67724.1 PAS_chr1-1_0348 "Protein involved in mating response, invasive/filamentous growth, and osmotolerance" GO:0007165 YCL032W STE50 "Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction" Protein STE50 PAS_1g03480 CAY67725.1 PAS_chr1-1_0349 Essential protein involved in rRNA processing and ribosome biogenesis YCL031C RRP7 Essential protein involved in rRNA processing and ribosome biogenesis Ribosomal RNA-processing protein 7 PAS_1g03485 CAY67726.1 PAS_chr1-1_0350 "Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenes" YDR511W ACN9 "Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes" "Acetate non-utilizing protein 9, mitochondrial " PAS_1g03490 CAY67727.1 PAS_chr1-1_0351 Hypothetical protein YDR515W SLF1 RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts Uncharacterized HTH La-type RNA-binding protein C1527.03 PAS_1g03495 CAY67728.1 PAS_chr1-1_0352 Hypothetical protein PAS_1g03500 CAY67729.1 PAS_chr1-1_0353 Vacuolar integral membrane protein YCL038C ATG22 Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation Autophagy-related protein 22 PAS_1g03505 CAY67730.1 PAS_chr1-1_0354 Allantoin permease Allantoate permease PAS_1g03510 CAY67731.1 PAS_chr1-1_0355 "glycosyl hydrolase family 88, putative" GO:0003824 Unsaturated rhamnogalacturonyl hydrolase yesR PAS_1g03515 CAY67732.1 PAS_chr1-1_0356 Hypothetical protein GO:0008152;GO:0016829 Dihydrodipicolinate synthase PAS_1g03520 CAY67733.1 PAS_chr1-1_0357 NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity GO:0008270;GO:0016491 NADP-dependent alcohol dehydrogenase 6 PAS_1g03525 CAY67734.1 PAS_chr1-1_0358 "Ceramide synthase component, involved in synthesis of ceramide" YHL003C LAG1 "Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p" Sphingosine N-acyltransferase LAC1 PAS_1g03530 CAY67735.1 PAS_chr1-1_0499 hypothetical protein PAS_1g03535 CAY67736.1 PAS_chr1-1_0359 Putative protein of unknown function YGR111W YGR111W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus PAS_1g03540 CAY67737.1 PAS_chr1-1_0360 "2-methylbutyraldehyde reductase, may be involved in isoleucine catabolism" GO:0016491 YDR368W YPR1 "NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases" Putative reductase 1 PAS_1g03545 CAY67738.1 PAS_chr1-1_0361 Putative protein of unknown function GO:0003676;GO:0005622;GO:0008270 Zinc finger protein YPR022C PAS_1g03550 CAY67739.1 PAS_chr1-1_0363 Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p GO:0004842;GO:0005622;GO:0006464;GO:0006512 YKL010C UFD4 "Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins" Ubiquitin fusion degradation protein 4 PAS_1g03555 CAY67740.1 PAS_chr1-1_0364 "Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus" GO:0005622;GO:0042254 YKL009W MRT4 "Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus" mRNA turnover protein 4 PAS_1g03560 CAY67741.1 PAS_chr1-1_0500 hypothetical protein Transcriptional regulator ATRX homolog PAS_1g03565 CAY67742.1 PAS_chr1-1_0365 Putative protein serine/threonine kinase expressed at the end of meiosis YDR523C SPS1 "Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis" Sporulation-specific protein 1 PAS_1g03570 CAY67743.1 PAS_chr1-1_0366 Ribonuclease H1 GO:0003676;GO:0004523 YMR234W RNH1 Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201) Ribonuclease H PAS_1g03575 CAY67744.1 PAS_chr1-1_0367 "Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins" GO:0006511 YGR048W UFD1 "Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol" Ubiquitin fusion degradation protein 1 PAS_1g03580 CAY67745.1 PAS_chr1-1_0368 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC) YGR047C TFC4 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 Transcription factor tau 131 kDa subunit PAS_1g03585 CAY67746.1 PAS_chr1-1_0369 Protein with a positive role in the multivesicular body sorting pathway YNL265C IST1 Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p IST1 homolog PAS_1g03590 CAY67747.1 PAS_chr1-1_0370 Hypothetical protein PAS_1g03595 CAY67748.1 PAS_chr1-1_0371 Transcription factor (bHLH) involved in interorganelle communication GO:0005634;GO:0030528;GO:0045449 YOL067C RTG1 "Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus" Retrograde regulation protein 1 PAS_1g03600 CAY67749.1 PAS_chr1-1_0372 Non-essential tetra-spanning membrane protein found mostly in the late Golgi YBL102W SFT2 "Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5" Protein transport protein SFT2 PAS_1g03605 CAY67750.1 PAS_chr1-1_0373 "Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p)" YDL040C NAT1 "Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing" N-terminal acetyltransferase A complex subunit NAT1 PAS_1g03610 CAY67751.1 PAS_chr1-1_0374 Conserved NAD+ dependent histone deacetylase of the Sirtuin family YDL042C SIR2 "Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication" NAD-dependent histone deacetylase SIR2 PAS_1g03615 CAY67752.1 PAS_chr1-1_0375 Mitochondrial ribosomal protein of the small subunit YDL045W-A MRP10 Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs "40S ribosomal protein MRP10, mitochondrial " PAS_1g03620 CAY67753.1 PAS_chr1-1_0501 hypothetical protein YDL044C MTF2 Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription "Protein NAM1, mitochondrial " PAS_1g03625 CAY67754.1 PAS_chr1-1_0376 DNA replication initiation factor GO:0006270 YLR103C CDC45 "DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes" Cell division control protein 45 PAS_1g03630 CAY67755.1 PAS_chr1-1_0377 RNA exonuclease YLR107W REX3 RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases RNA exonuclease 3 PAS_1g03635 CAY67756.1 PAS_chr1-1_0378 Putative transmembrane protein involved in export of ammonia GO:0016020 Accumulation of dyads protein 2 PAS_1g03640 CAY67757.1 PAS_chr1-1_0379 GPI-anchored aspartyl protease (yapsin) involved in protein processing GO:0004190;GO:0006508 Candidapepsin-5 PAS_1g03645 PAS_1g03650 CAY67758.1 PAS_chr1-1_0381 bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response GO:0003700;GO:0005634;GO:0006355;GO:0043565;GO:0046983 YFL031W HAC1 "Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis" Transcriptional activator HAC1 PAS_1g03655 CAY67759.1 PAS_chr1-1_0382 "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YNL067W RPL9B "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins" 60S ribosomal protein L9-B PAS_1g03660 CAY67760.1 PAS_chr1-1_0383 Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome GO:0003676;GO:0005622;GO:0008270 YDL098C SNU23 Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome Uncharacterized protein C22F3.11c PAS_1g03665 CAY67761.1 PAS_chr1-1_0384 Hypothetical protein YMR157C AIM36 "Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies" PAS_1g03670 CAY67762.1 PAS_chr1-1_0385 Mitochondrial ribosomal protein of the small subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YMR158W MRPS8 Mitochondrial ribosomal protein of the small subunit "37S ribosomal protein S8, mitochondrial " PAS_1g03675 CAY67763.1 PAS_chr1-1_0386 DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA YMR156C TPP1 "DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily" Putative bifunctional polynucleotide phosphatase/kinase PAS_1g03680 CAY67764.1 PAS_chr1-1_0387 Hypothetical protein PAS_1g03685 CAY67765.1 PAS_chr1-1_0388 Hypothetical protein PAS_1g03690 CAY67766.1 PAS_chr1-1_0389 "Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway" GO:0003824 YHR018C ARG4 "Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway" Argininosuccinate lyase PAS_1g03695 CAY67767.1 PAS_chr1-1_0390 "Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis" GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YHR019C DED81 "Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA" "Asparaginyl-tRNA synthetase, cytoplasmic " PAS_1g03700 CAY67768.1 PAS_chr1-1_0391 "Protein of unknown function that may interact with ribosomes, based on co-purification experiments" GO:0000166;GO:0004827;GO:0005524;GO:0005737;GO:0006412;GO:0006433 YHR020W YHR020W "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene" Putative prolyl-tRNA synthetase YHR020W PAS_1g03705 CAY67769.1 PAS_chr1-1_0392 Mitochondrial asparaginyl-tRNA synthetase YCR024C SLM5 Mitochondrial asparaginyl-tRNA synthetase Asparaginyl-tRNA synthetase PAS_1g03710 CAY67770.1 PAS_chr1-1_0393 Chitin synthase I YNL192W CHS1 "Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor" Chitin synthase C PAS_1g03715 CAY67771.1 PAS_chr1-1_0394 Hypothetical protein with low sequence identity to Pdc1p GO:0030976 YEL020C YEL020C Hypothetical protein with low sequence identity to Pdc1p Acetolactate synthase large subunit IlvB1 PAS_1g03720 CAY67772.1 PAS_chr1-1_0395 Nucleotide pyrophosphatase/phosphodiesterase family member GO:0003824;GO:0008152 YCR026C NPP1 Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation Uncharacterized pyrophosphatase/phosphodiesterase C725.05c PAS_1g03725 CAY67773.1 PAS_chr1-1_0396 Hypothetical protein PAS_1g03730 CAY67774.1 PAS_chr1-1_0397 "Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis" GO:0003824 YFR025C HIS2 "Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control" Probable histidinol-phosphatase PAS_1g03735 CAY67775.1 PAS_chr1-1_0398 Plasma membrane ATP binding cassette (ABC) transporter YOR153W PDR5 "Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth" ABC transporter CDR4 PAS_1g03740 CAY67776.1 PAS_chr1-1_0399 Hypothetical protein Ligand of Numb protein X 2 PAS_1g03745 CAY67777.1 PAS_chr1-1_0400 Hypothetical protein YJL019W MPS3 Nuclear envelope protein required for SPB duplication and nuclear fusion; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement PAS_1g03750 CAY67778.1 PAS_chr1-1_0401 "Mitochondrial protein, putative inner membrane transporter" GO:0005215;GO:0005743;GO:0006810 "Carrier protein YMC1, mitochondrial " PAS_1g03755 CAY67779.1 PAS_chr1-1_0402 Hypothetical protein Dentin sialophosphoprotein PAS_1g03760 CAY67780.1 PAS_chr1-1_0403 Hypothetical protein PAS_1g03765 CAY67781.1 PAS_chr1-1_0404 Putative integral membrane protein of unknown function YHR140W YHR140W Putative integral membrane protein of unknown function UPF0641 membrane protein YHR140W PAS_1g03770 CAY67782.1 PAS_chr1-1_0405 Subunit of the heterohexameric cochaperone prefoldin complex YNL153C GIM3 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Prefoldin subunit 4 PAS_1g03775 CAY67783.1 PAS_chr1-1_0406 Hypothetical protein PAS_1g03780 CAY67784.1 PAS_chr1-1_0407 Putative protein of unknown function YIL057C YIL057C Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose Uncharacterized protein YIL057C PAS_1g03785 CAY67785.1 PAS_chr1-1_0408 "Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane" GO:0004499;GO:0005792;GO:0031227;GO:0050660;GO:0050661 Thiol-specific monooxygenase PAS_1g03790 CAY67786.1 PAS_chr1-1_0409 "Karyopherin beta, mediates nuclear import of ribosomal proteins" GO:0005488 YER110C KAP123 "Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1" Importin subunit beta-4 PAS_1g03795 CAY67787.1 PAS_chr1-1_0410 Vacuolar ATPase assembly integral membrane protein VMA21 YGR105W VMA21 "Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)" Vacuolar ATPase assembly integral membrane protein VMA21 PAS_1g03800 CAY67788.1 PAS_chr1-1_0411 "C-14 sterol reductase, acts in ergosterol biosynthesis" GO:0003824;GO:0046872 YNL280C ERG24 "C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions" Delta(14)-sterol reductase PAS_1g03805 CAY67789.1 PAS_chr1-1_0412 Hypothetical protein YGR106C VOA1 "Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval" PAS_1g03810 CAY67790.1 PAS_chr1-1_0413 Hypothetical protein PAS_1g03815 CAY67791.1 PAS_chr1-1_0414 Nuclear protein involved in asymmetric localization of ASH1 mRNA YFR001W LOC1 Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles 60S ribosomal subunit assembly/export protein LOC1 PAS_1g03820 CAY67792.1 PAS_chr1-1_0415 Hypothetical protein YDR476C YDR476C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene PAS_1g03825 CAY67793.1 PAS_chr1-1_0416 Pre-mRNA splicing factor GO:0003676 YBR065C ECM2 "Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p" Pre-mRNA-splicing factor SLT11 PAS_1g03830 CAY67794.1 PAS_chr1-1_0502 hypothetical protein Thymocyte nuclear protein 1 PAS_1g03835 CAY67795.1 PAS_chr1-1_0417 Putative transmembrane protein involved in export of ammonia GO:0016020 Accumulation of dyads protein 2 PAS_1g03840 CAY67796.1 PAS_chr1-1_0418 Acetate transporter required for normal sporulation GO:0016020 Accumulation of dyads protein 2 PAS_1g03845 CAY67797.1 PAS_chr1-1_0419 Acyl-coenzymeA:ethanol O-acyltransferase GO:0016888 YBR177C EHT1 Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane Medium-chain fatty acid ethyl ester synthase/esterase 2 PAS_1g03850 CAY67798.1 PAS_chr1-1_0420 "Phosphatidylserine synthase, functions in phospholipid biosynthesis" YER026C CHO1 "Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline" CDP-diacylglycerol--serine O-phosphatidyltransferase PAS_1g03855 CAY67799.1 PAS_chr1-1_0421 Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV) YGR112W SHY1 Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome Cytochrome oxidase assembly protein SHY1 PAS_1g03860 CAY67800.1 PAS_chr1-1_0422 Hypothetical protein YNL314W DAL82 "Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain" PAS_1g03865 CAY67801.1 PAS_chr1-1_0423 Hypothetical protein YKL119C VPH2 "Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)" Vacuolar ATPase assembly integral membrane protein VPH2 PAS_1g03870 CAY67802.1 PAS_chr1-1_0424 Cis-prenyltransferase involved in synthesis of long-chain dolichols GO:0008152;GO:0016740 YMR101C SRT1 Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase Putative dehydrodolichyl diphosphate synthase PAS_1g03875 CAY67803.1 PAS_chr1-1_0425 Hypothetical protein Meiotically up-regulated gene 70 protein PAS_1g03880 CAY67804.1 PAS_chr1-1_0426 Hypothetical protein YKR006C MRPL13 "Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation" "54S ribosomal protein L13, mitochondrial " PAS_1g03885 CAY67805.1 PAS_chr1-1_0427 "Putative protein of unknown function with some similarity to GPM1/YKL152C, a phosphoglycerate mutase" GO:0003824;GO:0008152 YOR283W YOR283W "Phosphatase with some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene" Probable phosphoglycerate mutase YOR283W PAS_1g03890 CAY67806.1 PAS_chr1-1_0428 "P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance" GO:0006812;GO:0015662;GO:0016020 YDR040C ENA1 "P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance" Calcium-transporting ATPase 3 PAS_1g03895 PAS_1g03900 CAY67807.1 PAS_chr1-1_0430 Phosphoribosylpyrophosphate amidotransferase GO:0016740 YMR300C ADE4 "Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway" Amidophosphoribosyltransferase PAS_1g03905 CAY67808.1 PAS_chr1-1_0431 Hypothetical protein PAS_1g03910 CAY67809.1 PAS_chr1-1_0432 Acetohydroxyacid reductoisomerase GO:0003824;GO:0005488;GO:0008152 YLR355C ILV5 "Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids" "Ketol-acid reductoisomerase, mitochondrial " PAS_1g03915 CAY67810.1 PAS_chr1-1_0433 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity Mitochondrial peroxiredoxin PRX1 PAS_1g03920 CAY67811.1 PAS_chr1-1_0434 Zinc finger protein involved in control of meiosis GO:0003676;GO:0005622;GO:0008270 YGR044C RME1 Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation Zinc finger protein RME1 PAS_1g03925 CAY67812.1 PAS_chr1-1_0435 "Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific proteas" GO:0004221;GO:0006511 YBL067C UBP13 "Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions" Probable ubiquitin carboxyl-terminal hydrolase creB PAS_1g03930 CAY67813.1 PAS_chr1-1_0436 "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP" GO:0000287;GO:0004749;GO:0009156;GO:0044249 YBL068W PRS4 "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes" Ribose-phosphate pyrophosphokinase 4 PAS_1g03935 CAY67814.1 PAS_chr1-1_0437 Ubiquitin-conjugating enzyme involved in ER-associated protein degradation GO:0019787;GO:0043687;GO:0051246 YER100W UBC6 Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway Ubiquitin-conjugating enzyme E2 6 PAS_1g03940 CAY67815.1 PAS_chr1-1_0438 Zn-ribbon protein YBL071W-A KTI11 "Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs" Diphthamide biosynthesis protein 3 PAS_1g03945 CAY67816.1 PAS_chr1-1_0439 Protein component of the small (40S) ribosomal subunit GO:0005622 YBL072C RPS8A Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein 40S ribosomal protein S8 PAS_1g03950 CAY67817.1 PAS_chr1-1_0440 Hypothetical protein PAS_1g03955 CAY67818.1 PAS_chr1-1_0441 Hypothetical protein PAS_1g03960 CAY67819.1 PAS_chr1-1_0442 Protein related to mammalian high mobility group proteins GO:0003677;GO:0006355 YDL002C NHP10 "Protein related to mammalian high mobility group proteins; binds preferentially to DNA ends and is able to protect them from exonuclease cleavage; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex" Non-histone protein 10 PAS_1g03965 CAY67820.1 PAS_chr1-1_0443 Component of the small-subunit (SSU) processome GO:0005488 YBL004W UTP20 "Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA" U3 small nucleolar RNA-associated protein 20 PAS_1g03970 CAY67821.1 PAS_chr1-1_0444 Cytoplasmic protein required for sporulation YDL001W RMD1 Cytoplasmic protein required for sporulation Sad1-interacting factor 2 PAS_1g03975 CAY67822.1 PAS_chr1-1_0445 "Non-essential protein of unknown function, likely exists as tetrame" YBL001C ECM15 "Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis" UPF0045 protein ECM15 PAS_1g03980 CAY67823.1 PAS_chr1-1_0446 "Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis" YKL021C MAK11 "Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats" Protein MAK11 PAS_1g03985 CAY67824.1 PAS_chr1-1_0447 "Saccharopine dehydrogenase (NAD+, L-lysine-forming)" GO:0016491 YIR034C LYS1 "Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway" "Saccharopine dehydrogenase [NAD+, L-lysine-forming] " PAS_1g03990 CAY67825.1 PAS_chr1-1_0448 "Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus" YBR035C PDX3 "Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism" Pyridoxamine 5'-phosphate oxidase PAS_1g03995 CAY67826.1 PAS_chr1-1_0449 Protein with similarity to members of a family of flavodoxin-like proteins GO:0010181;GO:0016491 YDR032C PST2 "Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Protoplast secreted protein 2 PAS_1g04000 CAY67827.1 PAS_chr1-1_0450 Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C YCL016C DCC1 "Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance" Sister chromatid cohesion protein DCC1 PAS_1g04005 CAY67828.1 PAS_chr1-1_0451 Protein involved in bud-site selection and required for axial budding pattern YCL014W BUD3 Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding Bud site selection protein 3 homolog PAS_1g04010 PAS_1g04015 CAY67829.1 PAS_chr1-1_0453 "Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm" GO:0000166 YCL011C GBP2 "Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro" Protein HRB1 PAS_1g04020 CAY67830.1 PAS_chr1-1_0454 SaGa associated Factor 29kDa YCL010C SGF29 Probable subunit of SAGA histone acetyltransferase complex SAGA-associated factor 29 PAS_1g04025 CAY67831.1 PAS_chr1-1_0455 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YNL005C MRP7 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L2, mitochondrial " PAS_1g04030 CAY67832.1 PAS_chr1-1_0456 Hypothetical protein GO:0006777 Molybdopterin synthase catalytic subunit PAS_1g04035 CAY67833.1 PAS_chr1-1_0457 Phosphatidylinositol-4-phosphate 5-kinase GO:0016307;GO:0046488 YDR208W MSS4 "Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation" Probable phosphatidylinositol-4-phosphate 5-kinase MSS4 PAS_1g04040 PAS_1g04045 CAY67834.1 PAS_chr1-4_0001 Hypothetical protein PAS_1g04050 CAY67835.1 PAS_chr1-4_0002 hypothetical protein YKR074W AIM29 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss Altered inheritance rate of mitochondria protein 29 PAS_1g04055 CAY67836.1 PAS_chr1-4_0003 Mevalonate pyrophosphate decarboxylase YNR043W MVD1 "Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer" Diphosphomevalonate decarboxylase PAS_1g04060 CAY67837.1 PAS_chr1-4_0004 Hypothetical protein YCR086W CSM1 Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation PAS_1g04065 CAY67838.1 PAS_chr1-4_0005 hypothetical protein YCR087C-A YCR087C-A Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene UPF0743 protein C215.06c PAS_1g04070 YJL003W COX16 "Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase" "Cytochrome c oxidase assembly protein COX16, mitochondrial " PAS_1g04075 CAY67839.1 PAS_chr1-4_0006 mitochondrial inner membrane protein GO:0016491;GO:0050660 Thiol-specific monooxygenase PAS_1g04080 CAY67840.1 PAS_chr1-4_0007 Cytoplasmic DExD/H-box helicase YDL160C DHH1 "Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation" ATP-dependent RNA helicase DHH1 PAS_1g04085 CAY67841.1 PAS_chr1-4_0008 MAP kinase YDL159W STE7 "Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway" Dual specificity protein kinase FUZ7 PAS_1g04090 CAY67842.1 PAS_chr1-4_0009 Dihydrofolate synthetase GO:0004326;GO:0005524;GO:0009396 YMR113W FOL3 "Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis" Folylpolyglutamate synthase PAS_1g04095 CAY67843.1 PAS_chr1-4_0010 "Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex" GO:0005515;GO:0006461;GO:0006886;GO:0016192;GO:0030117 YKL135C APL2 "Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting" AP-1 complex subunit beta-1 PAS_1g04100 CAY67844.1 PAS_chr1-4_0653 hypothetical protein YDL156W YDL156W Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus WD repeat-containing protein CIMG_01763 PAS_1g04105 CAY67845.1 PAS_chr1-4_0011 Hypothetical protein PAS_1g04110 CAY67846.1 PAS_chr1-4_0012 TFIID subunit (145 kDa) GO:0003676;GO:0008270 YGR274C TAF1 "TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression" Transcription initiation factor TFIID subunit 1 PAS_1g04115 CAY67847.1 PAS_chr1-4_0013 carboxypeptidase Y GO:0004186 YMR297W PRC1 "Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family" Carboxypeptidase Y PAS_1g04120 CAY67848.1 PAS_chr1-4_0014 hypothetical protein YHR142W CHS7 "Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER" Chitin synthase export chaperone PAS_1g04125 CAY67849.1 PAS_chr1-4_0015 GTPase YNL163C RIA1 Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p) Ribosome assembly protein 1 PAS_1g04130 CAY67850.1 PAS_chr1-4_0016 Hypothetical protein PAS_1g04135 CAY67851.1 PAS_chr1-4_0017 Vacuolar endopolyphosphatase with a role in phosphate metabolism GO:0000298;GO:0005773;GO:0016021 YDR452W PPN1 Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer Endopolyphosphatase PAS_1g04140 CAY67852.1 PAS_chr1-4_0018 Putative protein of unknown function GO:0004129;GO:0005739;GO:0006118 YMR244C-A YMR244C-A Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene Uncharacterized protein YMR244C-A PAS_1g04145 CAY67853.1 PAS_chr1-4_0019 Phosphatidylserine decarboxylase of the mitochondrial inner membrane GO:0004609;GO:0008654 YNL169C PSD1 "Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine" "Phosphatidylserine decarboxylase proenzyme 1, mitochondrial " PAS_1g04150 CAY67854.1 PAS_chr1-4_0020 Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) YNL172W APC1 "Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition" Negative regulator of mitosis PAS_1g04155 CAY67855.1 PAS_chr1-4_0021 CBK1 kinase activator protein MOB2 GO:0005515 YFL034C-B MOB2 "Component of the RAM signaling network, that activates the Cbk1p kinase, thereby facilitating the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p" CBK1 kinase activator protein MOB2 PAS_1g04160 CAY67856.1 PAS_chr1-4_0022 Mitochondrial RNA polymerase GO:0003677;GO:0003899;GO:0006350 YFL036W RPO41 Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition "DNA-directed RNA polymerase, mitochondrial " PAS_1g04165 CAY67857.1 PAS_chr1-4_0023 One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III) GO:0015031 YLR025W SNF7 One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes Vacuolar-sorting protein SNF7 PAS_1g04170 CAY67858.1 PAS_chr1-4_0024 cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex GO:0016020 YLR026C SED5 "cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins" Syntaxin-5 PAS_1g04175 CAY67859.1 PAS_chr1-4_0025 "Frataxin, regulates mitochondrial iron accumulation" YDL120W YFH1 Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia "Frataxin homolog, mitochondrial " PAS_1g04180 CAY67860.1 PAS_chr1-4_0026 Hypothetical protein GO:0003677;GO:0045449 Probable serine/threonine-protein kinase roco8 PAS_1g04185 CAY67861.1 PAS_chr1-4_0027 "Cofilin, promotes actin filament depolarization in a pH-dependent manner" GO:0003779;GO:0005622 YLL050C COF1 "Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes" Cofilin PAS_1g04190 PAS_1g04195 CAY67862.1 PAS_chr1-4_0028 Hypothetical protein PAS_1g04200 CAY67863.1 PAS_chr1-4_0029 "tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNA" GO:0031177 YDL033C SLM3 "tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)" Mitochondrial tRNA-specific 2-thiouridylase 1 PAS_1g04205 CAY67864.1 PAS_chr1-4_0030 Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis GO:0006885;GO:0015299;GO:0016021 YJL094C KHA1 "Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies" K(+)/H(+) antiporter 1 PAS_1g04210 YDR150W NUM1 "Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex" Nuclear migration protein NUM1 PAS_1g04215 YJR144W MGM101 "Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage" Mitochondrial genome maintenance protein MGM101 PAS_1g04220 YJR143C PMT4 "Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals" Dolichyl-phosphate-mannose--protein mannosyltransferase 4 PAS_1g04225 CAY67865.1 PAS_chr1-4_0034 Putative protein of unknown function GO:0016787 YJR142W YJR142W Putative protein of unknown function; GST fusion protein is a Dbf2-Mob1 phosphoylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition Uncharacterized protein YJR142W PAS_1g04230 CAY67866.1 PAS_chr1-4_0035 Hypothetical protein Centromere protein F PAS_1g04235 CAY67867.1 PAS_chr1-4_0036 Hypothetical protein PAS_1g04240 CAY67868.1 PAS_chr1-4_0037 "Alpha-1,2-mannosyltransferase" Protein TTP1 PAS_1g04245 CAY67869.1 PAS_chr1-4_0038 Transcription elongation factor S-II GO:0006350 PAS_1g04250 CAY67870.1 PAS_chr1-4_0039 Hypothetical protein NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 PAS_1g04255 CAY67871.1 PAS_chr1-4_0040 High affinity iron permease involved in the transport of iron across the plasma membrane GO:0016020 YER145C FTR1 High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron Plasma membrane iron permease PAS_1g04260 CAY67872.1 PAS_chr1-4_0041 "Multicopper oxidase, integral membrane protein with similarity to Fet3p" GO:0016491 Iron transport multicopper oxidase FET5 PAS_1g04265 CAY67873.1 PAS_chr1-4_0042 Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase) GO:0005509 YMR099C YMR099C "Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS" Glucose-6-phosphate 1-epimerase PAS_1g04270 CAY67874.1 PAS_chr1-4_0043 Co-chaperone that binds to and regulates Hsp90 family chaperones YKL117W SBA1 Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity Protein wos2 PAS_1g04275 CAY67875.1 PAS_chr1-4_0044 Hypothetical protein YLR224W YLR224W F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene PAS_1g04280 CAY67876.1 PAS_chr1-4_0045 RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and subtelomeric DNA GO:0003723 YBL032W HEK2 "RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K" RNA-binding protein rnc1 PAS_1g04285 CAY67877.1 PAS_chr1-4_0046 Hypothetical protein PAS_1g04290 CAY67878.1 PAS_chr1-4_0047 Beta subunit of heterooctameric phosphofructokinase involved in glycolysis GO:0003872;GO:0005945;GO:0006096 YMR205C PFK2 "Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes" 6-phosphofructokinase subunit beta PAS_1g04295 CAY67879.1 PAS_chr1-4_0048 "Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p" GO:0016021 YPL246C RBD2 "Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p" Rhomboid protein 2 PAS_1g04300 CAY67880.1 PAS_chr1-4_0049 "Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme" YJR139C HOM6 "Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions" Homoserine dehydrogenase PAS_1g04305 CAY67881.1 PAS_chr1-4_0050 Putative mannosyltransferase involved in protein glycosylation GO:0004377;GO:0006486;GO:0016020 YBR199W KTR4 Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family Probable mannosyltransferase KTR4 PAS_1g04310 CAY67882.1 PAS_chr1-4_0051 RNA-dependent ATPase RNA helicase (DEIH box) YER172C BRR2 RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD Pre-mRNA-splicing helicase BRR2 PAS_1g04315 CAY67883.1 PAS_chr1-4_0052 Protein of unknown function that may interact with ribosomes YHL013C OTU2 "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization" OTU domain-containing protein 2 PAS_1g04320 CAY67884.1 PAS_chr1-4_0053 "Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1" YHL014C YLF2 "Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Uncharacterized GTP-binding protein C27E2.03c PAS_1g04325 CAY67885.1 PAS_chr1-4_0054 G1 cyclin involved in cell cycle progression YAL040C CLN3 "G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis" G1/S-specific cyclin CLN2 PAS_1g04330 CAY67886.1 PAS_chr1-4_0055 Clavaminate synthase JmjC domain-containing protein 4 PAS_1g04335 PAS_1g04340 CAY67887.1 PAS_chr1-4_0057 "Protein of unknown function, required for growth on glycerol as a carbon source" YOR355W GDS1 "Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Protein GDS1 PAS_1g04345 CAY67888.1 PAS_chr1-4_0058 Mitochondrial protein with similarity to flavoprotein-type oxidoreductases GO:0004174;GO:0006118 YOR356W YOR356W Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases "Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial " PAS_1g04350 CAY67889.1 PAS_chr1-4_0059 RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit YNL251C NRD1 "RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5; required for transcription termination and 3' end maturation of nonpolyadenylated RNAs" Protein NRD1 PAS_1g04355 CAY67890.1 PAS_chr1-4_0061 hypothetical protein YMR114C YMR114C "Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene" Uncharacterized protein YMR114C PAS_1g04360 CAY67891.1 PAS_chr1-4_0062 hypothetical protein YKL133C YKL133C "Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)" Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3 PAS_1g04365 CAY67892.1 PAS_chr1-4_0654 hypothetical protein Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3 PAS_1g04370 CAY67893.1 PAS_chr1-4_0063 G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p YMR116C ASC1 G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation Guanine nucleotide-binding protein subunit beta-like protein PAS_1g04375 CAY67894.1 PAS_chr1-4_0064 Putative fatty aldehyde dehydrogenase GO:0008152;GO:0016491 YMR110C HFD1 "Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome" Putative fatty aldehyde dehydrogenase HFD1 PAS_1g04380 PAS_1g04385 CAY67895.1 PAS_chr1-4_0066 "Effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p" YPR032W SRO7 "Effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor" Protein SNI2 PAS_1g04390 CAY67896.1 PAS_chr1-4_0067 F-Box protein YBR280C SAF1 F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1 SCF-associated factor 1 PAS_1g04395 CAY67897.1 PAS_chr1-4_0068 Putative protein of unknown function YBL107C YBL107C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBL107C is not an essential gene Uncharacterized protein YBL107C PAS_1g04400 CAY67898.1 PAS_chr1-4_0069 Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) YDR466W PKH3 "Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant" Serine/threonine-protein kinase PKH3 PAS_1g04405 CAY67899.1 PAS_chr1-4_0070 Hypothetical protein PAS_1g04410 CAY67900.1 PAS_chr1-4_0071 "Mitochondrial superoxide dismutase, protects cells against oxygen toxicity" GO:0004784;GO:0006801;GO:0046872 YHR008C SOD2 "Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated" "Probable superoxide dismutase [Mn], mitochondrial " PAS_1g04415 CAY67901.1 PAS_chr1-4_0072 Co-chaperone that binds to Hsp82p and activates its ATPase activity YDR214W AHA1 Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock Hsp90 co-chaperone AHA1 PAS_1g04420 CAY67902.1 PAS_chr1-4_0073 Hypothetical protein PAS_1g04425 CAY67903.1 PAS_chr1-4_0074 "Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme" GO:0008415 YAR035W YAT1 "Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated" Putative mitochondrial carnitine O-acetyltransferase PAS_1g04430 CAY67904.1 PAS_chr1-4_0075 L-rhamnonate dehydratase L-rhamnonate dehydratase PAS_1g04435 CAY67905.1 PAS_chr1-4_0076 Hypothetical protein PAS_1g04440 CAY67906.1 PAS_chr1-4_0077 Integral membrane protein required for efficient mating YBR040W FIG1 "Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating" Factor-induced gene 1 protein PAS_1g04445 CAY67907.1 PAS_chr1-4_0078 Multidrug transporter of the major facilitator superfamily YBR043C QDR3 "Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin" Uncharacterized transporter YBR043C PAS_1g04450 CAY67908.1 PAS_chr1-4_0079 "Protein of unknown function, affects chromosome stability when overexpressed" GO:0008152;GO:0008415 YBR042C CST26 Protein required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed Uncharacterized acyltransferase YDR018C PAS_1g04455 CAY67909.1 PAS_chr1-4_0080 Fatty acid transporter and very long-chain fatty acyl-CoA synthetase GO:0003824;GO:0008152 YBR041W FAT1 "Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids" Very long-chain fatty acid transport protein PAS_1g04460 CAY67910.1 PAS_chr1-4_0081 Protein phosphatase required for mitotic exit GO:0006470;GO:0008138 YFR028C CDC14 "Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit" Tyrosine-protein phosphatase CDC14 PAS_1g04465 CAY67911.1 PAS_chr1-4_0082 Putative cytoplasmic protein of unknown function GO:0003824;GO:0005975;GO:0043169 YBR056W YBR056W Putative cytoplasmic protein of unknown function Uncharacterized glycosyl hydrolase YBR056W PAS_1g04470 CAY67912.1 PAS_chr1-4_0083 "Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase" GO:0020037 YJR078W BNA2 "Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expresssion is upregulated upon telomere uncapping; regulated by Hst1p and Aft2p" "Indoleamine 2,3-dioxygenase family protein " PAS_1g04475 CAY67913.1 PAS_chr1-4_0084 Chromatin modification-related protein EAF6 YJR082C EAF6 Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3 Chromatin modification-related protein EAF6 PAS_1g04480 CAY67914.1 PAS_chr1-4_0085 Actin-related protein GO:0005515 YPR034W ARP7 Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Actin-related protein 4 PAS_1g04485 CAY67915.1 PAS_chr1-4_0086 Hypothetical protein UPF0394 membrane protein XF_0766 PAS_1g04490 CAY67916.1 PAS_chr1-4_0087 Putative protein of unknown function GO:0005525;GO:0005622 YGR210C YGR210C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Uncharacterized GTP-binding protein YGR210C PAS_1g04495 CAY67917.1 PAS_chr1-4_0088 Hypothetical protein PAS_1g04500 CAY67918.1 PAS_chr1-4_0089 Hypothetical protein GO:0005488 YIL017C VID28 "Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm" PAS_1g04505 CAY67919.1 PAS_chr1-4_0090 Polyamine transport protein specific for spermine YPR156C TPO3 Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily Polyamine transporter 3 PAS_1g04510 CAY67920.1 PAS_chr1-4_0091 Hypothetical protein GO:0005515;GO:0006915 PAS_1g04515 CAY67921.1 PAS_chr1-4_0092 exosome component GO:0000175;GO:0003723;GO:0006396 YGR158C MTR3 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) Exosome complex component mtr3 PAS_1g04520 CAY67922.1 PAS_chr1-4_0093 Phosphatidylethanolamine methyltransferase (PEMT) YGR157W CHO2 "Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis" Phosphatidylethanolamine N-methyltransferase PAS_1g04525 CAY67923.1 PAS_chr1-4_0094 GTP binding protein GO:0005525;GO:0005634;GO:0005737;n/a YGR163W GTR2 Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD GTP-binding protein GTR2 PAS_1g04530 CAY67924.1 PAS_chr1-4_0655 tRNA wybutosine-synthesizing protein YGL050W TYW3 "tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions" tRNA wybutosine-synthesizing protein 3 PAS_1g04535 CAY67925.1 PAS_chr1-4_0095 "Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme" GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YLL018C DPS1 "Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation" "Aspartyl-tRNA synthetase, cytoplasmic " PAS_1g04540 CAY67926.1 PAS_chr1-4_0096 "Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration" GO:0016020;GO:0030001;GO:0046873 YOL130W ALR1 "Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions" Magnesium transporter ALR1 PAS_1g04545 CAY67927.1 PAS_chr1-4_0097 Hypothetical protein PAS_1g04550 CAY67928.1 PAS_chr1-4_0098 Essential nucleolar protein required for 40S ribosome biogenesis YNL308C KRI1 Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p Protein KRI1 PAS_1g04555 CAY67929.1 PAS_chr1-4_0099 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) YFR029W PTR3 "Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes" SPS-sensor component PTR3 PAS_1g04560 CAY67930.1 PAS_chr1-4_0100 "Non-essential conserved protein of unknown function, plays a role in mRNA decapping" YEL015W EDC3 "Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies" Enhancer of mRNA-decapping protein 3 PAS_1g04565 CAY67931.1 PAS_chr1-4_0101 Phosphorylated vacuolar membrane protein that interacts with Atg13p GO:0005488 YEL013W VAC8 "Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions" Vacuolar protein 8 PAS_1g04570 CAY67932.1 PAS_chr1-4_0102 Myb-like DNA-binding protein GO:0003677;GO:0045449 Myb-like DNA-binding protein myb-1 PAS_1g04575 PAS_1g04580 CAY67933.1 PAS_chr1-4_0104 Probable mitochondrial seryl-tRNA synthetase GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YHR011W DIA4 "Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth" "Seryl-tRNA synthetase, mitochondrial " PAS_1g04585 CAY67934.1 PAS_chr1-4_0105 "Involved in vesicular transport, mediates transport between an endosomal compartment and the golgi" YLR309C IMH1 "Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi" Golgin IMH1 PAS_1g04590 CAY67935.1 PAS_chr1-4_0106 Arginine methyltransferase YDR465C RMT2 Arginine methyltransferase; ribosomal protein L12 is a substrate Arginine N-methyltransferase 2 PAS_1g04595 CAY67936.1 PAS_chr1-4_0107 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) GO:0005085;GO:0005622;GO:0051056 YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 Cell division control protein 25 (Fragment) PAS_1g04600 CAY67937.1 PAS_chr1-4_0108 Exonuclease component of the nuclear exosome GO:0003676;GO:0005622;GO:0006139;GO:0008408 YOR001W RRP6 "Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10)" Exosome complex exonuclease RRP6 PAS_1g04605 CAY67938.1 PAS_chr1-4_0109 Protein involved in iron metabolism in mitochondria GO:0005506 YKL040C NFU1 "Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria" "NifU-like protein, mitochondrial " PAS_1g04610 CAY67939.1 PAS_chr1-4_0110 pterin-4-alpha-carbinolamine dehydratase YHL018W YHL018W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS Putative pterin-4-alpha-carbinolamine dehydratase PAS_1g04615 CAY67940.1 PAS_chr1-4_0111 Hypothetical protein PAS_1g04620 CAY67941.1 PAS_chr1-4_0112 Mu1-like medium subunit of the clathrin-associated protein complex (AP-1) GO:0006810 Adaptin medium chain homolog APM2 PAS_1g04625 CAY67942.1 PAS_chr1-4_0113 Glutamine-rich cytoplasmic protein of unknown function YOR007C SGT2 "Glutamine-rich cytoplasmic protein of unknown function; contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions; has similarity to human SGT, which is a cochaperone that negatively regulates Hsp70" Small glutamine-rich tetratricopeptide repeat-containing protein 2 PAS_1g04630 CAY67943.1 PAS_chr1-4_0114 Putative protein of unknown function YML002W YML002W Putative protein of unknown function; expression induced by heat and by calcium shortage UPF0507 protein DEHA2G04334g PAS_1g04635 CAY67944.1 PAS_chr1-4_0115 Putative protein of unknown function YOR006C TSR3 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus UPF0293 protein YOR006C PAS_1g04640 CAY67945.1 PAS_chr1-4_0116 Hypothetical protein YJR080C AIM24 "Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss" PAS_1g04645 CAY67946.1 PAS_chr1-4_0117 Beta 4 subunit of the 20S proteasome GO:0004298;GO:0005839;GO:0006511 YER012W PRE1 Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle Probable proteasome subunit beta type-2 PAS_1g04650 CAY67947.1 PAS_chr1-4_0118 DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase YER013W PRP22 "DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes" Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22 PAS_1g04655 CAY67948.1 PAS_chr1-4_0119 Essential protein involved in the TOR signaling pathway GO:0009607;GO:0009966 YMR028W TAP42 Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits Type 2A phosphatase-associated protein 42 PAS_1g04660 CAY67949.1 PAS_chr1-4_0120 "Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport" Prenylated Rab acceptor 1 PAS_1g04665 CAY67950.1 PAS_chr1-4_0121 Transcription initiation factor IIA small subunit GO:0003702;GO:0005672;GO:0006367 YKL058W TOA2 "TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA" Transcription initiation factor IIA small subunit PAS_1g04670 CAY67951.1 PAS_chr1-4_0122 Essential conserved subunit of CPF (cleavage and polyadenylation factor) GO:0003676;GO:0008270 YKL059C MPE1 "Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif" Protein MPE1 PAS_1g04675 CAY67952.1 PAS_chr1-4_0123 Putative protein of unknown function YMR027W YMR027W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene UPF0364 protein YMR027W PAS_1g04680 CAY67953.1 PAS_chr1-4_0124 "Mitochondrial NADH kinase, phosphorylates NADH" GO:0003951;GO:0008152 YPL188W POS5 "Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress" "NADH kinase POS5, mitochondrial " PAS_1g04685 CAY67954.1 PAS_chr1-4_0125 Histone deacetylase YNL330C RPD3 Histone deacetylase; regulates transcription and silencing; plays a role in regulating Ty1 transposition Histone deacetylase RPD3 PAS_1g04690 CAY67955.1 PAS_chr1-4_0126 "Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion" GO:0008270 YNL326C PFA3 "Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions" Palmitoyltransferase PFA3 PAS_1g04695 CAY67956.1 PAS_chr1-4_0128 Essential protein required for determination of budding pattern GO:0005099;GO:0005622;GO:0007264 YPL242C IQG1 "Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family" Ras GTPase-activating-like protein rng2 PAS_1g04700 CAY67957.1 PAS_chr1-4_0129 Hypothetical protein PAS_1g04705 CAY67958.1 PAS_chr1-4_0130 Heat shock protein Hsp90 GO:0005524 YPL240C HSP82 "Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p" Heat shock protein HSP82 PAS_1g04710 CAY67959.1 PAS_chr1-4_0131 Hypothetical protein PAS_1g04715 CAY67960.1 PAS_chr1-4_0132 Protein with similarity to mammalian monocarboxylate permease YKL221W MCH2 "Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport" Probable transporter MCH2 PAS_1g04720 CAY67961.1 PAS_chr1-4_0133 AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p GO:0005524 YNL329C PEX6 AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol Peroxisomal biogenesis factor 6 PAS_1g04725 CAY67962.1 PAS_chr1-4_0134 Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex YPL243W SRP68 Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane Signal recognition particle subunit SRP68 PAS_1g04730 CAY67963.1 PAS_chr1-4_0135 Beta subunit of the translation initiation factor eIF2 GO:0003743;GO:0006413 YPL237W SUI3 "Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding" Eukaryotic translation initiation factor 2 subunit beta PAS_1g04735 CAY67964.1 PAS_chr1-4_0136 Membrane-associated RING finger protein 5 GO:0005515;GO:0008270 PAS_1g04740 CAY67965.1 PAS_chr1-4_0137 Cytoplasmic ankyrin-repeat containing protein of unknown function YPL239W YAR1 "Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock" Ankyrin repeat-containing protein YAR1 PAS_1g04745 CAY67966.1 PAS_chr1-4_0138 Putative protein of unknown function GO:0005488 YMR185W YMR185W "Putative protein of unknown function; conflicting evidence on whether null mutant is viable with elongated buds, or inviable" Uncharacterized protein YMR185W PAS_1g04750 CAY67967.1 PAS_chr1-4_0139 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) GO:0003824;GO:0008152 Putative NADPH dehydrogenase C23G7.10c PAS_1g04755 CAY67968.1 PAS_chr1-4_0140 "Protein of unknown function, localized in the nucleoplasm and the nucleolus" YAL059W ECM1 "Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export" Protein ECM1 PAS_1g04760 CAY67969.1 PAS_chr1-4_0141 Protein with similarity to hydroxymethylpyrimidine phosphate kinases YPR121W THI22 Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1 PAS_1g04765 CAY67970.1 PAS_chr1-4_0142 Essential helicase component of heterohexameric MCM2-7 complexes GO:0003677;GO:0005524;GO:0005634;GO:0006270 YPR019W MCM4 Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication; accumulates in the nucleus in G1; homolog of S. pombe Cdc21p Cell division control protein 54 PAS_1g04770 CAY67971.1 PAS_chr1-4_0143 Type II phosphatidylinositol 4-kinase that binds Las17p GO:0016773 YJL100W LSB6 "Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization" Phosphatidylinositol 4-kinase LSB6 PAS_1g04775 CAY67972.1 PAS_chr1-4_0144 pyridoxal kinase BUD16 YEL029C BUD16 "Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)" Putative pyridoxal kinase BUD16 PAS_1g04780 CAY67973.1 PAS_chr1-4_0656 hypothetical protein GO:0016787;GO:0046983 YBR281C DUG2 Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) Probable di- and tripeptidase DUG2 PAS_1g04785 CAY67974.1 PAS_chr1-4_0145 pirin Pirin-like protein PAS_1g04790 CAY67975.1 PAS_chr1-4_0146 Hypothetical protein PAS_1g04795 CAY67976.1 PAS_chr1-4_0147 eukaryotic translation initiation factor 3 subunit Eukaryotic translation initiation factor 3 subunit E PAS_1g04800 CAY67977.1 PAS_chr1-4_0148 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YJL063C MRPL8 Mitochondrial ribosomal protein of the large subunit "60S ribosomal protein L8, mitochondrial " PAS_1g04805 CAY67978.1 PAS_chr1-4_0694 hypothetical protein PAS_1g04810 CAY67979.1 PAS_chr1-4_0149 "3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis" GO:0008152;GO:0016491 YBR265W TSC10 "3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family" 3-ketodihydrosphingosine reductase TSC10 PAS_1g04815 CAY67980.1 PAS_chr1-4_0150 "Transketolase, similar to Tkl2p" YPR074C TKL1 "Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids" Transketolase PAS_1g04820 CAY67981.1 PAS_chr1-4_0151 Protein phosphotyrosine phosphatase GO:0004725;GO:0006470 YPR073C LTP1 Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine Low molecular weight phosphotyrosine protein phosphatase PAS_1g04825 CAY67982.1 PAS_chr1-4_0152 "Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcrip" GO:0005634;GO:0030528;GO:0045449 YPR072W NOT5 "Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation" General negative regulator of transcription subunit 3 PAS_1g04830 CAY67983.1 PAS_chr1-4_0153 Alpha aminoadipate reductase YBR115C LYS2 "Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p" L-aminoadipate-semialdehyde dehydrogenase large subunit PAS_1g04835 CAY67984.1 PAS_chr1-4_0154 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) GO:0003677;GO:0005524 YBR114W RAD16 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex DNA repair protein RAD16 PAS_1g04840 CAY67985.1 PAS_chr1-4_0155 Hypothetical protein GO:0006012;GO:0016563;GO:0045941 YOL051W GAL11 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors Mediator of RNA polymerase II transcription subunit 15 PAS_1g04845 CAY67986.1 PAS_chr1-4_0156 Hypothetical protein PAS_1g04850 CAY67987.1 PAS_chr1-4_0157 Hypothetical protein PAS_1g04855 CAY67988.1 PAS_chr1-4_0158 Clathrin light chain GO:0005198;GO:0005515;GO:0006461;GO:0006886;GO:0008565;GO:0016192;GO:0030130;GO:0030132 YGR167W CLC1 "Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component" Clathrin light chain PAS_1g04860 CAY67989.1 PAS_chr1-4_0159 Protein that interacts with exonuclease Rat1p and Rai1p YDR289C RTT103 "Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition" UPF0400 protein C337.03 PAS_1g04865 CAY67990.1 PAS_chr1-4_0160 Multifunctional enzyme HIS4 YCL030C HIS4 "Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis" Histidine biosynthesis trifunctional protein PAS_1g04870 CAY67991.1 PAS_chr1-4_0161 Nuclear fusion protein BIK1 YCL029C BIK1 "Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170" Tip elongation protein 1 PAS_1g04875 CAY67992.1 PAS_chr1-4_0162 "GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5" YKR014C YPT52 "GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis" GTP-binding protein ypt5 PAS_1g04880 CAY67993.1 PAS_chr1-4_0163 Putative protein of unknown function GO:0005524;GO:0006457 YOR020C HSP10 "Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES" "10 kDa heat shock protein, mitochondrial " PAS_1g04885 CAY67994.1 PAS_chr1-4_0695 hypothetical protein YBR030W RKM3 Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein Ribosomal N-lysine methyltransferase 3 PAS_1g04890 CAY67995.1 PAS_chr1-4_0164 "Protein of unknown function, has similarity to Pry1p and Pry3p" Protein PRY2 PAS_1g04895 CAY67996.1 PAS_chr1-4_0165 Class E protein of the vacuolar protein-sorting (Vps) pathway GO:0003700;GO:0005634;GO:0006355;GO:0008270;GO:0043565 PAS_1g04900 CAY67997.1 PAS_chr1-4_0657 Vacuolar protein sorting protein GO:0003700;GO:0005634;GO:0006355;GO:0008270;GO:0043565 YKR035W-A DID2 Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors Charged multivesicular body protein 1b-2 PAS_1g04905 CAY67998.1 PAS_chr1-4_0658 hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270;GO:0043565 YJL110C GZF3 GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p Protein GZF3 PAS_1g04910 CAY67999.1 PAS_chr1-4_0166 Hypothetical protein Uncharacterized 21.2 kDa protein PAS_1g04915 CAY68000.1 PAS_chr1-4_0167 Putative protein of unknown function YLR414C YLR414C Putative protein of unknown function; localizes to bud and cytoplasm; co-localizes with Sur7p in punctate patches in the plasma membrane; null mutant displays decreased thermotolerance; transcription induced on cell wall damage Cell membrane protein YLR414C PAS_1g04920 CAY68001.1 PAS_chr1-4_0168 hypothetical protein YPR098C YPR098C "Protein of unknown function, localized to the mitochondrial outer membrane" Uncharacterized mitochondrial outer membrane protein YPR098C PAS_1g04925 CAY68002.1 PAS_chr1-4_0169 actin GO:0005515 YJL081C ARP4 "Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes" Actin-related protein 4 PAS_1g04930 CAY68003.1 PAS_chr1-4_0170 Hypothetical protein PAS_1g04935 CAY68004.1 PAS_chr1-4_0171 Mitochondrial ribosomal protein of the large subunit YPR100W MRPL51 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L51, mitochondrial " PAS_1g04940 CAY68005.1 PAS_chr1-4_0172 hypothetical protein YKR016W FCJ1 Mitochondrial inner membrane protein involved in formation and molecular structure of crista junctions; impairs oligomerization of F1F0-ATP synthase; null shows altered mitochondrial morphology and abnormal mitochondrial genome maintenance Uncharacterized protein YKR016W PAS_1g04945 CAY68006.1 PAS_chr1-4_0173 hypothetical protein GO:0016491 YKR017C YKR017C Putative protein of unknown function; contains a RING finger motif RING finger protein YKR017C PAS_1g04950 CAY68007.1 PAS_chr1-4_0659 hypothetical protein GO:0016491 YLR109W AHP1 "Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p" Putative peroxisomal peroxiredoxin PAS_1g04955 CAY68008.1 PAS_chr1-4_0660 hypothetical protein YKR018C YKR018C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Mitochondrial outer membrane protein CAGL0G03245g PAS_1g04960 CAY68009.1 PAS_chr1-4_0175 Mitochondrial inner membrane localized ATP-dependent DNA helicase GO:0003677;GO:0004003;GO:0005524;GO:0006281 YOL095C HMI1 "Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD" "ATP-dependent DNA helicase HMI1, mitochondrial " PAS_1g04965 CAY68010.1 PAS_chr1-4_0176 Hypothetical protein YNL282W POP3 "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends" PAS_1g04970 CAY68011.1 PAS_chr1-4_0177 Hypothetical protein Rho-associated protein kinase 1 PAS_1g04975 CAY68012.1 PAS_chr1-4_0178 Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway YDR003W RCR2 "Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p" Protein RCR1 PAS_1g04980 CAY68013.1 PAS_chr1-4_0179 Meiosis-specific protein that initiates meiotic recombination GO:0003677;GO:0003918;GO:0005524;GO:0005694;GO:0006259;GO:0006265 YHL022C SPO11 Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation Meiotic recombination protein SPO11 PAS_1g04985 PAS_1g04990 CAY68014.1 PAS_chr1-4_0181 "Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis" GO:0009058;GO:0016779 YLR328W NMA1 "Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways" Nicotinamide-nucleotide adenylyltransferase 1 PAS_1g04995 CAY68015.1 PAS_chr1-4_0182 Subunit (145 kDa) of TFIID and SAGA complexes GO:0003702;GO:0005634;GO:0006352 YDR167W TAF10 "Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification" Transcription initiation factor TFIID subunit 10 PAS_1g05000 CAY68016.1 PAS_chr1-4_0183 "TATA-binding protein, general transcription factor" GO:0003677 YER148W SPT15 "TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability" TATA-box-binding protein PAS_1g05005 CAY68017.1 PAS_chr1-4_0184 Positive regulator of genes in multiple nitrogen degradation pathways GO:0003677;GO:0005634;GO:0006350;GO:0008270 YIR023W DAL81 Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Transcriptional activator protein DAL81 PAS_1g05010 CAY68018.1 PAS_chr1-4_0185 Subunit of the ARP2/3 complex GO:0005856;GO:0030041 YKL013C ARC19 "Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches" Actin-related protein 2/3 complex subunit 4 PAS_1g05015 CAY68019.1 PAS_chr1-4_0186 U1 snRNP protein involved in splicing GO:0005515 YKL012W PRP40 "U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex" Pre-mRNA-processing protein PRP40 PAS_1g05020 CAY68020.1 PAS_chr1-4_0187 18kDa catalytic subunit of the Signal Peptidase Complex GO:0006508;GO:0008236;GO:0016020 YIR022W SEC11 "18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum" Signal peptidase complex catalytic subunit SEC11 PAS_1g05025 CAY68021.1 PAS_chr1-4_0188 "Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification" GO:0006118;GO:0016491 YGR234W YHB1 "Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses" Flavohemoprotein PAS_1g05030 CAY68022.1 PAS_chr1-4_0189 Putative protein of unknown function GO:0004806;GO:0006629 YJR107W YJR107W Putative protein of unknown function; has sequence or structural similarity to lipases Putative lipase YJR107W PAS_1g05035 CAY68023.1 PAS_chr1-4_0190 Putative protein of unknown function YJL163C YJL163C Putative protein of unknown function Uncharacterized membrane protein YJL163C PAS_1g05040 CAY68024.1 PAS_chr1-4_0191 "ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p" GO:0008299 YPL029W SUV3 "ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs" "ATP-dependent RNA helicase SUV3, mitochondrial " PAS_1g05045 CAY68025.1 PAS_chr1-4_0192 DDK (Dbf4-dependent kinase) catalytic subunit YDL017W CDC7 DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression Cell cycle serine/threonine-protein kinase hsk1 PAS_1g05050 CAY68026.1 PAS_chr1-4_0193 Protein involved in bud-site selection YAR014C BUD14 "Protein involved in bud-site selection, Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern" Bud site selection protein 14 PAS_1g05055 CAY68027.1 PAS_chr1-4_0194 "Polyamine transporter that recognizes spermine, putrescine, and spermidine" YLL028W TPO1 "Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane" Polyamine transporter 1 PAS_1g05060 CAY68028.1 PAS_chr1-4_0195 Putative sulfate permease YPR003C YPR003C Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene Putative sulfate transporter YPR003C PAS_1g05065 CAY68029.1 PAS_chr1-4_0196 "Phosphatidylinositol 3,5-bisphosphate-binding protein" YGR223C HSV2 "Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization" SVP1-like protein 2 PAS_1g05070 CAY68030.1 PAS_chr1-4_0197 Subunit of the anaphase-promoting complex/cyclosome (APC/C) YKL022C CDC16 "Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation" Anaphase-promoting complex subunit CDC16 PAS_1g05075 CAY68031.1 PAS_chr1-4_0198 "Pantothenate synthase, also known as pantoate-beta-alanine ligase" GO:0003824;GO:0009058 YIL145C PAN6 "Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC" Pantoate--beta-alanine ligase PAS_1g05080 CAY68032.1 PAS_chr1-4_0199 Hypothetical protein YKR085C MRPL20 Mitochondrial ribosomal protein of the large subunit PAS_1g05085 CAY68033.1 PAS_chr1-4_0200 Hypothetical protein PAS_1g05090 CAY68034.1 PAS_chr1-4_0201 WD40 repeat-containing subunit of the Set3C histone deacetylase complex YBR103W SIF2 "WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus" F-box-like/WD repeat-containing protein ebi PAS_1g05095 CAY68035.1 PAS_chr1-4_0202 Mitochondrial protein involved in protein import into the mitochondrial matrix YGR046W TAM41 Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud Mitochondrial import protein MMP37 PAS_1g05100 CAY68036.1 PAS_chr1-4_0203 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex YIL144W TID3 "Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering" Kinetochore protein NDC80 PAS_1g05105 CAY68037.1 PAS_chr1-4_0204 Component of the holoenzyme form of RNA polymerase transcription factor TFIIH YIL143C SSL2 "Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3" DNA repair helicase RAD25 PAS_1g05110 CAY68038.1 PAS_chr1-4_0205 Ubiquitin-like protein of the SUMO family GO:0006464 YDR510W SMT3 "Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2" Ubiquitin-like protein SMT3 PAS_1g05115 CAY68039.1 PAS_chr1-4_0693 hypothetical protein Suppressor protein SRP40 PAS_1g05120 CAY68040.1 PAS_chr1-4_0206 "Oleic acid-inducible, peroxisomal matrix localized lipase" YOR084W LPX1 "Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction" Peroxisomal membrane protein LPX1 PAS_1g05125 CAY68041.1 PAS_chr1-4_0207 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase YPL059W GRX5 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p "Monothiol glutaredoxin-5, mitochondrial " PAS_1g05130 CAY68042.1 PAS_chr1-4_0661 hypothetical protein YKR086W PRP16 "RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-dependent RNA unwinding activity" Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16 PAS_1g05135 CAY68043.1 PAS_chr1-4_0208 "RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-" GO:0003824;GO:0005488;GO:0008152;n/a YER004W FMP52 "Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation" "Protein FMP52, mitochondrial " PAS_1g05140 CAY68044.1 PAS_chr1-4_0662 hypothetical protein GO:0004674;GO:0006468 YPL209C IPL1 "Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase" Spindle assembly checkpoint kinase PAS_1g05145 CAY68045.1 PAS_chr1-4_0209 Mitochondrial ATP-dependent RNA helicase of the DEAD-box family YGL064C MRH4 "Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function" "ATP-dependent RNA helicase MRH4, mitochondrial " PAS_1g05150 CAY68046.1 PAS_chr1-4_0210 Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex GO:0006614;GO:0008312;GO:0048500 YPL210C SRP72 Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane Signal recognition particle subunit SRP72 PAS_1g05155 CAY68047.1 PAS_chr1-4_0211 Nucleolar protein required for 60S ribosome subunit biogenesis GO:0005515;GO:0005634;GO:0042255 YPL211W NIP7 "Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p" 60S ribosome subunit biogenesis protein NIP7 PAS_1g05160 CAY68048.1 PAS_chr1-4_0212 "tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA" GO:0000049;GO:0001522;GO:0008033;GO:0016439 YPL212C PUS1 "tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA" tRNA pseudouridine synthase 1 PAS_1g05165 CAY68049.1 PAS_chr1-4_0213 Hypothetical protein PAS_1g05170 PAS_1g05175 CAY68050.1 PAS_chr1-4_0215 "Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme" YJL071W ARG2 "Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p" "Amino-acid acetyltransferase, mitochondrial " PAS_1g05180 CAY68051.1 PAS_chr1-4_0216 "Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p)" YJL072C PSF2 "Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery" DNA replication complex GINS protein PSF2 PAS_1g05185 CAY68052.1 PAS_chr1-4_0217 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family YBR271W YBR271W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis Uncharacterized protein YBR271W PAS_1g05190 CAY68053.1 PAS_chr1-4_0218 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase GO:0003849;GO:0009073 YBR249C ARO4 "3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan" "Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited " PAS_1g05195 CAY68054.1 PAS_chr1-4_0219 One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein YBR214W SDS24 "One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; may play an indirect role in fluid-phase endocytosis" Protein SDS24 PAS_1g05200 CAY68055.1 PAS_chr1-4_0220 Protein involved in transcription initiation at TATA-containing promoters YLR399C BDF1 Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p Bromodomain-containing factor 1 PAS_1g05205 PAS_1g05210 CAY68056.1 PAS_chr1-4_0222 "Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme" GO:0006779 YBR213W MET8 "Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis" Siroheme biosynthesis protein met8 PAS_1g05215 CAY68057.1 PAS_chr1-4_0223 RNA binding protein that negatively regulates growth rate GO:0000166 YBR212W NGR1 RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase Uncharacterized RNA-binding protein C23E6.01c PAS_1g05220 CAY68058.1 PAS_chr1-4_0224 Hypothetical protein PAS_1g05225 CAY68059.1 PAS_chr1-4_0225 ER-derived vesicles protein ERV14 GO:0007242;GO:0016020 YGL054C ERV14 "Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon" ER-derived vesicles protein ERV14 PAS_1g05230 CAY68060.1 PAS_chr1-4_0226 hypothetical protein Elongation factor 1-gamma 1 PAS_1g05235 CAY68061.1 PAS_chr1-4_0663 hypothetical protein GO:0003824;GO:0008152 YLR284C ECI1 "Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced" "3,2-trans-enoyl-CoA isomerase " PAS_1g05240 CAY68062.1 PAS_chr1-4_0227 hypothetical protein YLR283W YLR283W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene PAS_1g05245 CAY68063.1 PAS_chr1-4_0228 Core Sm protein Sm D2 GO:0016071;GO:0030529 YLR275W SMD2 "Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2" Small nuclear ribonucleoprotein Sm D2 PAS_1g05250 CAY68064.1 PAS_chr1-4_0229 Hypothetical protein PAS_1g05255 CAY68065.1 PAS_chr1-4_0230 Mitochondrial GTPase of unknown function YLR289W GUF1 Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor GTP-binding protein GUF1 PAS_1g05260 CAY68066.1 PAS_chr1-4_0231 Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles YDL195W SEC31 "Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p; required for ER-derived transport vesicle formation" Protein transport protein SEC31 PAS_1g05265 CAY68067.1 PAS_chr1-4_0232 Plasma membrane protein of unknown function YIL047C SYG1 Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency Protein SYG1 homolog PAS_1g05270 CAY68068.1 PAS_chr1-4_0233 Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis GO:0005524;GO:0006810;GO:0015662;GO:0016020 YIL048W NEO1 Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus Putative phospholipid-transporting ATPase C6C3.06c PAS_1g05275 CAY68069.1 PAS_chr1-4_0234 ATP phosphoribosyltransferase (hexameric enzyme) catalyzes the first step in histidine biosynthesis YER055C HIS1 "ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control" ATP phosphoribosyltransferase PAS_1g05280 CAY68070.1 PAS_chr1-4_0235 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YLR264W RPS28B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein 40S ribosomal protein S28 PAS_1g05285 CAY68071.1 PAS_chr1-4_0236 "Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p" YIL050W PCL7 "Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated" PHO85 cyclin-7 PAS_1g05290 CAY68072.1 PAS_chr1-4_0237 Hypothetical protein YER058W PET117 Protein required for assembly of cytochrome c oxidase "Protein PET117, mitochondrial " PAS_1g05295 CAY68073.1 PAS_chr1-4_0238 Mitochondrial protein involved in maintenance of the mitochondrial genome YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome "Protein MMF1, mitochondrial " PAS_1g05300 CAY68074.1 PAS_chr1-4_0239 "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YER056C-A RPL34A "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein" 60S ribosomal protein L34-A PAS_1g05305 CAY68075.1 PAS_chr1-4_0240 Hypothetical protein PAS_1g05310 CAY68076.1 PAS_chr1-4_0241 Putative protein of unknown function YNR018W AIM38 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; may interact with respiratory chain complex IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss Altered inheritance rate of mitochondria protein 38 PAS_1g05315 CAY68077.1 PAS_chr1-4_0242 "Putative mannosidase, GPI-anchored membrane protein" YKL046C DCW1 "Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p" "Mannan endo-1,6-alpha-mannosidase DCW1 " PAS_1g05320 CAY68078.1 PAS_chr1-4_0243 "Threonine deaminase, catalyzes the first step in isoleucine biosynthesis" GO:0006520;GO:0030170 YER086W ILV1 "Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation" "Threonine dehydratase, mitochondrial " PAS_1g05325 CAY68079.1 PAS_chr1-4_0244 Epsin-like protein involved in endocytosis and actin patch assembly YLR206W ENT2 Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus Epsin-2 PAS_1g05330 CAY68080.1 PAS_chr1-4_0245 Component of the core form of RNA polymerase transcription factor TFIIH YLR005W SSL1 "Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p" Suppressor of stem-loop protein 1 PAS_1g05335 CAY68081.1 PAS_chr1-4_0246 Divalent metal ion transporter involved in manganese homeostasis GO:0005215;GO:0006810;GO:0016020 YHR050W SMF2 Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins Manganese transporter SMF1 PAS_1g05340 CAY68082.1 PAS_chr1-4_0247 "Dihydrouridine synthase, member of a family of dihydrouridine synthases" GO:0008033;GO:0017150;GO:0050660 YNR015W SMM1 "Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs" tRNA-dihydrouridine synthase 2 PAS_1g05345 CAY68083.1 PAS_chr1-4_0248 "Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system" GO:0005743;GO:0008565;GO:0015031 YNR017W TIM23 "Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel" Mitochondrial import inner membrane translocase subunit TIM23 PAS_1g05350 CAY68084.1 PAS_chr1-4_0249 "Acetyl-CoA carboxylase, biotin containing enzyme" GO:0003824;GO:0005524;n/a YNR016C ACC1 "Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids" Acetyl-CoA carboxylase PAS_1g05355 CAY68085.1 PAS_chr1-4_0251 Putative protein of unknown function YCR045C RRT12 Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores Putative subtilase-type proteinase YCR045C PAS_1g05360 CAY68086.1 PAS_chr1-4_0252 Hypothetical protein PAS_1g05365 CAY68087.1 PAS_chr1-4_0253 "ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation" GO:0000103;GO:0004781 YJR010W MET3 "ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism" Sulfate adenylyltransferase PAS_1g05370 CAY68088.1 PAS_chr1-4_0254 Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) YGR193C PDX1 "Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core" "Pyruvate dehydrogenase complex protein X component, mitochondrial " PAS_1g05375 CAY68089.1 PAS_chr1-4_0255 Putative zinc-cluster protein of unknown function GO:0003700;GO:0005634;GO:0006355;GO:0008270 YNR063W YNR063W Putative zinc-cluster protein of unknown function Uncharacterized transcriptional regulatory protein YNR063W PAS_1g05380 CAY68090.1 PAS_chr1-4_0256 Putative membrane protein of unknown function YNR062C YNR062C Putative membrane protein of unknown function Uncharacterized membrane protein YNR062C PAS_1g05385 CAY68091.1 PAS_chr1-4_0257 Protein with similarity to mammalian monocarboxylate permeases YDL054C MCH1 "Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport" Probable transporter MCH1 PAS_1g05390 CAY68092.1 PAS_chr1-4_0258 Hypothetical protein PAS_1g05395 PAS_1g05400 CAY68093.1 PAS_chr1-4_0260 Hypothetical protein PAS_1g05405 CAY68094.1 PAS_chr1-4_0261 Hypothetical protein PAS_1g05410 CAY68095.1 PAS_chr1-4_0262 Alpha' catalytic subunit of casein kinase 2 GO:0004674;GO:0006468 YOR061W CKA2 "Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases" Casein kinase II subunit alpha' PAS_1g05415 CAY68096.1 PAS_chr1-4_0263 Protein required for maturation of the 25S and 5.8S ribosomal RNAs Alpha-actinin-like protein 1 PAS_1g05420 CAY68097.1 PAS_chr1-4_0664 hypothetical protein GO:0005634;GO:0006364 YMR049C ERB1 "Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1" Ribosome biogenesis protein ERB1 PAS_1g05425 CAY68098.1 PAS_chr1-4_0264 Phosphoglucomutase GO:0005975;GO:0016868 YMR105C PGM2 "Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase" Phosphoglucomutase PAS_1g05430 CAY68099.1 PAS_chr1-4_0265 Hypothetical protein YPL129W TAF14 "Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain" Transcription initiation factor TFIID subunit 14 PAS_1g05435 CAY68100.1 PAS_chr1-4_0665 hypothetical protein Cell wall protein DAN4 PAS_1g05440 CAY68101.1 PAS_chr1-4_0267 hypothetical protein GO:0006412;GO:0016884 YOR215C AIM41 Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss PAS_1g05445 CAY68102.1 PAS_chr1-4_0268 Golgi matrix protein involved in the structural organization of the cis-Golgi YOR216C RUD3 Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 GRIP domain-containing protein RUD3 PAS_1g05450 CAY68103.1 PAS_chr1-4_0269 Replication factor C subunit GO:0005622 YOR217W RFC1 "Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon" Replication factor C subunit 1 PAS_1g05455 CAY68104.1 PAS_chr1-4_0270 Hypothetical protein Uncharacterized protein yqjZ PAS_1g05460 CAY68105.1 PAS_chr1-4_0271 Mitogen-activated kinase kinase involved in protein kinase C signaling pathway GO:0004674;GO:0006468 YOR231W MKK1 "Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p" MAP kinase kinase MKK1/SSP32 PAS_1g05465 CAY68106.1 PAS_chr1-4_0272 "GrpE protein homolog, mitochondrial" GO:0005515;GO:0006457 YOR232W MGE1 "Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE" "GrpE protein homolog, mitochondrial " PAS_1g05470 PAS_1g05475 CAY68107.1 PAS_chr1-4_0273 Serine/threonine protein kinase GO:0004674;GO:0006468 YPL141C YPL141C Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene Putative serine/threonine-protein kinase YPL141C PAS_1g05480 CAY68108.1 PAS_chr1-4_0274 Hypothetical protein PAS_1g05485 CAY68109.1 PAS_chr1-4_0275 N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YPL143W RPL33A "N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable" 60S ribosomal protein L33-A PAS_1g05490 CAY68110.1 PAS_chr1-4_0697 hypothetical protein GO:0004146;GO:0006545;GO:0009165 YOR236W DFR1 "Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function" Dihydrofolate reductase PAS_1g05495 CAY68111.1 PAS_chr1-4_0276 WD-repeat protein involved in ribosome biogenesis YCR072C RSA4 "WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus" WD repeat-containing protein YCR072C PAS_1g05500 CAY68112.1 PAS_chr1-4_0277 Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p YGL246C RAI1 "Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing" Protein RAI1 PAS_1g05505 CAY68113.1 PAS_chr1-4_0278 "Member of the oxysterol binding protein family, which includes seven yeast homologs" GO:0008202 YPL145C KES1 "Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex" Protein KES1 PAS_1g05510 CAY68114.1 PAS_chr1-4_0279 MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway YNR031C SSK2 "MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress" Serine/threonine-protein kinase SSK22 PAS_1g05515 CAY68115.1 PAS_chr1-4_0280 "Putative serine/threonine protein phosphatase, required for glycogen accumulation" GO:0016787 YNR032W PPG1 "Putative serine/threonine protein phosphatase, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases" Putative serine/threonine-protein phosphatase C22H10.04 PAS_1g05520 YNR032C-A HUB1 "Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear" Ubiquitin-like modifier HUB1 PAS_1g05525 CAY68116.1 PAS_chr1-4_0698 hypothetical protein GO:0006812;GO:0008324;GO:0016020 YNR039C ZRG17 "Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc" Protein ZRG17 PAS_1g05530 CAY68117.1 PAS_chr1-4_0281 Telobox-containing general regulatory factor YPL128C TBF1 Telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by blocking silent chromatin propagation Protein TBF1 PAS_1g05535 CAY68118.1 PAS_chr1-4_0282 "Histone H1, a linker histone required for nucleosome packaging at restricted sites" GO:0000786;GO:0003677;GO:0005634;GO:0006334 YPL127C HHO1 "Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation" Histone H1 PAS_1g05540 CAY68119.1 PAS_chr1-4_0283 "Poly(A) binding protein, part of the 3'-end RNA-processing complex" GO:0000166 Polyadenylate-binding protein 1-A PAS_1g05545 CAY68120.1 PAS_chr1-4_0284 Protein involved in iron metabolism in mitochondria GO:0005506 NifU-like protein C1709.19c PAS_1g05550 CAY68121.1 PAS_chr1-4_0699 hypothetical protein GO:0008152;GO:0016787 AB hydrolase superfamily protein C1039.03 PAS_1g05555 CAY68122.1 PAS_chr1-4_0285 Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNA GO:0008152;GO:0016787 YKL014C URB1 "Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit" Nucleolar pre-ribosomal-associated protein 1 PAS_1g05560 CAY68123.1 PAS_chr1-4_0286 Forkhead transcription factor GO:0003700;GO:0005634;GO:0006355;GO:0043565 YCR065W HCM1 "Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role" Forkhead transcription factor HCM1 PAS_1g05565 CAY68124.1 PAS_chr1-4_0287 Histone methyltransferase YJL168C SET2 "Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p" "Histone-lysine N-methyltransferase, H3 lysine-36 specific " PAS_1g05570 CAY68125.1 PAS_chr1-4_0666 hypothetical protein YKL176C LST4 Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface PAS_1g05575 CAY68126.1 PAS_chr1-4_0288 Hypothetical protein YLR223C IFH1 "Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate" Dentin sialophosphoprotein PAS_1g05580 CAY68127.1 PAS_chr1-4_0289 Hypothetical protein Eukaryotic translation initiation factor 3 subunit F PAS_1g05585 CAY68128.1 PAS_chr1-4_0290 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 Autophagy-related protein 2 PAS_1g05590 CAY68129.1 PAS_chr1-4_0291 Hypothetical protein PAS_1g05595 CAY68130.1 PAS_chr1-4_0292 3-phosphoglycerate kinase GO:0004618;GO:0006096 YCR012W PGK1 "3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis" Phosphoglycerate kinase PAS_1g05600 CAY68131.1 PAS_chr1-4_0293 Inositol polyphosphate multikinase (IPMK) GO:0008440 YDR173C ARG82 "Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes" Inositol polyphosphate multikinase PAS_1g05605 CAY68132.1 PAS_chr1-4_0294 Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane GO:0016020 YMR183C SSO2 Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p Protein SSO2 PAS_1g05610 CAY68133.1 PAS_chr1-4_0295 Alpha subunit of fatty acid synthetase GO:0000287;GO:0006633;GO:0008897 YPL231W FAS2 "Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; phosphorylated" Fatty acid synthase subunit alpha PAS_1g05615 CAY68134.1 PAS_chr1-4_0296 Protein that binds Sin3p in a two-hybrid assay YDR169C STB3 Ribosomal RNA processing element (RRPE)-binding protein involved in the induction of non-ribosomal protein growth genes by glucose; binds Sin3p in a two-hybrid assay Protein STB3 PAS_1g05620 CAY68135.1 PAS_chr1-4_0297 Suppressor protein STM1 YLR150W STM1 Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure Suppressor protein STM1 PAS_1g05625 CAY68136.1 PAS_chr1-4_0667 hypothetical protein YDR170C SEC7 "Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles" Protein transport protein sec72 PAS_1g05630 CAY68137.1 PAS_chr1-4_0668 hypothetical protein Putative GTP cyclohydrolase URC1 PAS_1g05635 CAY68138.1 PAS_chr1-4_0298 Mitochondrially localized type 2C protein phosphatase GO:0003824 Putative protein phosphatase 2C 24 PAS_1g05640 CAY68139.1 PAS_chr1-4_0299 "Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase" GO:0016491;GO:0050660 YMR145C NDE1 "Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain" "Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial " PAS_1g05645 CAY68140.1 PAS_chr1-4_0300 Protein of unknown function required for sister chromatid cohesion YKR071C DRE2 Protein that may prevent apoptosis by forming a complex with Tah18p in the absence of stress; required for iron-sulfur cluster assembly and sister chromatid cohesion; homolog of human anti-apoptotic protein Ciapin1 Fe-S cluster assembly protein DRE2 PAS_1g05650 CAY68141.1 PAS_chr1-4_0301 Hypothetical protein PAS_1g05655 CAY68142.1 PAS_chr1-4_0302 Calmodulin-dependent protein kinase GO:0004674;GO:0006468 YOL016C CMK2 "Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II" Calcium/calmodulin-dependent protein kinase II PAS_1g05660 CAY68143.1 PAS_chr1-4_0303 Phorphobilinogen deaminase GO:0005975;GO:0016301 YDL205C HEM3 "Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme" Porphobilinogen deaminase PAS_1g05665 CAY68144.1 PAS_chr1-4_0669 hypothetical protein GO:0005975;GO:0016301 YDR248C YDR248C "Putative protein of unknown function; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1" Probable gluconokinase PAS_1g05670 CAY68145.1 PAS_chr1-4_0304 "Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme" GO:0003824;GO:0008152 YPL028W ERG10 "Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis" Acetyl-CoA acetyltransferase IA PAS_1g05675 CAY68146.1 PAS_chr1-4_0305 "Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme" GO:0004674;GO:0006468 YPL042C SSN3 "Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression" Serine/threonine-protein kinase SSN3 PAS_1g05680 CAY68147.1 PAS_chr1-4_0306 Hypothetical protein YPL041C YPL041C Protein of unknown function involved in maintenance of proper telomere length PAS_1g05685 CAY68148.1 PAS_chr1-4_0307 Hypothetical protein PHO85 cyclin-5 PAS_1g05690 CAY68149.1 PAS_chr1-4_0308 Golgi membrane protein with similarity to mammalian CASP GO:0006891;GO:0030173 YKL179C COY1 Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function Protein CASP PAS_1g05695 CAY68150.1 PAS_chr1-4_0309 Subunit of the SWI/SNF chromatin remodeling complex YJL176C SWI3 "Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2" SWI/SNF complex subunit SMARCC2 PAS_1g05700 CAY68151.1 PAS_chr1-4_0310 Autophagy-related protein GO:0003824;GO:0005488;GO:0008152 YHR171W ATG7 "Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation" Autophagy-related protein 7 PAS_1g05705 CAY68152.1 PAS_chr1-4_0311 Highly conserved nuclear protein required for actin cytoskeleton organization YGR245C SDA1 "Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis" Protein SDA1 PAS_1g05710 CAY68153.1 PAS_chr1-4_0312 Putative protein of unknown function YKL171W YKL171W Putative protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm Serine/threonine-protein kinase KIN2 PAS_1g05715 CAY68154.1 PAS_chr1-4_0313 Subunit 8 of ubiquinol cytochrome-c reductase complex GO:0006118;GO:0008121 YJL166W QCR8 "Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p" Cytochrome b-c1 complex subunit 8 PAS_1g05720 CAY68155.1 PAS_chr1-4_0314 Farnesyl pyrophosphate synthetase GO:0008299 YJL167W ERG20 "Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis" Farnesyl pyrophosphate synthase PAS_1g05725 CAY68156.1 PAS_chr1-4_0315 Member of silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases GO:0003677;GO:0005677;GO:0006342;GO:0006355;GO:0006476;GO:0008270;GO:0017136;GO:0051287 YPL015C HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro NAD-dependent deacetylase hst2 PAS_1g05730 CAY68157.1 PAS_chr1-4_0316 hypothetical protein YPL009C YPL009C "Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL009C is not an essential gene" Uncharacterized protein YPL009C PAS_1g05735 CAY68158.1 PAS_chr1-4_0317 "Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles" GO:0006810 YPL010W RET3 "Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER" Coatomer subunit zeta PAS_1g05740 CAY68159.1 PAS_chr1-4_0318 Transcription initiation factor TFIID subunit 3 YPL011C TAF3 "TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation" Transcription initiation factor TFIID subunit 3 PAS_1g05745 CAY68160.1 PAS_chr1-4_0319 Protein required for export of the ribosomal subunits YPL012W RRP12 Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats Ribosomal RNA-processing protein 12 PAS_1g05750 CAY68161.1 PAS_chr1-4_0320 Mitochondrial ribosomal protein of the small subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YPL013C MRPS16 Mitochondrial ribosomal protein of the small subunit "37S ribosomal protein S16, mitochondrial " PAS_1g05755 CAY68162.1 PAS_chr1-4_0321 Hypothetical protein Putative protein TPRXL PAS_1g05760 CAY68163.1 PAS_chr1-4_0322 "Activator of multidrug resistance genes, forms a heterodimer with Pdr1p" GO:0003677;GO:0005634;GO:0006350;GO:0008270 YHR178W STB5 "Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro" Protein STB5 PAS_1g05765 CAY68164.1 PAS_chr1-4_0323 tRNAHis guanylyltransferase YGR024C THG1 "tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes" tRNA(His) guanylyltransferase PAS_1g05770 CAY68165.1 PAS_chr1-4_0324 RNA polymerase I subunit A135 GO:0003677;GO:0003899;GO:0006350 YPR010C RPA135 RNA polymerase I subunit A135 DNA-directed RNA polymerase I subunit RPA2 PAS_1g05775 CAY68166.1 PAS_chr1-4_0325 High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi GO:0006812;GO:0015662;GO:0016020 YGL167C PMR1 High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease Calcium-transporting ATPase 1 PAS_1g05780 CAY68167.1 PAS_chr1-4_0326 Protein required for respiratory growth YGL169W SUA5 "Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family" Protein sua5 PAS_1g05785 CAY68168.1 PAS_chr1-4_0327 Hypothetical protein PAS_1g05790 CAY68169.1 PAS_chr1-4_0670 hypothetical protein GO:0019787;GO:0043687;GO:0051246 YLR306W UBC12 "Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes" NEDD8-conjugating enzyme ubc12 PAS_1g05795 CAY68170.1 PAS_chr1-4_0328 Ribosomal RNA-processing protein 8 GO:0019787;GO:0043687;GO:0051246 YDR083W RRP8 "Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation" Ribosomal RNA-processing protein 8 PAS_1g05800 CAY68171.1 PAS_chr1-4_0671 hypothetical protein YDR082W STN1 "Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping" PAS_1g05805 CAY68172.1 PAS_chr1-4_0329 Hypothetical protein GO:0005496;GO:0006810 5-hydroxyisourate hydrolase PAS_1g05810 CAY68173.1 PAS_chr1-4_0330 Hypothetical protein PAS_1g05815 CAY68174.1 PAS_chr1-4_0331 Hypothetical protein PAS_1g05820 CAY68175.1 PAS_chr1-4_0332 Hypothetical protein PAS_1g05825 CAY68176.1 PAS_chr1-4_0333 hypothetical protein GO:0016787 YDR182W CDC1 Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution Cell division control protein 1 PAS_1g05830 CAY68177.1 PAS_chr1-4_0334 Essential 100kDa subunit of the exocyst complex GO:0005737;GO:0006887;GO:0048278 YLR166C SEC10 "Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis" Exocyst complex component SEC10 PAS_1g05835 CAY68178.1 PAS_chr1-4_0335 Conserved nuclear RNA-binding protein GO:0003676 YER063W THO1 "Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation" Protein THO1 PAS_1g05840 CAY68179.1 PAS_chr1-4_0336 Transcriptional activator GO:0003723;GO:0004525;GO:0006396 YIL056W VHR1 "Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations" Putative transcription factor YER064C PAS_1g05845 PAS_1g05850 CAY68180.1 PAS_chr1-4_0338 "Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate" GO:0003824;GO:0008152 YER065C ICL1 "Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose" Isocitrate lyase PAS_1g05855 CAY68181.1 PAS_chr1-4_0339 Transcriptional activator GO:0003700;GO:0005634;GO:0006355;GO:0043565;GO:0046983 YEL009C GCN4 Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels General control protein GCN4 PAS_1g05860 CAY68182.1 PAS_chr1-4_0672 hypothetical protein GO:0020037;GO:0046914 Cytochrome b5 PAS_1g05865 CAY68183.1 PAS_chr1-4_0340 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector GO:0008060;GO:0008270;GO:0032312 YIL044C AGE2 "ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif" Uncharacterized protein C824.09c PAS_1g05870 CAY68184.1 PAS_chr1-4_0341 Ubiquitin-specific protease GO:0004221;GO:0006511 YMR223W UBP8 Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B Probable ubiquitin carboxyl-terminal hydrolase 8 PAS_1g05875 CAY68185.1 PAS_chr1-4_0342 "Essential protein with similarity to phosducins, which are G-protein regulators" YOR281C PLP2 Essential protein that interacts with the CCT (chaperonin containing TCP-1) complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP Phosducin-like protein C2A9.09 PAS_1g05880 CAY68186.1 PAS_chr1-4_0343 Essential protein GO:0005515;GO:0016070 YGR278W CWC22 "Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putative spliceosomal component, based on computational analysis of large-scale protein-protein interaction data" Pre-mRNA-splicing factor CWC22 homolog PAS_1g05885 CAY68187.1 PAS_chr1-4_0344 Essential nucleolar protein of unknown function YGR145W ENP2 "Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p" Ribosome biogenesis protein ENP2 PAS_1g05890 PAS_1g05895 CAY68188.1 PAS_chr1-4_0346 Hypothetical protein Dentin sialophosphoprotein PAS_1g05900 CAY68189.1 PAS_chr1-4_0347 Putative metalloprotease GO:0005737;GO:0006508;GO:0017039 YOL057W YOL057W Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers Probable dipeptidyl peptidase 3 PAS_1g05905 CAY68190.1 PAS_chr1-4_0348 Putative protein of unknown function YNL313C YNL313C Essential protein of unknown function; fluorescent protein (GFP or YFP)-tagged protein localizes to cytoplasm and nucleus Uncharacterized protein YNL313C PAS_1g05910 CAY68191.1 PAS_chr1-4_0349 Peroxisomal biogenesis factor 8 YGR077C PEX8 "Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p" Peroxisomal biogenesis factor 8 PAS_1g05915 CAY68192.1 PAS_chr1-4_0350 Putative protein of unknown function YOL073C YOL073C Putative protein of unknown function Uncharacterized membrane protein YOL073C PAS_1g05920 CAY68193.1 PAS_chr1-4_0351 hypothetical protein YGR078C PAC10 "Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding" Prefoldin subunit 3 PAS_1g05925 CAY68194.1 PAS_chr1-4_0352 Protein component of the large (60S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YNL301C RPL18B "Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein" 60S ribosomal protein L18 PAS_1g05930 CAY68195.1 PAS_chr1-4_0353 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YOL121C RPS19A "Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp" 40S ribosomal protein S19-A PAS_1g05935 CAY68196.1 PAS_chr1-4_0354 Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p) GO:0003676;GO:0008168;GO:0032259 YOL124C TRM11 "Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain" tRNA guanosine-2'-O-methyltransferase TRM11 PAS_1g05940 CAY68197.1 PAS_chr1-4_0355 Subunit of cleavage factor I GO:0000166 YOL123W HRP1 "Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences" Nuclear polyadenylated RNA-binding protein 4 PAS_1g05945 CAY68198.1 PAS_chr1-4_0673 hypothetical protein GO:0005737;GO:0006629;GO:0016021;GO:0016627 YIL049W DFG10 "Protein of unknown function, involved in filamentous growth" Protein DFG10 PAS_1g05950 CAY68199.1 PAS_chr1-4_0356 Putative ATP-dependent RNA helicase of the DEAD-box protein family YDL031W DBP10 "Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis" ATP-dependent RNA helicase DBP10 PAS_1g05955 CAY68200.1 PAS_chr1-4_0357 cAMP-dependent protein kinase catalytic subunit YPL203W TPK2 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase cAMP-dependent protein kinase type 2 PAS_1g05960 CAY68201.1 PAS_chr1-4_0358 Protein associated with the mitochondrial nucleoid GO:0003735;GO:0005622;GO:0005840;GO:0006412 YGL068W MNP1 Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth "60 ribosomal protein L12, mitochondrial " PAS_1g05965 CAY68202.1 PAS_chr1-4_0359 RNA polymerase II subunit B12.6 GO:0003677;GO:0003899;GO:0006350 YGL070C RPB9 RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance DNA-directed RNA polymerase II subunit RPB9 PAS_1g05970 CAY68203.1 PAS_chr1-4_0360 Protein involved in DNA replication GO:0003677;GO:0005524;GO:0005634;GO:0006270 YGL201C MCM6 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex DNA replication licensing factor mcm6 PAS_1g05975 CAY68204.1 PAS_chr1-4_0361 Hypothetical protein YGL071W AFT1 Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability Nuclear transcription factor Y subunit gamma PAS_1g05980 CAY68205.1 PAS_chr1-4_0362 Putative metalloprotease YIL108W YIL108W Putative metalloprotease Putative zinc metalloproteinase YIL108W PAS_1g05985 CAY68206.1 PAS_chr1-4_0363 Cyclin-dependent kinase-activating kinase required for passage through the cell cycle YFL029C CAK1 "Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases" Cell division protein kinase 2 PAS_1g05990 CAY68207.1 PAS_chr1-4_0364 Rab GTPase-activating protein GO:0005097;GO:0005622;GO:0032313 YFL027C GYP8 "GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport" GTPase-activating protein gyp10 PAS_1g05995 CAY68208.1 PAS_chr1-4_0365 Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SAL YLR055C SPT8 "Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters" Transcription factor SPT8 PAS_1g06000 CAY68209.1 PAS_chr1-4_0366 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex GO:0005524;GO:0016887 YFL028C CAF16 Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator Uncharacterized ABC transporter ATP-binding protein C20G4.01 PAS_1g06005 CAY68210.1 PAS_chr1-4_0367 "C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol" GO:0003824;GO:0008152 YLR056W ERG3 "C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources" C-5 sterol desaturase PAS_1g06010 CAY68211.1 PAS_chr1-4_0368 Protein kinase required for signal transduction during entry into meiosis GO:0004674;GO:0006468 YMR139W RIM11 Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta Protein kinase gsk3 PAS_1g06015 CAY68212.1 PAS_chr1-4_0369 Hypothetical protein GO:0016021 Plasma membrane proteolipid 3 PAS_1g06020 CAY68213.1 PAS_chr1-4_0370 hypothetical protein YLR050C YLR050C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene Uncharacterized membrane protein YLR050C PAS_1g06025 CAY68214.1 PAS_chr1-4_0674 hypothetical protein GO:0005488 YGR037C ACB1 "Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes" Acyl-CoA-binding protein 2 PAS_1g06030 CAY68215.1 PAS_chr1-4_0371 Hypothetical protein GO:0005743;GO:0006118;GO:0016651 "Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5, mitochondrial " PAS_1g06035 CAY68216.1 PAS_chr1-4_0652 hypothetical protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 YAL051W OAF1 "Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis" Heme-responsive zinc finger transcription factor HAP1 PAS_1g06040 CAY68217.1 PAS_chr1-4_0372 hypothetical protein YCR090C YCR090C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene UPF0587 protein C2D10.03c PAS_1g06045 CAY68218.1 PAS_chr1-4_0373 Hypothetical protein PAS_1g06050 CAY68219.1 PAS_chr1-4_0374 Subunit of an adoMet-dependent tRNA methyltransferase (MTase) complex (Trm11p-Trm112p) YNR046W TRM112 Subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin Multifunctional methyltransferase subunit TRM112 PAS_1g06055 CAY68220.1 PAS_chr1-4_0375 "Putative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest" GO:0004674;GO:0006468 YNR047W FPK1 "Ser/Thr protein kinase that regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane" Probable serine/threonine-protein kinase YNR047W PAS_1g06060 CAY68221.1 PAS_chr1-4_0376 Mismatch repair protein GO:0005524;GO:0006298;GO:0030983 YCR092C MSH3 "Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability" DNA mismatch repair protein MSH3 PAS_1g06065 CAY68222.1 PAS_chr1-4_0377 Hypothetical protein YDR482C CWC21 "Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; may bind RNA; has similarity to S. pombe Cwf21p" Pre-mRNA-splicing factor CWC21 PAS_1g06070 CAY68223.1 PAS_chr1-4_0378 Hypothetical protein GO:0005576;GO:0042381 Uncharacterized protein DDB_G0271670 PAS_1g06075 CAY68224.1 PAS_chr1-4_0379 Penta-EF-hand protein GO:0005509 YGR058W PEF1 "Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2" Peflin PAS_1g06080 CAY68225.1 PAS_chr1-4_0380 Phosphatidylinositol 4-kinase YNL267W PIK1 "Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton" Phosphatidylinositol 4-kinase PIK1 PAS_1g06085 CAY68226.1 PAS_chr1-4_0381 ER membrane localized phosphoryltransferase that adds phosphoethanolamine GO:0003824;GO:0008152 YLL031C GPI13 ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein GPI ethanolamine phosphate transferase 3 PAS_1g06090 CAY68227.1 PAS_chr1-4_0382 Hypothetical protein SWI/SNF chromatin-remodeling complex subunit SNF5 PAS_1g06095 CAY68228.1 PAS_chr1-4_0383 Hypothetical protein GO:0016021 Sterol regulatory element-binding protein cleavage-activating protein PAS_1g06100 CAY68229.1 PAS_chr1-4_0384 Amphiphysin-like lipid raft protein GO:0005515;GO:0005737 YCR009C RVS161 "Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress" Reduced viability upon starvation protein 161 PAS_1g06105 CAY68230.1 PAS_chr1-4_0700 hypothetical protein YCR008W SAT4 Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p Serine/threonine-protein kinase HAL4/SAT4 PAS_1g06110 CAY68231.1 PAS_chr1-4_0385 Ser/Thr protein kinase involved in salt tolerance YHL023C NPR3 "Component, with Npr2p, of an evolutionarily conserved complex that mediates downregulation of TOR Complex 1 activity in response to amino acid limitation; null mutant displays delayed meiotic DNA replication and double-strand break repair" Nitrogen permease regulator 3 PAS_1g06115 CAY68232.1 PAS_chr1-4_0388 Hypothetical protein Uncharacterized protein DDB_G0271670 PAS_1g06120 CAY68233.1 PAS_chr1-4_0389 Protein of unknown function that may interact with ribosomes GO:0003723 YLL032C YLL032C "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene" KH domain-containing protein YLL032C PAS_1g06125 CAY68234.1 PAS_chr1-4_0390 "Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline" YLR133W CKI1 "Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway" Choline kinase PAS_1g06130 CAY68235.1 PAS_chr1-4_0391 Oligopeptide transporter Oligopeptide transporter 5 PAS_1g06135 CAY68236.1 PAS_chr1-4_0392 hypothetical protein YMR095C SNO1 "Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase" Glutamine amidotransferase subunit pdxT PAS_1g06140 CAY68237.1 PAS_chr1-4_0393 Member of a stationary phase-induced gene family GO:0006118;GO:0016491 YNL333W SNZ2 "Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p" Probable pyridoxine biosynthesis protein SNZ2 PAS_1g06145 CAY68238.1 PAS_chr1-4_0675 hypothetical protein GO:0006118;GO:0016491 YHL021C AIM17 "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss" Uncharacterized oxidoreductase YHL021C PAS_1g06150 CAY68239.1 PAS_chr1-4_0394 Ammonium permease involved in regulation of pseudohyphal growth YNL142W MEP2 Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation Ammonium transporter MEP2 PAS_1g06155 CAY68240.1 PAS_chr1-4_0395 Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR) GO:0003700;GO:0005634;GO:0006355;GO:0008270;GO:0043565 GATA factor SREP PAS_1g06160 CAY68241.1 PAS_chr1-4_0396 Hypothetical protein PAS_1g06165 CAY68242.1 PAS_chr1-4_0676 hypothetical protein GO:0005743;GO:0008565;GO:0015031 YDL217C TIM22 Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported Mitochondrial import inner membrane translocase subunit TIM22 PAS_1g06170 CAY68243.1 PAS_chr1-4_0397 Probable glutamine amidotransferase GO:0005743;GO:0008565;GO:0015031 YNL191W DUG3 "Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)" Probable glutamine amidotransferase DUG3 PAS_1g06175 CAY68244.1 PAS_chr1-4_0398 Hypothetical protein GO:0006950;n/a Universal stress protein A family protein C25B2.10 PAS_1g06180 CAY68245.1 PAS_chr1-4_0399 D-Tyr-tRNA(Tyr) deacylase GO:0005737;GO:0016788;GO:0019478 YDL219W DTD1 "D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes" D-tyrosyl-tRNA(Tyr) deacylase PAS_1g06185 CAY68246.1 PAS_chr1-4_0677 hypothetical protein PAS_1g06190 CAY68247.1 PAS_chr1-4_0400 hypothetical protein YNL011C YNL011C Putative protein of unknown function; YNL011C is not an essential gene Uncharacterized protein YNL011C PAS_1g06195 CAY68248.1 PAS_chr1-4_0678 hypothetical protein YLR193C UPS1 "Mitochondrial intermembrane space protein that regulates mitochondrial cardiolipin levels, null has defects in Mgm1p processing, integrity of mitochondrial inner membrane complexes, and mitochondrial morphology; ortholog of human PRELI" Protein UPS1 PAS_1g06200 CAY68249.1 PAS_chr1-4_0401 transcriptional regulatory protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 YDL170W UGA3 "Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus" Uncharacterized transcriptional regulatory protein C965.10 PAS_1g06205 CAY68250.1 PAS_chr1-4_0402 Hypothetical protein YDL169C UGX2 "Protein of unknown function, transcript accumulates in response to any combination of stress conditions" PAS_1g06210 CAY68251.1 PAS_chr1-4_0403 Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes YLR197W NOP56 Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects Nucleolar protein 56 PAS_1g06215 CAY68252.1 PAS_chr1-4_0404 Hypothetical protein PAS_1g06220 CAY68253.1 PAS_chr1-4_0405 Subunit of the heterohexameric Gim/prefoldin protein complex YLR200W YKE2 "Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin" Prefoldin subunit 6 PAS_1g06225 CAY68254.1 PAS_chr1-4_0406 Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth GO:0006744 YLR201C COQ9 Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes "Ubiquinone biosynthesis protein COQ9, mitochondrial " PAS_1g06230 CAY68255.1 PAS_chr1-4_0407 Helix-loop-helix protein that binds the motif CACRTG GO:0005634;GO:0030528;GO:0045449 YJR060W CBF1 "Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA" Uncharacterized bHLH domain-containing protein C3F10.12c PAS_1g06235 CAY68256.1 PAS_chr1-4_0408 "Amidase, removes the amide group from N-terminal asparagine and glutamine residues" GO:0006807;GO:0016810 YJR062C NTA1 "Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation" Protein N-terminal amidase PAS_1g06240 CAY68257.1 PAS_chr1-4_0409 Putative positive regulator of mannosylphosphate transferase (Mnn6p) Protein MNN4 PAS_1g06245 CAY68258.1 PAS_chr1-4_0410 Putative positive regulator of mannosylphosphate transferase (Mnn6p) Uncharacterized protein YJR061W PAS_1g06250 CAY68259.1 PAS_chr1-4_0411 "Essential protein, component of a complex containing Cef1p" YLR323C CWC24 "Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p" Pre-mRNA-splicing factor cwc24 PAS_1g06255 CAY68260.1 PAS_chr1-4_0412 "Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YLR325C RPL38 "Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein" 60S ribosomal protein L38 PAS_1g06260 CAY68261.1 PAS_chr1-4_0413 "Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number" YLR324W PEX30 "Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p" Peroxisomal membrane protein PEX30 PAS_1g06265 CAY68262.1 PAS_chr1-4_0679 hypothetical protein GO:0003702;GO:0005524;GO:0005674;GO:0006367 YGR005C TFG2 TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30 Transcription initiation factor IIF subunit beta PAS_1g06270 CAY68263.1 PAS_chr1-4_0414 Splicing factor GO:0005681;GO:0008380 YGR006W PRP18 "Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p" Pre-mRNA-splicing factor 18 PAS_1g06275 CAY68264.1 PAS_chr1-4_0415 hypothetical protein YOL105C WSC3 "Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis" Uncharacterized protein DDB_G0271670 PAS_1g06280 CAY68265.1 PAS_chr1-4_0416 Hypothetical protein Uncharacterized protein DDB_G0271670 PAS_1g06285 CAY68266.1 PAS_chr1-4_0417 "Alpha-1,2-mannosyltransferase" GO:0009058 YNL048W ALG11 "Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER" "Alpha-1,2-mannosyltransferase ALG11 " PAS_1g06290 CAY68267.1 PAS_chr1-4_0418 "Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p" YIL105C SLM1 "Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex" "Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2 " PAS_1g06295 CAY68268.1 PAS_chr1-4_0419 Component of the mitotic exit network GO:0005515 YIL106W MOB1 Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex Mps one binder kinase activator-like 1B PAS_1g06300 CAY68269.1 PAS_chr1-4_0420 "Mitochondrial protein, putative inner membrane transporter" GO:0005488;GO:0006810;GO:0016020 Uncharacterized mitochondrial carrier C4G9.20c PAS_1g06305 CAY68270.1 PAS_chr1-4_0421 "Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate" GO:0019752;GO:0046912 "Homocitrate synthase, mitochondrial " PAS_1g06310 CAY68271.1 PAS_chr1-4_0422 40S small ribosomal subunit GO:0003723 YPL081W RPS9A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins 40S ribosomal protein S9-B PAS_1g06315 CAY68272.1 PAS_chr1-4_0680 60S ribosomal protein L21 GO:0003735;GO:0005622;GO:0005840;GO:0006412 YPL079W RPL21B "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein" 60S ribosomal protein L21-B PAS_1g06320 CAY68273.1 PAS_chr1-4_0423 Mitochondrial pyrimidine nucleotide transporter GO:0005488;GO:0006810;GO:0016020 YBR192W RIM2 Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family Mitochondrial carrier protein RIM2 PAS_1g06325 CAY68274.1 PAS_chr1-4_0424 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization GO:0005622;GO:0007165 YPL115C BEM3 "Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly" Probable Rho-type GTPase-activating protein 2 PAS_1g06330 CAY68275.1 PAS_chr1-4_0425 Protein involved in biosynthesis of the coenzyme lipoic acid GO:0003824;GO:0051536 YOR196C LIP5 "Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase" "Lipoyl synthase, mitochondrial " PAS_1g06335 CAY68276.1 PAS_chr1-4_0426 "Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance" GO:0003824;GO:0005975;GO:0043169 YGR282C BGL2 "Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance" "Glucan 1,3-beta-glucosidase " PAS_1g06340 CAY68277.1 PAS_chr1-4_0427 Putative protein of unknown function YMR310C YMR310C Putative protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene Uncharacterized protein YMR310C PAS_1g06345 CAY68278.1 PAS_chr1-4_0428 Component of mRNP complexes associated with polyribosomes YOR198C BFR1 Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity Nuclear segregation protein BFR1 PAS_1g06350 CAY68279.1 PAS_chr1-4_0429 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase) GO:0016787 YPL117C IDI1 "Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability" Isopentenyl-diphosphate Delta-isomerase PAS_1g06355 CAY68280.1 PAS_chr1-4_0430 Putative cysteine protease similar to mammalian caspases GO:0006508;GO:0030693 YOR197W MCA1 Putative cysteine protease similar to mammalian caspases; involved in regulation of apoptosis upon hydrogen peroxide treatment; proposed to be involved in cell cycle progression Metacaspase-1 PAS_1g06360 CAY68281.1 PAS_chr1-4_0431 Plasma membrane multidrug transporter of the major facilitator superfamily YBR008C FLR1 "Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin" Benomyl/methotrexate resistance protein PAS_1g06365 CAY68282.1 PAS_chr1-4_0432 Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs) GO:0005086;GO:0005622;GO:0032012 YEL022W GEA2 "Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p" ARF guanine-nucleotide exchange factor 2 PAS_1g06370 CAY68283.1 PAS_chr1-4_0433 Peroxisomal signal receptor for the N-terminal nonapeptide signal of peroxisomal matrix proteins YDR142C PEX7 Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) Peroxisomal targeting signal 2 receptor PAS_1g06375 CAY68284.1 PAS_chr1-4_0434 Hypothetical protein YMR179W SPT21 "Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; involved in telomere maintenance" PAS_1g06380 CAY68285.1 PAS_chr1-4_0435 "Meiosis-specific protein of unknown function, required for spore wall formation during sporulation" YDR104C SPO71 "Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis" Sporulation-specific protein 71 PAS_1g06385 CAY68286.1 PAS_chr1-4_0436 Putative protein of unknown function GO:0008270;GO:0016491 Quinone oxidoreductase PAS_1g06390 CAY68287.1 PAS_chr1-4_0437 Hypothetical protein Dibenzothiophene desulfurization enzyme A PAS_1g06395 CAY68288.1 PAS_chr1-4_0681 hypothetical protein Dibenzothiophene desulfurization enzyme A PAS_1g06400 CAY68289.1 PAS_chr1-4_0438 Hypothetical protein YDR103W STE5 "Pheromone-response scaffold protein; binds Ste11p, Ste7p, and Fus3p kinases, forming a MAPK cascade complex that interacts with the plasma membrane and Ste4p-Ste18p; allosteric activator of Fus3p that facilitates Ste7p-mediated activation" PAS_1g06405 CAY68290.1 PAS_chr1-4_0439 Integral membrane protein of unknown function YOR154W SLP1 Integral membrane protein of unknown function; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins Uncharacterized protein SLP1 PAS_1g06410 CAY68291.1 PAS_chr1-4_0440 B-type cyclin involved in cell cycle progression G1/S-specific cyclin CLN1 PAS_1g06415 CAY68292.1 PAS_chr1-4_0441 Peroxisomal primary amine oxidase GO:0005507;GO:0008131;GO:0009308;GO:0048038 Peroxisomal primary amine oxidase PAS_1g06420 CAY68293.1 PAS_chr1-4_0442 Putative protein of unknown function YOL138C RTC1 "Protein of unknown function; may interact with ribosomes, based on co-purification experiments; null mutation suppresses cdc13-1 temperature sensitivity" Uncharacterized WD repeat-containing protein C4F8.11 PAS_1g06425 CAY68294.1 PAS_chr1-4_0443 Hypothetical protein PAS_1g06430 CAY68295.1 PAS_chr1-4_0444 "Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p)" YDR489W SLD5 "Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery" DNA replication complex GINS protein SLD5 PAS_1g06435 CAY68296.1 PAS_chr1-4_0445 Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase GO:0015986;GO:0016469;GO:0046933;GO:0046961 YDL004W ATP16 "Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated" "ATP synthase subunit delta, mitochondrial " PAS_1g06440 CAY68297.1 PAS_chr1-4_0446 Hypothetical protein Uncharacterized protein PF11_0213 PAS_1g06445 CAY68298.1 PAS_chr1-4_0447 Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol GO:0004396;GO:0005524;GO:0006096 Hexokinase-1 PAS_1g06450 CAY68299.1 PAS_chr1-4_0448 Catalytic component of UDP-GlcNAc transferase GO:0005975;GO:0016758;GO:0030246;GO:0030259 YGL047W ALG13 "Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases" UDP-N-acetylglucosamine transferase subunit ALG13 PAS_1g06455 CAY68300.1 PAS_chr1-4_0449 Hypothetical protein PAS_1g06460 CAY68301.1 PAS_chr1-4_0450 N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase GO:0004639;GO:0006164 YAR015W ADE1 "N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine" Phosphoribosylaminoimidazole-succinocarboxamide synthase PAS_1g06465 CAY68302.1 PAS_chr1-4_0451 protein kinase GO:0004674;GO:0006468 YAR018C KIN3 Nonessential protein kinase with unknown cellular role G2-specific protein kinase nimA PAS_1g06470 CAY68303.1 PAS_chr1-4_0452 Essential 88kDa subunit of the exocyst complex YIL068C SEC6 "Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly" Exocyst complex component SEC6 PAS_1g06475 CAY68304.1 PAS_chr1-4_0453 Hypothetical protein PAS_1g06480 CAY68305.1 PAS_chr1-4_0454 COP9 signalosome complex subunit 2 COP9 signalosome complex subunit 2 PAS_1g06485 CAY68306.1 PAS_chr1-4_0682 hypothetical protein Regulator of Ty1 transposition protein 105 PAS_1g06490 CAY68307.1 PAS_chr1-4_0455 Protein involved in rRNA processing GO:0003723 YOL142W RRP40 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; has similarity to human hRrp40p (EXOSC3) Exosome complex component RRP40 PAS_1g06495 CAY68308.1 PAS_chr1-4_0456 Polyphosphatidylinositol phosphatase YNL325C FIG4 "Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain" Polyphosphoinositide phosphatase PAS_1g06500 CAY68309.1 PAS_chr1-4_0457 tRNA methyltransferase required for the synthesis of wybutosine YOL141W PPM2 "AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p" Leucine carboxyl methyltransferase 2 PAS_1g06505 CAY68310.1 PAS_chr1-4_0458 Dihydroxyacid dehydratase GO:0003824;GO:0008152 YJR016C ILV3 "Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids" "Dihydroxy-acid dehydratase, mitochondrial " PAS_1g06510 CAY68311.1 PAS_chr1-4_0459 Malate synthase GO:0004474;GO:0006097 "Malate synthase, glyoxysomal " PAS_1g06515 CAY68312.1 PAS_chr1-4_0460 Uridine kinase (Uridine monophosphokinase) GO:0005524;GO:0016773 YDR020C DAS2 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases Putative uridine kinase YDR020C PAS_1g06520 CAY68313.1 PAS_chr1-4_0461 Nucleolar protein required for maturation of 18S rRNA YDR021W FAL1 "Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases" ATP-dependent RNA helicase FAL1 PAS_1g06525 PAS_1g06530 CAY68314.1 PAS_chr1-4_0462 Membrane glycoprotein v-SNARE YDR498C SEC20 Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p Protein transport protein SEC20 PAS_1g06535 CAY68315.1 PAS_chr1-4_0463 "Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase" GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YDR023W SES1 "Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p" "Seryl-tRNA synthetase, cytoplasmic " PAS_1g06540 CAY68316.1 PAS_chr1-4_0464 Hypothetical protein PAS_1g06545 CAY68317.1 PAS_chr1-4_0465 Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase GO:0015986;GO:0016020;GO:0016469;GO:0046933;GO:0046961 YBR039W ATP3 "Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis" "ATP synthase subunit gamma, mitochondrial " PAS_1g06550 CAY68318.1 PAS_chr1-4_0466 Putative protein of unknown function YER077C YER077C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport Uncharacterized protein YER077C PAS_1g06555 CAY68319.1 PAS_chr1-4_0467 Cop9 signalosome complex subunit 11 YIL071C PCI8 "Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain" Cop9 signalosome complex subunit 11 PAS_1g06560 CAY68320.1 PAS_chr1-4_0468 Putative mitochondrial metallopeptidase GO:0006508;GO:0008235 YER078C ICP55 "Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family" Uncharacterized peptidase YER078C PAS_1g06565 CAY68321.1 PAS_chr1-4_0469 Mitochondrial ribosomal protein of the small subunit YGR215W RSM27 Mitochondrial ribosomal protein of the small subunit Mitochondral 37S ribosomal protein S27 PAS_1g06570 CAY68322.1 PAS_chr1-4_0470 Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) GO:0006506;GO:0016021;GO:0017176 YGR216C GPI1 "Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs" N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1 PAS_1g06575 CAY68323.1 PAS_chr1-4_0471 "Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp" GO:0003735;GO:0006412;GO:0015935 YGR214W RPS0A "Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal" 40S ribosomal protein S0 PAS_1g06580 CAY68324.1 PAS_chr1-4_0472 "Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis" GO:0005506;GO:0006118;GO:0016021;GO:0016491;GO:0050660 YLR047C FRE8 "Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p" Probable ferric reductase transmembrane component 8 PAS_1g06585 CAY68325.1 PAS_chr1-4_0473 Meiosis-specific APC/C activator protein AMA1 YGR225W AMA1 Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis Meiosis-specific APC/C activator protein AMA1 PAS_1g06590 CAY68326.1 PAS_chr1-4_0474 Hypothetical protein YHR151C MTC6 Protein of unknown function; mtc6 is synthetically sick with cdc13-1 Uncharacterized protein YHR151C PAS_1g06595 CAY68327.1 PAS_chr1-4_0475 "Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER" YGR227W DIE2 "Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1" "Alpha-1,2 glucosyltransferase ALG10 " PAS_1g06600 CAY68328.1 PAS_chr1-4_0476 Cell wall assembly regulator SMI1 GO:0042546 YGR229C SMI1 Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity KNR4/SMI1 homolog PAS_1g06605 CAY68329.1 PAS_chr1-4_0683 hypothetical protein YGR231C PHB2 "Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation" Prohibitin-2 PAS_1g06610 CAY68330.1 PAS_chr1-4_0478 "Regulatory, non-ATPase subunit of the 26S proteasome" YGR232W NAS6 "Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6" Probable 26S proteasome regulatory subunit p28 PAS_1g06615 CAY68331.1 PAS_chr1-4_0479 General amino acid permease GO:0006810;GO:0016020 General amino-acid permease GAP1 PAS_1g06620 CAY68332.1 PAS_chr1-4_0480 "Essential protein with two zinc fingers, present in the nucleus of growing cells" GO:0005515;GO:0008270 YGR211W ZPR1 "Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p)" Zinc finger protein ZPR1 PAS_1g06625 CAY68333.1 PAS_chr1-4_0481 Hypothetical protein PAS_1g06630 CAY68334.1 PAS_chr1-4_0482 Evolutionarily conserved copper-binding protein of the mitochondrial inner membrane YKL137W CMC1 "Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif" COX assembly mitochondrial protein PAS_1g06635 CAY68335.1 PAS_chr1-4_0483 Hypothetical protein YMR117C SPC24 "Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering" Probable kinetochore protein SPC24 PAS_1g06640 CAY68336.1 PAS_chr1-4_0484 Mitochondrial ribosomal protein of the large subunit YKL138C MRPL31 Mitochondrial ribosomal protein of the large subunit "60S ribosomal protein L31, mitochondrial " PAS_1g06645 CAY68337.1 PAS_chr1-4_0485 Hypothetical protein High osmolarity sensitivity protein 3 PAS_1g06650 CAY68339.1 PAS_chr1-4_0486 Hypothetical protein PAS_1g06655 CAY68340.1 PAS_chr1-4_0487 Putative protein of unknown function YMR118C YMR118C Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene "Succinate dehydrogenase cytochrome B subunit, mitochondrial " PAS_1g06660 CAY68341.1 PAS_chr1-4_0684 hypothetical protein YER080W AIM9 "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss" Uncharacterized protein YER080W PAS_1g06665 CAY68342.1 PAS_chr1-4_0488 Hypothetical protein Uncharacterized protein DDB_G0271670 PAS_1g06670 CAY68343.1 PAS_chr1-4_0489 Cystathionine gamma-lyase GO:0003824;GO:0030170 YAL012W CYS3 "Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine" Cystathionine gamma-lyase PAS_1g06675 CAY68344.1 PAS_chr1-4_0490 60S acidic ribosomal protein P2-A GO:0003735;GO:0005622;GO:0005840;GO:0006414 YDR382W RPP2B "Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm" 60S acidic ribosomal protein P2-A PAS_1g06680 CAY68345.1 PAS_chr1-4_0491 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YOL040C RPS15 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins 40S ribosomal protein S15 PAS_1g06685 CAY68346.1 PAS_chr1-4_0492 Transcriptional modulator YAL013W DEP1 "Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation" Transcriptional regulatory protein DEP1 PAS_1g06690 CAY68347.1 PAS_chr1-4_0493 "Nucleolar protein, required for pre-25S rRNA processing" GO:0000166 YOL041C NOP12 Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p Nucleolar protein 12 PAS_1g06695 YNL239W LAP3 Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH "Cysteine proteinase 1, mitochondrial " PAS_1g06700 CAY68348.1 PAS_chr1-4_0495 Hypothetical protein YOL048C RRT8 Putative protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles Uncharacterized membrane protein YOL048C PAS_1g06705 CAY68349.1 PAS_chr1-4_0496 Glutathione synthetase GO:0004363;GO:0005524;GO:0006750 YOL049W GSH2 "Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock" Glutathione synthetase PAS_1g06710 CAY68350.1 PAS_chr1-4_0685 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 GO:0004576;GO:0006486;GO:0016020 YGL022W STT3 "Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis" Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 PAS_1g06715 CAY68351.1 PAS_chr1-4_0497 Kinesin-related motor protein involved in mitotic spindle positioning GO:0003777;GO:0005524;GO:0005875;GO:0007018 YGL216W KIP3 Kinesin-related motor protein involved in mitotic spindle positioning Kinesin-like protein KIP3 PAS_1g06720 CAY68352.1 PAS_chr1-4_0498 One of three possible beta-subunits of the Snf1 kinase complex YER027C GAL83 "One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain" SNF1 protein kinase subunit beta-2 PAS_1g06725 CAY68353.1 PAS_chr1-4_0499 Hypothetical protein YGL219C MDM34 Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Mitochondrial distribution and morphology protein 34 PAS_1g06730 CAY68354.1 PAS_chr1-4_0500 Hypothetical protein GO:0005515;GO:0007154;GO:0035091 YGL212W VAM7 Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking Vacuolar morphogenesis protein 7 homolog PAS_1g06735 CAY68355.1 PAS_chr1-4_0501 Protein involved in exosome mediated 3' to 5' mRNA degradation YGL213C SKI8 "Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype" Antiviral protein SKI8 PAS_1g06740 CAY68356.1 PAS_chr1-4_0502 Essential nuclear protein possibly involved in bud formation and morphogenesis YKR063C LAS1 Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the SSD1-v allele for viability Protein LAS1 PAS_1g06745 CAY68357.1 PAS_chr1-4_0503 Endosomal subunit of membrane-associated retromer complex required for retrograde transport YJL154C VPS35 "Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval" Vacuolar protein sorting-associated protein 35 PAS_1g06750 CAY68358.1 PAS_chr1-4_0504 40S ribosomal protein subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YLR388W RPS29A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins 40S ribosomal protein S29 PAS_1g06755 PAS_1g06760 CAY68359.1 PAS_chr1-4_0506 Protein required for processing of 20S pre-rRNA in the cytoplasm YDL060W TSR1 "Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles" Ribosome biogenesis protein TSR1 PAS_1g06765 CAY68360.1 PAS_chr1-4_0507 Zinc finger protein GO:0003676;GO:0005622;GO:0008270 YLR387C REH1 "Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains" Zinc finger protein REH1 PAS_1g06770 CAY68361.1 PAS_chr1-4_0508 "Protein involved in regulated synthesis of PtdIns(3,5)P(2)" GO:0005488 YLR386W VAC14 "Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p" Protein VAC14 homolog PAS_1g06775 PAS_1g06780 CAY68362.1 PAS_chr1-4_0510 CFEM protein YLR390W-A CCW14 "Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall" Covalently-linked cell wall protein 14 PAS_1g06785 CAY68363.1 PAS_chr1-4_0511 Metalloprotease GO:0003824;GO:0046872 YLR389C STE23 "Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme family" A-factor-processing enzyme PAS_1g06790 CAY68364.1 PAS_chr1-4_0512 Hypothetical protein PAS_1g06795 CAY68365.1 PAS_chr1-4_0513 DNA repair protein RAD50 GO:0005524;GO:0005694;GO:0006259 YNL250W RAD50 "Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining" DNA repair protein RAD50 PAS_1g06800 CAY68366.1 PAS_chr1-4_0514 Essential protein of unknown function GO:0000166;GO:0004817;GO:0005524;GO:0005737;GO:0006412;GO:0006423 YNL247W YNL247W "Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments" Cysteinyl-tRNA synthetase PAS_1g06805 CAY68367.1 PAS_chr1-4_0515 Protein involved in nitrosoguanidine (MNNG) resistance Nitrosoguanidine resistance protein SNG1 PAS_1g06810 CAY68368.1 PAS_chr1-4_0516 Putative transcription factor GO:0003700;GO:0005634;GO:0006355;GO:0008270 YPR009W SUT2 Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p PAS_1g06815 CAY68369.1 PAS_chr1-4_0517 "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P" GO:0001682;GO:0004526 YNL221C POP1 "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P" Ribonucleases P/MRP protein subunit POP1 PAS_1g06820 CAY68370.1 PAS_chr1-4_0518 Hypothetical protein GO:0005215;GO:0006810;GO:0016020 Purine permease PAS_1g06825 CAY68371.1 PAS_chr1-4_0519 Co-chaperone that stimulates the ATPase activity of Ssa1p GO:0003676;GO:0005622;GO:0008270 YNL227C JJJ1 "Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis" J protein JJJ1 PAS_1g06830 CAY68372.1 PAS_chr1-4_0520 "Guanine deaminase, a catabolic enzyme of the guanine salvage pathway" GO:0016787 Uncharacterized protein C1F8.04c PAS_1g06835 CAY68373.1 PAS_chr1-4_0521 Protein SQS1 GO:0003676;GO:0005622 YNL224C SQS1 Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles Protein SQS1 PAS_1g06840 CAY68374.1 PAS_chr1-4_0522 Conserved cysteine protease required for autophagy YNL223W ATG4 Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation Probable cysteine protease ATG4 PAS_1g06845 CAY68375.1 PAS_chr1-4_0523 Transcription/RNA-processing factor YNL222W SSU72 Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo RNA polymerase II subunit A C-terminal domain phosphatase SSU72 PAS_1g06850 CAY68376.1 PAS_chr1-4_0524 "Guanine deaminase, a catabolic enzyme of the guanine salvage pathway" GO:0016787 YDL238C GUD1 "Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures" Probable guanine deaminase PAS_1g06855 CAY68377.1 PAS_chr1-4_0525 Hypothetical protein PAS_1g06860 CAY68378.1 PAS_chr1-4_0526 Regulatory protein MIG1 GO:0003676;n/a Regulatory protein MIG1 PAS_1g06865 CAY68379.1 PAS_chr1-4_0686 Small nuclear ribonucleoprotein-associated protein GO:0016071;GO:0030529 YER029C SMB1 "Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'" Small nuclear ribonucleoprotein-associated protein B PAS_1g06870 CAY68380.1 PAS_chr1-4_0527 Hypothetical protein Histone H2A.Z-specific chaperone CHZ1 PAS_1g06875 CAY68381.1 PAS_chr1-4_0528 "GTPase of the Ypt/Rab family, very similar to Ypt31p" GO:0005525;GO:0007264;GO:0015031 YGL210W YPT32 "GTPase of the Ypt/Rab family, very similar to Ypt31p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi" GTP-binding protein YPT32/YPT11 PAS_1g06880 CAY68382.1 PAS_chr1-4_0529 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) YGL207W SPT16 "Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure" FACT complex subunit SPT16 PAS_1g06885 CAY68383.1 PAS_chr1-4_0530 hypothetical protein YKL043W PHD1 "Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate" Enhanced filamentous growth protein PAS_1g06890 CAY68384.1 PAS_chr1-4_0531 Hypothetical protein PAS_1g06895 CAY68385.1 PAS_chr1-4_0532 Phosphatidylinositol transfer protein YLR380W CSR1 Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance Phosphatidylinositol transfer protein CSR1 PAS_1g06900 CAY68386.1 PAS_chr1-4_0533 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p YAL041W CDC24 "Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing" Cell division control protein 24 PAS_1g06905 CAY68387.1 PAS_chr1-4_0534 Mitochondrial leucyl-tRNA synthetase GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YLR382C NAM2 "Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance" "Leucyl-tRNA synthetase, mitochondrial " PAS_1g06910 CAY68388.1 PAS_chr1-4_0535 Structural maintenance of chromosomes protein GO:0005524;GO:0005694;GO:0006259 YLR383W SMC6 "Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18" Structural maintenance of chromosomes protein 6 PAS_1g06915 CAY68389.1 PAS_chr1-4_0687 hypothetical protein YLR381W CTF3 Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules PAS_1g06920 CAY68390.1 PAS_chr1-4_0536 BolA-like protein YGL220W FRA2 "Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel" Uncharacterized bolA-like protein YGL220W PAS_1g06925 CAY68391.1 PAS_chr1-4_0537 "Protein of unknown function, similar to Listeria monocytogenes major sigma factor" YGL221C NIF3 "Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Protein NIF3 homolog PAS_1g06930 CAY68392.1 PAS_chr1-4_0688 hypothetical protein YGR165W MRPS35 Mitochondrial ribosomal protein of the small subunit "37S ribosomal protein S35, mitochondrial " PAS_1g06935 CAY68393.1 PAS_chr1-4_0538 Fatty-acyl coenzyme A oxidase GO:0006118;GO:0016627 YGL205W POX1 "Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix" Acyl-coenzyme A oxidase PAS_1g06940 CAY68394.1 PAS_chr1-4_0539 Essential nucleolar protein involved in pre-18S rRNA processing GO:0003676 YNR054C ESF2 Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome Pre-rRNA-processing protein ESF2 PAS_1g06945 CAY68395.1 PAS_chr1-4_0540 Hypothetical protein PAS_1g06950 CAY68396.1 PAS_chr1-4_0541 "Separase, a caspase-like cysteine proteas" GO:0005634;GO:0006508;GO:0008233 YGR098C ESP1 "Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p" Separin PAS_1g06955 CAY68397.1 PAS_chr1-4_0542 Hypothetical protein YPR116W RRG8 "Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport" PAS_1g06960 CAY68398.1 PAS_chr1-4_0543 Hypothetical protein PAS_1g06965 CAY68399.1 PAS_chr1-4_0544 Hypothetical protein YGR089W NNF2 "Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation" Protein NNF2 PAS_1g06970 CAY68400.1 PAS_chr1-4_0545 Methylthioribose-1-phosphate isomerase GO:0044249 YPR118W MRI1 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway Methylthioribose-1-phosphate isomerase PAS_1g06975 CAY68401.1 PAS_chr1-4_0689 hypothetical protein PAS_1g06980 CAY68402.1 PAS_chr1-4_0546 "Clathrin heavy chain, subunit of the major coat protein" GO:0005198;GO:0005515;GO:0006461;GO:0006886;GO:0008565;GO:0016192;GO:0030130;GO:0030132 YGL206C CHC1 "Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function" Clathrin heavy chain PAS_1g06985 CAY68403.1 PAS_chr1-4_0547 peroxiredoxin Putative peroxiredoxin-B PAS_1g06990 CAY68404.1 PAS_chr1-4_0548 "Vacuolar proteinase B (yscB), a serine protease of the subtilisin family" Cerevisin PAS_1g06995 CAY68405.1 PAS_chr1-4_0549 ATP-dependent DNA helicase YIR002C MPH1 "Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, binds to flap DNA and stimulates activity of Rad27p and Dna2p; mutations confer a mutator phenotype" ATP-dependent DNA helicase MPH1 PAS_1g07000 CAY68406.1 PAS_chr1-4_0550 hypothetical protein YER008C SEC3 "Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion" Exocyst complex component SEC3 PAS_1g07005 CAY68407.1 PAS_chr1-4_0551 Formylglycinamidine-ribonucleotide (FGAM)-synthetase YGR061C ADE6 "Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway" Phosphoribosylformylglycinamidine synthase PAS_1g07010 CAY68408.1 PAS_chr1-4_0552 Ammonium permease Ammonium transporter 1 PAS_1g07015 CAY68409.1 PAS_chr1-4_0553 hypothetical protein YBR096W YBR096W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER Uncharacterized protein YBR096W PAS_1g07020 CAY68410.1 PAS_chr1-4_0554 Hypothetical protein PAS_1g07025 CAY68411.1 PAS_chr1-4_0555 Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway YPR049C ATG11 Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) Autophagy-related protein 11 (Fragment) PAS_1g07030 CAY68412.1 PAS_chr1-4_0556 Replication factor C GO:0003677;GO:0005634;GO:0006260 YBR087W RFC5 "Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon" Replication factor C subunit 5 PAS_1g07035 CAY68413.1 PAS_chr1-4_0557 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YBL038W MRPL16 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L16, mitochondrial " PAS_1g07040 CAY68414.1 PAS_chr1-4_0558 "Mitochondrial phenylalanyl-tRNA synthetase alpha subunit, active as a monomer" GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YPR047W MSF1 "Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase" "Phenylalanyl-tRNA synthetase, mitochondrial " PAS_1g07045 CAY68415.1 PAS_chr1-4_0559 NADPH reductase GO:0006118 YPR048W TAH18 Protein of unknown function that plays a pro-death role in response to oxidative stress; highly conserved across species and similar to human protein NDOR1; allele is synthetically lethal with the pol3-13 allele of DNA polymerase delta Probable NADPH reductase TAH18 PAS_1g07050 CAY68416.1 PAS_chr1-4_0560 Hypothetical protein PAS_1g07055 CAY68417.1 PAS_chr1-4_0561 Hexokinase-2 GO:0004396;GO:0005524;GO:0006096 Hexokinase-2 PAS_1g07060 CAY68418.1 PAS_chr1-4_0562 Bile pigment transporter GO:0005524;GO:0006810;GO:0016021;GO:0042626 Bile pigment transporter 1 PAS_1g07065 PAS_1g07070 CAY68419.1 PAS_chr1-4_0563 "Mitochondrial protein, forms a heterodimer complex with Mto1p" GO:0005525;GO:0005622 YMR023C MSS1 "Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3" "tRNA modification GTPase MSS1, mitochondrial " PAS_1g07075 CAY68420.1 PAS_chr1-4_0564 Iron-sulfur protein IND1 Iron-sulfur protein IND1 PAS_1g07080 CAY68421.1 PAS_chr1-4_0565 Hypothetical protein PAS_1g07085 CAY68422.1 PAS_chr1-4_0566 Low-affinity cyclic AMP phosphodiesterase GO:0004114;GO:0006198 YGL248W PDE1 "Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation" "3',5'-cyclic-nucleotide phosphodiesterase 1 " PAS_1g07090 CAY68423.1 PAS_chr1-4_0567 Beta 7 subunit of the 20S proteasome GO:0004298;GO:0005839;GO:0006511 YFR050C PRE4 Beta 7 subunit of the 20S proteasome Proteasome component PRE4 PAS_1g07095 CAY68424.1 PAS_chr1-4_0568 Hypothetical protein PAS_1g07100 CAY68425.1 PAS_chr1-4_0569 Primary component of eisosomes YGR086C PIL1 "Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria" Sphingolipid long chain base-responsive protein PIL1 PAS_1g07105 CAY68426.1 PAS_chr1-4_0570 High-affinity glucose transporter of the major facilitator superfamily YLR081W GAL2 "Galactose permease, required for utilization of galactose; also able to transport glucose" Low-affinity glucose transporter HXT4 PAS_1g07110 CAY68427.1 PAS_chr1-4_0690 hypothetical protein PAS_1g07115 CAY68428.1 PAS_chr1-4_0571 Transcription-associated protein YHR099W TRA1 "Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation" Transcription-associated protein 1 PAS_1g07120 CAY68429.1 PAS_chr1-4_0572 hypothetical protein YHR100C GEP4 Protein of unknown function required for respiratory growth; detected in highly purified mitochondria in high-throughput studies; null mutation confers sensitivity to tunicamycin and DTT and decreased levels of phosphatidylethanol "Phosphatidylglycerophosphatase GEP4, mitochondrial " PAS_1g07125 CAY68430.1 PAS_chr1-4_0573 zinc finger protein YDR266C YDR266C "Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain" LIM domain and RING finger protein YDR266C PAS_1g07130 YDR265W PEX10 Peroxisomal membrane E3 ubiquitin ligase required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders Peroxisome biogenesis factor 10 PAS_1g07135 CAY68431.1 PAS_chr1-4_0703 hypothetical protein GO:0006281 YDR419W RAD30 "DNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteins" N-acetyltransferase eso1 PAS_1g07140 CAY68432.1 PAS_chr1-4_0575 NADH-ubiquinone oxidoreductase NADH-ubiquinone oxidoreductase 10.5 kDa subunit PAS_1g07145 CAY68433.1 PAS_chr1-4_0576 Hypothetical protein GO:0006118;GO:0006725;GO:0008198;GO:0016491 "4,5-DOPA dioxygenase extradiol-like protein " PAS_1g07150 CAY68434.1 PAS_chr1-4_0577 Mitochondrial inner membrane insertase GO:0016021;GO:0051205 YER154W OXA1 "Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals" Mitochondrial inner membrane protein OXA1 PAS_1g07155 CAY68435.1 PAS_chr1-4_0578 Hypothetical protein PAS_1g07160 CAY68436.1 PAS_chr1-4_0579 Putative protein of unknown function GO:0003824;GO:0030170 YER152C YER152C Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene Uncharacterized protein YER152C PAS_1g07165 CAY68437.1 PAS_chr1-4_0580 Hypothetical protein GO:0008270 PAS_1g07170 CAY68438.1 PAS_chr1-4_0581 Hypothetical protein PAS_1g07175 CAY68439.1 PAS_chr1-4_0582 Hypothetical protein PAS_1g07180 CAY68440.1 PAS_chr1-4_0583 Hypothetical protein PAS_1g07185 CAY68441.1 PAS_chr1-4_0584 "Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation" Flocculation protein FLO5 PAS_1g07190 CAY68442.1 PAS_chr1-4_0585 Ubiquitin-specific protease that interacts with Bre5p GO:0004221;GO:0006511 YER151C UBP3 Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin Probable ubiquitin carboxyl-terminal hydrolase 3 PAS_1g07195 CAY68443.1 PAS_chr1-4_0586 Hypothetical protein YER150W SPI1 GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p Cell wall protein SED1 PAS_1g07200 CAY68444.1 PAS_chr1-4_0587 Hypothetical protein GO:0003677;GO:0005524;GO:0006259;GO:0008094 YDR076W RAD55 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p PAS_1g07205 CAY68445.1 PAS_chr1-4_0691 hypothetical protein PAS_1g07210 CAY68446.1 PAS_chr1-4_0588 Hypothetical protein PAS_1g07215 CAY68447.1 PAS_chr1-4_0589 "Protein component of the small (40S) subunit, essential for control of translational accuracy" GO:0003723;GO:0003735;GO:0005622;GO:0005840;GO:0006412 YGL123W RPS2 "Protein component of the small (40S) subunit, essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p" 40S ribosomal protein S2 PAS_1g07220 CAY68448.1 PAS_chr1-4_0590 Nuclear polyadenylated RNA-binding protein YGL122C NAB2 Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p Nuclear polyadenylated RNA-binding protein NAB2 PAS_1g07225 CAY68449.1 PAS_chr1-4_0591 Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth GO:0001584;GO:0007186;GO:0016021;n/a YGL140C YGL140C Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains Uncharacterized protein C26F1.08c PAS_1g07230 CAY68450.1 PAS_chr1-4_0692 hypothetical protein YGL119W ABC1 "Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis" "Protein ABC1, mitochondrial " PAS_1g07235 CAY68451.1 PAS_chr1-4_0592 RNA helicase in the DEAH-box family YGL120C PRP43 "RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome" Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 PAS_1g07240 CAY68452.1 PAS_chr1-4_0593 E1 beta subunit of the pyruvate dehydrogenase (PDH) complex YBR221C PDB1 "E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria" "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial " PAS_1g07245 CAY68453.1 PAS_chr1-4_0594 General negative regulator of transcription subunit 4 GO:0000166 YER068W MOT2 "Subunit of the CCR4-NOT complex, which has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p" General negative regulator of transcription subunit 4 PAS_1g07250 CAY68454.1 PAS_chr1-4_0595 "Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p" GO:0005488 YGL241W KAP114 "Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear" Importin subunit beta-5 PAS_1g07255 CAY68455.1 PAS_chr1-4_0596 Subunit of the RNA polymerase II-associated Paf1 complex YGL244W RTF1 Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance RNA polymerase-associated protein RTF1 PAS_1g07260 CAY68456.1 PAS_chr1-4_0597 Cytosolic protein required for sporulation YFR048W RMD8 Cytosolic protein required for sporulation Sporulation protein RMD8 PAS_1g07265 CAY68457.1 PAS_chr1-4_0598 "Glutamyl-tRNA synthetase, cytoplasmic" GO:0006412 YGL245W GUS1 "Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm" "Glutamyl-tRNA synthetase, cytoplasmic " PAS_1g07270 CAY68458.1 PAS_chr1-4_0599 Essential nuclear envelope integral membrane protein required for nuclear transport YGL247W BRR6 "Essential nuclear envelope integral membrane protein required for nuclear transport; depletion alters nucleoporin distribution and nuclear envelope morphology, suggesting a role in the spatial organization of nuclear pores" Nucleus export protein BRR6 PAS_1g07275 CAY68459.1 PAS_chr1-4_0600 Hypothetical protein PAS_1g07280 CAY68460.1 PAS_chr1-4_0601 "Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization" GO:0006810;GO:0016020 YEL063C CAN1 "Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance" Lysine-specific permease PAS_1g07285 CAY68461.1 PAS_chr1-4_0602 N(6)-adenine-specific DNA methyltransferase GO:0003676;GO:0008168;GO:0032259 YGR001C YGR001C Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae N(6)-adenine-specific DNA methyltransferase-like 1 PAS_1g07290 CAY68462.1 PAS_chr1-4_0603 Hypothetical protein YAR002W NUP60 "Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance" PAS_1g07295 CAY68463.1 PAS_chr1-4_0604 C-3 sterol dehydrogenase GO:0003854;GO:0006694 YGL001C ERG26 "C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis" "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating " PAS_1g07300 CAY68464.1 PAS_chr1-4_0605 Hypothetical protein PAS_1g07305 CAY68465.1 PAS_chr1-4_0606 Membrane-associated protein YAL002W VPS8 Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif Vacuolar protein sorting-associated protein 8 PAS_1g07310 CAY68466.1 PAS_chr1-4_0607 COMPASS component SWD1 YAR003W SWD1 "Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7" Set1 complex component swd1 PAS_1g07315 CAY68467.1 PAS_chr1-4_0608 "Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis" GO:0003824;GO:0030170 YGL202W ARO8 "Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis" Aromatic amino acid aminotransferase 1 PAS_1g07320 CAY68468.1 PAS_chr1-4_0609 "Cullin, structural protein of SCF complexes" Cullin-4 PAS_1g07325 CAY68469.1 PAS_chr1-4_0610 Hypothetical protein Set1 complex component shg1 PAS_1g07330 CAY68470.1 PAS_chr1-4_0611 "Vacuolar aminopeptidase Y, processed to mature form by Prb1p" GO:0006508;GO:0008233 YBR286W APE3 "Vacuolar aminopeptidase Y, processed to mature form by Prb1p" Aminopeptidase Y PAS_1g07335 CAY68471.1 PAS_chr1-4_0612 Hypothetical protein PAS_1g07340 CAY68472.1 PAS_chr1-4_0613 Probable transporter SEO1 YAL067C SEO1 "Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide" Probable transporter SEO1 PAS_1g07345 CAY68473.1 PAS_chr1-4_0614 Core Sm protein Sm D3 GO:0016071;GO:0030529 YLR147C SMD3 "Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3" Small nuclear ribonucleoprotein Sm D3 PAS_1g07350 CAY68474.1 PAS_chr1-4_0615 mitochondrial phosphate carrier protein GO:0005488;GO:0006810;GO:0016020 YJR077C MIR1 "Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated" Mitochondrial phosphate carrier protein PAS_1g07355 CAY68475.1 PAS_chr1-4_0616 Hypothetical protein GO:0000166 "RNA-binding motif protein, X-linked 2 " PAS_1g07360 CAY68476.1 PAS_chr1-4_0617 Phosphatidylinositol (PI) phosphatase YKL212W SAC1 "Phosphatidylinositol phosphate (PtdInsP) phosphatase involved in hydrolysis of PtdIns[4]P; transmembrane protein localizes to ER and Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance" Phosphoinositide phosphatase SAC1 PAS_1g07365 CAY68477.1 PAS_chr1-4_0618 WD repeat protein required for ubiquitin-mediated protein degradation YKL213C DOA1 "WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase" Protein DOA1 PAS_1g07370 CAY68478.1 PAS_chr1-4_0619 Metal resistance protein YCF1 GO:0005524;GO:0006810;GO:0016021;GO:0042626 YDR135C YCF1 "Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR" Metal resistance protein YCF1 PAS_1g07375 CAY68479.1 PAS_chr1-4_0620 hypothetical protein YOL148C SPT20 "Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex" "Adenylate cyclase, terminal-differentiation specific " PAS_1g07380 CAY68480.1 PAS_chr1-4_0696 hypothetical protein Protein MNN4 PAS_1g07385 CAY68481.1 PAS_chr1-4_0621 Major facilitator superfamily Uncharacterized transporter YIL166C PAS_1g07390 CAY68482.1 PAS_chr1-4_0622 Hypothetical protein GO:0004867 Uncharacterized protein yetA PAS_1g07395 CAY68483.1 PAS_chr1-4_0623 "Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments" YOR181W LAS17 "Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)" Proline-rich protein LAS17 PAS_1g07400 CAY68484.1 PAS_chr1-4_0624 Hypothetical protein YLR287C YLR287C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene PAS_1g07405 CAY68485.1 PAS_chr1-4_0625 Hypothetical protein PAS_1g07410 CAY68486.1 PAS_chr1-4_0626 GTP-binding protein YPT10 GO:0005525;GO:0007264;GO:0015031;n/a YBR264C YPT10 GTP binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles GTP-binding protein YPT10 PAS_1g07415 CAY68487.1 PAS_chr1-4_0627 Putative serine/threonine kinase GO:0004674;GO:0006468;n/a YJL057C IKS1 Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p Probable serine/threonine-protein kinase IKS1 PAS_1g07420 CAY68488.1 PAS_chr1-4_0628 hypothetical protein GO:0005737 YOL022C TSR4 "Cytoplasmic protein of unknown function; essential gene in S288C background, while tsr4 null mutations in a CEN.PK2 background confer a reduced growth rate" Uncharacterized protein YOL022C PAS_1g07425 CAY68489.1 PAS_chr1-4_0629 Subunit of the Ssh1 translocon complex GO:0009306;GO:0015450;GO:0016020 YBR283C SSH1 Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential Sec sixty-one protein homolog PAS_1g07430 CAY68490.1 PAS_chr1-4_0630 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family YBR261C TAE1 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; has a role in protein synthesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR261C is not an essential gene Methyltransferase-like protein YBR261C PAS_1g07435 CAY68491.1 PAS_chr1-4_0704 hypothetical protein PAS_1g07440 CAY68492.1 PAS_chr1-4_0631 Protein of unknown function that may interact with ribosomes YKR096W YKR096W "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain" Uncharacterized protein YIL151C PAS_1g07445 CAY68493.1 PAS_chr1-4_0632 "C-1-tetrahydrofolate synthase, mitochondrial" GO:0004329;GO:0005524;GO:0009396 YBR084W MIS1 "Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase" "C-1-tetrahydrofolate synthase, mitochondrial " PAS_1g07450 CAY68494.1 PAS_chr1-4_0633 "5' to 3' exonuclease, 5' flap endonuclease" GO:0004518;GO:0006281 YKL113C RAD27 "5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family" Structure-specific endonuclease RAD27 PAS_1g07455 CAY68495.1 PAS_chr1-4_0634 Protein that forms heterodimers with Msh3p and Msh6p GO:0005524;GO:0006298;GO:0030983 YOL090W MSH2 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP DNA mismatch repair protein msh-2 PAS_1g07460 CAY68496.1 PAS_chr1-4_0635 Hypothetical protein YBR047W FMP23 "Putative protein of unknown function; proposed to be involved in iron or copper homeostatis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" "Protein FMP23, mitochondrial " PAS_1g07465 CAY68497.1 PAS_chr1-4_0636 Major facilitator superfamily Uncharacterized transporter YIL166C PAS_1g07470 CAY68498.1 PAS_chr1-4_0637 Protein kti12 YKL110C KTI12 "Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p" PAS_1g07475 CAY68499.1 PAS_chr1-4_0638 Mitochondrial protein required for the stability of Oli1p mRNA and for the Oli1p ring formation YMR098C ATP25 Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene Uncharacterized protein YMR098C PAS_1g07480 CAY68500.1 PAS_chr1-4_0639 transcription factor GO:0003700;GO:0005634;GO:0006355;GO:0043565;GO:0046983 YHL009C YAP3 Basic leucine zipper (bZIP) transcription factor Fluconazole resistance protein 3 PAS_1g07485 CAY68501.1 PAS_chr1-4_0640 U3 small nucleolar RNA-associated protein YMR093W UTP15 "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" U3 small nucleolar RNA-associated protein 15 PAS_1g07490 CAY68502.1 PAS_chr1-4_0641 Actin-interacting protein YMR092C AIP1 "Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats" Uncharacterized WD repeat-containing protein C9G1.05 PAS_1g07495 CAY68503.1 PAS_chr1-4_0642 U3 small nucleolar RNA-associated protein GO:0006364;GO:0032040 YKL099C UTP11 Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit U3 small nucleolar RNA-associated protein 11 PAS_1g07500 CAY68504.1 PAS_chr1-4_0643 Hypothetical protein YKL098W MTC2 Protein of unknown function; mtc2 is synthetically sick with cdc13-1 Uncharacterized protein YKL098W PAS_1g07505 CAY68505.1 PAS_chr1-4_0644 Dynamin-like GTPase required for vacuolar sorting GO:0005525 YKR001C VPS1 "Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis" Vacuolar protein sorting-associated protein 1 PAS_1g07510 CAY68506.1 PAS_chr1-4_0701 hypothetical protein PAS_1g07515 CAY68507.1 PAS_chr1-4_0645 Poly(A) polymerase GO:0003723;GO:0004652;GO:0005634;GO:0043631 YKR002W PAP1 "Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs" Poly(A) polymerase PAPalpha PAS_1g07520 CAY68508.1 PAS_chr1-4_0646 Oxysterol-binding protein GO:0008202 YHR001W OSH7 "Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability" Oxysterol-binding protein homolog 6 PAS_1g07525 CAY68509.1 PAS_chr1-4_0647 Hypothetical protein YKR004C ECM9 Non-essential protein of unknown function Protein ECM9 PAS_1g07530 CAY68510.1 PAS_chr1-4_0648 Sorting and Assembly Machinery complex GO:0019867 SAM50-like protein SpAC17C9.06 PAS_1g07535 CAY68511.1 PAS_chr1-4_0649 Mitochondrial respiratory chain complexes assembly protein RCA1 GO:0004222;GO:0005524;GO:0008270;GO:0016021 YMR089C YTA12 "Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes" Mitochondrial respiratory chain complexes assembly protein RCA1 PAS_1g07540 CAY68512.1 PAS_chr1-4_0650 Chromatin structure-remodeling complex protein RSC7 YMR091C NPL6 "Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length" Chromatin structure-remodeling complex subunit rsc7 PAS_1g07545 CAY68513.1 PAS_chr1-4_0651 Subunit of SAGA histone acetyltransferase complex YGL066W SGF73 Subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters; null mutant displays defects in premeiotic DNA synthesis "Adenylate cyclase, terminal-differentiation specific " PAS_1g07550 CAY68514.1 PAS_c121_0002 Hypothetical protein GO:0009058 YGL065C ALG2 Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol "Alpha-1,3-mannosyltransferase ALG2 " PAS_1g07555 CAY68515.1 PAS_c121_0003 Hypothetical protein GO:0005097;GO:0005622;GO:0032313 YJL044C GYP6 "GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport" PAS_1g07560 CAY68516.1 PAS_c121_0004 Hypothetical protein GO:0005515 YJL042W MHP1 Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins MAP-homologous protein 1 PAS_1g07565 CAY68517.1 PAS_c121_0018 Hypothetical protein GO:0019722 PAS_1g07570 CAY68518.1 PAS_c121_0005 Hypothetical protein GO:0003735;GO:0005622;GO:0005840;GO:0006412 YHR052W CIC1 Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles Putative ribosome biogenesis protein C8F11.04 PAS_1g07575 CAY68519.1 PAS_c121_0006 Hypothetical protein YKL160W ELF1 Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression Transcription elongation factor 1 PAS_1g07580 CAY68520.1 PAS_c121_0007 Hypothetical protein YMR247C RKR1 "Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential gene" RING finger protein YMR247C PAS_1g07585 CAY68521.1 PAS_c121_0008 Hypothetical protein YML034W SRC1 Inner nuclear membrane protein that functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; possible role in chromatid segregation Inner nuclear membrane protein SRC1 PAS_1g07590 CAY68522.1 PAS_c121_0009 Hypothetical protein GO:0003876;GO:0009168 YML035C AMD1 "AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools" AMP deaminase PAS_1g07595 CAY68523.1 PAS_c121_0010 Hypothetical protein GO:0008270 YDR459C PFA5 Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain Palmitoyltransferase PFA5 PAS_1g07600 CAY68524.1 PAS_c121_0011 Hypothetical protein YML036W CGI121 "Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121" Protein cgi121 PAS_1g07605 CAY68525.1 PAS_c121_0012 Hypothetical protein GO:0016740 YJL218W YJL218W "Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene" Putative acetyltransferase C18B11.09c PAS_1g07610 CAY68526.1 PAS_c121_0019 Hypothetical protein PAS_1g07615 CAY68527.1 PAS_c121_0013 Hypothetical protein Formin-like protein 14 PAS_1g07620 CAY68528.1 PAS_c121_0014 Hypothetical protein YDR462W MRPL28 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L28, mitochondrial " PAS_1g07625 CAY68529.1 PAS_c121_0015 Hypothetical protein YGR233C PHO81 "Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p" Ankyrin repeat protein nuc-2 PAS_1g07630 CAY68530.1 PAS_c121_0016 Hypothetical protein PAS_1g07635 CAY68531.1 PAS_c121_0017 Hypothetical protein GO:0003677;GO:0005634;GO:0006355;GO:0030528 PAS_1g07640 PAS_1g07645 CAY68532.1 PAS_FragB_0071 hypothetical protein GO:0016021;GO:0042765 YLR088W GAA1 "Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER" GPI transamidase component GAA1 PAS_1g07650 CAY68533.1 PAS_FragB_0002 Protein CSF1 GO:0016021;GO:0042765 YLR087C CSF1 "Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Protein CSF1 PAS_1g07655 CAY68534.1 PAS_FragB_0003 Rho GTPase activating protein GO:0005622;GO:0007165 Rho GTPase-activating protein gacX PAS_1g07660 CAY68535.1 PAS_FragB_0004 Small nuclear ribonucleoprotein G YFL017W-A SMX2 "Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G" Small nuclear ribonucleoprotein G PAS_1g07665 CAY68536.1 PAS_FragB_0005 Ino eighty subunit 1 YFL013C IES1 Subunit of the INO80 chromatin remodeling complex Ino eighty subunit 1 PAS_1g07670 CAY68537.1 PAS_FragB_0006 Synaptobrevin homolog YKT6 GO:0016021;GO:0016192 YKL196C YKT6 "Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus" Synaptobrevin homolog YKT6 PAS_1g07675 CAY68538.1 PAS_FragB_0007 Protein VTS1 YOR359W VTS1 "Post-transcriptional gene regulator, flap-structured DNA-binding and RNA-binding protein; shows genetic interactions with Vti1p, a v-SNARE involved in cis-Golgi membrane traffic; stimulates Dna2p endonuclease activity; contains a SAM domain" Protein VTS1 PAS_1g07680 CAY68539.1 PAS_FragB_0008 cyclic AMP phosphodiesterase GO:0003824 YOR360C PDE2 "High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon" "3',5'-cyclic-nucleotide phosphodiesterase 2 " PAS_1g07685 CAY68540.1 PAS_FragB_0009 H subunit of the mitochondrial glycine decarboxylase complex YAL044C GCV3 "H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF" "Glycine cleavage system H protein, mitochondrial " PAS_1g07690 CAY68541.1 PAS_FragB_0010 hypothetical protein YAL044W-A YAL044W-A Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein "SufE-like protein, chloroplastic " PAS_1g07695 CAY68542.1 PAS_FragB_0011 Synaptobrevin homolog 2 GO:0016021;GO:0016192 YOR327C SNC2 Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins Synaptobrevin homolog 2 PAS_1g07700 CAY68543.1 PAS_FragB_0012 Myosin-2 YOR326W MYO2 "One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle" Myosin-2 PAS_1g07705 CAY68544.1 PAS_FragB_0072 hypothetical protein PAS_1g07710 CAY68545.1 PAS_FragB_0013 Leucine-rich repeat-containing protein GO:0005515 YOR353C SOG2 "Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis" Leucine-rich repeat-containing protein SOG2 PAS_1g07715 CAY68546.1 PAS_FragB_0014 Mitochondrial DNA replication protein GO:0005488;GO:0006810;GO:0016020 YMR241W YHM2 "Mitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family" Mitochondrial DNA replication protein YHM2 PAS_1g07720 CAY68547.1 PAS_FragB_0015 Hypothetical protein PAS_1g07725 PAS_1g07730 CAY68548.1 PAS_FragB_0018 Hypothetical protein PAS_1g07735 CAY68549.1 PAS_FragB_0019 tRNA-dihydrouridine synthase 1 GO:0008033;GO:0017150;GO:0050660 YML080W DUS1 "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17" tRNA-dihydrouridine synthase 1 PAS_1g07740 CAY68550.1 PAS_FragB_0020 Vacuolar protein sorting-associated protein 70 GO:0003755;GO:0006457 YJR126C VPS70 Protein of unknown function involved in vacuolar protein sorting Vacuolar protein sorting-associated protein 70 PAS_1g07745 CAY68551.1 PAS_FragB_0073 hypothetical protein YJR125C ENT3 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p Epsin-3 PAS_1g07750 CAY68552.1 PAS_FragB_0022 "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial" GO:0003824;GO:0008152 "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial " PAS_1g07755 CAY68553.1 PAS_FragB_0023 Vitamin H transporter 1 Vitamin H transporter 1 PAS_1g07760 CAY68554.1 PAS_FragB_0024 hypothetical protein GO:0003824;GO:0005488;GO:0008152 YMR315W YMR315W Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site Uncharacterized protein YMR315W PAS_1g07765 CAY68555.1 PAS_FragB_0025 Phytanoyl-CoA dioxygenase domain-containing protein Phytanoyl-CoA dioxygenase domain-containing protein 1 homolog PAS_1g07770 CAY68556.1 PAS_FragB_0026 Hypothetical protein YGL079W YGL079W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; identified as a transcriptional activator in a high-throughput yeast one-hybrid assay PAS_1g07775 CAY68557.1 PAS_FragB_0027 AP-3 complex subunit delta GO:0005515;GO:0006461;GO:0006886;GO:0016192;GO:0030117 YPL195W APL5 "Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function" AP-3 complex subunit delta PAS_1g07780 CAY68558.1 PAS_FragB_0028 Hypothetical protein YPL194W DDC1 "DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate" PAS_1g07785 CAY68559.1 PAS_FragB_0029 hypothetical protein YGL080W FMP37 "Putative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" UPF0041 protein FMP37 PAS_1g07790 CAY68560.1 PAS_FragB_0030 Hypothetical protein GO:0003676;GO:0008270 YPL193W RSA1 Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly Ribosome assembly 1 protein PAS_1g07795 CAY68561.1 PAS_FragB_0031 Hypothetical protein Retrotransposon-like protein 1 PAS_1g07800 CAY68562.1 PAS_FragB_0032 Hypothetical protein PAS_1g07805 CAY68563.1 PAS_FragB_0033 hypothetical protein YMR194C-B CMC4 Protein that is necessary for respiratory growth and that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs Uncharacterized protein YMR194C-B PAS_1g07810 CAY68564.1 PAS_FragB_0034 hypothetical protein GO:0003824;GO:0005488;GO:0008152 YMR090W YMR090W "Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability" UPF0659 protein YMR090W PAS_1g07815 CAY68565.1 PAS_FragB_0035 Hypothetical protein PAS_1g07820 CAY68566.1 PAS_FragB_0036 60S ribosomal protein L36 GO:0003735;GO:0005622;GO:0005840;GO:0006412 YMR194W RPL36A "N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA" 60S ribosomal protein L36-A PAS_1g07825 CAY68567.1 PAS_FragB_0037 "54S ribosomal protein L24, mitochondrial" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YMR193W MRPL24 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L24, mitochondrial " PAS_1g07830 CAY68568.1 PAS_FragB_0038 GTPase-activating protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 YPL249C GYP5 "GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p" GTPase-activating protein GYP5 PAS_1g07835 CAY68569.1 PAS_FragB_0074 hypothetical protein YMR191W SPG5 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources PAS_1g07840 CAY68570.1 PAS_FragB_0075 Lactose regulatory protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 YPL248C GAL4 DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p Regulatory protein GAL4 PAS_1g07845 CAY68571.1 PAS_FragB_0039 DNA-dependent ATPase GO:0003677;GO:0005524 YBR073W RDH54 "DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference" DNA repair and recombination protein RDH54 PAS_1g07850 CAY68572.1 PAS_FragB_0076 hypothetical protein GO:0005085;GO:0007264 YPR017C DSS4 "Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol" PAS_1g07855 CAY68573.1 PAS_FragB_0040 Serine palmitoyltransferase 1 GO:0003824;GO:0030170 YMR296C LCB1 "Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine" Serine palmitoyltransferase 1 PAS_1g07860 CAY68574.1 PAS_FragB_0041 hypothetical protein YHR198C AIM18 "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss" Uncharacterized protein YHR198C PAS_1g07865 CAY68575.1 PAS_FragB_0042 "Adrenodoxin homolog, mitochondrial" YPL252C YAH1 Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin "Adrenodoxin homolog, mitochondrial " PAS_1g07870 CAY68576.1 PAS_FragB_0043 Hypothetical protein Myosin-2 heavy chain PAS_1g07875 CAY68577.1 PAS_FragB_0044 Transcriptional coactivator HFI1/ADA1 YPL254W HFI1 "Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions" Transcriptional coactivator HFI1/ADA1 PAS_1g07880 CAY68578.1 PAS_FragB_0045 Hypothetical protein PAS_1g07885 CAY68579.1 PAS_FragB_0046 G1/S-specific cyclin YPL256C CLN2 "G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)" G1/S-specific cyclin CLN1 PAS_1g07890 CAY68580.1 PAS_FragB_0048 Protein ROT1 YMR200W ROT1 "Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations" Protein ROT1 PAS_1g07895 CAY68581.1 PAS_FragB_0049 Vacuolar protein sorting-associated protein 27 GO:0008270 YNR006W VPS27 "Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)" Vacuolar protein sorting-associated protein 27 PAS_1g07900 CAY68582.1 PAS_FragB_0050 Uncharacterized transporter GO:0006855;GO:0015238;GO:0015297;GO:0016020 Uncharacterized transporter YDR338C PAS_1g07905 CAY68583.1 PAS_FragB_0051 Hypothetical protein PAS_1g07910 CAY68584.1 PAS_FragB_0052 Translational elongation factor EF-1 alpha GO:0003746;GO:0005525;GO:0005737;GO:0006414 YBR118W TEF2 Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes Elongation factor 1-alpha PAS_1g07915 CAY68585.1 PAS_FragB_0053 "Glycine dehydrogenase [decarboxylating], mitochondrial" GO:0004375;GO:0006544 YMR189W GCV2 "P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm" "Glycine dehydrogenase [decarboxylating], mitochondrial " PAS_1g07920 CAY68586.1 PAS_FragB_0054 WD repeat-containing protein YPL247C YPL247C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest Uncharacterized WD repeat-containing protein C17D11.08 PAS_1g07925 CAY68587.1 PAS_FragB_0055 ubiquitin-conjugating enzyme GO:0019787;GO:0043687;GO:0051246 Probable ubiquitin-conjugating enzyme E2 16 PAS_1g07930 CAY68588.1 PAS_FragB_0056 ATP-dependent helicase GO:0003676;GO:0005622 YMR190C SGS1 Nucleolar DNA helicase of the RecQ family involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes ATP-dependent helicase SGS1 PAS_1g07935 CAY68589.1 PAS_FragB_0057 "Exoribonuclease II, mitochondrial" GO:0003723;GO:0004540 YMR287C DSS1 "3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs" "Exoribonuclease II, mitochondrial " PAS_1g07940 CAY68590.1 PAS_FragB_0058 hypothetical protein PAS_1g07943 Protein BNI1 PAS_1g07945 CAY68591.1 PAS_FragB_0059 hypothetical protein GO:0004518;GO:0006281 YER041W YEN1 Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p Uncharacterized protein YER041W PAS_1g07950 PAS_1g07955 CAY68592.1 PAS_FragB_0061 Phosphoenolpyruvate carboxykinase GO:0004611;GO:0006094;GO:0017076 YKR097W PCK1 "Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol" Phosphoenolpyruvate carboxykinase [ATP] PAS_1g07960 CAY68593.1 PAS_FragB_0062 Uncharacterized transporter GO:0016020 Uncharacterized vacuolar membrane protein YML018C PAS_1g07965 CAY68594.1 PAS_FragB_0063 Polyadenylation factor subunit 2 YNL317W PFS2 Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex Polyadenylation factor subunit 2 PAS_1g07970 CAY68595.1 PAS_FragB_0064 6-phosphofructo-2-kinase YOL136C PFK27 "6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A" 6-phosphofructo-2-kinase 2 PAS_1g07975 CAY68596.1 PAS_FragB_0077 Phosphatidylglycerol/phosphatidylinositol transfer protein YDL046W NPC2 "Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes" Phosphatidylglycerol/phosphatidylinositol transfer protein PAS_1g07980 CAY68597.1 PAS_FragB_0065 Putative ABC transporter Uncharacterized ABC transporter ATP-binding protein/permease YOL075C PAS_1g07985 CAY68598.1 PAS_FragB_0066 Putative transcription factor GO:0003700;GO:0005634;GO:0006355;GO:0043565;GO:0046983 YDR259C YAP6 Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism AP-1-like transcription factor YAP6 PAS_1g07990 CAY68599.1 PAS_FragB_0067 Mucin-like protein GO:0004553;GO:0005576;GO:0005975;GO:0030248 Serine-rich adhesin for platelets PAS_1g07995 PAS_1g08000 CAY68600.1 PAS_FragB_0069 Hypothetical protein PAS_2g00000 CAY68601.1 PAS_chr2-1_0002 Hypothetical protein PAS_2g00005 CAY68602.1 PAS_chr2-1_0003 Hypothetical protein PAS_2g00010 CAY68603.1 PAS_chr2-1_0004 Hypothetical protein PAS_2g00015 CAY68604.1 PAS_chr2-1_0005 Hypothetical protein PAS_2g00020 CAY68605.1 PAS_chr2-1_0006 "High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low" Probable quinate permease PAS_2g00025 CAY68606.1 PAS_chr2-1_0007 Hypothetical protein PAS_2g00030 CAY68607.1 PAS_chr2-1_0008 Putative protein-methionine-R-oxide reductase YCL033C MXR2 "Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan" Peptide methionine sulfoxide reductase B3 PAS_2g00035 CAY68608.1 PAS_chr2-1_0009 Hypothetical protein PAS_2g00040 CAY68609.1 PAS_chr2-1_0010 Hypothetical protein PAS_2g00045 CAY68610.1 PAS_chr2-1_0011 "ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has sim" GO:0005524;GO:0016887 Uncharacterized ABC transporter ATP-binding protein ydiF PAS_2g00050 CAY68611.1 PAS_chr2-1_0012 "Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize sid" Siderophore iron transporter mirA PAS_2g00055 CAY68612.1 PAS_chr2-1_0013 Hypothetical protein PAS_2g00060 CAY68613.1 PAS_chr2-1_0014 "Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use" GO:0006118;GO:0016491 Alpha-ketoglutarate-dependent sulfonate dioxygenase PAS_2g00065 CAY68614.1 PAS_chr2-1_0015 Putative protein of unknown function identified by fungal homology comparisons and RT-PCR Uncharacterized protein YLR154C-H/YLR156C-A/YLR157C-C/YLR159C-A PAS_2g00070 CAY68615.1 PAS_chr2-1_0016 "2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight" YHR044C DOG1 "2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified" (DL)-glycerol-3-phosphatase 2 PAS_2g00075 CAY68616.1 PAS_chr2-1_0017 Heme-dependent repressor of hypoxic genes GO:0003677;GO:0006355 YPR065W ROX1 Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity Mating-type protein MAT-2 PAS_2g00080 CAY68617.1 PAS_chr2-1_0018 Hypothetical protein PAS_2g00085 CAY68618.1 PAS_chr2-1_0019 Hypothetical protein PAS_2g00090 CAY68619.1 PAS_chr2-1_0020 Hypothetical protein PAS_2g00095 CAY68620.1 PAS_chr2-1_0021 Hypothetical protein YPL199C YPL199C "Putative protein of unknown function, predicted to be palmitoylated" Smr domain-containing protein YPL199C PAS_2g00100 CAY68621.1 PAS_chr2-1_0022 "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarit" GO:0003735;GO:0005840;GO:0006412;n/a YGL076C RPL7A "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)" 60S ribosomal protein L7 PAS_2g00105 CAY68622.1 PAS_chr2-1_0023 "Protein of unknown function that may interact with ribosomes, based on co-purification experiments" YPL225W YPL225W "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" UPF0368 protein YPL225W PAS_2g00110 CAY68623.1 PAS_chr2-1_0024 Putative protein of unknown function GO:0006777;n/a YMR178W YMR178W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene Uncharacterized protein YMR178W PAS_2g00115 CAY68624.1 PAS_chr2-1_0806 hypothetical protein GO:0006812;GO:0008324;GO:0016020 YPL224C MMT2 Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p Mitochondrial metal transporter 1 PAS_2g00120 CAY68625.1 PAS_chr2-1_0025 "Non-essential protein of unknown function, contains ATP/GTP-binding site motif A" GO:0003677;GO:0005622 YMR176W ECM5 "Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks" Protein ECM5 PAS_2g00125 CAY68626.1 PAS_chr2-1_0026 "Trimeric heat shock transcription factor, activates multiple genes in response to stresses that incl" GO:0003700;GO:0005634;GO:0006355;GO:0043565 YGL073W HSF1 "Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated" Heat shock factor protein PAS_2g00130 CAY68627.1 PAS_chr2-1_0027 Putative protein of unknown function YPL191C YPL191C Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Uncharacterized protein YPL191C PAS_2g00135 CAY68628.1 PAS_chr2-1_0028 "Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase" YGL083W SCY1 "Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase" Protein kinase-like protein SCY1 PAS_2g00140 CAY68629.1 PAS_chr2-1_0029 "Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the" GO:0003700;GO:0005634;GO:0006355;GO:0008270;n/a YML099C ARG81 "Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p" Arginine metabolism regulation protein II PAS_2g00145 CAY68630.1 PAS_chr2-1_0030 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis YGL078C DBP3 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis ATP-dependent RNA helicase DBP3 PAS_2g00150 CAY68631.1 PAS_chr2-1_0031 "Protein of unknown function required for normal levels of resistance to oxidative damage, null mutan" YPL196W OXR1 "Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes but not in prokaryotes" Oxidation resistance protein 1 (Fragment) PAS_2g00155 CAY68632.1 PAS_chr2-1_0032 Putative protein of unknown function with similarity to glutamine amidotransferase proteins YLR126C YLR126C Putative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein PAS_2g00160 CAY68633.1 PAS_chr2-1_0033 Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcripti YNL229C URE2 Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion Protein URE2 PAS_2g00165 CAY68634.1 PAS_chr2-1_0034 Hypothetical protein YDL233W YDL233W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL233W is not an essential gene PAS_2g00170 CAY68635.1 PAS_chr2-1_0035 Hypothetical protein PAS_2g00175 CAY68636.1 PAS_chr2-1_0036 Hypothetical protein YNL215W IES2 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; essential for growth under anaerobic conditions Uncharacterized protein C6B12.05c PAS_2g00180 CAY68637.1 PAS_chr2-1_0037 "Nitrilase, member of the nitrilase branch of the nitrilase superfamily" GO:0016810;n/a YIL164C NIT1 "Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene" Putative nitrilase-like protein NIT1 PAS_2g00185 CAY68638.1 PAS_chr2-1_0038 Protein of unknown function GO:0005783;GO:0006886;GO:0006915;GO:0016021;n/a YDL072C YET3 Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein Endoplasmic reticulum transmembrane protein 3 PAS_2g00190 CAY68639.1 PAS_chr2-1_0039 "Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p," GO:0000145;GO:0006904;GO:0015031;n/a YPR055W SEC8 "Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis" Exocyst complex component SEC8 PAS_2g00195 CAY68640.1 PAS_chr2-1_0040 Protein with similarity to ATP-binding cassette (ABC) transporter family members GO:0005524;GO:0016887;n/a YDR061W YDR061W Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance Uncharacterized ABC transporter ATP-binding protein YDR061W PAS_2g00200 CAY68641.1 PAS_chr2-1_0041 Hypothetical protein YBR098W MMS4 "Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination" PAS_2g00205 CAY68642.1 PAS_chr2-1_0042 "Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchan" GO:0005488;n/a YBR101C FES1 "Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum" Hsp70 nucleotide exchange factor FES1 PAS_2g00210 CAY68643.1 PAS_chr2-1_0043 "Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human T" YPR056W TFB4 "Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p" RNA polymerase II transcription factor B subunit 4 PAS_2g00215 CAY68644.1 PAS_chr2-1_0044 Hypothetical protein GO:0003676;GO:0005622;GO:0008270;n/a Protein lethal(2)k10201 PAS_2g00220 CAY68645.1 PAS_chr2-1_0045 Hypothetical protein PAS_2g00225 CAY68646.1 PAS_chr2-1_0046 Hypothetical protein YPR063C YPR063C ER-localized protein of unknown function Uncharacterized protein YPR063C PAS_2g00230 CAY68647.1 PAS_chr2-1_0047 "Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to urac" GO:0008270;GO:0016787;n/a YPR062W FCY1 "Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)" Cytosine deaminase PAS_2g00235 CAY68648.1 PAS_chr2-1_0048 "Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to u" GO:0005506;GO:0006118;GO:0016021;GO:0016491;GO:0050660;n/a Ferric reductase transmembrane component 6 PAS_2g00240 CAY68649.1 PAS_chr2-1_0049 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secre GO:0006810;GO:0016020 YBR132C AGP2 "High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease" General amino acid permease AGP2 PAS_2g00245 CAY68650.1 PAS_chr2-1_0807 hypothetical protein GO:0005524;GO:0006810;GO:0015662;GO:0016020 YMR162C DNF3 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase Probable phospholipid-transporting ATPase DNF3 PAS_2g00250 CAY68651.1 PAS_chr2-1_0050 "Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyze" GO:0005524;GO:0006810;GO:0016021;GO:0042626 Multidrug resistance protein 1 PAS_2g00255 CAY68652.1 PAS_chr2-1_0051 Hypothetical protein Inositol oxygenase 1 PAS_2g00260 CAY68653.1 PAS_chr2-1_0052 Cell wall protein with similarity to glucanases YGL028C SCW11 Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p Probable family 17 glucosidase SCW11 PAS_2g00265 CAY68654.1 PAS_chr2-1_0053 Hypothetical protein PAS_2g00270 CAY68655.1 PAS_chr2-1_0054 "Putative hexose transporter, expressed at low levels and expression is repressed by glucose" Hexose transporter HXT10 PAS_2g00275 CAY68656.1 PAS_chr2-1_0055 "Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen" GO:0005215;GO:0006810;GO:0016020 YHL016C DUR3 "Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway" Urea active transporter PAS_2g00280 CAY68657.1 PAS_chr2-1_0056 "Palmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs" GO:0008270 YDR126W SWF1 "Palmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion" Palmitoyltransferase SWF1 PAS_2g00285 CAY68658.1 PAS_chr2-1_0057 Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane GO:0005524;GO:0006810;GO:0015662;GO:0016020 YER166W DNF1 "Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase" Probable phospholipid-transporting ATPase DNF1 PAS_2g00290 CAY68659.1 PAS_chr2-1_0058 Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway GO:0019787;GO:0043687;GO:0051246 YDR092W UBC13 Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus Ubiquitin-conjugating enzyme E2 13 PAS_2g00295 CAY68660.1 PAS_chr2-1_0059 Hypothetical protein PAS_2g00300 CAY68661.1 PAS_chr2-1_0060 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase YDR098C GRX3 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage Monothiol glutaredoxin-3 PAS_2g00305 CAY68662.1 PAS_chr2-1_0061 "Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints" GO:0005634;GO:0006281;GO:0007049 YER173W RAD24 "Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein" PAS_2g00310 CAY68663.1 PAS_chr2-1_0062 JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri-and dimethy YER169W RPH1 JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway DNA damage-responsive transcriptional repressor RPH1 PAS_2g00315 CAY68664.1 PAS_chr2-1_0063 Hypothetical protein PAS_2g00320 CAY68665.1 PAS_chr2-1_0064 Hypothetical protein PAS_2g00325 CAY68666.1 PAS_chr2-1_0065 "Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin" GO:0016758 YBR023C CHS3 "Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan" Chitin synthase 3 PAS_2g00330 CAY68667.1 PAS_chr2-1_0066 "Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p a" YNL297C MON2 "Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins" Protein MON2 PAS_2g00335 CAY68668.1 PAS_chr2-1_0067 "Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved" GO:0003723;GO:0016439;GO:0031119 YNL292W PUS4 "Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)" tRNA pseudouridine synthase 4 PAS_2g00340 CAY68669.1 PAS_chr2-1_0068 "N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stre" YNL291C MID1 "N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer" Stretch-activated cation channel MID1 PAS_2g00345 CAY68670.1 PAS_chr2-1_0069 "Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase t" GO:0003689;GO:0005524;GO:0005663;GO:0006260 YNL290W RFC3 "Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon" Replication factor C subunit 3 PAS_2g00350 CAY68671.1 PAS_chr2-1_0070 "Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite" YBR022W POA1 "Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing" ADP-ribose 1''-phosphate phosphatase PAS_2g00355 CAY68672.1 PAS_chr2-1_0071 "Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA)" GO:0004674;GO:0006468 YBR028C YBR028C "Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA)" Serine/threonine-protein kinase Sgk1 PAS_2g00360 CAY68673.1 PAS_chr2-1_0072 Delta(9) fatty acid desaturase GO:0020037;GO:0046914 YGL055W OLE1 "Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria" Acyl-CoA desaturase 1 PAS_2g00365 CAY68674.1 PAS_chr2-1_0073 "Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response" YNL294C RIM21 "Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH" pH-response regulator protein palH/RIM21 PAS_2g00370 CAY68675.1 PAS_chr2-1_0074 "GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its acti" GO:0005097;GO:0005622;GO:0032313 YNL293W MSB3 "GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth" GTPase-activating protein MSB4 PAS_2g00375 CAY68676.1 PAS_chr2-1_0075 Hypothetical protein YOL110W SHR5 "Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization" Ras modification protein ERF4 PAS_2g00380 CAY68677.1 PAS_chr2-1_0076 Hypothetical protein GO:0006464 YOL111C MDY2 Protein required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes and interacts with Get4p; has a possible role in insertion of tail-anchored proteins into the ER membrane Ubiquitin-like protein MDY2 PAS_2g00385 CAY68678.1 PAS_chr2-1_0077 Hypothetical protein GO:0004067;GO:0006516 PAS_2g00390 CAY68679.1 PAS_chr2-1_0078 Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein a YDL035C GPR1 "Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis" G protein-coupled receptor GPR1 PAS_2g00395 CAY68680.1 PAS_chr2-1_0079 "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of" GO:0005524;GO:0006457;GO:0051082 YJL111W CCT7 "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo" T-complex protein 1 subunit eta PAS_2g00400 CAY68681.1 PAS_chr2-1_0080 "Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochond" YJL112W MDV1 "Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats" Mitochondrial division protein 1 PAS_2g00405 CAY68682.1 PAS_chr2-1_0081 Hypothetical protein YKR037C SPC34 "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body" DASH complex subunit SPC34 PAS_2g00410 CAY68683.1 PAS_chr2-1_0082 "Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation an" GO:0005524;GO:0005694;GO:0006259 YFL008W SMC1 "Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure" Structural maintenance of chromosomes protein 1 PAS_2g00415 CAY68684.1 PAS_chr2-1_0083 Hypothetical protein UV radiation resistance-associated gene protein PAS_2g00420 CAY68685.1 PAS_chr2-1_0084 Protein possibly involved in a post-Golgi secretory pathway YGR057C LST7 Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface Protein LST7 PAS_2g00425 CAY68686.1 PAS_chr2-1_0085 Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex wit GO:0006508;GO:0008450 YKR038C KAE1 "Highly conserved putative glycoprotease proposed to be involved in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex" Putative glycoprotein endopeptidase KAE1 PAS_2g00430 CAY68687.1 PAS_chr2-1_0086 "Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has simi" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YGR148C RPL24B "Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate" 60S ribosomal protein L24 PAS_2g00435 CAY68688.1 PAS_chr2-1_0087 "Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YGL030W RPL30 "Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript" 60S ribosomal protein L30 PAS_2g00440 CAY68689.1 PAS_chr2-1_0088 Hypothetical protein GO:0005215;GO:0006810;GO:0016020 Sodium-dependent multivitamin transporter PAS_2g00445 CAY68690.1 PAS_chr2-1_0089 "Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step" GO:0008152;GO:0016624 YIL125W KGD1 "Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA" "2-oxoglutarate dehydrogenase, mitochondrial " PAS_2g00450 CAY68691.1 PAS_chr2-1_0090 "tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base" GO:0003723;GO:0004809;GO:0008033 YDR120C TRM1 "tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments" "N(2),N(2)-dimethylguanosine tRNA methyltransferase, mitochondrial " PAS_2g00455 YLR099W-A YLR099W-A Putative protein of unknown function Uncharacterized protein YLR099W-A PAS_2g00460 CAY68692.1 PAS_chr2-1_0091 Hypothetical protein PAS_2g00465 CAY68693.1 PAS_chr2-1_0092 "Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulat" YNL289W PCL1 "Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth" PHO85 cyclin-1 PAS_2g00470 CAY68694.1 PAS_chr2-1_0093 "GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from" GO:0009058;GO:0016779 Mannose-1-phosphate guanyltransferase alpha PAS_2g00475 CAY68695.1 PAS_chr2-1_0094 "Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair bo" GO:0005524;GO:0006298;GO:0030983 YDR097C MSH6 "Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p" DNA mismatch repair protein MSH6 PAS_2g00480 CAY68696.1 PAS_chr2-1_0808 hypothetical protein Uncharacterized protein DDB_G0271670 PAS_2g00485 CAY68697.1 PAS_chr2-1_0095 Nucleosome remodeling factor that functions in regulation of transcription elongation GO:0003677;GO:0005524 YER164W CHD1 "Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes" Chromo domain-containing protein 1 PAS_2g00490 CAY68698.1 PAS_chr2-1_0096 Essential iron-sulfur protein required for ribosome biogenesis and translation initiation YDR091C RLI1 Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase Translation initiation factor RLI1 PAS_2g00495 CAY68699.1 PAS_chr2-1_0097 "Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between th" GO:0000166 YER165W PAB1 "Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G" "Polyadenylate-binding protein, cytoplasmic and nuclear " PAS_2g00500 CAY68700.1 PAS_chr2-1_0098 Hypothetical protein PAS_2g00505 CAY68701.1 PAS_chr2-1_0099 Hypothetical protein GO:0016021;GO:0016192 YLR093C NYV1 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane Vesicle-associated membrane protein 711 PAS_2g00510 CAY68702.1 PAS_chr2-1_0100 Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex GO:0003677 YDR121W DPB4 Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing DNA polymerase epsilon subunit D PAS_2g00515 CAY68703.1 PAS_chr2-1_0101 "Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues" GO:0005737;GO:0016462 YHR201C PPX1 "Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix" Exopolyphosphatase PAS_2g00520 CAY68704.1 PAS_chr2-1_0102 B-type cyclin involved in cell cycle progression YPR119W CLB2 "B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome" G2/mitotic-specific cyclin CYB1 PAS_2g00525 CAY68705.1 PAS_chr2-1_0103 "One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface" YAR071W PHO11 "One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2" Acid phosphatase PHO1 PAS_2g00530 CAY68706.1 PAS_chr2-1_0104 Hypothetical protein YDR100W TVP15 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p Golgi apparatus membrane protein tvp15 PAS_2g00535 CAY68707.1 PAS_chr2-1_0809 hypothetical protein GO:0019904 YER177W BMH1 "14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling" 14-3-3 protein homolog PAS_2g00540 CAY68708.1 PAS_chr2-1_0105 Shuttling pre-60S factor GO:0019904 YDR101C ARX1 Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex Probable metalloprotease ARX1 PAS_2g00545 CAY68709.1 PAS_chr2-1_0106 Protein necessary for structural stability of L-A double-stranded RNA-containing particles YCR019W MAK32 Protein necessary for structural stability of L-A double-stranded RNA-containing particles Protein MAK32 PAS_2g00550 CAY68710.1 PAS_chr2-1_0107 Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobu GO:0003824;GO:0030170 4-aminobutyrate aminotransferase PAS_2g00555 CAY68711.1 PAS_chr2-1_0108 Hypothetical protein PAS_2g00560 CAY68712.1 PAS_chr2-1_0109 Putative protein of unknown function YMR221C YMR221C "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy" Protein FMP42 PAS_2g00565 CAY68713.1 PAS_chr2-1_0810 hypothetical protein YOR280C FSH3 Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2 Dihydrofolate reductase PAS_2g00570 CAY68714.1 PAS_chr2-1_0110 "Fructose-2,6-bisphosphatase, required for glucose metabolism" YJL155C FBP26 "Fructose-2,6-bisphosphatase, required for glucose metabolism" "Fructose-2,6-bisphosphatase " PAS_2g00575 CAY68715.1 PAS_chr2-1_0111 "Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP" GO:0005524;GO:0019201 YER170W ADK2 "Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background" Adenylate kinase 2 PAS_2g00580 CAY68716.1 PAS_chr2-1_0112 "Small rho-like GTPase, essential for establishment and maintenance of cell polarity" GO:0005525;GO:0005622;GO:0007264 YLR229C CDC42 "Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins" Cell division control protein 42 PAS_2g00585 CAY68717.1 PAS_chr2-1_0113 "Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol" GO:0005524;GO:0006457;GO:0051082 YDR212W TCP1 "Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein" T-complex protein 1 subunit alpha PAS_2g00590 CAY68718.1 PAS_chr2-1_0114 "Sterol regulatory element binding protein, induces transcription of sterol transport and biosyntheti" GO:0003700;GO:0005634;GO:0006355 YDR213W UPC2 "Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion" Sterol uptake control protein 2 PAS_2g00595 CAY68719.1 PAS_chr2-1_0115 Mitochondrial cytochrome-c peroxidase GO:0004601;GO:0006118;GO:0006979;GO:0020037 Putative heme-binding peroxidase PAS_2g00600 CAY68720.1 PAS_chr2-1_0116 "Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p)" GO:0005515;GO:0005737 YDR388W RVS167 "Actin-associated protein, interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin" Reduced viability upon starvation protein 167 PAS_2g00605 CAY68721.1 PAS_chr2-1_0117 "GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mut" GO:0005622;GO:0007165 GTPase-activating protein SAC7 PAS_2g00610 CAY68722.1 PAS_chr2-1_0118 "GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mut" GO:0005622;GO:0007165 YDR389W SAC7 "GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate" GTPase-activating protein SAC7 PAS_2g00615 CAY68723.1 PAS_chr2-1_0119 Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugatio GO:0003824;GO:0005488;GO:0008152 YDR390C UBA2 "Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability" Ubiquitin-activating enzyme E1-like PAS_2g00620 CAY68724.1 PAS_chr2-1_0120 "Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of" GO:0004449;GO:0005739;GO:0006099 YOR136W IDH2 "Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated" "Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial " PAS_2g00625 CAY68725.1 PAS_chr2-1_0121 "Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosy" GO:0009058;GO:0016742 YDR408C ADE8 "Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway" Phosphoribosylglycinamide formyltransferase PAS_2g00630 CAY68726.1 PAS_chr2-1_0122 Endopeptidase with trypsin-like activity that cleaves after basic residues GO:0004298;GO:0005839;GO:0006511 YOR157C PUP1 Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z Proteasome component PUP1 PAS_2g00635 CAY68727.1 PAS_chr2-1_0123 "Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth" GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YPL040C ISM1 "Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth" Isoleucyl-tRNA synthetase PAS_2g00640 CAY68728.1 PAS_chr2-1_0811 hypothetical protein YDR407C TRS120 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic Transport protein particle 120 kDa subunit PAS_2g00645 CAY68729.1 PAS_chr2-1_0812 hypothetical protein GO:0005525;n/a YDR385W EFT2 "Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin" Elongation factor 2 PAS_2g00650 CAY68730.1 PAS_chr2-1_0124 "Elongation factor 2 (EF-2), also encoded by EFT1" YBL105C PKC1 "Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)" Protein kinase C-like PAS_2g00655 CAY68731.1 PAS_chr2-1_0125 "RNA polymerase II second largest subunit B150, part of central core" GO:0003677;GO:0003899;GO:0006350 YOR151C RPB2 "RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit" DNA-directed RNA polymerase II subunit RPB2 PAS_2g00660 CAY68732.1 PAS_chr2-1_0126 Mitochondrial ribosomal protein of the large subunit YDR405W MRP20 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L41, mitochondrial " PAS_2g00665 CAY68733.1 PAS_chr2-1_0127 Hypothetical protein HVA22-like protein a PAS_2g00670 CAY68734.1 PAS_chr2-1_0128 Hypothetical protein PAS_2g00675 CAY68735.1 PAS_chr2-1_0129 "Proline permease, required for high-affinity transport of proline" GO:0006810;GO:0016020 YOR348C PUT4 "Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells" Proline-specific permease PAS_2g00680 CAY68736.1 PAS_chr2-1_0130 Hypothetical protein YDR363W ESC2 Protein involved in silencing; may recruit or stabilize Sir proteins; role in Rad51-dependent homologous recombination repair and intra S-phase DNA damage checkpoint; member of the RENi (Rad60-Esc2-Nip45) family of SUMO-like domain proteins Protein ESC2 PAS_2g00685 CAY68737.1 PAS_chr2-1_0131 Hypothetical protein PAS_2g00690 CAY68738.1 PAS_chr2-1_0132 Hypothetical protein PAS_2g00695 CAY68739.1 PAS_chr2-1_0133 Hypothetical protein PAS_2g00700 CAY68740.1 PAS_chr2-1_0134 Hypothetical protein GO:0015662;GO:0016021;GO:0030001 PAS_2g00705 CAY68741.1 PAS_chr2-1_0813 "Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytos" GO:0015662;GO:0016021;GO:0030001 YDR270W CCC2 "Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases" Copper-transporting ATPase PAS_2g00710 CAY68742.1 PAS_chr2-1_0135 "Helix-hairpin-helix protein, involved in DNA repair and replication fork stability" GO:0003677 YDR386W MUS81 "Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein" Crossover junction endonuclease MUS81 PAS_2g00715 CAY68743.1 PAS_chr2-1_0136 Protein of unknown function YOR161C PNS1 "Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport" Protein PNS1 PAS_2g00720 CAY68744.1 PAS_chr2-1_0137 "Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus expo" GO:0005488 YOR160W MTR10 "Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p" mRNA transport regulator MTR10 PAS_2g00725 CAY68745.1 PAS_chr2-1_0138 Core Sm protein Sm E GO:0016071;GO:0030529 YOR159C SME1 "Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E" Small nuclear ribonucleoprotein E PAS_2g00730 CAY68746.1 PAS_chr2-1_0139 Mitochondrial ribosomal protein of the small subunit YOR158W PET123 "Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator" "37S ribosomal protein PET123, mitochondrial " PAS_2g00735 CAY68747.1 PAS_chr2-1_0140 "ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding i" YJL034W KAR2 "ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p" 78 kDa glucose-regulated protein homolog PAS_2g00740 CAY68748.1 PAS_chr2-1_0141 "Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms th" YOR299W BUD7 "Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane" Uncharacterized protein C31F10.16 PAS_2g00745 CAY68749.1 PAS_chr2-1_0142 "Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation" GO:0003677 YMR236W TAF9 "Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3" Transcription initiation factor TFIID subunit 9 PAS_2g00750 CAY68750.1 PAS_chr2-1_0143 "Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of ir" GO:0005506;GO:0005515;GO:0016226;GO:0051536 YPL135W ISU1 "Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable" "Iron sulfur cluster assembly protein 1, mitochondrial " PAS_2g00755 CAY68751.1 PAS_chr2-1_0144 Subunit of the RNA polymerase II mediator complex GO:0005634;GO:0030528;GO:0045449 YHR058C MED6 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Mediator of RNA polymerase II transcription subunit 6 PAS_2g00760 CAY68752.1 PAS_chr2-1_0145 "Protein of unknown function, required for survival upon exposure to K1 killer toxin" YHR059W FYV4 "Protein of unknown function, required for survival upon exposure to K1 killer toxin" "Protein FYV4, mitochondrial " PAS_2g00765 CAY68753.1 PAS_chr2-1_0146 Dinucleoside triphosphate hydrolase GO:0003824 YDR305C HNT2 Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins Bis(5'-adenosyl)-triphosphatase PAS_2g00770 CAY68754.1 PAS_chr2-1_0147 Hypothetical protein PAS_2g00775 CAY68755.1 PAS_chr2-1_0148 Hypothetical protein PAS_2g00780 CAY68756.1 PAS_chr2-1_0149 Protein involved in DNA replication GO:0003677;GO:0005524;GO:0005634;GO:0006270 YEL032W MCM3 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex DNA replication licensing factor MCM3 PAS_2g00785 CAY68757.1 PAS_chr2-1_0150 "Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as" YGR029W ERV1 "Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)" Mitochondrial FAD-linked sulfhydryl oxidase ERV1 PAS_2g00790 CAY68758.1 PAS_chr2-1_0151 Hypothetical protein Vegetative cell wall protein gp1 PAS_2g00795 CAY68759.1 PAS_chr2-1_0152 Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylat GO:0006464;GO:0006512;GO:0008641 YPR066W UBA3 "Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern" NEDD8-activating enzyme E1 catalytic subunit PAS_2g00800 CAY68760.1 PAS_chr2-1_0153 Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA GO:0006281;GO:0006310 YML032C RAD52 Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis DNA repair and recombination protein RAD52 PAS_2g00805 CAY68761.1 PAS_chr2-1_0154 Nuclear envelope protein with multiple putative transmembrane domains YML031W NDC1 "Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II" Nucleoporin NDC1 PAS_2g00810 CAY68762.1 PAS_chr2-1_0156 "Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+" GO:0006885;GO:0015299;GO:0016021 YDR456W NHX1 "Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock" Endosomal/prevacuolar sodium/hydrogen exchanger PAS_2g00815 CAY68763.1 PAS_chr2-1_0157 Hypothetical protein GO:0031072 J domain-containing protein spf31 PAS_2g00820 CAY68764.1 PAS_chr2-1_0158 "Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional" GO:0000162;GO:0004049 YER090W TRP2 "Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p" Anthranilate synthase component 1 PAS_2g00825 CAY68765.1 PAS_chr2-1_0159 UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and YBL058W SHP1 UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate UBX domain-containing protein 1 PAS_2g00830 CAY68766.1 PAS_chr2-1_0160 "Cobalamin-independent methionine synthase, involved in amino acid biosynthesis" GO:0003871;GO:0009086 YER091C MET6 "Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs" 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase PAS_2g00835 CAY68767.1 PAS_chr2-1_0161 "v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28" GO:0006886;GO:0016020 YHL031C GOS1 "v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28" Protein transport protein GOS1 PAS_2g00840 CAY68768.1 PAS_chr2-1_0162 Histidine kinase osmosensor that regulates a MAP kinase cascade GO:0016310;GO:0016772 Hybrid signal transduction histidine kinase J PAS_2g00845 CAY68769.1 PAS_chr2-1_0163 Catalytic subunit of DNA polymerase delta GO:0000166;GO:0003677;GO:0003887;GO:0006260 YDL102W POL3 "Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)" DNA polymerase delta catalytic subunit PAS_2g00850 CAY68770.1 PAS_chr2-1_0164 "Ubiquitin-conjugating enzyme (E4), elongates polyubiquitin chains on substrate proteins" YGL141W HUL5 "Ubiquitin-conjugating enzyme (E4), elongates polyubiquitin chains on substrate proteins; works in opposition to Ubp6p polyubiquitin-shortening activity; required for retrograde transport of misfolded proteins into cytoplasm during ERAD" Probable E3 ubiquitin protein ligase C167.07c PAS_2g00855 CAY68771.1 PAS_chr2-1_0165 Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis GO:0005524 YMR167W MLH1 Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer DNA mismatch repair protein MLH1 PAS_2g00860 CAY68772.1 PAS_chr2-1_0166 Predicted transporter of the mitochondrial inner membrane GO:0005488;GO:0006810;GO:0016020 YMR166C YMR166C Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene Uncharacterized mitochondrial carrier YMR166C PAS_2g00865 CAY68773.1 PAS_chr2-1_0167 "Putative metalloprotease, similar to O-sialoglycoprotein metallopeptidase from P. haemolytica" GO:0006508;GO:0008450 YDL104C QRI7 "Highly conserved mitochondrial protein, essential for stability of the mitochondrial genome; functional homolog of the essential E. coli ygjD gene; member of a family of proteins putatively involved in genome maintenance" Putative protease QRI7 PAS_2g00870 CAY68774.1 PAS_chr2-1_0814 hypothetical protein YDL105W NSE4 Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex Non-structural maintenance of chromosome element 4 PAS_2g00875 CAY68775.1 PAS_chr2-1_0168 Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-gl GO:0003824;GO:0005488;GO:0008152 YER069W "ARG5,6" "Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p" "Protein ARG5,6, mitochondrial " PAS_2g00880 CAY68776.1 PAS_chr2-1_0169 "Mitochondrial outer membrane protein involved in membrane fission, required for localization of Dnm1" GO:0005488 YIL065C FIS1 Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation Mitochondria fission 1 protein PAS_2g00885 CAY68777.1 PAS_chr2-1_0170 "tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala" GO:0003723;GO:0004000;GO:0006396 YGL243W TAD1 "tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala" tRNA-specific adenosine deaminase 1 PAS_2g00890 CAY68778.1 PAS_chr2-1_0171 Putative protein of unknown function YGL242C YGL242C Putative protein of unknown function; deletion mutant is viable Ankyrin repeat-containing protein YGL242C PAS_2g00895 CAY68779.1 PAS_chr2-1_0172 Hypothetical protein Cell surface glycoprotein 1 PAS_2g00900 CAY68780.1 PAS_chr2-1_0173 "Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulate" GO:0004645;GO:0005975 YPR160W GPH1 "Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway" Glycogen phosphorylase 1 PAS_2g00905 CAY68781.1 PAS_chr2-1_0174 Protease involved in the processing of killer toxin and alpha factor precursor GO:0004185;GO:0006508 YGL203C KEX1 Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins Carboxypeptidase KEX1 PAS_2g00910 CAY68782.1 PAS_chr2-1_0175 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0043565;GO:0046983 YIR017C MET28 "Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism" Regulatory protein cys-3 PAS_2g00915 CAY68783.1 PAS_chr2-1_0176 ATP (CTP):tRNA-specific tRNA nucleotidyltransferase GO:0008152;GO:0008168 YER168C CCA1 "ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites" "tRNA nucleotidyltransferase, mitochondrial " PAS_2g00920 CAY68784.1 PAS_chr2-1_0815 hypothetical protein GO:0008152;GO:0008168 YHR209W CRG1 Putative S-adenosylmethionine-dependent methyltransferase; mediates cantharidin resistance Trans-aconitate 3-methyltransferase PAS_2g00925 CAY68785.1 PAS_chr2-1_0177 Hypothetical protein GO:0005634;GO:0030528;GO:0045449 Phosphate system positive regulatory protein PHO4 PAS_2g00930 CAY68786.1 PAS_chr2-1_0178 "Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols" YOR109W INP53 "Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains" "Inositol-1,4,5-trisphosphate 5-phosphatase 3 " PAS_2g00935 PAS_2g00940 CAY68787.1 PAS_chr2-1_0816 hypothetical protein YLR115W CFT2 "Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein." Cleavage factor two protein 2 PAS_2g00945 CAY68788.1 PAS_chr2-1_0179 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family GO:0003676;GO:0008168;GO:0032259 YDR140W MTQ2 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC eRF1 methyltransferase catalytic subunit MTQ2 PAS_2g00950 CAY68789.1 PAS_chr2-1_0180 "Protein of unknown function, essential for viability" GO:0031177 YDR141C DOP1 "Protein of unknown function, essential for viability, involved in establishing cellular polarity and morphogenesis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Protein dopey PAS_2g00955 CAY68790.1 PAS_chr2-1_0182 "Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin" YPL065W VPS28 "Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p" Vacuolar protein sorting-associated protein 28 PAS_2g00960 CAY68791.1 PAS_chr2-1_0183 Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p YLR118C YLR118C Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS Acyl-protein thioesterase 1 PAS_2g00965 CAY68792.1 PAS_chr2-1_0184 Hypothetical protein PAS_2g00970 CAY68793.1 PAS_chr2-1_0185 "Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitoch" YML091C RPM2 "Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus" "Ribonuclease P protein component, mitochondrial " PAS_2g00975 CAY68794.1 PAS_chr2-1_0186 Alpha-tubulin GO:0003924;GO:0005525;GO:0043234;GO:0051258 YML085C TUB1 "Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules" Tubulin alpha chain PAS_2g00980 CAY68795.1 PAS_chr2-1_0187 Hypothetical protein GO:0003723;GO:0005634 Splicing factor U2AF 23 kDa subunit PAS_2g00985 CAY68796.1 PAS_chr2-1_0188 Alpha 2 subunit of the 20S proteasome GO:0004298;GO:0005839;GO:0006511 YML092C PRE8 Alpha 2 subunit of the 20S proteasome Proteasome component Y7 PAS_2g00990 CAY68797.1 PAS_chr2-1_0189 Protein required for respiratory growth and stability of the mitochondrial genome YCR020C PET18 "Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin" Protein PET18 PAS_2g00995 CAY68798.1 PAS_chr2-1_0190 Putative ABC transporter YOL075C YOL075C Putative ABC transporter Uncharacterized ABC transporter ATP-binding protein/permease YOL075C PAS_2g01000 CAY68799.1 PAS_chr2-1_0191 "3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-Co" GO:0004421;GO:0008299 YML126C ERG13 "3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis" Hydroxymethylglutaryl-CoA synthase PAS_2g01005 CAY68800.1 PAS_chr2-1_0192 Protein of unknown function YML128C MSC1 "Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated" Meiotic sister chromatid recombination protein 1 PAS_2g01010 CAY68801.1 PAS_chr2-1_0193 Component of the RSC chromatin remodeling complex YML127W RSC9 Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Chromatin structure-remodeling complex subunit RSC9 PAS_2g01015 CAY68802.1 PAS_chr2-1_0194 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic c GO:0006457;GO:0016272;GO:0051082 YML094W GIM5 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Prefoldin subunit 5 PAS_2g01020 CAY68803.1 PAS_chr2-1_0195 "Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excisio" YML095C RAD10 "Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein" Mating-type switching protein swi10 PAS_2g01025 CAY68804.1 PAS_chr2-1_0196 Hypothetical protein PAS_2g01030 CAY68805.1 PAS_chr2-1_0197 "D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of D-erythroascorbic acid," GO:0016491;GO:0050660 YML086C ALO1 "D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress" "D-arabinono-1,4-lactone oxidase " PAS_2g01035 CAY68806.1 PAS_chr2-1_0198 "Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use" GO:0006118;GO:0016491 Alpha-ketoglutarate-dependent sulfonate dioxygenase PAS_2g01040 CAY68807.1 PAS_chr2-1_0199 "Essential protein required for maturation of Gas1p and Pho8p, proposed to be involved in protein tra" GO:0006118;GO:0016491 YML125C PGA3 "Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking" Uncharacterized oxidoreductase YML125C PAS_2g01045 CAY68808.1 PAS_chr2-1_0200 "F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex" YML088W UFO1 "F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation" F-box/WD repeat-containing protein pof10 PAS_2g01050 CAY68809.1 PAS_chr2-1_0201 Hypothetical protein PAS_2g01055 CAY68810.1 PAS_chr2-1_0202 "S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine" GO:0004014;GO:0006597;GO:0008295 YOL052C SPE2 "S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically" S-adenosylmethionine decarboxylase proenzyme PAS_2g01060 CAY68811.1 PAS_chr2-1_0203 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated prote GO:0004725;GO:0006470 YOR208W PTP2 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus Receptor-type tyrosine-protein phosphatase eta PAS_2g01065 CAY68812.1 PAS_chr2-1_0204 RNAse GO:0003723;GO:0004521 YPL123C RNY1 "Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity" Ribonuclease T2-like PAS_2g01070 CAY68813.1 PAS_chr2-1_0205 Subunit of the Hat1p-Hat2p histone acetyltransferase complex Probable histone-binding protein lin-53 PAS_2g01075 CAY68814.1 PAS_chr2-1_0206 "Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in tel" GO:0008270 YPL138C SPP1 "Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein" Set1 complex component spp1 PAS_2g01080 CAY68815.1 PAS_chr2-1_0207 "Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p" GO:0005525 YOR211C MGM1 "Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy" "Protein msp1, mitochondrial " PAS_2g01085 CAY68816.1 PAS_chr2-1_0208 "Protein of unknown function, localized to the mitochondrial outer membrane" YOR228C YOR228C "Protein of unknown function, localized to the mitochondrial outer membrane" PAS_2g01090 CAY68817.1 PAS_chr2-1_0209 One of two large regulatory subunits of ribonucleotide-diphosphate reductase GO:0004748;GO:0005515;GO:0005971;GO:0006260 Ribonucleoside-diphosphate reductase large subunit PAS_2g01095 CAY68818.1 PAS_chr2-1_0210 Hypothetical protein Period circadian protein (Fragments) PAS_2g01100 CAY68819.1 PAS_chr2-1_0211 Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II GO:0006914 YPL120W VPS30 Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1 Vacuolar protein sorting-associated protein 30 PAS_2g01105 CAY68820.1 PAS_chr2-1_0212 "Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to prote" GO:0016020 YDL095W PMT1 "Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; one of seven related proteins involved in O-glycosylation which is essential for cell wall rigidity" Dolichyl-phosphate-mannose--protein mannosyltransferase 1 PAS_2g01110 CAY68821.1 PAS_chr2-1_0213 Protein of unknown function YOR205C GEP3 "Protein of unknown function; null mutant is defective in respiration and interacts synthetically with prohibitin (phb1); the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies" Mitochondrial protein FMP38 PAS_2g01115 CAY68822.1 PAS_chr2-1_0214 Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome YGL133W ITC1 "Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1" Imitation switch two complex protein 1 PAS_2g01120 CAY68823.1 PAS_chr2-1_0817 hypothetical protein YPL215W CBP3 Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4p "Protein CBP3, mitochondrial " PAS_2g01125 CAY68824.1 PAS_chr2-1_0818 hypothetical protein YPL213W LEA1 Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; invovled in telomere maintenance; putative homolog of human U2A' snRNP protein U2 small nuclear ribonucleoprotein A' PAS_2g01130 CAY68825.1 PAS_chr2-1_0215 DNA binding protein with similarity to the S. pombe Snt2 protein GO:0008270 YGL131C SNT2 DNA binding protein with similarity to the S. pombe Snt2 protein; computational analysis suggests a role in regulation of expression of genes encoding amine transporters Lid2 complex component snt2 PAS_2g01135 CAY68826.1 PAS_chr2-1_0216 "Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is" GO:0004484;GO:0006370;GO:0006397 YGL130W CEG1 "Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphophatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide" mRNA-capping enzyme subunit alpha PAS_2g01140 CAY68827.1 PAS_chr2-1_0217 "Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator" YGL129C RSM23 "Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p" "37S ribosomal protein S23, mitochondrial " PAS_2g01145 CAY68828.1 PAS_chr2-1_0218 Hypothetical protein Uncharacterized protein PF11_0207 PAS_2g01150 CAY68829.1 PAS_chr2-1_0219 "Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, an" YPL204W HRR25 "Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)" Casein kinase I homolog hhp1 PAS_2g01155 CAY68830.1 PAS_chr2-1_0220 Karyopherin with a role in the assembly or export of 60S ribosomal subunits GO:0005488 YPL125W KAP120 Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p Importin beta-like protein KAP120 PAS_2g01160 CAY68831.1 PAS_chr2-1_0221 "Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis" YOR209C NPT1 "Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus" Nicotinate phosphoribosyltransferase PAS_2g01165 CAY68832.1 PAS_chr2-1_0222 "U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRN" YPL126W NAN1 "U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA" NET1-associated nuclear protein 1 PAS_2g01170 CAY68833.1 PAS_chr2-1_0223 "RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III" GO:0003677;GO:0045449 YOR210W RPB10 "RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III" "DNA-directed RNA polymerases I, II, and III subunit RPABC5 " PAS_2g01175 CAY68834.1 PAS_chr2-1_0224 Hypothetical protein GO:0008152;GO:0016740 YOR221C MCT1 "Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling" "Malonyl CoA-acyl carrier protein transacylase, mitochondrial " PAS_2g01180 CAY68835.1 PAS_chr2-1_0225 Zinc cluster transcriptional activator involved in conferring resistance to ketoconazole GO:0003700;GO:0005634;GO:0006355;GO:0008270 YPL133C RDS2 Zinc cluster transcriptional activator involved in conferring resistance to ketoconazole Regulator of drug sensitivity 2 PAS_2g01185 CAY68836.1 PAS_chr2-1_0226 Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochr GO:0005507 YPL132W COX11 Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p "Cytochrome c oxidase assembly protein COX11, mitochondrial " PAS_2g01190 CAY68837.1 PAS_chr2-1_0227 Hypothetical protein PAS_2g01195 CAY68838.1 PAS_chr2-1_0228 DNA helicase involved in rDNA replication and Ty1 transposition YHR031C RRM3 DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p Uncharacterized ATP-dependent helicase YHR031C PAS_2g01200 CAY68839.1 PAS_chr2-1_0229 "Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene e" GO:0008270 Phosphatidylinositol-3-phosphate-binding protein 2 PAS_2g01205 CAY68840.1 PAS_chr2-1_0230 Mitochondrial ribosomal protein of the small subunit GO:0004784;GO:0006801;GO:0046872 YDR347W MRP1 "Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein" "37S ribosomal protein MRP1, mitochondrial " PAS_2g01210 CAY68841.1 PAS_chr2-1_0231 Putative protein of unknown function YHR097C YHR097C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus Uncharacterized protein YHR097C PAS_2g01215 CAY68842.1 PAS_chr2-1_0232 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of m GO:0005634;GO:0006397 YMR061W RNA14 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex mRNA 3'-end-processing protein RNA14 PAS_2g01220 CAY68843.1 PAS_chr2-1_0233 "Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM)" GO:0000166 Polyadenylate-binding protein 2 PAS_2g01225 CAY68844.1 PAS_chr2-1_0234 "Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis" YER002W NOP16 "Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis" Nucleolar protein 16 PAS_2g01230 CAY68845.1 PAS_chr2-1_0235 "Na+/Pi cotransporter, active in early growth phase" GO:0005315;GO:0006817;GO:0016020 YBR296C PHO89 "Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p" Phosphate permease PHO89 PAS_2g01235 CAY68846.1 PAS_chr2-1_0236 "Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups i" YKL086W SRX1 "Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes" Sulfiredoxin PAS_2g01240 CAY68847.1 PAS_chr2-1_0237 Putative protein of unknown function GO:0005525;GO:0005622 YDR336W YDR336W Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene Uncharacterized GTP-binding protein YDR336W PAS_2g01245 CAY68848.1 PAS_chr2-1_0238 "Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate" GO:0003824;GO:0005975 YKL085W MDH1 "Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated" "Malate dehydrogenase, mitochondrial " PAS_2g01250 CAY68849.1 PAS_chr2-1_0819 hypothetical protein GO:0003676 Regulatory protein brlA PAS_2g01255 CAY68850.1 PAS_chr2-1_0239 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p YMR071C TVP18 "Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments" Golgi apparatus membrane protein TVP18 PAS_2g01260 CAY68851.1 PAS_chr2-1_0240 Hypothetical protein Uncharacterized RING finger protein C2F3.16 PAS_2g01265 CAY68852.1 PAS_chr2-1_0241 "Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regu" YMR068W AVO2 "Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth" Target of rapamycin complex 2 subunit AVO2 PAS_2g01270 CAY68853.1 PAS_chr2-1_0242 Putative protein of unknown function Uncharacterized protein C6G10.03c PAS_2g01275 CAY68854.1 PAS_chr2-1_0243 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p YMR067C UBX4 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p Uncharacterized protein C21C3.11 PAS_2g01280 CAY68855.1 PAS_chr2-1_0820 hypothetical protein YMR066W SOV1 Mitochondrial protein of unknown function "Protein SOV1, mitochondrial " PAS_2g01285 CAY68856.1 PAS_chr2-1_0244 Mitochondrial translation initiation factor 2 YOL023W IFM1 Mitochondrial translation initiation factor 2 "Translation initiation factor IF-2, mitochondrial " PAS_2g01290 CAY68857.1 PAS_chr2-1_0245 "Essential protein, constituent of 66S pre-ribosomal particles" YKL082C RRP14 "Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family" Ribosomal RNA-processing protein 14 PAS_2g01295 CAY68858.1 PAS_chr2-1_0246 Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) GO:0005524;GO:0016469;GO:0016820 YKL080W VMA5 "Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane" V-type proton ATPase subunit C PAS_2g01300 CAY68859.1 PAS_chr2-1_0247 Kinesin-related motor protein involved in mitotic spindle positioning GO:0003777;GO:0005524;GO:0005875;GO:0007018 Kinesin heavy chain PAS_2g01305 CAY68860.1 PAS_chr2-1_0248 Catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme YHR004C NEM1 "Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard" Nuclear envelope morphology protein 1 PAS_2g01310 CAY68861.1 PAS_chr2-1_0249 "Hypothetical protein, peroxisomal 2,4-dienoyl-CoA reductase" GO:0008152;GO:0016491 3-oxoacyl-[acyl-carrier-protein] reductase PAS_2g01315 CAY68862.1 PAS_chr2-1_0250 Hypothetical protein GO:0004197;GO:0006508 Uncharacterized protein C16H5.12c PAS_2g01320 CAY68863.1 PAS_chr2-1_0251 "N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2" YMR069W NAT4 "N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A" Histone-specific N-acetyltransferase NAT4 PAS_2g01325 CAY68864.1 PAS_chr2-1_0252 Putative protein of unknown function GO:0003676 YPR015C YPR015C Putative protein of unknown function; overexpression causes a cell cycle delay or arrest Wilms tumor protein homolog B PAS_2g01330 CAY68865.1 PAS_chr2-1_0253 Hypothetical protein PAS_2g01335 CAY68866.1 PAS_chr2-1_0254 Hypothetical protein Uncharacterized PH domain-containing protein C637.13c PAS_2g01340 CAY68867.1 PAS_chr2-1_0255 Protein of unknown function involved in maintenance of proper telomere length YOR322C LDB19 Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; localization changes in response to nutrient levels; null mutant has reduced affinity for alcian blue dye Protein LDB19 PAS_2g01345 CAY68868.1 PAS_chr2-1_0256 "Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to prote" GO:0016020 YAL023C PMT2 "Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals" Dolichyl-phosphate-mannose--protein mannosyltransferase 2 PAS_2g01350 CAY68869.1 PAS_chr2-1_0257 Nucleoside transporter with broad nucleoside selectivity GO:0005337;GO:0006810;GO:0016020 YAL022C FUN26 Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes Nucleoside transporter FUN26 PAS_2g01355 CAY68870.1 PAS_chr2-1_0258 "Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitoc" GO:0005198;GO:0016226;GO:0051536 YPR067W ISA2 "Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations" Iron-sulfur assembly protein 2 PAS_2g01360 CAY68871.1 PAS_chr2-1_0259 Hypothetical protein PAS_2g01365 CAY68872.1 PAS_chr2-1_0260 Hypothetical protein Putative mediator of RNA polymerase II transcription subunit 26 PAS_2g01370 CAY68873.1 PAS_chr2-1_0261 "Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p" YBL061C SKT5 "Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation" Protein SKT5 PAS_2g01375 CAY68874.1 PAS_chr2-1_0262 Protein of unknown function YCR061W YCR061W Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation Uncharacterized membrane protein YCR061W PAS_2g01380 CAY68875.1 PAS_chr2-1_0263 "Catalytic subunit of 1,3-beta-D-glucan synthase" GO:0000148;GO:0003843;GO:0006075;GO:0016020 "1,3-beta-glucan synthase component FKS1 " PAS_2g01385 CAY68876.1 PAS_chr2-1_0264 Mitochondrial outer membrane protein with similarity to Tom70p RNA polymerase II-associated protein 3 PAS_2g01390 CAY68877.1 PAS_chr2-1_0265 "Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase" YCR059C YIH1 "Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene" Protein IMPACT homolog PAS_2g01395 CAY68878.1 PAS_chr2-1_0266 Hypothetical protein PAS_2g01400 CAY68879.1 PAS_chr2-1_0267 Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA YCR057C PWP2 "Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis" Periodic tryptophan protein 2 PAS_2g01405 CAY68880.1 PAS_chr2-1_0268 Essential protein of unknown function YCR054C CTR86 Essential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesis Copper transport protein 86 PAS_2g01410 CAY68881.1 PAS_chr2-1_0269 "Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine" GO:0006520;GO:0030170 YCR053W THR4 "Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway" Threonine synthase PAS_2g01415 CAY68882.1 PAS_chr2-1_0270 Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme GO:0004867 YGR213C RTA1 Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein Protein RTM1 PAS_2g01420 CAY68883.1 PAS_chr2-1_0821 hypothetical protein GO:0005634 YNR023W SNF12 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; deletion mutants are temperature-sensitive SWI/SNF and RSC complexes subunit ssr3 PAS_2g01425 CAY68884.1 PAS_chr2-1_0822 hypothetical protein PAS_2g01430 CAY68885.1 PAS_chr2-1_0271 Subunit of the Hat1p-Hat2p histone acetyltransferase complex YEL056W HAT2 "Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing" Histone acetyltransferase type B subunit 2 PAS_2g01435 CAY68886.1 PAS_chr2-1_0272 Hypothetical protein YNR022C MRPL50 "Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation" "54S ribosomal protein L50, mitochondrial " PAS_2g01440 CAY68887.1 PAS_chr2-1_0273 Protein involved in bud-site selection GO:0008478;GO:0008615 Putative pyridoxal kinase BUD17 PAS_2g01445 CAY68888.1 PAS_chr2-1_0274 Protein involved in postreplication repair YCR066W RAD18 "E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair" Postreplication repair E3 ubiquitin-protein ligase RAD18 PAS_2g01450 CAY68889.1 PAS_chr2-1_0275 Subunit of the RNA polymerase II mediator complex YBR193C MED8 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Mediator of RNA polymerase II transcription subunit 8 PAS_2g01455 CAY68890.1 PAS_chr2-1_0276 Hypothetical protein YOR195W SLK19 "Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate" Kinetochore protein SLK19 PAS_2g01460 CAY68891.1 PAS_chr2-1_0277 TFIIA large subunit GO:0003702;GO:0005672;GO:0006367 YOR194C TOA1 "TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA" Transcription initiation factor IIA large subunit PAS_2g01465 CAY68892.1 PAS_chr2-1_0278 Hypothetical protein PAS_2g01470 CAY68893.1 PAS_chr2-1_0279 "Triacylglycerol lipase of the lipid particle, responsible for all the TAG lipase activity of the lip" GO:0006629 YMR313C TGL3 "Triacylglycerol lipase of the lipid particle, responsible for all the TAG lipase activity of the lipid particle; contains the consensus sequence motif GXSXG, which is found in lipolytic enzymes; required with Tgl4p for timely bud formation" Uncharacterized protein C1450.16c PAS_2g01475 CAY68894.1 PAS_chr2-1_0280 "Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug" YDR011W SNQ2 "Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species" Protein SNQ2 PAS_2g01480 CAY68895.1 PAS_chr2-1_0281 "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA" YMR312W ELP6 "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity" Elongator complex protein 6 PAS_2g01485 CAY68896.1 PAS_chr2-1_0282 Cytosolic ribosome-associated chaperone GO:0031072 YGR285C ZUO1 "Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p" Zuotin PAS_2g01490 YPL099C AIM43 "Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss" PAS_2g01495 CAY68897.1 PAS_chr2-1_0283 Putative tRNA acetyltransferase YGL232W TAN1 "Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA" tRNA acetyltransferase TAN1 PAS_2g01500 CAY68898.1 PAS_chr2-1_0284 "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA" YPL101W ELP4 "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity" Elongator complex protein 4 PAS_2g01505 CAY68899.1 PAS_chr2-1_0285 Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenanceof the mitoc YBR179C FZO1 "Mitofusin, mitochondrial integral membrane protein involved in mitochondrial fusion and mitochondrial genome maintenance; contains N-terminal GTPase domain; targeted for destruction by cytosolic components of the ubiquitin-proteasome system" Transmembrane GTPase FZO1 PAS_2g01510 CAY68900.1 PAS_chr2-1_0287 Protein localized to COPII-coated vesicles YGR284C ERV29 "Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo" ER-derived vesicles protein ERV29 PAS_2g01515 CAY68901.1 PAS_chr2-1_0288 Hypothetical protein YMR311C GLC8 "Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2" Protein GLC8 PAS_2g01520 CAY68902.1 PAS_chr2-1_0289 Hypothetical protein PAS_2g01525 CAY68903.1 PAS_chr2-1_0290 Late endosomal protein involved in late endosome to vacuole trafficking Vacuolar protein sorting-associated protein 55 PAS_2g01530 CAY68904.1 PAS_chr2-1_0291 Alpha 6 subunit of the 20S proteasome GO:0004298;GO:0005839;GO:0006511 YMR314W PRE5 Alpha 6 subunit of the 20S proteasome Probable proteasome subunit alpha type-1 PAS_2g01535 CAY68905.1 PAS_chr2-1_0292 Ureidoglycolate hydrolase GO:0000256;GO:0004848 YIR032C DAL3 "Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression" Ureidoglycolate hydrolase PAS_2g01540 CAY68906.1 PAS_chr2-1_0293 Hypothetical protein UPF0047 protein C4A8.02c PAS_2g01545 CAY68907.1 PAS_chr2-1_0294 Hypothetical protein PAS_2g01550 CAY68908.1 PAS_chr2-1_0823 hypothetical protein YPL108W YPL108W Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Uncharacterized protein YPL108W PAS_2g01555 CAY68909.1 PAS_chr2-1_0295 Subunit of both RNase MRP YBR167C POP7 "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends" Ribonucleases P/MRP protein subunit POP7 PAS_2g01560 CAY68910.1 PAS_chr2-1_0296 Putative protein of unknown function YGL231C EMC4 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; human ortholog TMEM85 may function in apoptosis ER membrane protein complex subunit 4 PAS_2g01565 CAY68911.1 PAS_chr2-1_0297 Essential 113kDa subunit of the exocyst complex GO:0000145;GO:0006904 YGL233W SEC15 "Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles" Exocyst complex component SEC15 PAS_2g01570 CAY68912.1 PAS_chr2-1_0298 Hypothetical protein YFR043C IRC6 Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci PAS_2g01575 CAY68913.1 PAS_chr2-1_0824 hypothetical protein PAS_2g01580 CAY68914.1 PAS_chr2-1_0299 "Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase" YGL227W VID30 "Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); binds FBPase; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm" Ran-binding protein 9 PAS_2g01585 PAS_2g01590 CAY68915.1 PAS_chr2-1_0301 Voltage-gated high-affinity calcium channel GO:0005216;GO:0006811;GO:0016020 YGR217W CCH1 "Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together" Calcium-channel protein cch1 PAS_2g01595 CAY68916.1 PAS_chr2-1_0302 Putative catalytic subunit of a class II histone deacetylase complex YNL021W HDA1 "Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation" Histone deacetylase HDA1 PAS_2g01600 CAY68917.1 PAS_chr2-1_0825 hypothetical protein YOR256C TRE2 Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31 Putative zinc metalloprotease TRE2 PAS_2g01605 CAY68918.1 PAS_chr2-1_0303 UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in GPI synthesis GO:0009058 YPL175W SPT14 "UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins" Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit PAS_2g01610 YLL004W ORC3 "Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing" Origin recognition complex subunit 3 PAS_2g01615 CAY68919.1 PAS_chr2-1_0304 Kex2 proprotein convertase YNL238W KEX2 "Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway" Kexin PAS_2g01620 CAY68920.1 PAS_chr2-1_0305 Nuclear architecture related protein YNL240C NAR1 "Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf" Cytosolic Fe-S cluster assembly factor NAR1 PAS_2g01625 CAY68921.1 PAS_chr2-1_0306 Hypothetical protein PAS_2g01630 CAY68922.1 PAS_chr2-1_0307 Hypothetical protein GO:0005507;GO:0008131;GO:0009308;GO:0048038 Membrane primary amine oxidase PAS_2g01635 CAY68923.1 PAS_chr2-1_0308 "Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway" GO:0004345;GO:0006006 YNL241C ZWF1 "Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia" Glucose-6-phosphate 1-dehydrogenase PAS_2g01640 CAY68924.1 PAS_chr2-1_0309 Protein with similarity to mammalian monocarboxylate permeases YOL119C MCH4 "Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport" Riboflavin transporter MCH5 PAS_2g01645 CAY68925.1 PAS_chr2-1_0310 Hypothetical protein PAS_2g01650 CAY68926.1 PAS_chr2-1_0311 "NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate" GO:0003824;GO:0005488;GO:0008152 YDL215C GDH2 "NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels" NAD-specific glutamate dehydrogenase PAS_2g01655 CAY68927.1 PAS_chr2-1_0312 Hypothetical protein PAS_2g01660 CAY68928.1 PAS_chr2-1_0313 Bifunctional enzyme with alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase GO:0008270;GO:0016491 Uncharacterized zinc-type alcohol dehydrogenase-like protein yjmD PAS_2g01665 CAY68929.1 PAS_chr2-1_0314 Protein that binds tRNA and methionyl-and glutamyl-tRNA synthetases (Mes1p and Gus1p) GO:0000049 GU4 nucleic-binding protein 1 PAS_2g01670 CAY68930.1 PAS_chr2-1_0315 Omega class glutathione transferase YKR076W ECM4 Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Glutathione S-transferase omega-like 2 PAS_2g01675 CAY68931.1 PAS_chr2-1_0316 Hypothetical protein PAS_2g01680 CAY68932.1 PAS_chr2-1_0317 Hypothetical protein PAS_2g01685 CAY68933.1 PAS_chr2-1_0318 Hypothetical protein PAS_2g01690 CAY68934.1 PAS_chr2-1_0319 Hypothetical protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 PAS_2g01695 CAY68935.1 PAS_chr2-1_0320 Protein containing a UCS (UNC-45/CRO1/SHE4) domain GO:0005488 YOR035C SHE4 "Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization" SWI5-dependent HO expression protein 4 PAS_2g01700 CAY68936.1 PAS_chr2-1_0321 Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A GO:0008270 YHR090C YNG2 Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1 and its isoforms ING4 and ING5 Chromatin modification-related protein YNG2 PAS_2g01705 CAY68937.1 PAS_chr2-1_0827 hypothetical protein PAS_2g01710 CAY68938.1 PAS_chr2-1_0322 Calnexin YAL058W CNE1 "Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast" Calnexin homolog PAS_2g01715 CAY68939.1 PAS_chr2-1_0323 Essential Hsp90p co-chaperone YOL071W EMI5 "Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)" "Succinate dehydrogenase assembly factor 2, mitochondrial " PAS_2g01720 CAY68940.1 PAS_chr2-1_0828 hypothetical protein YDR168W CDC37 Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding Hsp90 co-chaperone Cdc37 PAS_2g01725 CAY68941.1 PAS_chr2-1_0324 Oligomeric mitochondrial matrix chaperone GO:0005524 YDR258C HSP78 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates "Heat shock protein 78, mitochondrial " PAS_2g01730 CAY68942.1 PAS_chr2-1_0325 Hypothetical protein PAS_2g01735 CAY68943.1 PAS_chr2-1_0326 Hypothetical protein Mitochondrial inner membrane i-AAA protease complex subunit MGR1 PAS_2g01740 CAY68944.1 PAS_chr2-1_0327 Protein of unknown function YCL045C EMC1 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p ER membrane protein complex subunit 1 PAS_2g01745 CAY68945.1 PAS_chr2-1_0328 Palmitoyl transferase involved in protein palmitoylation PAS_2g01750 CAY68946.1 PAS_chr2-1_0829 hypothetical protein YDR264C AKR1 Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats Palmitoyltransferase AKR1 PAS_2g01755 CAY68947.1 PAS_chr2-1_0830 hypothetical protein GO:0003676;GO:0005622;GO:0008270 YDR323C PEP7 "Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance" Vacuolar segregation protein PEP7 PAS_2g01760 CAY68948.1 PAS_chr2-1_0329 Transcriptional activator of proline utilization genes GO:0003677;GO:0005634;GO:0006350;GO:0008270 YKL015W PUT3 "Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain" Proline utilization trans-activator PAS_2g01765 CAY68949.1 PAS_chr2-1_0330 "Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase)" YOR057W SGT1 Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes Suppressor of G2 allele of SKP1 homolog PAS_2g01770 CAY68950.1 PAS_chr2-1_0331 Mitotic spindle midzone localized microtubule-associated protein (MAP) family member YOR058C ASE1 Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate Anaphase spindle elongation protein PAS_2g01775 CAY68952.1 PAS_chr2-1_0333 "Zeta-crystallin homolog, found in the cytoplasm and nucleus" GO:0008270;GO:0016491 YBR046C ZTA1 "NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin" Probable quinone oxidoreductase PAS_2g01780 CAY68953.1 PAS_chr2-1_0334 Hypothetical protein PAS_2g01785 CAY68954.1 PAS_chr2-1_0335 Hypothetical protein PAS_2g01790 CAY68955.1 PAS_chr2-1_0336 Hypothetical protein PAS_2g01795 CAY68956.1 PAS_chr2-1_0337 Hypothetical protein PAS_2g01800 CAY68957.1 PAS_chr2-1_0338 Hypothetical protein GO:0004089;GO:0008270;GO:0015976 PAS_2g01805 CAY68958.1 PAS_chr2-1_0339 Putative protein of unknown function YOR223W YOR223W Putative protein of unknown function Uncharacterized membrane protein YOR223W PAS_2g01810 CAY68959.1 PAS_chr2-1_0340 Hypothetical protein Uncharacterized protein YLR363W-A PAS_2g01815 CAY68960.1 PAS_chr2-1_0341 Hypothetical protein PAS_2g01820 CAY68961.1 PAS_chr2-1_0342 ER localized integral membrane protein that may promote secretion of certain hexose transporters YML048W GSF2 "ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression" Glucose-signaling factor 2 PAS_2g01825 CAY68962.1 PAS_chr2-1_0343 Hypothetical protein GO:0003824;GO:0030170 Glutamate decarboxylase 2 PAS_2g01830 CAY68963.1 PAS_chr2-1_0344 Protein required for assembly of cytochrome c oxidase YJR034W PET191 Protein required for assembly of cytochrome c oxidase; exists as an oligomer that is integral to the mitochondrial inner membrane and faces the intermembrane space; contains a twin Cx9C motif Mitochondrial protein PET191 PAS_2g01835 CAY68964.1 PAS_chr2-1_0345 "Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzym" YJR033C RAV1 "Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate" Regulator of V-ATPase in vacuolar membrane protein 1 PAS_2g01840 CAY68965.1 PAS_chr2-1_0893 hypothetical protein PAS_2g01845 CAY68966.1 PAS_chr2-1_0346 "Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p" GO:0000166;GO:0004825;GO:0005524;GO:0005737;GO:0006412;GO:0006431 YGR264C MES1 "Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs" "Methionyl-tRNA synthetase, cytoplasmic " PAS_2g01850 CAY68967.1 PAS_chr2-1_0347 Protein kinase YGR262C BUD32 "Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p" Serine/threonine-protein kinase BUD32 PAS_2g01855 CAY68968.1 PAS_chr2-1_0348 Hypothetical protein GO:0005622;GO:0043565 PAS_2g01860 CAY68969.1 PAS_chr2-1_0349 Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p GO:0016021;GO:0051205 YGR062C COX18 "Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC" Mitochondrial inner membrane protein COX18 PAS_2g01865 CAY68970.1 PAS_chr2-1_0350 Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription YGR063C SPT4 "Protein involved in the regulating Pol I and Pol II transcription, pre-mRNA processing, kinetochore function, and gene silencing; forms a complex with Spt5p" Transcription elongation factor SPT4 PAS_2g01870 CAY68971.1 PAS_chr2-1_0351 High affinity methionine permease GO:0006810;GO:0016020 YGR055W MUP1 "High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake" High-affinity methionine permease PAS_2g01875 CAY68972.1 PAS_chr2-1_0352 Hypothetical protein PAS_2g01880 CAY68973.1 PAS_chr2-1_0353 Hypothetical protein PAS_2g01885 CAY68974.1 PAS_chr2-1_0354 Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation GO:0005515 YER125W RSP5 "Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain" E3 ubiquitin-protein ligase RSP5 PAS_2g01890 CAY68975.1 PAS_chr2-1_0355 Hypothetical protein YER124C DSE1 "Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall" Protein DSE1 PAS_2g01895 CAY68976.1 PAS_chr2-1_0356 "Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex" GO:0000785;GO:0003682;GO:0005634;GO:0006333 YPR023C EAF3 "Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition" Chromatin modification-related protein EAF3 PAS_2g01900 CAY68977.1 PAS_chr2-1_0357 "Palmitoylated, plasma membrane-bound casein kinase I isoform" Casein kinase I homolog 2 PAS_2g01905 CAY68978.1 PAS_chr2-1_0358 "Cystathionine beta-lyase, converts cystathionine into homocysteine" GO:0003824;GO:0030170 YGL184C STR3 "Cystathionine beta-lyase, converts cystathionine into homocysteine" Cystathionine beta-lyase PAS_2g01910 CAY68979.1 PAS_chr2-1_0359 Hypothetical protein "NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial " PAS_2g01915 CAY68980.1 PAS_chr2-1_0360 Putative protein with sequence similarity to hydroxyacid dehydrogenases GO:0003824;GO:0005488;GO:0008152 YGL185C YGL185C Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Putative 2-hydroxyacid dehydrogenase YPL113C PAS_2g01920 CAY68981.1 PAS_chr2-1_0361 Subunit IV of cytochrome c oxidase GO:0004129;GO:0005740;GO:0006118 YGL187C COX4 "Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation" "Cytochrome c oxidase subunit 4, mitochondrial " PAS_2g01925 CAY68982.1 PAS_chr2-1_0362 "Non-essential regulatory subunit B of protein phosphatase 2A, which has multiple roles in mitosis an" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YER131W RPS26B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein 40S ribosomal protein S26-B PAS_2g01930 CAY68983.1 PAS_chr2-1_0831 hypothetical protein YGL190C CDC55 "Non-essential regulatory subunit B of protein phosphatase 2A (PP2A), which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at bud neck and bud tip" Protein phosphatase PP2A regulatory subunit B PAS_2g01935 CAY68984.1 PAS_chr2-1_0363 "Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membran" GO:0004129;GO:0005740;GO:0006118 YGL191W COX13 "Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP" "Cytochrome c oxidase subunit 6A, mitochondrial " PAS_2g01940 CAY68985.1 PAS_chr2-1_0364 Probable mRNA N6-adenosine methyltransferase GO:0005634;GO:0006139;GO:0008168 YGL192W IME4 Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids N6-adenosine-methyltransferase IME4 PAS_2g01945 CAY68986.1 PAS_chr2-1_0365 Putative protein of unknown function YGL010W YGL010W Putative protein of unknown function; YGL010W is not an essential gene Uncharacterized endoplasmic reticulum membrane protein YGL010W PAS_2g01950 CAY68987.1 PAS_chr2-1_0366 Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton YBL007C SLA1 Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains Actin cytoskeleton-regulatory complex protein sla1 PAS_2g01955 CAY68988.1 PAS_chr2-1_0367 Essential protein required for chromosome condensation GO:0005509 YBL097W BRN1 Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission Condensin complex subunit 2 PAS_2g01960 CAY68989.1 PAS_chr2-1_0368 "Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway" GO:0008152 YGL009C LEU1 "Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway" 3-isopropylmalate dehydratase PAS_2g01965 CAY68990.1 PAS_chr2-1_0369 "Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3" YGR003W CUL3 "Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21" Cullin-3 PAS_2g01970 CAY68991.1 PAS_chr2-1_0370 Component of the Swr1p complex that incorporates Htz1p into chromatin GO:0003677 YGR002C SWC4 Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex SWR1-complex protein 4 PAS_2g01975 CAY68992.1 PAS_chr2-1_0371 Hypothetical protein YLR320W MMS22 Protein that acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; required for accurate meiotic chromosome segregation PAS_2g01980 CAY68993.1 PAS_chr2-1_0372 "Actin-and formin-interacting protein, involved in actin cable nucleation and polarized cell growth" YLR319C BUD6 "Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate" Bud site selection protein 6 PAS_2g01985 CAY68994.1 PAS_chr2-1_0373 Reverse transcriptase subunit of the telomerase holoenzyme GO:0003723;GO:0003964;GO:0006278 YLR318W EST2 "Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia" Telomerase reverse transcriptase PAS_2g01990 CAY68995.1 PAS_chr2-1_0374 Subunit of tRNA-specific adenosine-34 deaminase GO:0003824 YLR316C TAD3 "Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs" tRNA-specific adenosine deaminase subunit TAD3 PAS_2g01995 CAY68996.1 PAS_chr2-1_0375 Component of the RSC chromatin remodeling complex GO:0000228;GO:0006338 YLR321C SFH1 Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog Chromatin structure-remodeling complex subunit SFH1 PAS_2g02000 CAY68997.1 PAS_chr2-1_0376 "Putative GTPase, member of the Obg family" GO:0003746;GO:0005853;GO:0006414 YAL003W EFB1 "Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site" Elongation factor 1-beta PAS_2g02005 CAY68998.1 PAS_chr2-1_0832 hypothetical protein YHR168W MTG2 "Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly" "GTPase MTG2, mitochondrial " PAS_2g02010 CAY68999.1 PAS_chr2-1_0377 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex GO:0000226;GO:0000922;GO:0005815 YHR172W SPC97 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque Spindle pole body component alp4 PAS_2g02015 CAY69000.1 PAS_chr2-1_0378 Putative ATP-dependent RNA helicase of the DEAD-box family YHR169W DBP8 "ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esp2p" ATP-dependent RNA helicase DBP8 PAS_2g02020 CAY69001.1 PAS_chr2-1_0379 Signal recognition particle (SRP) receptor-alpha subunit GO:0005525;GO:0006614;GO:0008312;GO:0016020 YDR292C SRP101 Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with Srp102p Signal recognition particle receptor subunit alpha homolog PAS_2g02025 CAY69002.1 PAS_chr2-1_0380 Protein involved in nuclear export of the large ribosomal subunit YHR170W NMD3 Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex 60S ribosomal export protein NMD3 PAS_2g02030 CAY69003.1 PAS_chr2-1_0381 Hypothetical protein PAS_2g02035 CAY69004.1 PAS_chr2-1_0382 Hypothetical protein PAS_2g02040 CAY69005.1 PAS_chr2-1_0383 "L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine" Uncharacterized protein C106.17c PAS_2g02045 CAY69006.1 PAS_chr2-1_0384 Mitochondrial ribosomal protein of the small subunit YDR337W MRPS28 Mitochondrial ribosomal protein of the small subunit "37S ribosomal protein S28, mitochondrial " PAS_2g02050 CAY69007.1 PAS_chr2-1_0385 Hypothetical protein YDR319C YDR319C "Putative protein of unknown function, identified as an ortholog of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens" Fat storage-inducing transmembrane protein 2 PAS_2g02055 CAY69008.1 PAS_chr2-1_0386 Protein involved in minichromosome maintenance YDR318W MCM21 "Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules" Central kinetochore subunit MCM21 PAS_2g02060 CAY69009.1 PAS_chr2-1_0387 Subunit of RNase MRP YLR145W RMP1 "Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P" PAS_2g02065 CAY69010.1 PAS_chr2-1_0388 Subunit of tRNA-specific adenosine-34 deaminase GO:0008270;GO:0016787 YJL035C TAD2 "Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs" tRNA-specific adenosine deaminase subunit TAD2 PAS_2g02070 CAY69011.1 PAS_chr2-1_0389 Sorting nexin GO:0005515;GO:0007154;GO:0035091 YJL036W SNX4 "Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p" Sorting nexin-4 PAS_2g02075 Probable M1 family aminopeptidase 1 PAS_2g02080 CAY69012.1 PAS_chr2-1_0391 "Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide" GO:0003824 YHR072W ERG7 "Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis" Lanosterol synthase PAS_2g02085 CAY69013.1 PAS_chr2-1_0392 Protein with similarity to the p27 subunit of mammalian proteasome modulator GO:0005515 YIL007C NAS2 Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p Probable 26S proteasome regulatory subunit p27 PAS_2g02090 CAY69014.1 PAS_chr2-1_0393 Ubiquitin-like protein with weak sequence similarity to ubiquitin YIL008W URM1 "Ubiquitin-like protein with weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature" Ubiquitin-related modifier 1 PAS_2g02095 CAY69015.1 PAS_chr2-1_0394 TFIIIB B-related factor GO:0008270;GO:0045449 YGR246C BRF1 "TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB" Transcription factor IIIB 70 kDa subunit PAS_2g02100 CAY69016.1 PAS_chr2-1_0395 "DNA polymerase III (delta) subunit, essential for cell viability" GO:0003677;GO:0003887;GO:0005634;GO:0006260 YJR006W POL31 "DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair" DNA polymerase delta small subunit PAS_2g02105 CAY69017.1 PAS_chr2-1_0396 Mitochondrial methionyl-tRNA synthetase (MetRS) GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YGR171C MSM1 "Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p" "Probable methionyl-tRNA synthetase, mitochondrial " PAS_2g02110 CAY69018.1 PAS_chr2-1_0397 Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles YGR172C YIP1 "Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles" Protein transport protein YIP1 PAS_2g02115 CAY69019.1 PAS_chr2-1_0398 DNA repair protein Nse1 YLR007W NSE1 Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth; has a nonstructural role in the maintenance of chromosomes Non-structural maintenance of chromosomes element 1 homolog PAS_2g02120 CAY69020.1 PAS_chr2-1_0399 Hypothetical protein YLR015W BRE2 "Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L" Set1 complex component ash2 PAS_2g02125 CAY69021.1 PAS_chr2-1_0400 Putative protein similar to bacterial glutamyl-tRNA amidotransferases GO:0016884 YMR293C HER2 Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial " PAS_2g02130 CAY69022.1 PAS_chr2-1_0401 Protein that localizes to chromatin and has a role in regulation of histone gene expression YGR270W YTA7 "Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p" Tat-binding homolog 7 PAS_2g02135 CAY69023.1 PAS_chr2-1_0402 Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis GO:0003872;GO:0005945;GO:0006096 YGR240C PFK1 "Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes" 6-phosphofructokinase PAS_2g02140 CAY69024.1 PAS_chr2-1_0403 Hypothetical protein PAS_2g02145 CAY69025.1 PAS_chr2-1_0404 Transcriptional repressor and activator GO:0003700;GO:0005634;GO:0006355;GO:0043565 Flocculation suppression protein PAS_2g02150 CAY69026.1 PAS_chr2-1_0405 Hypothetical protein PAS_2g02155 CAY69027.1 PAS_chr2-1_0406 "tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNAs" GO:0008152;GO:0008168 YML014W TRM9 "tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNA(Arg3) and tRNA(Glu), likely as part of a complex with Trm112p; deletion confers resistance to zymocin" tRNA (uracil-5-)-methyltransferase TRM9 PAS_2g02160 CAY69028.1 PAS_chr2-1_0407 "Serine/threonine protein phosphatase Z, isoform of Ppz2p" GO:0016787 YML016C PPZ1 "Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance" Serine/threonine-protein phosphatase PP-Z1 PAS_2g02165 CAY69029.1 PAS_chr2-1_0408 Putative transporter (DHA1 family) of multidrug resistance transporter YNR055C HOL1 Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake Protein HOL1 PAS_2g02170 CAY69030.1 PAS_chr2-1_0409 "Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane" YLR020C YEH2 "Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism" Sterol esterase 2 PAS_2g02175 CAY69031.1 PAS_chr2-1_0410 Essential protein involved in 60S ribosome maturation YLR022C SDO1 Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes Ribosome maturation protein SDO1 PAS_2g02180 CAY69032.1 PAS_chr2-1_0411 "Membrane protein involved in zinc metabolism, member of the four-protein IZH family" GO:0016021 YLR023C IZH3 "Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity" ADIPOR-like receptor IZH3 PAS_2g02185 CAY69033.1 PAS_chr2-1_0412 Protein of unknown function GO:0008270;GO:0016491 YMR152W YIM1 "Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Protein AST2 PAS_2g02190 CAY69034.1 PAS_chr2-1_0413 Putative protein of unknown function YLR001C YLR001C "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated" FAS1 domain-containing protein YLR001C PAS_2g02195 CAY69035.1 PAS_chr2-1_0414 "Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM)" GO:0000166 YIR001C SGN1 "Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation" Polyadenylate-binding protein 2 PAS_2g02200 CAY69036.1 PAS_chr2-1_0415 Alpha-isopropylmalate synthase (2-isopropylmalate synthase) GO:0003852;GO:0009098 YNL104C LEU4 Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway 2-isopropylmalate synthase PAS_2g02205 CAY69037.1 PAS_chr2-1_0834 hypothetical protein GO:0016020;GO:0030001;GO:0046873 YPL060W LPE10 "Mitochondrial inner membrane magnesium transporter, involved in maintenance of magnesium concentrations inside mitochondria; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p" Mitochondrial inner membrane magnesium transporter mrs2 PAS_2g02210 CAY69038.1 PAS_chr2-1_0416 Protein kinase that forms a complex with Mad1p and Bub3p YGR188C BUB1 "Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p" Checkpoint serine/threonine-protein kinase BUB1 PAS_2g02215 CAY69039.1 PAS_chr2-1_0417 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex GO:0016021;GO:0042765 YHR188C GPI16 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog GPI transamidase component GPI16 PAS_2g02220 CAY69040.1 PAS_chr2-1_0418 U2-snRNP associated splicing factor GO:0005488 YMR288W HSH155 U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 U2 snRNP component prp10 PAS_2g02225 CAY69041.1 PAS_chr2-1_0419 "Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria" GO:0005215;GO:0005743;GO:0006810 YIL006W YIA6 "Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs" Uncharacterized mitochondrial carrier YIL006W PAS_2g02230 CAY69042.1 PAS_chr2-1_0420 Hypothetical protein PAS_2g02235 CAY69043.1 PAS_chr2-1_0421 "ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins" YIL005W EPS1 "ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family" Putative protein disulfide-isomerase YIL005W PAS_2g02240 CAY69044.1 PAS_chr2-1_0422 Acireductone dioxygenease involved in the methionine salvage pathway YMR009W ADI1 Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase " PAS_2g02245 CAY69045.1 PAS_chr2-1_0833 hypothetical protein GO:0006457;GO:0016272;GO:0051082 YEL003W GIM4 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Prefoldin subunit 2 PAS_2g02250 CAY69046.1 PAS_chr2-1_0423 Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex GO:0004579;GO:0005789;GO:0018279 YEL002C WBP1 Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1 PAS_2g02255 CAY69047.1 PAS_chr2-1_0424 "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sa" YIL002C INP51 "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth" "Inositol-1,4,5-trisphosphate 5-phosphatase 1 " PAS_2g02260 CAY69048.1 PAS_chr2-1_0425 Hypothetical protein YIL001W YIL001W Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm Ankyrin repeat-containing protein YIL001W PAS_2g02265 CAY69049.1 PAS_chr2-1_0426 Putative protein of unknown function YEL001C IRC22 Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci PAS_2g02270 CAY69050.1 PAS_chr2-1_0427 Putative high affinity iron transporter involved in transport of intravacuolar stores of iron GO:0016020 YBR207W FTH1 Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis Iron transporter FTH1 PAS_2g02275 CAY69051.1 PAS_chr2-1_0428 One of two nearly identical (see HTB1) histone H2B subtypes GO:0003677 YBL002W HTB2 "Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation" Histone H2B.2 PAS_2g02280 CAY69052.1 PAS_chr2-1_0429 One of two nearly identical (see also HTA1) histone H2A subtypes GO:0003677 YBL003C HTA2 "Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p" Histone H2A.1 PAS_2g02285 CAY69053.1 PAS_chr2-1_0430 Essential subunit of the COMPASS (Set1C) complex YBR175W SWD3 "Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5" WD repeat-containing protein 5 PAS_2g02290 CAY69054.1 PAS_chr2-1_0431 Short-lived chaperone required for correct maturation of the 20S proteasome YBR173C UMP1 Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly Proteasome maturation factor UMP1 PAS_2g02295 CAY69055.1 PAS_chr2-1_0432 Hypothetical protein YBR172C SMY2 Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; has similarity to S. pombe Mpd2 GYF domain-containing protein mpd2 PAS_2g02300 CAY69056.1 PAS_chr2-1_0433 "Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p)" GO:0008152;GO:0008415 YBR171W SEC66 "Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER" Translocation protein SEC66 PAS_2g02305 CAY69057.1 PAS_chr2-1_0835 hypothetical protein GO:0008152;GO:0008415 YPR139C VPS66 Cytoplasmic protein of unknown function involved in vacuolar protein sorting. PAS_2g02310 CAY69058.1 PAS_chr2-1_0434 Hypothetical protein Uncharacterized protein DDB_G0271670 PAS_2g02315 CAY69059.1 PAS_chr2-1_0840 hypothetical protein GO:0005525;GO:0005622;GO:0007264 YIL118W RHO3 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p GTP-binding protein RHO3 PAS_2g02320 CAY69060.1 PAS_chr2-1_0845 hypothetical protein GO:0005622 YMR277W FCP1 "Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)" RNA polymerase II subunit A C-terminal domain phosphatase PAS_2g02325 CAY69061.1 PAS_chr2-1_0838 hypothetical protein YML114C TAF8 "TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation" Transcription initiation factor TFIID subunit 8 PAS_2g02330 CAY69062.1 PAS_chr2-1_0892 hypothetical protein YMR276W DSK2 "Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome" Ubiquitin domain-containing protein DSK2 PAS_2g02335 CAY69063.1 PAS_chr2-1_0435 Mitochondrial intermediate peptidase GO:0005622 YKL134C 1-Oct "Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis" Mitochondrial intermediate peptidase PAS_2g02340 CAY69064.1 PAS_chr2-1_0436 Putative RNA binding protein GO:0003676 Negative regulator of differentiation 1 PAS_2g02345 CAY69065.1 PAS_chr2-1_0437 "Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis" GO:0003824;GO:0005488;GO:0008152 YGR192C TDH3 "Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall" Glyceraldehyde-3-phosphate dehydrogenase PAS_2g02350 PAS_2g02355 CAY69066.1 PAS_chr2-1_0439 DNA helicase involved in telomere formation and elongation GO:0000166;GO:0017111 YML061C PIF1 DNA helicase; exists in two forms; the nuclear form is involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; the mitochondrial form is involved in repair and recombination of mitochondrial DNA DNA repair and recombination protein PIF1 PAS_2g02360 CAY69067.1 PAS_chr2-1_0440 Hypothetical protein YLR440C SEC39 Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope PAS_2g02365 CAY69068.1 PAS_chr2-1_0441 Hypothetical protein PAS_2g02370 CAY69069.1 PAS_chr2-1_0442 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0005761;GO:0006412 YLR439W MRPL4 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L4, mitochondrial " PAS_2g02375 CAY69070.1 PAS_chr2-1_0443 Hypothetical protein GO:0003747;GO:0006415 YLR281C YLR281C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene "Uncharacterized peptide chain release factor-like protein YLR281C, mitochondrial " PAS_2g02380 CAY69071.1 PAS_chr2-1_0444 Hypothetical protein GO:0005622 PAS_2g02385 CAY69072.1 PAS_chr2-1_0445 Zinc-cluster protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 YLR278C YLR278C Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene Uncharacterized transcriptional regulatory protein YLR278C PAS_2g02390 CAY69073.1 PAS_chr2-1_0446 Hypothetical protein YLR301W YLR301W Protein of unknown function that interacts with Sec72p PAS_2g02395 CAY69074.1 PAS_chr2-1_0447 RING finger protein involved in proteolytic control of sumoylated substrates GO:0003677;GO:0005524 YOR191W ULS1 RING finger protein involved in proteolytic control of sumoylated substrates; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching Uncharacterized ATP-dependent helicase C23E6.02 PAS_2g02400 CAY69075.1 PAS_chr2-1_0448 "Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p)" YLR292C SEC72 "Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER" Translocation protein SEC72 PAS_2g02405 CAY69076.1 PAS_chr2-1_0449 GTP binding protein (mammalian Ranp homolog) YOR185C GSP2 "GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability" GTP-binding nuclear protein GSP1/Ran PAS_2g02410 CAY69077.1 PAS_chr2-1_0450 Component of the U1 snRNP complex required for pre-mRNA splicing GO:0003676;GO:0005634;GO:0008270 YLR298C YHC1 "Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site" U1 small nuclear ribonucleoprotein C homolog PAS_2g02415 CAY69078.1 PAS_chr2-1_0451 Hypothetical protein YLR295C ATP14 "Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis" "ATP synthase subunit H, mitochondrial " PAS_2g02420 CAY69079.1 PAS_chr2-1_0452 Hypothetical protein PAS_2g02425 CAY69080.1 PAS_chr2-1_0453 "Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis" GO:0008152;GO:0016491 YMR170C ALD2 "Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p" Putative aldehyde dehydrogenase-like protein C922.07c PAS_2g02430 CAY69081.1 PAS_chr2-1_0454 "Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly" GO:0003824;GO:0005975;GO:0043169 YLR300W EXG1 "Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes" "Glucan 1,3-beta-glucosidase 2 " PAS_2g02435 CAY69082.1 PAS_chr2-1_0455 "Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh1" GO:0005634;GO:0006397 YMR240C CUS1 "Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p" Splicing factor 3B subunit 2 PAS_2g02440 CAY69083.1 PAS_chr2-1_0456 Hypothetical protein "NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial " PAS_2g02445 CAY69084.1 PAS_chr2-1_0457 Protein involved in ER-to-Golgi transport YOR307C SLY41 Protein involved in ER-to-Golgi transport Uncharacterized transporter SLY41 PAS_2g02450 CAY69085.1 PAS_chr2-1_0458 Peroxin 20 PAS_2g02455 CAY69086.1 PAS_chr2-1_0459 "Subunit of TORC1, a rapamycin-sensitive complex involved in growth control" GO:0005488 YHR186C KOG1 "Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors" Target of rapamycin complex 1 subunit KOG1 PAS_2g02460 CAY69087.1 PAS_chr2-1_0460 Protein serine/threonine kinase GO:0004674;GO:0006468 YIL095W PRK1 Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex Actin-regulating kinase PRK1 PAS_2g02465 CAY69088.1 PAS_chr2-1_0461 Putative protein of unknown function YGR235C YGR235C "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Uncharacterized protein YGR235C PAS_2g02470 CAY69089.1 PAS_chr2-1_0848 hypothetical protein PAS_2g02475 CAY69090.1 PAS_chr2-1_0462 Mitochondrial protein of the mitochondrial carrier family GO:0005488;GO:0006810;GO:0016020 YGR257C MTM1 "Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor" Mitochondrial carrier protein MTM1 PAS_2g02480 CAY69091.1 PAS_chr2-1_0463 Hypothetical protein PAS_2g02485 CAY69092.1 PAS_chr2-1_0464 Metalloendopeptidase of the mitochondrial inner membrane GO:0004222;GO:0006508;GO:0016020 YKR087C OMA1 "Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes" Mitochondrial metalloendopeptidase OMA1 PAS_2g02490 CAY69093.1 PAS_chr2-1_0465 Basic zinc-finger protein GO:0003676;GO:0005622;GO:0008270 YOR077W RTS2 "Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication" KIN17-like protein PAS_2g02495 CAY69094.1 PAS_chr2-1_0466 Triacylglycerol lipase involved in triacylglycerol mobilization and degradation GO:0006629 YKR089C TGL4 Triacylglycerol lipase involved in triacylglycerol mobilization and degradation; found in lipid particles; phosphorylated and activated by Cdc28p; required with Tgl3p for timely bud formation Lipase 4 PAS_2g02500 CAY69095.1 PAS_chr2-1_0467 Putative protein of unknown function Uncharacterized protein C26A3.14c PAS_2g02505 CAY69096.1 PAS_chr2-1_0468 "Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-termina" GO:0004674;GO:0006468;n/a YKL139W CTK1 "Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity" CTD kinase subunit alpha PAS_2g02510 CAY69097.1 PAS_chr2-1_0849 hypothetical protein YBR155W CNS1 "TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion" Hsp70/Hsp90 co-chaperone CNS1 PAS_2g02515 CAY69098.1 PAS_chr2-1_0469 Protein with similarity to hect domain E3 ubiquitin-protein ligases GO:0006118;GO:0008121 YJR036C HUL4 "Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability" Probable E3 ubiquitin-protein ligase HUL4 PAS_2g02520 CAY69099.1 PAS_chr2-1_0850 hypothetical protein GO:0006118;GO:0008121 YEL024W RIP1 "Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration" "Cytochrome b-c1 complex subunit Rieske, mitochondrial " PAS_2g02525 CAY69100.1 PAS_chr2-1_0470 Putative protein of unknown function YEL023C YEL023C Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene Uncharacterized protein YEL023C PAS_2g02530 CAY69101.1 PAS_chr2-1_0471 "Chloride channel localized to late-or post-Golgi vesicles, involved in iron metabolism" YJR040W GEF1 "Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels" Probable chloride channel protein UM03490-D PAS_2g02535 CAY69102.1 PAS_chr2-1_0472 Mitochondrial alcohol dehydrogenase isozyme III GO:0008270;GO:0016491 YMR083W ADH3 Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production Alcohol dehydrogenase 2 PAS_2g02540 CAY69103.1 PAS_chr2-1_0473 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase GO:0003849;GO:0009073 "Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited " PAS_2g02545 CAY69104.1 PAS_chr2-1_0474 Hypothetical protein Mediator of RNA polymerase II transcription subunit 22 PAS_2g02550 CAY69105.1 PAS_chr2-1_0475 Hypothetical protein Kinetochore protein mis13 PAS_2g02555 CAY69106.1 PAS_chr2-1_0476 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates GO:0006810 YBR254C TRS20 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder Transport protein particle 20 kDa subunit PAS_2g02560 CAY69107.1 PAS_chr2-1_0477 "Protein of unknown function, required for normal growth rate at 15 degrees C" YBR255W MTC4 "Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1" PAS_2g02565 CAY69108.1 PAS_chr2-1_0478 "dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi" GO:0009117;GO:0016787 YBR252W DUT1 "dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability" Deoxyuridine 5'-triphosphate nucleotidohydrolase PAS_2g02570 CAY69109.1 PAS_chr2-1_0479 Pleckstrin homology domain containing protein proposed to function as a glycerol channel activator "Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2 " PAS_2g02575 CAY69110.1 PAS_chr2-1_0480 Mitochondrial inner membrane protein YOL027C MDM38 "Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome" Mitochondrial distribution and morphology protein 38 PAS_2g02580 CAY69111.1 PAS_chr2-1_0481 "Ribosomal protein 59 of small subunit, required for ribosome assembly and 20S pre-rRNA processing" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YJL191W RPS14B "Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins" 40S ribosomal protein S14-A PAS_2g02585 CAY69112.1 PAS_chr2-1_0482 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YJL190C RPS22A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins 40S ribosomal protein S22 PAS_2g02590 CAY69113.1 PAS_chr2-1_0483 Hypothetical protein GO:0003735;GO:0005622;GO:0005840;GO:0006412 YJL189W RPL39 "Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1" 60S ribosomal protein L39 PAS_2g02595 CAY69114.1 PAS_chr2-1_0484 "Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport" YNL044W YIP3 "Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p" Prenylated Rab acceptor 1 PAS_2g02600 CAY69115.1 PAS_chr2-1_0485 Hypothetical protein PAS_2g02605 CAY69116.1 PAS_chr2-1_0486 "Fusion protein, identical to Rpl40Bp" GO:0006464 YIL148W RPL40A "Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes" Ubiquitin-60S ribosomal protein L40 PAS_2g02610 CAY69117.1 PAS_chr2-1_0487 Leucyl aminopeptidase (leukotriene A4 hydrolase) with epoxide hydrolase activity GO:0005488 YNL045W LAP2 "Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus" Leukotriene A-4 hydrolase PAS_2g02615 CAY69118.1 PAS_chr2-1_0488 Hypothetical protein PAS_2g02620 CAY69119.1 PAS_chr2-1_0489 Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p YOL103W ITR2 "Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively" Myo-inositol transporter 2 PAS_2g02625 CAY69120.1 PAS_chr2-1_0851 hypothetical protein Myo-inositol transporter 1 PAS_2g02630 CAY69121.1 PAS_chr2-1_0490 Nitrogen catabolite repression transcriptional regulator Uncharacterized GST-like protein yfcG PAS_2g02635 CAY69122.1 PAS_chr2-1_0491 Deletion suppressor of mpt5 mutation YBR007C DSF2 Deletion suppressor of mpt5 mutation Protein DSF2 PAS_2g02640 CAY69123.1 PAS_chr2-1_0492 Protein whose overexpression suppresses growth defect of mutants lacking protein kinase A activity YDR006C SOK1 Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 Protein SOK1 PAS_2g02645 CAY69124.1 PAS_chr2-1_0493 Essential NTPase required for small ribosome subunit synthesis YDL166C FAP7 "Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D" Putative adenylate kinase HBR1 PAS_2g02650 CAY69125.1 PAS_chr2-1_0494 "Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels" GO:0005634;GO:0030528;GO:0045449 YDL165W CDC36 "Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor" General negative regulator of transcription subunit 2 PAS_2g02655 Mitochondrial mRNA-processing protein COX24 PAS_2g02660 CAY69126.1 PAS_chr2-1_0496 "Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2)" GO:0005515;GO:0006461;GO:0006886;GO:0008565;GO:0016192;GO:0030117 YBL037W APL3 "Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport" AP-2 complex subunit alpha-2 PAS_2g02665 CAY69127.1 PAS_chr2-1_0497 "Single-domain racemase, possibly non-specific due to the lack of the second domain" YBL036C YBL036C Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS UPF0001 protein YBL036C PAS_2g02670 CAY69128.1 PAS_chr2-1_0498 "Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis" GO:0004605;GO:0008654;GO:0016020 YMR013C SEC59 "Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation" Dolichol kinase PAS_2g02675 CAY69129.1 PAS_chr2-1_0499 RNA binding protein required for maturation of tRNA and snRNA precursors GO:0000166 PAS_2g02680 CAY69130.1 PAS_chr2-1_0852 hypothetical protein GO:0000166 YDL051W LHP1 RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen La protein homolog PAS_2g02685 CAY69131.1 PAS_chr2-1_0500 B subunit of DNA polymerase alpha-primase complex YBL035C POL12 "B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation" DNA polymerase alpha subunit B PAS_2g02690 CAY69132.1 PAS_chr2-1_0501 Plasma membrane protein that may be involved in osmotolerance YBR086C IST2 "Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process" Increased sodium tolerance protein 2 PAS_2g02695 CAY69133.1 PAS_chr2-1_0502 "Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage" "Peroxiredoxin-5, mitochondrial " PAS_2g02700 CAY69134.1 PAS_chr2-1_0503 Hypothetical protein GO:0003747;GO:0006415 YOL114C YOL114C Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene PAS_2g02705 CAY69135.1 PAS_chr2-1_0504 Peroxisomal membrane protein GO:0005778;GO:0016559 YOL147C PEX11 "Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elements" Peroxisomal membrane protein PMP30B PAS_2g02710 CAY69136.1 PAS_chr2-1_0505 "Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p)" YOL146W PSF3 "Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery" DNA replication complex GINS protein PSF3 PAS_2g02715 CAY69137.1 PAS_chr2-1_0506 Mitochondrial aldehyde dehydrogenase GO:0008152;GO:0016491 PAS_2g02720 CAY69138.1 PAS_chr2-1_0853 hypothetical protein GO:0008152;GO:0016491 YOR374W ALD4 "Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed" Aldehyde dehydrogenase PAS_2g02725 CAY69139.1 PAS_chr2-1_0507 Hypothetical protein Uncharacterized protein DDB_G0271670 PAS_2g02730 CAY69140.1 PAS_chr2-1_0508 Transcription factor involved in regulation of cell cycle progression from G1 to S phase YDL056W MBP1 "Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes" Transcription factor MBP1 PAS_2g02735 CAY69141.1 PAS_chr2-1_0509 Putative protein of unknown function GO:0016311;GO:0016791 YDL057W YDL057W Putative protein of unknown function; YDL057W is not an essential gene Putative uncharacterized protein YDL057W PAS_2g02740 CAY69142.1 PAS_chr2-1_0510 Hypothetical protein GO:0020037;GO:0046914 Probable steroid-binding protein 3 PAS_2g02745 CAY69143.1 PAS_chr2-1_0511 Homodimeric Zn2Cys6 zinc finger transcription factor GO:0003700;GO:0005634;GO:0006355;GO:0008270 YML076C WAR1 "Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively" Weak acid resistance protein 1 PAS_2g02750 CAY69144.1 PAS_chr2-1_0512 "Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair" GO:0003896;GO:0005658;GO:0006269 YKL045W PRI2 "Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair" DNA primase large subunit PAS_2g02755 CAY69145.1 PAS_chr2-1_0513 Member of the Sir2 family of NAD(+)-dependent protein deacetylases GO:0003677;GO:0005677;GO:0006342;GO:0006355;GO:0006476;GO:0008270;GO:0017136;GO:0051287 YOR025W HST3 "Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism" NAD-dependent histone deacetylase HST3 PAS_2g02760 PAS_2g02765 CAY69146.1 PAS_chr2-1_0514 Peroxisomal integral membrane peroxin YDR479C PEX29 "Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p" Peroxisomal membrane protein PEX29 PAS_2g02770 CAY69147.1 PAS_chr2-1_0515 Kinetochore checkpoint WD40 repeat protein YOR026W BUB3 "Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p" Mitotic checkpoint protein bub3 PAS_2g02775 CAY69148.1 PAS_chr2-1_0516 Hypothetical protein PAS_2g02780 CAY69149.1 PAS_chr2-1_0854 hypothetical protein GO:0005215;GO:0005743;GO:0006810 Uncharacterized mitochondrial carrier C4G9.20c PAS_2g02785 CAY69150.1 PAS_chr2-1_0517 Nuclear protein that contains a SET-domain GO:0005215;GO:0005743;GO:0006810 YDR257C RKM4 Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein Ribosomal N-lysine methyltransferase 4 PAS_2g02790 CAY69151.1 PAS_chr2-1_0518 "Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones" YOR027W STI1 "Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein" Heat shock protein STI1 PAS_2g02795 CAY69152.1 PAS_chr2-1_0519 AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the GO:0004672;GO:0005524;GO:0006468 YOR019W YOR019W "Protein of unknown function that may interact with ribosomes, based on co-purification experiments" Uncharacterized protein YOR019W PAS_2g02800 CAY69153.1 PAS_chr2-1_0855 hypothetical protein GO:0004672;GO:0005524;GO:0006468 YDR477W SNF1 "AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis" Carbon catabolite-derepressing protein kinase PAS_2g02805 CAY69154.1 PAS_chr2-1_0520 Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase GO:0008152;GO:0016491 YMR014W BUD22 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern BUD22 family protein C4F10.06 PAS_2g02810 CAY69155.1 PAS_chr2-1_0856 3-oxoacyl-[acyl-carrier-protein] reductase GO:0008152;GO:0016491 YKL055C OAR1 "Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p" 3-oxoacyl-[acyl-carrier-protein] reductase PAS_2g02815 CAY69156.1 PAS_chr2-1_0521 Hypothetical protein PAS_2g02820 CAY69157.1 PAS_chr2-1_0522 Protein that associates with ribosomes YKL056C TMA19 Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress Translationally-controlled tumor protein homolog PAS_2g02825 CAY69158.1 PAS_chr2-1_0523 2'-O-methyltransferase responsible for modification of tRNA at position 4 YOL125W TRM13 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases tRNA guanosine-2'-O-methyltransferase TRM13 PAS_2g02830 UPF0676 protein C1494.01 PAS_2g02835 PAS_2g02840 CAY69159.1 PAS_chr2-1_0858 hypothetical protein PAS_2g02845 CAY69160.1 PAS_chr2-1_0526 Putative protein of unknown function Protein FMP42 PAS_2g02850 CAY69161.1 PAS_chr2-1_0527 Hypothetical protein GO:0005525;GO:0005622;GO:0007264 PAS_2g02855 CAY69162.1 PAS_chr2-1_0528 Hypothetical protein GO:0006397 PWI domain-containing protein C825.05c PAS_2g02860 Serine-rich adhesin for platelets PAS_2g02865 CAY69163.1 PAS_chr2-1_0530 Ornithine transporter of the mitochondrial inner membrane GO:0005488;GO:0006810;GO:0016020 Uncharacterized mitochondrial carrier C29A3.11c PAS_2g02870 CAY69164.1 PAS_chr2-1_0531 Hypothetical protein Glutamic acid-rich protein PAS_2g02875 CAY69165.1 PAS_chr2-1_0532 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi YMR218C TRS130 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1 PAS_2g02880 CAY69166.1 PAS_chr2-1_0533 Uroporphyrinogen III synthase GO:0004852;GO:0033014 YOR278W HEM4 "Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria" Uroporphyrinogen-III synthase PAS_2g02885 CAY69167.1 PAS_chr2-1_0534 Hypothetical protein GO:0005096;GO:0005622;GO:0051056 Tuberous sclerosis 2 protein homolog PAS_2g02890 CAY69168.1 PAS_chr2-1_0535 Protein of the mitochondrial outer surface GO:0005488 YLL013C PUF3 "Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins" mRNA-binding protein PUF3 PAS_2g02895 CAY69169.1 PAS_chr2-1_0536 Hypothetical protein GO:0016021 Plasma membrane proteolipid 3 PAS_2g02900 CAY69170.1 PAS_chr2-1_0537 "Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex" GO:0005515;GO:0006461;GO:0006886;GO:0016192;GO:0030117 YPR029C APL4 "Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport" AP-1 complex subunit gamma-1 PAS_2g02905 CAY69171.1 PAS_chr2-1_0538 Membrane protein that interacts with Yip1p to mediate membrane traffic YPR028W YOP1 Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes Protein YOP1 PAS_2g02910 CAY69172.1 PAS_chr2-1_0539 Hypothetical protein Cell wall integrity and stress response component 2 PAS_2g02915 CAY69173.1 PAS_chr2-1_0540 Hypothetical protein PAS_2g02920 CAY69174.1 PAS_chr2-1_0541 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex YKL025C PAN3 "Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes" PAB-dependent poly(A)-specific ribonuclease subunit PAN3 PAS_2g02925 CAY69175.1 PAS_chr2-1_0542 Putative benzil reductase GO:0008152;GO:0016491 YIR036C IRC24 Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci Uncharacterized oxidoreductase YIR035C PAS_2g02930 CAY69176.1 PAS_chr2-1_0543 "Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines" GO:0005524;GO:0019201 YKL024C URA6 "Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)" Uridylate kinase PAS_2g02935 CAY69177.1 PAS_chr2-1_0544 Hypothetical protein PAS_2g02940 CAY69178.1 PAS_chr2-1_0545 Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation GO:0006637;GO:0016291 YJR019C TES1 Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids Peroxisomal acyl-coenzyme A thioester hydrolase 1 PAS_2g02945 CAY69179.1 PAS_chr2-1_0546 Hypothetical protein Derlin-1.1 PAS_2g02950 CAY69180.1 PAS_chr2-1_0860 hypothetical protein PAS_2g02955 CAY69181.1 PAS_chr2-1_0547 "Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis" GO:0006790;GO:0008441 YOL064C MET22 "Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway" "3'(2'),5'-bisphosphate nucleotidase 2 " PAS_2g02960 CAY69182.1 PAS_chr2-1_0548 "Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis" GO:0005515;GO:0007154;GO:0035091 YBR200W BEM1 "Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p" Bud emergence protein 1 PAS_2g02965 CAY69183.1 PAS_chr2-1_0549 "Alpha 1,3 glucosyltransferase" YOR002W ALG6 "Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease" "Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase " PAS_2g02970 CAY69184.1 PAS_chr2-1_0550 glycosyl hydrolase GO:0003824;GO:0005975;GO:0043169;n/a "Probable glucan endo-1,3-beta-glucosidase btgC " PAS_2g02975 CAY69185.1 PAS_chr2-1_0551 Putative protein of unknown function YKL207W AIM27 Member of a transmembrane complex required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response ER membrane protein complex subunit 3 PAS_2g02980 CAY69186.1 PAS_chr2-1_0552 Protein involved in 20S proteasome assembly YKL206C ADD66 Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly Proteasome assembly chaperone 2 PAS_2g02985 CAY69187.1 PAS_chr2-1_0553 "Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation" YJR070C LIA1 "Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning" Deoxyhypusine hydroxylase PAS_2g02990 CAY69188.1 PAS_chr2-1_0554 RNA polymerase I subunit A12.2 GO:0003677;GO:0003899;GO:0006350 YJR063W RPA12 "RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex" DNA-directed RNA polymerase I subunit RPA12 PAS_2g02995 CAY69189.1 PAS_chr2-1_0555 "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p" GO:0005524;GO:0006457;GO:0051082 YJR064W CCT5 "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo" T-complex protein 1 subunit epsilon PAS_2g03000 CAY69190.1 PAS_chr2-1_0556 Essential component of the Arp2/3 complex GO:0005515 YJR065C ARP3 "Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity" Actin-related protein 3 PAS_2g03005 CAY69191.1 PAS_chr2-1_0557 PIK-related protein kinase and rapamycin target YKL203C TOR2 "PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis" Target of rapamycin PAS_2g03010 CAY69192.1 PAS_chr2-1_0558 Hypothetical protein YJR067C YAE1 "Protein of unknown function, essential for growth under standard (aerobic) conditions but not under anaerobic conditions" Uncharacterized protein YAE1 PAS_2g03015 CAY69193.1 PAS_chr2-1_0559 "Protein required, with binding partner Psr1p, for full activation of the general stress response" GO:0005515 YOR043W WHI2 "Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression" Growth regulation protein PAS_2g03020 CAY69194.1 PAS_chr2-1_0560 "Protein with similarity to human cystinosin, which is a H(+)-driven transporter" Cystinosin homolog PAS_2g03025 CAY69195.1 PAS_chr2-1_0861 hypothetical protein YJR002W MPP10 "Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p" U3 small nucleolar RNA-associated protein MPP10 PAS_2g03030 CAY69196.1 PAS_chr2-1_0862 hypothetical protein GO:0003824;GO:0008152;GO:0030170 Cysteine synthase PAS_2g03035 CAY69197.1 PAS_chr2-1_0562 "Protein phosphatase with specificity for serine, threonine, and tyrosine residues" GO:0006470;GO:0008138 YBR276C PPS1 "Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle" Dual specificity protein phosphatase PPS1 PAS_2g03040 CAY69198.1 PAS_chr2-1_0563 Protein that activates Urm1p before its conjugation to proteins (urmylation) YHR111W UBA4 "Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response" Adenylyltransferase and sulfurtransferase UBA4 PAS_2g03045 CAY69199.1 PAS_chr2-1_0564 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA GO:0006810;GO:0016021 YHR110W ERP5 "Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport" Protein ERP5 PAS_2g03050 CAY69200.1 PAS_chr2-1_0863 hypothetical protein YJL069C UTP18 "Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data" Probable U3 small nucleolar RNA-associated protein 18 PAS_2g03055 CAY69201.1 PAS_chr2-1_0565 "Putative protein of unknown function, identified based on comparison to related yeast species" YJL062W-A RRG10 "Putative protein of unknown function, proposed to be involved in the expression of mitochondrial proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Mitochondrial membrane protein YJL062W-A PAS_2g03060 CAY69202.1 PAS_chr2-1_0566 Vacuolar protein of unknown function YJR054W YJR054W Vacuolar protein of unknown function; potential Cdc28p substrate Uncharacterized vacuolar membrane protein YJR054W PAS_2g03065 CAY69203.1 PAS_chr2-1_0567 Hypothetical protein Coiled-coil domain-containing protein 18 PAS_2g03070 CAY69204.1 PAS_chr2-1_0568 Protein involved in error-free postreplication DNA repair GO:0019787;GO:0043687;GO:0051246 YGL087C MMS2 "Ubiquitin-conjugating enzyme variant involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p" Ubiquitin-conjugating enzyme spm2 PAS_2g03075 CAY69205.1 PAS_chr2-1_0569 Hypothetical protein YEL059C-A SOM1 "Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs" "Protein SOM1, mitochondrial " PAS_2g03080 CAY69206.1 PAS_chr2-1_0570 Subunit of the origin recognition complex GO:0000166;GO:0017111 YPR162C ORC4 "Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing" Origin recognition complex subunit 4 PAS_2g03085 CAY69207.1 PAS_chr2-1_0571 Putative protein of unknown function YLR456W YLR456W "Putative protein of unknown function; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2" Pyridoxamine 5'-phosphate oxidase C1952.08c homolog PAS_2g03090 CAY69208.1 PAS_chr2-1_0572 AAA-type ATPase that is regulated by Vta1p YPR173C VPS4 "AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism" Vacuolar protein sorting-associated protein 4 PAS_2g03095 CAY69209.1 PAS_chr2-1_0573 Putative xylose and arabinose reductase GO:0016491 YJR096W YJR096W Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Uncharacterized oxidoreductase YJR096W PAS_2g03100 CAY69210.1 PAS_chr2-1_0574 Component of CORVET tethering complex GO:0005515;GO:0008270 YLR148W PEP3 "Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis" Vacuolar membrane protein PEP3 PAS_2g03105 PAS_2g03110 CAY69211.1 PAS_chr2-1_0576 Putative protein of unknown function GO:0016020 YMR253C YMR253C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene Uncharacterized membrane protein YMR253C PAS_2g03115 CAY69212.1 PAS_chr2-1_0577 Methyltransferase required for synthesis of diphthamide GO:0008152;GO:0008168 YLR172C DPH5 "Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm" Diphthine synthase PAS_2g03120 CAY69213.1 PAS_chr2-1_0578 Hypothetical protein PAS_2g03125 CAY69214.1 PAS_chr2-1_0579 Regulatory subunit of acetolactate synthase GO:0008152;GO:0016597 PAS_2g03130 CAY69215.1 PAS_chr2-1_0864 hypothetical protein GO:0008152;GO:0016597 YCL009C ILV6 "Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria" "Acetolactate synthase small subunit, mitochondrial " PAS_2g03135 CAY69216.1 PAS_chr2-1_0580 Cytosolic NADP-specific isocitrate dehydrogenase GO:0004450 YLR174W IDP2 "Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose" Isocitrate dehydrogenase [NADP] peroxisomal PAS_2g03140 CAY69217.1 PAS_chr2-1_0581 Putative protein of unknown function YLR253W YLR253W "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene" ABC1 family protein YLR253W PAS_2g03145 CAY69218.1 PAS_chr2-1_0582 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 YLR256W HAP1 Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus Putative mediator of RNA polymerase II transcription subunit 26 PAS_2g03150 CAY69219.1 PAS_chr2-1_0583 "Protein of unknown function that may interact with ribosomes, based on co-purification experiments" GO:0003677;GO:0045449 YDR026C YDR026C "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p" DNA-binding protein REB1 PAS_2g03155 CAY69220.1 PAS_chr2-1_0584 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YBR048W RPS11B Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins 40S ribosomal protein S11 PAS_2g03160 CAY69221.1 PAS_chr2-1_0585 Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster YDL010W GRX6 Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX7 Monothiol glutaredoxin-6 PAS_2g03165 CAY69222.1 PAS_chr2-1_0586 Guanine nucleotide exchange factor (GEF) YLR425W TUS1 Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate Rho1 guanine nucleotide exchange factor 3 PAS_2g03170 CAY69223.1 PAS_chr2-1_0587 Hypothetical protein GO:0005515 PAS_2g03175 CAY69224.1 PAS_chr2-1_0588 Subunit (61/68 kDa) of TFIID and SAGA complexes GO:0008152;GO:0016491 YDR145W TAF12 "Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A" Transcription initiation factor TFIID subunit 12 PAS_2g03180 CAY69225.1 PAS_chr2-1_0865 hypothetical protein GO:0008152;GO:0016491 Uncharacterized oxidoreductase YLR426W PAS_2g03185 CAY69226.1 PAS_chr2-1_0589 "Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p)" GO:0005787;GO:0005792;GO:0006465;GO:0009003;GO:0016021 YML055W SPC2 "Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25" PAS_2g03190 CAY69227.1 PAS_chr2-1_0590 Cytoplasmic protein of unknown function predicted to encode a DNA-3-methyladenine glycosidase II YLR427W MAG2 Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1 RING-finger protein MAG2 PAS_2g03195 CAY69228.1 PAS_chr2-1_0591 "Coronin, cortical actin cytoskeletal component" YLR429W CRN1 "Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly" Coronin-like protein PAS_2g03200 CAY69229.1 PAS_chr2-1_0592 Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs YLR430W SEN1 Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis Helicase SEN1 PAS_2g03205 CAY69230.1 PAS_chr2-1_0593 "Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines" GO:0004151;GO:0019856 YLR420W URA4 "Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate" Dihydroorotase PAS_2g03210 CAY69231.1 PAS_chr2-1_0594 "Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide" YKL191W DPH2 "Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p" Diphthamide biosynthesis protein 2 PAS_2g03215 CAY69232.1 PAS_chr2-1_0595 Calcineurin B GO:0005509 YKL190W CNB1 "Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1" Calcineurin subunit B PAS_2g03220 CAY69233.1 PAS_chr2-1_0596 "ATG28, autophagy related protein" Autophagy-related protein 28 PAS_2g03225 CAY69234.1 PAS_chr2-1_0597 Hypothetical protein GO:0005634;GO:0005737;n/a YLR421C RPN13 Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability 26S proteasome regulatory subunit RPN13 PAS_2g03230 CAY69235.1 PAS_chr2-1_0598 Hypothetical protein CinA-like protein PAS_2g03235 CAY69236.1 PAS_chr2-1_0599 Protein of unknown function with similarity to human DOCK proteins YLR422W YLR422W "Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein" DOCK-like protein YLR422W PAS_2g03240 "Acyl carrier protein, mitochondrial " PAS_2g03245 CAY69237.1 PAS_chr2-1_0601 Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1) GO:0005515 YKL193C SDS22 "Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis" Protein phosphatase 1 regulatory subunit SDS22 PAS_2g03250 CAY69238.1 PAS_chr2-1_0602 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 Fluconazole resistance protein 1 PAS_2g03255 CAY69239.1 PAS_chr2-1_0866 hypothetical protein YDR464W SPP41 Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 Uncharacterized protein C17D1.01 PAS_2g03260 CAY69240.1 PAS_chr2-1_0603 Putative helicase with limited sequence similarity to human Rb protein YLR419W YLR419W "Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene" Putative ATP-dependent RNA helicase YLR419W PAS_2g03265 CAY69241.1 PAS_chr2-1_0604 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) GO:0006511;GO:0031461;GO:0031625 YLR127C APC2 "Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53p" Anaphase-promoting complex subunit 2 PAS_2g03270 CAY69242.1 PAS_chr2-1_0605 Putative Nedd8 ligase YLR128W DCN1 Putative Nedd8 ligase; binds Nedd8; involved in cullin neddylation; not essential; similar to C.elegans DCN-1; contains UBA-like ubiquitin-binding domain and a DUF298 domain Defective in cullin neddylation protein 1 PAS_2g03275 CAY69243.1 PAS_chr2-1_0606 "Nucleolar protein, specifically associated with the U3 snoRNA" GO:0006364;GO:0032040 YLR129W DIP2 "Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex" U3 small nucleolar RNA-associated protein 12 PAS_2g03280 CAY69244.1 PAS_chr2-1_0607 Hypothetical protein GO:0003677;GO:0006306 PAS_2g03285 CAY69245.1 PAS_chr2-1_0608 Activating gamma subunit of the AMP-activated Snf1p kinase complex YGL115W SNF4 "Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis" Nuclear protein SNF4 PAS_2g03290 CAY69246.1 PAS_chr2-1_0609 protein of OPT family transporter YGL114W YGL114W Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters Putative oligopeptide transporter YGL114W PAS_2g03295 CAY69247.1 PAS_chr2-1_0610 Putative protein of unknown function with similarity to dehydrogenases from other model organisms GO:0008270;GO:0016491 YBR231C SWC5 "Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A" SWR1-complex protein 5 PAS_2g03300 CAY69248.1 PAS_chr2-1_0867 hypothetical protein GO:0008270;GO:0016491 YNL134C YNL134C Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS Uncharacterized protein YNL134C PAS_2g03305 CAY69249.1 PAS_chr2-1_0611 DNA Polymerase phi GO:0004896;GO:0016020 YGR197C SNG1 Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance Nitrosoguanidine resistance protein SNG1 PAS_2g03310 CAY69250.1 PAS_chr2-1_0868 hypothetical protein GO:0004896;GO:0016020 YEL055C POL5 "DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA" DNA polymerase V PAS_2g03315 CAY69251.1 PAS_chr2-1_0612 Hypothetical protein GO:0005739;GO:0015986;GO:0016469;GO:0046933;GO:0046961 PAS_2g03320 CAY69252.1 PAS_chr2-1_0613 Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter GO:0005524;GO:0006810;GO:0016021;GO:0042626 YPL270W MDL2 Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter "ATP-dependent permease MDL2, mitochondrial " PAS_2g03325 CAY69253.1 PAS_chr2-1_0869 hypothetical protein YPL269W KAR9 "Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase" Immediate-early protein 2 PAS_2g03330 CAY69254.1 PAS_chr2-1_0614 Hypothetical protein PAS_2g03335 CAY69255.1 PAS_chr2-1_0615 Essential 18S rRNA dimethylase (dimethyladenosine transferase) GO:0000154;GO:0000179;GO:0008649 YPL266W DIM1 "Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing" Dimethyladenosine transferase PAS_2g03340 CAY69256.1 PAS_chr2-1_0616 Cytoplasmic protein of unknown function YPL263C KEL3 Cytoplasmic protein of unknown function Kelch repeat-containing protein 3 PAS_2g03345 CAY69257.1 PAS_chr2-1_0617 Nuclear pore protein involved in nuclear export of pre-tRNA GO:0005488 YKL205W LOS1 Nuclear pore protein involved in nuclear export of pre-tRNA Exportin-T PAS_2g03350 CAY69258.1 PAS_chr2-1_0618 Hypothetical protein G-box-binding factor PAS_2g03355 CAY69259.1 PAS_chr2-1_0619 Subunit of heteropentameric Replication factor C (RF-C) GO:0003689;GO:0005524;GO:0005663;GO:0006260 YJR068W RFC2 "Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon" Replication factor C subunit 2 PAS_2g03360 CAY69260.1 PAS_chr2-1_0620 Hypothetical protein GO:0005622;GO:0043565 YBR278W DPB3 "Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle" DNA polymerase epsilon subunit C PAS_2g03365 CAY69261.1 PAS_chr2-1_0621 Mitochondrial ribosomal protein of the large subunit YBR282W MRPL27 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L27, mitochondrial " PAS_2g03370 CAY69262.1 PAS_chr2-1_0622 Hypothetical protein Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007 PAS_2g03375 CAY69263.1 PAS_chr2-1_0623 Hypothetical protein PAS_2g03380 CAY69264.1 PAS_chr2-1_0624 6-phosphofructo-2-kinase GO:0016491 YPL088W YPL088W Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance Putative aryl-alcohol dehydrogenase YPL088W PAS_2g03385 CAY69265.1 PAS_chr2-1_0870 hypothetical protein 6-phosphofructo-2-kinase 1 PAS_2g03390 CAY69266.1 PAS_chr2-1_0625 Type I transmembrane sorting receptor for multiple vacuolar hydrolases GO:0016021 YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments Uncharacterized membrane glycoprotein YNR065C PAS_2g03395 CAY69267.1 PAS_chr2-1_0871 hypothetical protein GO:0003824 YKL088W CAB3 "Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC" Uncharacterized protein YKL088W PAS_2g03400 CAY69268.1 PAS_chr2-1_0626 Glutamine-fructose-6-phosphate amidotransferase GO:0004360;GO:0005737;GO:0016051 YKL104C GFA1 "Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis" Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] PAS_2g03405 CAY69269.1 PAS_chr2-1_0627 Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p) GO:0005488 YDR325W YCG1 "Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus" Condensin complex subunit 3 PAS_2g03410 CAY69270.1 PAS_chr2-1_0628 3-keto sterol reductase GO:0008152;GO:0016491 YLR100W ERG27 "3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs" 3-keto-steroid reductase PAS_2g03415 CAY69271.1 PAS_chr2-1_0872 hypothetical protein GO:0004672;GO:0005524;GO:0006468 YBL016W FUS3 "Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation" Mitogen-activated protein kinase FUS3 PAS_2g03420 CAY69272.1 PAS_chr2-1_0629 Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesion GO:0003677;GO:0005524;n/a YJR035W RAD26 Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSB protein DNA repair and recombination protein RAD26 PAS_2g03425 CAY69273.1 PAS_chr2-1_0630 Microtubule effector required for tubulin heterodimer formation YER007W PAC2 "Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl" Tubulin-specific chaperone E PAS_2g03430 CAY69274.1 PAS_chr2-1_0631 "Fimbrin, actin-bundling protein" GO:0005509 YDR129C SAC6 "Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton" Fimbrin PAS_2g03435 CAY69275.1 PAS_chr2-1_0632 Hypothetical protein PAS_2g03440 CAY69276.1 PAS_chr2-1_0633 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles GO:0006810;GO:0016021 YGL200C EMP24 "Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport" Endosomal protein P24B PAS_2g03445 CAY69277.1 PAS_chr2-1_0634 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YKL156W RPS27A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein 40S ribosomal protein S27-B PAS_2g03450 CAY69278.1 PAS_chr2-1_0635 Catalytic subunit of type 1 serine/threonine protein phosphatase GO:0016787 YER133W GLC7 "Type 1 serine/threonine protein phosphatase catalytic subunit, involved in many processes (eg: glycogen metabolism, sporulation, mitosis); accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits" Serine/threonine-protein phosphatase PP1 PAS_2g03455 CAY69279.1 PAS_chr2-1_0873 hypothetical protein YER128W YER128W Putative protein of unknown function UPF0589 protein C32H8.01c PAS_2g03460 CAY69280.1 PAS_chr2-1_0636 Signal recognition particle (SRP) receptor beta subunit YKL154W SRP102 Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane Signal recognition particle receptor subunit beta PAS_2g03465 CAY69281.1 PAS_chr2-1_0637 Bifunctional chorismate synthase and flavin reductase GO:0004107;GO:0009073 YGL148W ARO2 "Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids" Chorismate synthase PAS_2g03470 CAY69282.1 PAS_chr2-1_0638 Hypothetical protein GO:0005515 PAS_2g03475 CAY69283.1 PAS_chr2-1_0639 Upstream serine/threonine kinase for the SNF1 complex YER129W SAK1 "Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome" Serine/threonine-protein kinase ssp1 PAS_2g03480 CAY69284.1 PAS_chr2-1_0640 Putative protein of unknown function GO:0006118;GO:0016491 YCL026C-B HBN1 Putative protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion Putative nitroreductase HBN1 PAS_2g03485 CAY69285.1 PAS_chr2-1_0641 Protein serine/threonine kinase required for vesicle formation in autophagy YGL180W ATG1 Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p Serine/threonine-protein kinase ATG1 PAS_2g03490 CAY69286.1 PAS_chr2-1_0642 Hypothetical protein PAS_2g03495 CAY69287.1 PAS_chr2-1_0643 Protein implicated in Mms22-dependent DNA repair during S phase GO:0005622 YHR154W RTT107 "Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition" Regulator of Ty1 transposition protein 107 PAS_2g03500 CAY69288.1 PAS_chr2-1_0644 Peripheral membrane protein required for vesicular transport between ER and Golgi GO:0005488 YBL050W SEC17 "Peripheral membrane protein required for vesicular transport between ER and Golgi and for the 'priming' step in homotypic vacuole fusion, part of the cis-SNARE complex; has similarity to alpha-SNAP" Vesicular-fusion protein SEC17 PAS_2g03505 CAY69289.1 PAS_chr2-1_0645 Hypothetical protein YDR437W GPI19 "Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P" Phosphatidylinositol N-acetylglucosaminyltransferase subunit P PAS_2g03510 CAY69290.1 PAS_chr2-1_0646 Hypothetical protein Putative uncharacterized protein DDB_G0271982 PAS_2g03515 CAY69291.1 PAS_chr2-1_0647 Hypothetical protein PAS_2g03520 CAY69292.1 PAS_chr2-1_0648 Protein component of the H/ACA snoRNP pseudouridylase complex GO:0005732;GO:0006364;GO:0019843 YHR089C GAR1 "Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA" H/ACA ribonucleoprotein complex subunit 1 PAS_2g03525 CAY69293.1 PAS_chr2-1_0649 Acetate transporter required for normal sporulation GO:0016020 Lysine-specific permease PAS_2g03530 CAY69294.1 PAS_chr2-1_0874 hypothetical protein GO:0016020 Accumulation of dyads protein 2 PAS_2g03535 CAY69295.1 PAS_chr2-1_0650 Hypothetical protein Uncharacterized protein C11E3.10 PAS_2g03540 CAY69296.1 PAS_chr2-1_0651 Key endocytic protein involved in a network of interactions with other endocytic proteins YBL047C EDE1 "Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins" EH domain-containing and endocytosis protein 1 PAS_2g03545 CAY69297.1 PAS_chr2-1_0652 "Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation" GO:0006508;GO:0008237;GO:0008270 Puromycin-sensitive aminopeptidase PAS_2g03550 CAY69298.1 PAS_chr2-1_0653 Mitochondrial cruciform cutting endonuclease YKL011C CCE1 "Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA" "Cruciform cutting endonuclease 1, mitochondrial " PAS_2g03555 CAY69299.1 PAS_chr2-1_0654 Hypothetical protein PAS_2g03560 CAY69300.1 PAS_chr2-1_0655 "Nucleolar protein, component of the small subunit (SSU) processome" YER082C UTP7 "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" Probable U3 small nucleolar RNA-associated protein 7 PAS_2g03565 CAY69301.1 PAS_chr2-1_0656 "Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p" YIL075C RPN2 "Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p" 26S proteasome regulatory subunit RPN2 PAS_2g03570 CAY69302.1 PAS_chr2-1_0657 "3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis" GO:0003824;GO:0005488;GO:0008152 YER081W SER3 "3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p" D-3-phosphoglycerate dehydrogenase 1 PAS_2g03575 CAY69303.1 PAS_chr2-1_0658 "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap" YMR121C RPL15B "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA" 60S ribosomal protein L15 PAS_2g03580 CAY69304.1 PAS_chr2-1_0659 "Proline permease, required for high-affinity transport of proline" GO:0006810;GO:0016020 Proline-specific permease PAS_2g03585 CAY69305.1 PAS_chr2-1_0660 Enzyme of 'de novo' purine biosynthesis YMR120C ADE17 "Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine" Bifunctional purine biosynthesis protein ADE17 PAS_2g03590 CAY69306.1 PAS_chr2-1_0661 "Catalytic subunit of 1,3-beta-D-glucan synthase" GO:0000148;GO:0003843;GO:0006075;GO:0016020 YLR342W FKS1 "Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling" "1,3-beta-glucan synthase component GSC2 " PAS_2g03595 CAY69307.1 PAS_chr2-1_0662 Large subunit of the nuclear mRNA cap-binding protein complex GO:0005515;GO:0016070 YMR125W STO1 "Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80" Nuclear cap-binding protein complex subunit 1 PAS_2g03600 CAY69308.1 PAS_chr2-1_0875 hypothetical protein YMR123W PKR1 "V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0)" V-type ATPase assembly factor PKR1 PAS_2g03605 CAY69309.1 PAS_chr2-1_0664 Hypothetical protein YMR124W YMR124W "Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization" LRR domain-containing protein PFC0760c PAS_2g03610 CAY69310.1 PAS_chr2-1_0665 Hypothetical protein GO:0005634;GO:0008270 PAS_2g03615 CAY69311.1 PAS_chr2-1_0666 F-box protein required for G1/S and G2/M transition YFL009W CDC4 "F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p" Cell division control protein 4 PAS_2g03620 CAY69312.1 PAS_chr2-1_0876 hypothetical protein GO:0005515 YFL010C WWM1 "WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes Gi phase growth arrest and clonal death that is suppressed by overexpression of MCA1" WW domain-containing protein YFL010C PAS_2g03625 CAY69313.1 PAS_chr2-1_0667 Protein involved in negative regulation of transcription of iron regulon GO:0006508;GO:0008235 Uncharacterized peptidase C22G7.01c PAS_2g03630 CAY69314.1 PAS_chr2-1_0668 Vacuolar membrane protein involved in vacuolar polyphosphate accumulation YFL004W VTC2 "Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion" Vacuolar transporter chaperone 3 PAS_2g03635 CAY69315.1 PAS_chr2-1_0669 GTPase GO:0005525;GO:0007264;GO:0015031 GTP-binding protein ypt7 PAS_2g03640 CAY69316.1 PAS_chr2-1_0670 Essential protein of the mitochondrial intermembrane space (IMS) YKL195W MIA40 Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins Mitochondrial intermembrane space import and assembly protein 40 PAS_2g03645 CAY69317.1 PAS_chr2-1_0671 Hypothetical protein GO:0003676;GO:0005622 YLR424W SPP382 "Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation" G-patch domain-containing protein C1486.03 PAS_2g03650 CAY69318.1 PAS_chr2-1_0672 Scaffold protein responsible for pre-autophagosomal structure organization YLR423C ATG17 Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity Autophagy-related protein 17 PAS_2g03655 CAY69319.1 PAS_chr2-1_0673 Mitochondrial threonyl-tRNA synthetase GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YKL194C MST1 Mitochondrial threonyl-tRNA synthetase "Threonyl-tRNA synthetase, mitochondrial " PAS_2g03660 CAY69320.1 PAS_chr2-1_0674 "Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p" YLR418C CDC73 "Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance" Cell division control protein 73 PAS_2g03665 CAY69321.1 PAS_chr2-1_0675 Mitochondrial inner membrane protein with similarity to Mdm32p GO:0005743;GO:0007005 YHR194W MDM31 "Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34" Mitochondrial distribution and morphology protein 31 PAS_2g03670 CAY69322.1 PAS_chr2-1_0877 hypothetical protein PAS_2g03675 CAY69323.1 PAS_chr2-1_0676 Hypothetical protein PAS_2g03680 CAY69324.1 PAS_chr2-1_0677 "Karyopherin, a carrier protein involved in nuclear import of proteins" GO:0005488 YJR132W NMD5 "Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog" Nonsense-mediated mRNA decay protein 5 PAS_2g03685 CAY69325.1 PAS_chr2-1_0678 Protein involved in the transcription of 35S rRNA genes by RNA polymerase I YBL014C RRN6 "Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p" PAS_2g03690 CAY69326.1 PAS_chr2-1_0679 Tryptophan synthase involved in tryptophan biosynthesis GO:0004834;GO:0006568 YGL026C TRP5 "Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis" Tryptophan synthase PAS_2g03695 CAY69327.1 PAS_chr2-1_0680 Hypothetical protein U3 small nucleolar RNA-associated protein 5 PAS_2g03700 CAY69328.1 PAS_chr2-1_0681 Xanthine-guanine phosphoribosyl transferase YJR133W XPT1 "Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine" Xanthine phosphoribosyltransferase 1 PAS_2g03705 CAY69329.1 PAS_chr2-1_0682 Hypothetical protein YJR134C SGM1 "Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus" Protein SGM1 PAS_2g03710 CAY69330.1 PAS_chr2-1_0683 Mitochondrial ribosomal protein of the small subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YMR188C MRPS17 Mitochondrial ribosomal protein of the small subunit "37S ribosomal protein S17, mitochondrial " PAS_2g03715 CAY69331.1 PAS_chr2-1_0684 "Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis" GO:0003824;GO:0030170 YIL116W HIS5 "Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts" Histidinol-phosphate aminotransferase PAS_2g03720 CAY69332.1 PAS_chr2-1_0685 Hypothetical protein GO:0016787 PAS_2g03725 CAY69333.1 PAS_chr2-1_0686 Hypothetical protein YPL233W NSL1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation Kinetochore protein mis14 PAS_2g03730 CAY69334.1 PAS_chr2-1_0687 "Vacuolar ATPase V0 domain subunit c', involved in proton transport activity" GO:0005524;GO:0016021;GO:0016469;GO:0042626;GO:0046961 YPL234C TFP3 "Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen" V-type proton ATPase 16 kDa proteolipid subunit 2 PAS_2g03735 CAY69335.1 PAS_chr2-1_0688 Essential protein involved in transcription regulation GO:0003678;GO:0005524;GO:0005634 YPL235W RVB2 Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as reptin; member of the RUVB-like protein family RuvB-like helicase 2 PAS_2g03740 CAY69336.1 PAS_chr2-1_0689 Putative protein kinase that exhibits Akr1p-dependent palmitoylation YPL236C YPL236C Serine/threonine-protein kinase YPL236C PAS_2g03745 CAY69337.1 PAS_chr2-1_0690 Hypothetical protein PAS_2g03750 CAY69338.1 PAS_chr2-1_0691 Constituent of the mitochondrial import motor associated with the presequence translocase GO:0031072 YNL328C MDJ2 Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain Mitochondrial DnaJ homolog 2 PAS_2g03755 CAY69339.1 PAS_chr2-1_0692 Protein with a role in UDP-galactose transport to the Golgi lumen YPL244C HUT1 "Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1" UDP-galactose transporter homolog 1 PAS_2g03760 CAY69340.1 PAS_chr2-1_0693 Hypothetical protein PAS_2g03765 CAY69341.1 PAS_chr2-1_0878 hypothetical protein GO:0004607;GO:0006629 YNR008W LRO1 Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase Phospholipid:diacylglycerol acyltransferase PAS_2g03770 CAY69342.1 PAS_chr2-1_0694 Acyltransferase that catalyzes diacylglycerol esterification GO:0004607;GO:0006629 YHR197W RIX1 "Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles" Pre-rRNA-processing protein RIX1 PAS_2g03775 CAY69343.1 PAS_chr2-1_0695 "Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol" YPR113W PIS1 "Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins" CDP-diacylglycerol--inositol 3-phosphatidyltransferase PAS_2g03780 YOR249C APC5 "Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition" Anaphase-promoting complex subunit 5 PAS_2g03785 CAY69344.1 PAS_chr2-1_0697 "Catalytic subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis" GO:0000166;GO:0003677;GO:0003887;GO:0006260 YPL167C REV3 "Catalytic subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage" DNA polymerase zeta catalytic subunit PAS_2g03790 CAY69345.1 PAS_chr2-1_0879 hypothetical protein PAS_2g03795 CAY69346.1 PAS_chr2-1_0698 Putative protein of unknown function with similarity to human thiosulfate sulfurtransferase YOR251C TUM1 "Mitochondrial protein, required for formation of the 2-thio group of the 5-methoxycarbonylmethyl-2-thiouridine modified base in some tRNAs; has similarity to mammalian thiosulfate sulfurtransferase (rhodanese)" Putative thiosulfate sulfurtransferase PAS_2g03800 CAY69347.1 PAS_chr2-1_0699 GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation GO:0006505;GO:0006886;GO:0016788;GO:0031227 YFL025C BST1 "GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules" GPI inositol-deacylase PAS_2g03805 CAY69348.1 PAS_chr2-1_0700 Integral plasma membrane protein required for axial budding in haploid cells YIL140W AXL2 "Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate" Protein AXL2 PAS_2g03810 CAY69349.1 PAS_chr2-1_0701 Hypothetical protein "Acyl-coenzyme A thioesterase 9, mitochondrial " PAS_2g03815 CAY69350.1 PAS_chr2-1_0702 Protein that recognizes and binds damaged DNA during nucleotide excision repair GO:0003684;GO:0005634;GO:0006289 YMR201C RAD14 Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein DNA repair protein RAD14 PAS_2g03820 CAY69351.1 PAS_chr2-1_0703 Putative protein of unknown function YGL159W YGL159W Putative protein of unknown function; deletion mutant has no detectable phenotype Uncharacterized protein YGL159W PAS_2g03825 CAY69352.1 PAS_chr2-1_0704 Protein of unknown function YOR305W RRG7 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene "Uncharacterized protein YOR305W, mitochondrial " PAS_2g03830 CAY69353.1 PAS_chr2-1_0705 Hypothetical protein PAS_2g03835 CAY69354.1 PAS_chr2-1_0706 Putative protein of unknown function PAS_2g03840 CAY69355.1 PAS_chr2-1_0707 "Probable serine protease of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), wh" YJL156C SSY5 "Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p" SPS-sensor serine protease component SSY5 PAS_2g03845 CAY69356.1 PAS_chr2-1_0708 Mitochondrial inner membrane protein YLR393W ATP10 "Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6" Mitochondrial ATPase complex subunit ATP10 PAS_2g03850 CAY69357.1 PAS_chr2-1_0709 Putative RNA helicase YLR398C SKI2 "Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay" Uncharacterized helicase C550.03c PAS_2g03855 CAY69358.1 PAS_chr2-1_0880 hypothetical protein PAS_2g03860 CAY69359.1 PAS_chr2-1_0710 "ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex" GO:0005488 YLR397C AFG2 "ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs" ATPase family gene 2 protein PAS_2g03865 CAY69360.1 PAS_chr2-1_0711 Hypothetical protein PAS_2g03870 CAY69361.1 PAS_chr2-1_0712 Putative protein of unknown function YLR390W ECM19 "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Protein ECM19 PAS_2g03875 CAY69362.1 PAS_chr2-1_0713 Putative protein of unknown function YDL063C YDL063C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; predicted to be involved in ribosome biogenesis Uncharacterized protein YDL063C PAS_2g03880 CAY69363.1 PAS_chr2-1_0714 SUMO-conjugating enzyme involved in the Smt3p conjugation pathway GO:0019787;GO:0043687;GO:0051246 YDL064W UBC9 SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) SUMO-conjugating enzyme UBC9 PAS_2g03885 CAY69364.1 PAS_chr2-1_0715 PEX19; peroxisomal biogenesis protein GO:0005777 YDL065C PEX19 "Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane" Peroxisomal membrane protein import receptor PEX19 PAS_2g03890 CAY69365.1 PAS_chr2-1_0716 "5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway" GO:0003824;GO:0030170 YDR232W HEM1 "5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p" "5-aminolevulinate synthase, mitochondrial " PAS_2g03895 CAY69366.1 PAS_chr2-1_0717 Hypothetical protein YHR001W-A QCR10 "Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain" Cytochrome b-c1 complex subunit 10 PAS_2g03900 CAY69367.1 PAS_chr2-1_0718 Putative positive regulator of mannosylphosphate transferase (Mnn6p) YKL201C MNN4 "Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases" Protein MNN4 PAS_2g03905 CAY69368.1 PAS_chr2-1_0719 "Putative transporter, member of the SLC10 carrier family" GO:0006814;GO:0008508;GO:0016020 YMR034C YMR034C "Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene" Uncharacterized membrane protein YMR034C PAS_2g03910 CAY69369.1 PAS_chr2-1_0720 Component of both the SWI/SNF and RSC chromatin remodeling complexes GO:0005515 YMR033W ARP9 Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Actin-like protein ARP9 PAS_2g03915 CAY69370.1 PAS_chr2-1_0721 "Centromere protein that resembles histones, required for proper kinetochore function" GO:0003677 YKL049C CSE4 "Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A" Histone H3-like centromeric protein cse-4 PAS_2g03920 CAY69371.1 PAS_chr2-1_0722 Protein of unknown function with similarity to Ykl050cp and Uso1p Uncharacterized protein YKL050C PAS_2g03925 CAY69372.1 PAS_chr2-1_0723 Transcriptional activator related to Msn2p GO:0003676 YKL062W MSN4 "Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression" Zinc finger protein MSN4 PAS_2g03930 CAY69373.1 PAS_chr2-1_0724 Hypothetical protein YJR112W NNF1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation Kinetochore-associated protein NNF1 PAS_2g03935 CAY69374.1 PAS_chr2-1_0725 "Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis" YGL111W NSA1 "Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis" Ribosome biogenesis protein NSA1 PAS_2g03940 CAY69375.1 PAS_chr2-1_0726 Protein of unknown function YGL110C CUE3 "Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination" CUE domain-containing protein 3 PAS_2g03945 CAY69376.1 PAS_chr2-1_0727 UDP-N-acetyl-glucosamine-1-P transferase GO:0008963;GO:0016021 YBR243C ALG7 "UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin" UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase PAS_2g03950 YBR242W YBR242W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene HD domain-containing protein YBR242W PAS_2g03955 CAY69377.1 PAS_chr2-1_0728 "Putative transporter, member of the sugar porter family" GO:0003735;GO:0005622;GO:0005840;GO:0006412;n/a YGL103W RPL28 "Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance" 60S ribosomal protein L28 PAS_2g03960 CAY69378.1 PAS_chr2-1_0881 hypothetical protein YBR241C YBR241C "Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene" Probable metabolite transport protein YBR241C PAS_2g03965 CAY69379.1 PAS_chr2-1_0729 Hypothetical protein PAS_2g03970 CAY69380.1 PAS_chr2-1_0730 Endoribonuclease GO:0005634;GO:0006412 YNL001W DOM34 "Endoribonuclease; functions in no-go mRNA decay, protein translation to promote G1 progression and differentiation, required for meiotic cell division; similar to the eukaryotic Pelota" Protein dom34 PAS_2g03975 CAY69381.1 PAS_chr2-1_0731 Protein that binds tRNA and methionyl-and glutamyl-tRNA synthetases (Mes1p and Gus1p) GO:0000049 YGL105W ARC1 "Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids" GU4 nucleic-binding protein 1 PAS_2g03980 CAY69382.1 PAS_chr2-1_0732 Putative protein of unknown function GO:0003700;GO:0005634;GO:0006355;GO:0008270 YBR239C YBR239C Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm and nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays a role in restricting Ty1 transposition Uncharacterized transcriptional regulatory protein YBR239C PAS_2g03985 CAY69383.1 PAS_chr2-1_0733 "Essential light chain for Myo1p, light chain for Myo2p" GO:0005509 YGL106W MLC1 "Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition" Myosin regulatory light chain cdc4 PAS_2g03990 CAY69384.1 PAS_chr2-1_0734 Putative protein of unknown function YBR246W RRT2 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; null mutants display a weak carboxypeptidase Y missorting/secretion phenotype Uncharacterized WD repeat-containing protein C18.15 PAS_2g03995 CAY69385.1 PAS_chr2-1_0735 Hypothetical protein PAS_2g04000 CAY69386.1 PAS_chr2-1_0736 GTP cyclohydrolase II GO:0003935;GO:0009231 YBL033C RIB1 GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway GTP cyclohydrolase-2 PAS_2g04005 CAY69387.1 PAS_chr2-1_0737 Hypothetical protein GO:0004866 PAS_2g04010 CAY69388.1 PAS_chr2-1_0738 Protein of unknown function GO:0016888 YMR262W YMR262W Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene Uncharacterized protein YMR262W PAS_2g04015 CAY69389.1 PAS_chr2-1_0739 Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex GO:0003824;GO:0005992 YMR261C TPS3 "Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway" Trehalose synthase complex regulatory subunit TPS3 PAS_2g04020 CAY69390.1 PAS_chr2-1_0740 Hypothetical protein YML112W CTK3 "Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity" CTD kinase subunit gamma PAS_2g04025 CAY69391.1 PAS_chr2-1_0741 Translation initiation factor eIF1A GO:0003743;GO:0006413 YMR260C TIF11 "Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3" Eukaryotic translation initiation factor 1A PAS_2g04030 CAY69392.1 PAS_chr2-1_0742 Hypothetical protein Magnesium transporter NIPA2 PAS_2g04035 CAY69393.1 PAS_chr2-1_0743 Putative protein of unknown function GO:0005488 YMR259C YMR259C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene Uncharacterized protein C1494.07 PAS_2g04040 CAY69394.1 PAS_chr2-1_0744 "Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation" YKR054C DYN1 "Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p" "Dynein heavy chain, cytoplasmic " PAS_2g04045 CAY69395.1 PAS_chr2-1_0745 Protein of unknown function with similarity to F-box proteins YMR258C YMR258C Protein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene SCF E3 ubiquitin ligase complex F-box protein YMR258C PAS_2g04050 CAY69396.1 PAS_chr2-1_0882 hypothetical protein YOL054W PSH1 "Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein" RING finger protein PSH1 PAS_2g04055 CAY69397.1 PAS_chr2-1_0746 Hypothetical protein YMR256C COX7 "Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain" Cytochrome c oxidase subunit 7 PAS_2g04060 CAY69398.1 PAS_chr2-1_0747 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 Uncharacterized transcriptional regulatory protein C1399.05c PAS_2g04065 CAY69399.1 PAS_chr2-1_0748 Hypothetical protein PAS_2g04070 CAY69400.1 PAS_chr2-1_0749 "Allantoicase, converts allantoate to urea and ureidoglycolate" YIR029W DAL2 "Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation" Allantoicase PAS_2g04075 CAY69401.1 PAS_chr2-1_0750 Putative protein of unknown function YGR127W YGR127W "Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response" Uncharacterized protein YGR127W PAS_2g04080 CAY69402.1 PAS_chr2-1_0751 Subunit of the mitochondrial F1F0 ATP synthase GO:0015986;GO:0016469;GO:0046933;GO:0046961 YML081C-A ATP18 "Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms" "ATP synthase subunit J, mitochondrial " PAS_2g04085 CAY69403.1 PAS_chr2-1_0752 "Cystathionine gamma-synthase, converts cysteine into cystathionine" GO:0003824;GO:0030170 YJR130C STR2 "Cystathionine gamma-synthase, converts cysteine into cystathionine" Probable cystathionine gamma-synthase PAS_2g04090 CAY69404.1 PAS_chr2-1_0753 "Alpha-1,2-mannosidase involved in ER quality control" GO:0004571;GO:0005509;GO:0016020 YJR131W MNS1 "Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane" "Mannosyl-oligosaccharide 1,2-alpha-mannosidase " PAS_2g04095 CAY69405.1 PAS_chr2-1_0883 hypothetical protein Mating factor alpha-1 PAS_2g04100 CAY69406.1 PAS_chr2-1_0754 Hypothetical protein YHR191C CTF8 Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion Chromosome transmission fidelity protein 8 PAS_2g04105 CAY69407.1 PAS_chr2-1_0884 hypothetical protein YHR192W YHR192W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS Protein lunapark homolog PAS_2g04110 CAY69408.1 PAS_chr2-1_0755 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) YHR193C EGD2 "Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes" Nascent polypeptide-associated complex subunit alpha PAS_2g04115 CAY69409.1 PAS_chr2-1_0756 Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane Probable phospholipid-transporting ATPase DNF1 PAS_2g04120 CAY69410.1 PAS_chr2-1_0757 Zinc cluster transcriptional activator GO:0003677;GO:0005634;GO:0006350;GO:0008270 YMR280C CAT8 "Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements" Regulatory protein CAT8 PAS_2g04125 CAY69411.1 PAS_chr2-1_0758 Calmodulin GO:0005509 YBR109C CMD1 "Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin" Calmodulin PAS_2g04130 CAY69412.1 PAS_chr2-1_0759 "Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER)" GO:0009058 YBR110W ALG1 "Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog" Chitobiosyldiphosphodolichol beta-mannosyltransferase PAS_2g04135 CAY69413.1 PAS_chr2-1_0885 hypothetical protein GO:0003824 YPR069C SPE3 "Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells" Spermidine synthase PAS_2g04140 CAY69414.1 PAS_chr2-1_0760 "Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic" GO:0016787 YBR111C YSA1 Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate ADP-ribose pyrophosphatase PAS_2g04145 CAY69415.1 PAS_chr2-1_0761 Protein involved in mRNA export coupled transcription activation YBR111W-A SUS1 "Protein involved in mRNA export coupled transcription activation and elongation; component of both the SAGA histone acetylase complex and TREX-2, and interacts with RNAPII" Protein SUS1 PAS_2g04150 CAY69416.1 PAS_chr2-1_0762 "General transcriptional co-repressor, acts together with Tup1p" YBR112C CYC8 "General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]" General transcriptional corepressor CYC8 PAS_2g04155 CAY69417.1 PAS_chr2-1_0886 hypothetical protein PAS_2g04160 CAY69418.1 PAS_chr2-1_0763 "2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase" GO:0008168 YML110C COQ5 "2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes" "Ubiquinone biosynthesis methyltransferase COQ5, mitochondrial " PAS_2g04165 CAY69419.1 PAS_chr2-1_0764 Hypothetical protein PAS_2g04170 CAY69420.1 PAS_chr2-1_0765 Putative FAD transporter YAL053W FLC2 Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance Flavin carrier protein 2 PAS_2g04175 CAY69421.1 PAS_chr2-1_0767 Acetyl-coA synthetase isoform GO:0003824;GO:0008152 YAL054C ACS1 "Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions" Acetyl-coenzyme A synthetase 1 PAS_2g04180 CAY69422.1 PAS_chr2-1_0768 "Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p" GO:0005622 YOR346W REV1 "Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA" DNA repair protein REV1 PAS_2g04185 CAY69423.1 PAS_chr2-1_0769 Pyruvate kinase GO:0000287;GO:0004743;GO:0006096;GO:0030955 YAL038W CDC19 "Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration" Pyruvate kinase PAS_2g04190 CAY69424.1 PAS_chr2-1_0770 "Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway" GO:0005524;GO:0016773 YNR012W URK1 "Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP" Uridine kinase PAS_2g04195 CAY69425.1 PAS_chr2-1_0887 hypothetical protein YKL163W PIR3 "O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway" Cell wall mannoprotein HSP150 PAS_2g04200 CAY69426.1 PAS_chr2-1_0771 "Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate" GO:0005975;GO:0016868 YMR278W PGM3 "Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential" Phosphoglucomutase YMR278W PAS_2g04205 CAY69427.1 PAS_chr2-1_0772 Component of the mannan polymerase I YML115C VAN1 "Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant" Mannan polymerase I complex VAN1 subunit PAS_2g04210 CAY69428.1 PAS_chr2-1_0773 Protein with a role in cellular adhesion and filamentous growth GO:0016021 YLR083C EMP70 Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions Transmembrane 9 superfamily member 1 PAS_2g04215 CAY69429.1 PAS_chr2-1_0774 Subunit of TRAPP (transport protein particle) YDR108W GSG1 "Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication" Transport protein particle subunit trs85-1 PAS_2g04220 CAY69430.1 PAS_chr2-1_0775 "NAD-dependent arabinose dehydrogenase, involved in biosynthesis of erythroascorbic acid" GO:0016491 YMR041C ARA2 "NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase" D-arabinose 1-dehydrogenase PAS_2g04225 CAY69431.1 PAS_chr2-1_0776 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway GO:0008152;GO:0016491 YKR009C FOX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities Peroxisomal hydratase-dehydrogenase-epimerase PAS_2g04230 CAY69432.1 PAS_chr2-1_0888 hypothetical protein PAS_2g04235 CAY69433.1 PAS_chr2-1_0777 Mitochondrial tRNA pseudouridine synthase involved in pseudouridylation of mitochondrial tRNAs GO:0001522;GO:0003723;GO:0009982 "tRNA pseudouridine synthase 9, mitochondrial " PAS_2g04240 CAY69434.1 PAS_chr2-1_0778 Glucosidase II catalytic subunit required for normal cell wall synthesis GO:0004553;GO:0005975 YBR229C ROT2 "Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations" Glucosidase 2 subunit alpha PAS_2g04245 CAY69435.1 PAS_chr2-1_0889 hypothetical protein GO:0005375;GO:0006825;GO:0016021 YHR175W CTR2 "Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation" Copper transport protein CTR2 PAS_2g04250 CAY69436.1 PAS_chr2-1_0779 Ribosomal protein 51 (rp51) of the small (40s) subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YDR447C RPS17B Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein 40S ribosomal protein S17-A PAS_2g04255 CAY69437.1 PAS_chr2-1_0780 "Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT complexes" GO:0008270 YDR448W ADA2 "Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes" Transcriptional adapter 2 PAS_2g04260 CAY69438.1 PAS_chr2-1_0781 "Nucleolar protein, component of the small subunit (SSU) processome" YDR449C UTP6 "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" U3 small nucleolar RNA-associated protein 6 PAS_2g04265 CAY69439.1 PAS_chr2-1_0782 Putative protein of unknown function Uncharacterized protein PB7E8.02 PAS_2g04270 CAY69440.1 PAS_chr2-1_0890 hypothetical protein GO:0003735;GO:0005622;GO:0005840;GO:0006412 YML025C YML6 "Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins" "54S ribosomal protein YmL6, mitochondrial " PAS_2g04275 CAY69441.1 PAS_chr2-1_0783 Protein component of the small (40S) ribosomal subunit GO:0003723;GO:0003735;GO:0005622;GO:0005840;GO:0006412 YDR450W RPS18A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins 40S ribosomal protein S18 PAS_2g04280 CAY69442.1 PAS_chr2-1_0784 Homeodomain-containing transcriptional repressor GO:0003677;GO:0045449 YML027W YOX1 "Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate" Homeobox protein YHP1 PAS_2g04285 CAY69443.1 PAS_chr2-1_0785 Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids GO:0003824;GO:0008152 YOR317W FAA1 Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase Long-chain-fatty-acid--CoA ligase 1 PAS_2g04290 CAY69444.1 PAS_chr2-1_0786 Putative protein of unknown function YGR110W CLD1 Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 Uncharacterized protein YGR110W PAS_2g04295 CAY69445.1 PAS_chr2-1_0787 Ferro-O2-oxidoreductase GO:0016491 YMR058W FET3 "Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases" Iron transport multicopper oxidase FET3 PAS_2g04300 CAY69446.1 PAS_chr2-1_0788 Mu3-like subunit of the clathrin associated protein complex (AP-3) GO:0006810 YBR288C APM3 Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway AP-3 complex subunit mu PAS_2g04305 CAY69447.1 PAS_chr2-1_0789 Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde prote GO:0005515;GO:0007154;GO:0035091 YOR132W VPS17 Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation Vacuolar protein sorting-associated protein 17 PAS_2g04310 CAY69448.1 PAS_chr2-1_0790 Hypothetical protein PAS_2g04315 CAY69449.1 PAS_chr2-1_0791 Hypothetical protein PAS_2g04320 CAY69450.1 PAS_chr2-1_0792 Hypothetical protein YDR106W ARP10 "Component of the dynactin complex, localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex" Actin-like protein ARP10 PAS_2g04325 CAY69451.1 PAS_chr2-1_0793 Vacuolar membrane protein of unknown function that is conserved in mammals GO:0016020 YDR105C TMS1 "Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance" Membrane protein TMS1 PAS_2g04330 CAY69452.1 PAS_chr2-1_0794 Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. co YDR058C TGL2 Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; role in yeast lipid degradation is unclear Lipase 2 PAS_2g04335 CAY69453.1 PAS_chr2-1_0795 Protein that activates transcription through interaction with DNA-bound Snf YNL257C SIP3 "Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate" Protein SIP3 PAS_2g04340 CAY69454.1 PAS_chr2-1_0891 hypothetical protein YNL252C MRPL17 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L17, mitochondrial " PAS_2g04345 CAY69455.1 PAS_chr2-1_0796 "Protein localized to COPII-coated vesicles, forms a complex with Erv41p" YAL042W ERV46 "Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport" ER-derived vesicles protein ERV46 PAS_2g04350 CAY69456.1 PAS_chr2-1_0797 "5' to 3' DNA helicase, involved in nucleotide excision repair and transcription" GO:0004003;GO:0005634;GO:0006289;GO:0016818 YER171W RAD3 "5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein" DNA repair helicase RAD3 PAS_2g04355 CAY69457.1 PAS_chr2-1_0798 Putative protein of unknown function YJR141W YJR141W Essential protein of unknown function Uncharacterized protein YJR141W PAS_2g04360 CAY69458.1 PAS_chr2-1_0799 "Subunit of the HIR complex, a nucleosome assembly complex" YJR140C HIR3 "Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly" Histone transcription regulator 3 homolog PAS_2g04365 CAY69459.1 PAS_chr2-1_0800 Subunit of the RNA polymerase II mediator complex YLR071C RGR1 "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation" Mediator of RNA polymerase II transcription subunit 14 PAS_2g04370 CAY69460.1 PAS_chr2-1_0801 Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK GO:0004674;GO:0006468 YKL116C PRR1 "Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor" Probable serine/threonine-protein kinase YKL116C PAS_2g04375 CAY69461.1 PAS_chr2-1_0802 Putative protein of unknown function GO:0004607;GO:0006629 YJR098C YJR098C "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Uncharacterized protein YJR098C PAS_2g04380 CAY69462.1 PAS_chr2-1_0803 "Protein of unknown function, contains a J-domain" YJR097W JJJ3 "Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein" Diphthamide biosynthesis protein 4 PAS_2g04385 PAS_2g04390 PAS_2g04395 CAY69463.1 PAS_chr2-2_0446 "Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases" YEL038W UTR4 "Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus" Enolase-phosphatase E1 PAS_2g04400 CAY69464.1 PAS_chr2-2_0445 "Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p)" YEL037C RAD23 "Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins" UV excision repair protein rhp23 PAS_2g04405 CAY69465.1 PAS_chr2-2_0444 "U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats" GO:0005622;GO:0006396 YML046W PRP39 "U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats" Pre-mRNA-processing factor 39 PAS_2g04410 CAY69466.1 PAS_chr2-2_0443 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) YJR052W RAD7 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex DNA repair protein RAD7 PAS_2g04415 CAY69467.1 PAS_chr2-2_0442 Hypothetical protein PAS_2g04420 CAY69468.1 PAS_chr2-2_0441 Gluconolactonase putatively involved in growth regulation Cell growth-regulated gene 1 protein PAS_2g04425 CAY69469.1 PAS_chr2-2_0440 "Protein of unknown function, required for growth at high temperature" YJR055W HIT1 "Protein of unknown function, required for growth at high temperature" Protein HIT1 PAS_2g04430 CAY69470.1 PAS_chr2-2_0439 Putative protein of unknown function Uncharacterized abhydrolase domain-containing protein YGR031W PAS_2g04435 CAY69471.1 PAS_chr2-2_0438 Protein of unknown function Actin patches distal protein 1 PAS_2g04440 CAY69472.1 PAS_chr2-2_0437 "Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities" GO:0003824;GO:0005975;GO:0043169 YPR184W GDB1 "Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria" Glycogen debranching enzyme PAS_2g04445 CAY69473.1 PAS_chr2-2_0436 Involved in exosome mediated 3' to 5' mRNA degradation & translation inhibition of non-poly(A) mRNAs YPR189W SKI3 "Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay" Superkiller protein 3 PAS_2g04450 CAY69474.1 PAS_chr2-2_0435 Hypothetical protein GO:0005509 Calmodulin PAS_2g04455 CAY69475.1 PAS_chr2-2_0434 "RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III" GO:0003677;GO:0003899;GO:0006351 YPR187W RPO26 "RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit" "DNA-directed RNA polymerases I, II, and III subunit RPABC2 " PAS_2g04460 CAY69476.1 PAS_chr2-2_0433 "Transcription factor IIIA (TFIIIA), essential protein with nine C2H2 Zn-fingers" GO:0003676 YPR186C PZF1 "Transcription factor IIIA (TFIIIA), essential protein with nine C2H2 Zn-fingers, binds the 5S rRNA gene through the zinc finger domain and directs assembly of a multiprotein initiation complex for RNA polymerase III; also binds DNA" Zinc finger protein 710 PAS_2g04465 CAY69477.1 PAS_chr2-2_0432 Regulatory subunit of the Atg1p signaling complex YPR185W ATG13 "Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling" Autophagy-related protein 13 PAS_2g04470 CAY69478.1 PAS_chr2-2_0431 RNA polymerase III subunit C82 GO:0003677;GO:0003899;GO:0006350 YPR190C RPC82 RNA polymerase III subunit C82 DNA-directed RNA polymerase III subunit RPC3 PAS_2g04475 CAY69479.1 PAS_chr2-2_0430 Subunit 2 of the ubiquinol cytochrome-c reductase complex GO:0003824;GO:0046872 YPR191W QCR2 "Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme" "Cytochrome b-c1 complex subunit 2, mitochondrial " PAS_2g04480 CAY69480.1 PAS_chr2-2_0429 Core Sm protein Sm F GO:0016071;GO:0030529 YPR182W SMX3 "Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F" Small nuclear ribonucleoprotein F PAS_2g04485 CAY69481.1 PAS_chr2-2_0428 Hypothetical protein PAS_2g04490 CAY69482.1 PAS_chr2-2_0427 GPI transamidase subunit GO:0005789;GO:0006506;GO:0016021 YLR459W GAB1 "GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI" GPI transamidase component GAB1 PAS_2g04495 CAY69483.1 PAS_chr2-2_0426 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex YPR179C HDA3 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p HDA1 complex subunit 3 PAS_2g04500 CAY69484.1 PAS_chr2-2_0425 Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) GO:0006464;GO:0006512;GO:0008641 YPR180W AOS1 "Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability" DNA damage tolerance protein RHC31 PAS_2g04505 CAY69485.1 PAS_chr2-2_0424 "Splicing factor, component of the U4/U6-U5 snRNP complex" YPR178W PRP4 "Splicing factor, component of the U4/U6-U5 snRNP complex" U4/U6 small nuclear ribonucleoprotein PRP4 PAS_2g04510 CAY69486.1 PAS_chr2-2_0423 Putative protein of unknown function YKL215C YKL215C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Uncharacterized protein YKL215C PAS_2g04515 CAY69487.1 PAS_chr2-2_0422 Hypothetical protein Uncharacterized serine/threonine-rich protein PB15E9.01c PAS_2g04520 CAY69488.1 PAS_chr2-2_0498 hypothetical protein GO:0005515 Uncharacterized leucine-rich repeat-containing protein C926.06c PAS_2g04525 YOR155C ISN1 "Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms" IMP-specific 5'-nucleotidase 1 PAS_2g04530 CAY69489.1 PAS_chr2-2_0420 Vacuolar membrane protein involved in vacuolar polyphosphate accumulation YJL012C VTC4 Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion Vacuolar transporter chaperone 4 PAS_2g04535 CAY69490.1 PAS_chr2-2_0419 Putative protein of unknown function GO:0003824;GO:0008152 Uncharacterized protein YKR070W PAS_2g04540 PAS_2g04545 CAY69491.1 PAS_chr2-2_0417 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YNL284C MRPL10 Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels "54S ribosomal protein L10, mitochondrial " PAS_2g04550 CAY69492.1 PAS_chr2-2_0416 "Subunit of the condensin complex, which reorganizes chromosomes during cell division" GO:0005524;GO:0005694;GO:0006259 YLR086W SMC4 Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate Structural maintenance of chromosomes protein 4 PAS_2g04555 CAY69493.1 PAS_chr2-2_0415 Beta3-like subunit of the yeast AP-3 complex GO:0005515;GO:0006461;GO:0006886;GO:0016192;GO:0030117 YGR261C APL6 Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools AP-3 complex subunit beta PAS_2g04560 CAY69494.1 PAS_chr2-2_0414 Protein with a role in maintenance of cellular integrity GO:0003723;GO:0004540 YDR293C SSD1 "Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence" Protein SSD1 PAS_2g04565 CAY69495.1 PAS_chr2-2_0413 J-protein co-chaperone of the mitochondrial import motor GO:0031072 YLR008C PAM18 Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p Mitochondrial import inner membrane translocase subunit TIM14 PAS_2g04570 CAY69496.1 PAS_chr2-2_0412 "Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits" YLR009W RLP24 "Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis" Ribosome biogenesis protein RLP24 PAS_2g04575 CAY69497.1 PAS_chr2-2_0497 hypothetical protein PAS_2g04580 PAS_2g04585 CAY69498.1 PAS_chr2-2_0410 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain GO:0003677;GO:0005634;GO:0006350;GO:0008270 YLR014C PPR1 "Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p" Pyrimidine pathway regulatory protein 1 PAS_2g04590 CAY69499.1 PAS_chr2-2_0496 hypothetical protein GO:0008152;GO:0016491 YHR037W PUT2 "Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism" "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial " PAS_2g04595 CAY69500.1 PAS_chr2-2_0409 Mitochondrial elongation factor involved in translational elongation YLR069C MEF1 Mitochondrial elongation factor involved in translational elongation "Elongation factor G, mitochondrial " PAS_2g04600 CAY69501.1 PAS_chr2-2_0408 "Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of L-serine and L-threonine" GO:0006520;GO:0030170 YCL064C CHA1 "Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine" Catabolic L-serine/threonine dehydratase PAS_2g04605 CAY69502.1 PAS_chr2-2_0407 "Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle" YGR244C LSC2 "Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate" "Probable succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial " PAS_2g04610 CAY69503.1 PAS_chr2-2_0406 Hypothetical protein General alpha-glucoside permease PAS_2g04615 CAY69504.1 PAS_chr2-2_0405 Protein involved in clathrin cage assembly YHR161C YAP1801 "Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family" Clathrin coat assembly protein AP180B PAS_2g04620 PAS_2g04625 CAY69505.1 PAS_chr2-2_0403 Hypothetical protein PAS_2g04630 CAY69506.1 PAS_chr2-2_0495 hypothetical protein YGL003C CDH1 "Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p" WD repeat-containing protein srw1 PAS_2g04635 CAY69507.1 PAS_chr2-2_0402 "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p" GO:0005515;GO:0005524;GO:0044267;n/a YJL014W CCT3 "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo" T-complex protein 1 subunit gamma PAS_2g04640 CAY69508.1 PAS_chr2-2_0401 "Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase" GO:0009058;GO:0016779 YGR202C PCT1 "Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding" Choline-phosphate cytidylyltransferase PAS_2g04645 CAY69509.1 PAS_chr2-2_0400 WD repeat-containing protein YPR169W JIP5 "Essential protein of unknown function; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; tagged protein localizes to nucleus and nucleolus; similar to WDR55, a human WD repeat protein" WD repeat-containing protein JIP5 PAS_2g04650 CAY69510.1 PAS_chr2-2_0399 Hypothetical protein PAS_2g04655 CAY69511.1 PAS_chr2-2_0398 "Protein, unknown function, involved in proteolytic activation of Rim101p in response to alkaline pH" GO:0006508;GO:0009268;GO:0016020;GO:0051090 YMR063W RIM9 "Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein" pH-response regulator protein palI/RIM9 PAS_2g04660 CAY69512.1 PAS_chr2-2_0397 Putative protein of unknown function YGR237C YGR237C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Uncharacterized protein JIP4 PAS_2g04665 PAS_2g04670 CAY69513.1 PAS_chr2-2_0395 Hypothetical protein PAS_2g04675 CAY69514.1 PAS_chr2-2_0394 Hypothetical protein Putative band 7 family protein R614 PAS_2g04680 CAY69515.1 PAS_chr2-2_0393 Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p YNL056W OCA2 Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene Tyrosine-protein phosphatase-like protein OCA2 PAS_2g04685 CAY69516.1 PAS_chr2-2_0392 "Mitochondrial porin (voltage-dependent anion channel), outer membrane protein" GO:0005741;GO:0006820;GO:0008308 YNL055C POR1 "Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated" Mitochondrial outer membrane protein porin PAS_2g04690 CAY69517.1 PAS_chr2-2_0391 Ammonium permease YGR121C MEP1 Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation Ammonium transporter MEP1 PAS_2g04695 PAS_2g04700 PAS_2g04705 CAY69518.1 PAS_chr2-2_0388 Hypothetical protein PAS_2g04710 CAY69519.1 PAS_chr2-2_0387 RNA polymerase I subunit GO:0003677;GO:0003899;GO:0006350 YOR341W RPA190 RNA polymerase I subunit; largest subunit of RNA polymerase I DNA-directed RNA polymerase I subunit RPA1 PAS_2g04715 PAS_2g04720 CAY69520.1 PAS_chr2-2_0385 Essential nucleoporin GO:0005643;GO:0006810 YGL092W NUP145 "Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p" Nucleoporin NUP145 PAS_2g04725 CAY69521.1 PAS_chr2-2_0384 Essential iron-sulfur cluster binding protein localized in the cytoplasm GO:0005524 YGL091C NBP35 Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases Cytosolic Fe-S cluster assembly factor NBP35 PAS_2g04730 CAY69522.1 PAS_chr2-2_0383 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes YBR245C ISW1 "Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation" ISWI chromatin-remodeling complex ATPase ISW1 PAS_2g04735 CAY69523.1 PAS_chr2-2_0382 Thiol peroxidase that functions as a hydroperoxide receptor GO:0004602;GO:0006979 YIR037W HYR1 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor Peroxiredoxin HYR1 PAS_2g04740 CAY69524.1 PAS_chr2-2_0381 Peptidylprolyl-cis/trans-isomerase (PPIase) GO:0016853 YJR017C ESS1 Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain Peptidyl-prolyl cis-trans isomerase ESS1 PAS_2g04745 CAY69525.1 PAS_chr2-2_0380 "Zinc-dependent metallopeptidase yscII, may have a role in obtaining leucine from dipeptide substrate" GO:0006508;GO:0008237;GO:0008270 YKL157W APE2 Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W Aminopeptidase 2 PAS_2g04750 CAY69526.1 PAS_chr2-2_0379 Probable RNA m(5)C methyltransferase YNL061W NOP2 "Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles" Putative ribosomal RNA methyltransferase Nop2 PAS_2g04755 CAY69527.1 PAS_chr2-2_0378 Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor YCR077C PAT1 "Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p" DNA topoisomerase 2-associated protein PAT1 PAS_2g04760 CAY69528.1 PAS_chr2-2_0377 Mitochondrial ribosomal component of the small subunit GO:0003723 YNL137C NAM9 Mitochondrial ribosomal component of the small subunit "37S ribosomal protein NAM9, mitochondrial " PAS_2g04765 CAY69529.1 PAS_chr2-2_0376 Hypothetical protein PAS_2g04770 CAY69530.1 PAS_chr2-2_0375 "Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin" GO:0006457 YNL135C FPR1 "Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function" FK506-binding protein 1 PAS_2g04775 CAY69531.1 PAS_chr2-2_0374 Hypothetical protein PAS_2g04780 CAY69532.1 PAS_chr2-2_0373 Protein with a role in urmylation and in invasive and pseudohyphal growth YNL119W NCS2 Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae Cytoplasmic tRNA 2-thiolation protein 2 PAS_2g04785 CAY69533.1 PAS_chr2-2_0372 Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis YHR116W COX23 "Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs" "Cytochrome c oxidase-assembly factor COX23, mitochondrial " PAS_2g04790 CAY69534.1 PAS_chr2-2_0371 Hypothetical protein PAS_2g04795 CAY69535.1 PAS_chr2-2_0370 Component (70 kDa) of the TOM (translocase of outer membrane) complex YNL121C TOM70 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins Protein TOM71 PAS_2g04800 CAY69536.1 PAS_chr2-2_0369 Hypothetical protein PAS_2g04805 CAY69537.1 PAS_chr2-2_0368 Putative protein of unknown function GO:0003735;GO:0005622;GO:0005840;GO:0006412 YNL122C YNL122C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene Putative mitochondrial ribosomal protein SCY_4673 PAS_2g04810 CAY69538.1 PAS_chr2-2_0367 Protein of unknown function which may contribute to lipid homeostasis and/or apoptosis GO:0005515 YNL123W NMA111 Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Pro-apoptotic serine protease NMA111 PAS_2g04815 CAY69539.1 PAS_chr2-2_0366 Hypothetical protein GO:0006118;GO:0016651 "NADH-ubiquinone oxidoreductase 21 kDa subunit, mitochondrial " PAS_2g04820 CAY69540.1 PAS_chr2-2_0365 Hypothetical protein GO:0003723;GO:0004525;GO:0006396 PAS_2g04825 CAY69541.1 PAS_chr2-2_0494 hypothetical protein GO:0005634 YHR119W SET1 "Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain" "Histone-lysine N-methyltransferase, H3 lysine-4 specific " PAS_2g04830 CAY69542.1 PAS_chr2-2_0364 DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA GO:0005524;GO:0006298;GO:0030983 YHR120W MSH1 "DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis" "DNA mismatch repair protein MSH1, mitochondrial " PAS_2g04835 CAY69543.1 PAS_chr2-2_0363 Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing YNL124W NAF1 "RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p" H/ACA ribonucleoprotein complex non-core subunit NAF1 PAS_2g04840 CAY69544.1 PAS_chr2-2_0362 Meiosis-specific transcription factor YHR124W NDT80 Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) Meiosis-specific transcription factor NDT80 PAS_2g04845 PAS_2g04850 CAY69545.1 PAS_chr2-2_0360 Essential protein of unknown function YNL132W KRE33 Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance UPF0202 protein KRE33 PAS_2g04855 CAY69546.1 PAS_chr2-2_0359 Nicotinamide riboside kinase GO:0005524;GO:0016773 YNL129W NRK1 "Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis" Nicotinamide riboside kinase PAS_2g04860 CAY69547.1 PAS_chr2-2_0358 Protein of unknown function required for establishment of sister chromatid cohesion YHR122W YHR122W "Protein of unknown function required for establishment of sister chromatid cohesion; synthetically lethal with RFC5, an RF-C subunit that links replication to cohesion establishment; YHR122W is an essential gene" UPF0195 protein YHR122W PAS_2g04865 CAY69548.1 PAS_chr2-2_0357 "sn-1,2-diacylglycerol ethanolamine-and cholinephosphotranferase" GO:0008654;GO:0016020;GO:0016780 YHR123W EPT1 "sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability" Choline/ethanolaminephosphotransferase 1 PAS_2g04870 CAY69549.1 PAS_chr2-2_0356 Hypothetical protein GO:0005741;GO:0006886;GO:0015450 YNL131W TOM22 Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes Mitochondrial import receptor subunit TOM22 PAS_2g04875 CAY69550.1 PAS_chr2-2_0355 Mitochondrial inner membrane carnitine transporter GO:0005488;GO:0006810;GO:0016020 YOR100C CRC1 "Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation" Mitochondrial carnitine carrier PAS_2g04880 CAY69551.1 PAS_chr2-2_0354 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex GO:0000226;GO:0000922;GO:0005815 YNL126W SPC98 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque Spindle pole body component SPC98 PAS_2g04885 CAY69552.1 PAS_chr2-2_0353 Protein involved in G1 cell cycle arrest in response to pheromon YNL127W FAR11 "Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2" Factor arrest protein 11 PAS_2g04890 CAY69553.1 PAS_chr2-2_0352 Protein of unknown function that may function in RNA processing YHR121W LSM12 Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS PAS_2g04895 CAY69554.1 PAS_chr2-2_0351 Hypothetical protein GO:0006470;GO:0008138 YNL128W TEP1 Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation "Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase cnrN " PAS_2g04900 CAY69555.1 PAS_chr2-2_0350 Target membrane receptor (t-SNARE) GO:0005484;GO:0006886;GO:0016020 Syntaxin VAM3 PAS_2g04905 CAY69556.1 PAS_chr2-2_0349 Catalytic subunit of the DNA polymerase I alpha-primase complex GO:0000166;GO:0003677;GO:0003887;GO:0006260 YNL102W POL1 "Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis" DNA polymerase alpha catalytic subunit A PAS_2g04910 CAY69557.1 PAS_chr2-2_0348 Hypothetical protein PAS_2g04915 CAY69558.1 PAS_chr2-2_0493 hypothetical protein GO:0003676 Putative protein TPRXL PAS_2g04920 CAY69559.1 PAS_chr2-2_0347 GTP-binding protein of the ras superfamily required for bud site selection GO:0003676;GO:0005622;GO:0008270 YGR152C RSR1 "GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases" Ras-related protein RSR1 PAS_2g04925 CAY69560.1 PAS_chr2-2_0346 Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen YOR103C OST2 "Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins" Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1 PAS_2g04930 CAY69561.1 PAS_chr2-2_0345 Putative protein tyrosine phosphatase YNL099C OCA1 "Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA" Putative tyrosine-protein phosphatase OCA1 PAS_2g04935 CAY69562.1 PAS_chr2-2_0344 Mitochondrial inner membrane protein YDR231C COX20 "Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase" "Cytochrome c oxidase protein 20, mitochondrial " PAS_2g04940 CAY69563.1 PAS_chr2-2_0343 "Vacuolar transporter, exports large neutral amino acids from the vacuole" YNL101W AVT4 "Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" Vacuolar amino acid transporter 3 PAS_2g04945 CAY69564.1 PAS_chr2-2_0342 Hypothetical protein GO:0004871 PAS_2g04950 CAY69565.1 PAS_chr2-2_0341 Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid YFR004W RPN11 "Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes" 26S proteasome regulatory subunit RPN11 PAS_2g04955 CAY69566.1 PAS_chr2-2_0340 Conserved zinc-finger domain protein involved in pre-mRNA splicing GO:0008270 YFR005C SAD1 "Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle" Probable mRNA-splicing protein ubp10 PAS_2g04960 CAY69567.1 PAS_chr2-2_0339 Component of the hexameric MCM complex GO:0003677;GO:0005524;GO:0005634;GO:0006270 YLR274W MCM5 "Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase" DNA replication licensing factor mcm5 PAS_2g04965 CAY69568.1 PAS_chr2-2_0338 "Transaldolase, enzyme in the non-oxidative pentose phosphate pathway" GO:0005975 Transaldolase PAS_2g04970 CAY69569.1 PAS_chr2-2_0337 "Transaldolase, enzyme in the non-oxidative pentose phosphate pathway" GO:0005975 YLR354C TAL1 "Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate" Transaldolase PAS_2g04975 CAY69570.1 PAS_chr2-2_0336 Hypothetical protein YGR042W YGR042W Putative protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus PAS_2g04980 CAY69571.1 PAS_chr2-2_0335 Hypothetical protein PAS_2g04985 CAY69572.1 PAS_chr2-2_0334 Protein with similarity to mammalian electron transfer flavoprotein complex subunit ETF-alpha GO:0006118;GO:0009055;GO:0050660 YPR004C AIM45 "Protein with similarity to mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss" "Probable electron transfer flavoprotein subunit alpha, mitochondrial " PAS_2g04990 CAY69573.1 PAS_chr2-2_0333 Putative kinase YFR007W YFH7 Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases Putative uridine kinase C227.14 PAS_2g04995 CAY69574.1 PAS_chr2-2_0332 Protein kinase involved in the response to oxidative and osmotic stress GO:0004674;GO:0006468 Serine/threonine-protein kinase srk1 PAS_2g05000 CAY69575.1 PAS_chr2-2_0331 Hypothetical protein Uncharacterized protein DDB_G0271670 PAS_2g05005 CAY69576.1 PAS_chr2-2_0330 Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase) GO:0003824;GO:0016020 YKL004W AUR1 "Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance" Inositol phosphorylceramide synthase PAS_2g05010 DASH complex subunit DAD3 PAS_2g05015 CAY69577.1 PAS_chr2-2_0329 "Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway" GO:0003824 YLR359W ADE13 "Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency" Adenylosuccinate lyase PAS_2g05020 CAY69578.1 PAS_chr2-2_0328 Subunit of the ARP2/3 complex YBR234C ARC40 "Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches" Actin-related protein 2/3 complex subunit 1 PAS_2g05025 CAY69579.1 PAS_chr2-2_0327 Putative protein of unknown function YGR026W YGR026W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Uncharacterized membrane protein YGR026W PAS_2g05030 CAY69580.1 PAS_chr2-2_0326 Protein component of the small (40S) ribosomal subunit YGR027C RPS25A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein 40S ribosomal protein S25-A PAS_2g05035 CAY69581.1 PAS_chr2-2_0325 Nucleoporin involved in nucleocytoplasmic transport YLR335W NUP2 "Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization" Uncharacterized protein DDB_G0271670 PAS_2g05040 CAY69582.1 PAS_chr2-2_0324 Hypothetical protein GO:0005097;GO:0005622;GO:0032313;n/a TBC1 domain family member 12 PAS_2g05045 CAY69583.1 PAS_chr2-2_0323 Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p GO:0006457;GO:0031072;GO:0051082 YFL016C MDJ1 Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones "DnaJ homolog 1, mitochondrial " PAS_2g05050 CAY69584.1 PAS_chr2-2_0322 Hypothetical protein Cysteine dioxygenase PAS_2g05055 CAY69585.1 PAS_chr2-2_0321 Hypothetical protein PAS_2g05060 CAY69586.1 PAS_chr2-2_0320 Actin-binding protein of the cortical actin cytoskeleton GO:0003779;GO:0005622 YCR088W ABP1 "Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization" Protein TsetseEP PAS_2g05065 CAY69587.1 PAS_chr2-2_0319 Hypothetical protein YOR059C YOR059C Hypothetical protein Putative lipase YOR059C PAS_2g05070 CAY69588.1 PAS_chr2-2_0318 "Phosphomevalonate kinase, an essential cytosolic enzyme" YMR220W ERG8 "Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate" Phosphomevalonate kinase PAS_2g05075 CAY69589.1 PAS_chr2-2_0317 Prephenate dehydrogenase involved in tyrosine biosynthesis GO:0003824;GO:0005488;GO:0008152 YBR166C TYR1 "Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels" Prephenate dehydrogenase [NADP+] PAS_2g05080 CAY69590.1 PAS_chr2-2_0316 Soluble GTPase with a role in regulation of membrane traffic GO:0005525 YBR164C ARL1 "Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor" ADP-ribosylation factor-like protein 1 PAS_2g05085 CAY69591.1 PAS_chr2-2_0315 Putative protein of unknown function YPL109C YPL109C "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" "ABC1 family protein YPL109C, mitochondrial " PAS_2g05090 CAY69592.1 PAS_chr2-2_0314 Glycerophosphocholine (GroPCho) phosphodiesterase YPL110C GDE1 "Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes" Glycerophosphodiester phosphodiesterase GDE1 PAS_2g05095 CAY69593.1 PAS_chr2-2_0313 mitochondrial rhodanese-like protein YOR286W RDL2 "Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss" "Putative thiosulfate sulfurtransferase FMP31, mitochondrial " PAS_2g05100 CAY69594.1 PAS_chr2-2_0312 Hypothetical protein PAS_2g05105 CAY69595.1 PAS_chr2-2_0311 "3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan" YJR025C BNA1 "3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p" "3-hydroxyanthranilate 3,4-dioxygenase " PAS_2g05110 CAY69596.1 PAS_chr2-2_0310 "Dipeptidyl aminopeptidase, Golgi integral membrane protein" GO:0004274;GO:0006508;GO:0016020 YOR219C STE13 "Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor" Putative dipeptidyl aminopeptidase C2E11.08 PAS_2g05115 CAY69597.1 PAS_chr2-2_0309 "RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III" GO:0006350 YOR224C RPB8 "RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III" "DNA-directed RNA polymerases I, II, and III subunit RPABC3 " PAS_2g05120 CAY69598.1 PAS_chr2-2_0308 "Protein involved in DNA repair, related to the human CSA protein" YDR030C RAD28 "Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair" Uncharacterized WD repeat-containing protein C577.09 PAS_2g05125 CAY69599.1 PAS_chr2-2_0307 Hypothetical protein YKR010C TOF2 Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site Uncharacterized protein DDB_G0271670 PAS_2g05130 CAY69600.1 PAS_chr2-2_0306 Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells GO:0005524;GO:0005694;GO:0006259 YJL074C SMC3 "Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member" Structural maintenance of chromosomes protein 3 PAS_2g05135 CAY69601.1 PAS_chr2-2_0492 hypothetical protein GO:0004047;GO:0005737;GO:0006546 YDR019C GCV1 "T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm" "Aminomethyltransferase, mitochondrial " PAS_2g05140 CAY69602.1 PAS_chr2-2_0305 Putative kinase YDR109C YDR109C Putative kinase Uncharacterized sugar kinase YDR109C PAS_2g05145 CAY69603.1 PAS_chr2-2_0304 Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p GO:0003677 YER159C BUR6 Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha DNA polymerase epsilon subunit C PAS_2g05150 CAY69604.1 PAS_chr2-2_0303 "Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis" GO:0008152;GO:0016491 YGR255C COQ6 "Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes" Ubiquinone biosynthesis monooxygenase COQ6 PAS_2g05155 CAY69605.1 PAS_chr2-2_0302 Multifunctional enzyme of the folic acid biosynthesis pathway GO:0004156;GO:0009396 YNL256W FOL1 "Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities" Folic acid synthesis protein FOL1 PAS_2g05160 CAY69606.1 PAS_chr2-2_0301 "Protein with seven cysteine-rich CCHC zinc-finger motifs, similar to human CNBP" GO:0003676;GO:0008270 YNL255C GIS2 "Protein with seven cysteine-rich CCHC zinc-finger motifs, similar to human CNBP, proposed to be involved in the RAS/cAMP signaling pathway" Cellular nucleic acid-binding protein homolog PAS_2g05165 CAY69607.1 PAS_chr2-2_0300 Hypothetical protein YNL254C RTC4 Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus PAS_2g05170 CAY69608.1 PAS_chr2-2_0299 Plasma membrane ATP binding cassette (ABC) transporter ABC transporter CDR4 PAS_2g05175 CAY69609.1 PAS_chr2-2_0298 Cyclin-dependent protein kinase regulatory subunit and adaptor GO:0007049;GO:0016538 YBR135W CKS1 "Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters" Cyclin-dependent kinases regulatory subunit PAS_2g05180 CAY69610.1 PAS_chr2-2_0297 Genome integrity checkpoint protein and PI kinase superfamily member YBR136W MEC1 Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination Serine/threonine-protein kinase MEC1 PAS_2g05185 CAY69611.1 PAS_chr2-2_0296 Putative protein of unknown function YPR091C YPR091C "Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YPR091C is not an essential gene" Uncharacterized PH domain-containing protein YPR091C PAS_2g05190 CAY69612.1 PAS_chr2-2_0491 hypothetical protein GO:0005737;GO:0008168 YBR133C HSL7 "Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p" Protein arginine N-methyltransferase HSL7 PAS_2g05195 CAY69613.1 PAS_chr2-2_0295 "TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation" GO:0005737;GO:0008168 YCR042C TAF2 "TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation" Transcription initiation factor TFIID subunit 2 PAS_2g05200 CAY69614.1 PAS_chr2-2_0294 E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex YER178W PDA1 "E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose" "Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial " PAS_2g05205 CAY69615.1 PAS_chr2-2_0293 "Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c" GO:0004408;GO:0005739 YAL039C CYC3 "Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)" Cytochrome c heme lyase PAS_2g05210 CAY69616.1 PAS_chr2-2_0490 hypothetical protein Pentatricopeptide repeat-containing protein At1g62590 PAS_2g05215 CAY69617.1 PAS_chr2-2_0292 Protein containing a CUE domain that binds ubiquitin YOR042W CUE5 "Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern" Ubiquitin-binding protein CUE5 PAS_2g05220 CAY69618.1 PAS_chr2-2_0291 "Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p" GO:0006626;GO:0042719;GO:0045039 YHR005C-A TIM10 "Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane" Mitochondrial import inner membrane translocase subunit Tim10 PAS_2g05225 CAY69619.1 PAS_chr2-2_0290 "Cytochrome c1 heme lyase, involved in maturation of cytochrome c1" GO:0004408;GO:0005739 YKL087C CYT2 "Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1" Cytochrome c1 heme lyase PAS_2g05230 CAY69620.1 PAS_chr2-2_0489 hypothetical protein Uncharacterized protein AFUA_6G14090 PAS_2g05235 CAY69621.1 PAS_chr2-2_0289 Hypothetical protein GO:0000166 Protein vip1 PAS_2g05240 CAY69622.1 PAS_chr2-2_0288 "Arginase, responsible for arginine degradation" GO:0004053;GO:0006527 YPL111W CAR1 "Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance" Arginase PAS_2g05245 CAY69623.1 PAS_chr2-2_0287 Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome GO:0003677;GO:0006355 YNL218W MGS1 Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP) DNA-dependent ATPase MGS1 PAS_2g05250 CAY69624.1 PAS_chr2-2_0488 hypothetical protein GO:0003677;GO:0006355 YDR174W HMO1 "Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase" High mobility group protein 1 PAS_2g05255 CAY69625.1 PAS_chr2-2_0286 Hypothetical protein GO:0005215;GO:0006810;GO:0008289 PAS_2g05260 CAY69626.1 PAS_chr2-2_0285 Hypothetical protein GO:0003676;GO:0005622;GO:0008270 DNA topoisomerase 1 PAS_2g05265 CAY69627.1 PAS_chr2-2_0487 hypothetical protein YDR175C RSM24 Mitochondrial ribosomal protein of the small subunit "37S ribosomal protein S24, mitochondrial " PAS_2g05270 CAY69628.1 PAS_chr2-2_0284 Transcriptional regulator involved in glucose repression of Gal4p-regulated genes YDR176W NGG1 "Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex" Chromatin-remodeling complexes subunit NGG1 PAS_2g05275 CAY69629.1 PAS_chr2-2_0486 hypothetical protein PAS_2g05280 CAY69630.1 PAS_chr2-2_0283 "Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p)" GO:0005506;GO:0005740;GO:0006099;GO:0006118;GO:0016021;GO:0020037 YDR178W SDH4 "Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone" "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial " PAS_2g05285 CAY69631.1 PAS_chr2-2_0282 Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitat Uncharacterized transporter YIL166C PAS_2g05290 Uncharacterized protein YLR154C-H/YLR156C-A/YLR157C-C/YLR159C-A PAS_2g05295 CAY69632.1 PAS_chr2-2_0280 Mitochondrial glycosylase/lyase GO:0003684;GO:0006289;GO:0008534 YML060W OGG1 "Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance" N-glycosylase/DNA lyase PAS_2g05300 CAY69633.1 PAS_chr2-2_0279 Hypothetical protein GO:0004846;GO:0006144 Uricase PAS_2g05305 CAY69634.1 PAS_chr2-2_0278 Protein with an apparent role in acetylation of N-terminal methionine residues YGR147C NAT2 Protein with an apparent role in acetylation of N-terminal methionine residues Uncharacterized protein C106.07c PAS_2g05310 CAY69635.1 PAS_chr2-2_0277 "Protein of unknown function, localized to the mitochondrial outer membrane" GO:0003824;GO:0005488;GO:0008152 YKL027W YKL027W "Protein of unknown function, localized to the mitochondrial outer membrane" Uncharacterized protein YKL027W PAS_2g05315 CAY69636.1 PAS_chr2-2_0276 Plasma membrane sulfite pump involved in sulfite metabolism GO:0016021 YPL092W SSU1 Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein Uncharacterized transporter PB10D8.04c/PB10D8.05c/PB10D8.06c/PB10D8.07c PAS_2g05320 CAY69637.1 PAS_chr2-2_0485 hypothetical protein YGR084C MRP13 Mitochondrial ribosomal protein of the small subunit PAS_2g05325 CAY69638.1 PAS_chr2-2_0275 Delta subunit of the translation initiation factor eIF2B GO:0044237 YGR083C GCD2 "Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression" Translation initiation factor eIF-2B subunit delta PAS_2g05330 CAY69639.1 PAS_chr2-2_0274 B-type regulatory subunit of protein phosphatase 2A (PP2A) GO:0000159;GO:0007165;GO:0008601 YOR014W RTS1 B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PAS_2g05335 CAY69640.1 PAS_chr2-2_0273 Protein required for ethanol metabolism GO:0016021 YLR251W SYM1 Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 Protein SYM1 PAS_2g05340 CAY69641.1 PAS_chr2-2_0272 Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p) GO:0005524;GO:0006810;GO:0016021;GO:0042626 YKL188C PXA2 "Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins" Peroxisomal long-chain fatty acid import protein 1 PAS_2g05345 CAY69642.1 PAS_chr2-2_0484 hypothetical protein GO:0019211 YIL153W RRD1 "Peptidyl-prolyl cis/trans-isomerase, activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex" Serine/threonine-protein phosphatase 2A activator 1 PAS_2g05350 CAY69643.1 PAS_chr2-2_0271 GPI-anchored cell wall protein of unknown function GO:0019211 YJL171C YJL171C "GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein" Uncharacterized protein YJL171C PAS_2g05355 CAY69644.1 PAS_chr2-2_0270 Essential structural subunit of the nuclear pore complex (NPC) YJL039C NUP192 "Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205" Nucleoporin NUP192 PAS_2g05360 CAY69645.1 PAS_chr2-2_0268 Hypothetical protein Uncharacterized WD repeat-containing protein C12B10.03 PAS_2g05365 CAY69646.1 PAS_chr2-2_0267 3-ketoacyl-CoA thiolase with broad chain length specificity GO:0003824;GO:0008152 YIL160C POT1 "3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids" "3-ketoacyl-CoA thiolase 2, peroxisomal " PAS_2g05370 CAY69647.1 PAS_chr2-2_0266 Subunit VIII of cytochrome c oxidase GO:0004129;GO:0006118 YLR395C COX8 "Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain" "Cytochrome c oxidase polypeptide VIII, mitochondrial " PAS_2g05375 CAY69648.1 PAS_chr2-2_0265 Hypothetical protein GO:0004129;GO:0005746;GO:0006118;GO:0009055 YDL067C COX9 "Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain" Cytochrome c oxidase subunit 7A PAS_2g05380 CAY69649.1 PAS_chr2-2_0264 ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex GO:0006904;GO:0016192 YLR396C VPS33 ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport Vacuolar protein sorting-associated protein 33 PAS_2g05385 CAY69650.1 PAS_chr2-2_0263 "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA" YLR384C IKI3 "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)" Elongator complex protein 1 PAS_2g05390 CAY69651.1 PAS_chr2-2_0483 hypothetical protein YBL029C-A YBL029C-A Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica PAS_2g05395 CAY69652.1 PAS_chr2-2_0262 Hypothetical protein PAS_2g05400 CAY69653.1 PAS_chr2-2_0261 Hypothetical protein GO:0003677;GO:0005488;GO:0006355 YMR039C SUB1 "Transcriptional coactivator, facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes" RNA polymerase II transcriptional coactivator SUB1 PAS_2g05405 CAY69654.1 PAS_chr2-2_0260 Putative magnesium transporter GO:0005507 YKL064W MNR2 "Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations" Manganese resistance protein MNR2 PAS_2g05410 CAY69655.1 PAS_chr2-2_0259 "Bud neck-localized, SH3 domain-containing protein required for cytokinesis" YMR032W HOF1 "Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p" Septation protein imp2 PAS_2g05415 CAY69656.1 PAS_chr2-2_0258 Hypothetical protein GO:0016021 PAS_2g05420 CAY69657.1 PAS_chr2-2_0257 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YHL015W RPS20 Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins 40S ribosomal protein S20 PAS_2g05425 CAY69658.1 PAS_chr2-2_0256 Hypothetical protein Uracil catabolism protein 4 PAS_2g05430 CAY69659.1 PAS_chr2-2_0255 Hypothetical protein PAS_2g05435 CAY69660.1 PAS_chr2-2_0254 DNA repair methyltransferase (6-O-methylguanine-DNA methylase) GO:0003824;GO:0006281 YDL200C MGT1 DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage Methylated-DNA--protein-cysteine methyltransferase PAS_2g05440 CAY69661.1 PAS_chr2-2_0482 hypothetical protein YDL037C BSC1 "Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression" Cell surface glycoprotein 1 PAS_2g05445 CAY69662.1 PAS_chr2-2_0252 "Alkaline dihydroceramidase, involved in sphingolipid metabolism" GO:0000139;GO:0005789;GO:0006672;GO:0016021;GO:0016811 YPL087W YDC1 "Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity" Alkaline ceramidase 3 PAS_2g05450 CAY69663.1 PAS_chr2-2_0251 Hypothetical protein SAGA-associated factor 11 PAS_2g05455 CAY69664.1 PAS_chr2-2_0250 "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p" YPL083C SEN54 "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p" tRNA-splicing endonuclease subunit SEN54 PAS_2g05460 CAY69665.1 PAS_chr2-2_0249 "Cell-wall L-asparaginase II, involved in asparagine catabolism" GO:0004067;GO:0006528 YMR097C MTG1 "Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals" Mitochondrial GTPase 1 PAS_2g05465 CAY69666.1 PAS_chr2-2_0481 hypothetical protein GO:0004067;GO:0006528 YLR155C ASP3-1 "Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C" L-asparaginase 2 PAS_2g05470 CAY69667.1 PAS_chr2-2_0247 "Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase" GO:0005956;GO:0008605 YOR039W CKB2 "Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases" Casein kinase II subunit beta' PAS_2g05475 CAY69668.1 PAS_chr2-2_0246 "Subunit of the HIR complex, a nucleosome assembly complex involved in histone gene transcription" YOR038C HIR2 "Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p" Protein HIR2 PAS_2g05480 CAY69669.1 PAS_chr2-2_0245 Mitochondrial tryptophanyl-tRNA synthetase GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YDR268W MSW1 Mitochondrial tryptophanyl-tRNA synthetase Tryptophanyl-tRNA synthetase PAS_2g05485 CAY69670.1 PAS_chr2-2_0244 Hypothetical protein GO:0005515;GO:0007154;GO:0035091 YHR105W YPT35 Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport PX domain-containing protein YPT35 PAS_2g05490 CAY69671.1 PAS_chr2-2_0480 hypothetical protein GO:0016491;GO:0050660 YDR353W TRR1 "Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress" Thioredoxin reductase 1 PAS_2g05495 CAY69672.1 PAS_chr2-2_0243 "Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus" GO:0005488 YGR218W CRM1 "Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin" Exportin-1 PAS_2g05500 CAY69673.1 PAS_chr2-2_0479 hypothetical protein PAS_2g05505 CAY69674.1 PAS_chr2-2_0242 "Component of the SSU processome, which is required for pre-18S rRNA processing" GO:0003723 YHR148W IMP3 "Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA" U3 small nucleolar ribonucleoprotein protein IMP3 PAS_2g05510 CAY69675.1 PAS_chr2-2_0241 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YHR147C MRPL6 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L6, mitochondrial " PAS_2g05515 CAY69676.1 PAS_chr2-2_0240 Mitochondrial ribosomal protein of the large subunit YGR220C MRPL9 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L9, mitochondrial " PAS_2g05520 CAY69677.1 PAS_chr2-2_0239 RING finger protein that interacts with the arginine methyltransferase Hmt1p GO:0003676;GO:0008270 YDL175C AIR2 "Zinc knuckle protein, involved in nuclear RNA processing and degredation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air1p" Protein AIR2 PAS_2g05525 CAY69678.1 PAS_chr2-2_0238 "Threonyl-tRNA synthetase, essential cytoplasmic protein" GO:0004812;GO:0005524;GO:0006412 YIL078W THS1 "Threonyl-tRNA synthetase, essential cytoplasmic protein" "Threonyl-tRNA synthetase, cytoplasmic " PAS_2g05530 CAY69679.1 PAS_chr2-2_0237 Hypothetical protein YIL077C YIL077C "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)" PAS_2g05535 CAY69680.1 PAS_chr2-2_0236 Hypothetical protein PAS_2g05540 CAY69681.1 PAS_chr2-2_0235 Hypothetical protein Lactobacillus shifted protein PAS_2g05545 CAY69682.1 PAS_chr2-2_0234 Carboxyl methyltransferase YDR435C PPM1 "Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits" Leucine carboxyl methyltransferase 1 PAS_2g05550 CAY69683.1 PAS_chr2-2_0233 Hypothetical protein "Protein midA homolog, mitochondrial " PAS_2g05555 CAY69684.1 PAS_chr2-2_0232 Haploid specific endoprotease GO:0003824;GO:0046872 YPR122W AXL1 Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells Putative protease AXL1 PAS_2g05560 CAY69685.1 PAS_chr2-2_0231 Hypothetical protein GO:0003677 YML015C TAF11 "TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors" Transcription initiation factor TFIID subunit 11 PAS_2g05565 CAY69686.1 PAS_chr2-2_0230 One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate GO:0004420;GO:0015936;GO:0050662 YML075C HMG1 "One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae" 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 PAS_2g05570 CAY69687.1 PAS_chr2-2_0476 hypothetical protein GO:0006457 YML074C FPR3 Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p FK506-binding protein 3 PAS_2g05575 CAY69688.1 PAS_chr2-2_0229 Protein component of the large (60S) ribosomal subunit 60S ribosomal protein L6-B PAS_2g05580 CAY69689.1 PAS_chr2-2_0228 Hypothetical protein YML071C COG8 "Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" Conserved oligomeric Golgi complex subunit 8 PAS_2g05585 CAY69690.1 PAS_chr2-2_0227 Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase) YLR447C VMA6 "Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane" V-type proton ATPase subunit d PAS_2g05590 CAY69691.1 PAS_chr2-2_0226 Hypothetical protein F-box/LRR-repeat protein 2 PAS_2g05595 PAS_2g05600 CAY69692.1 PAS_chr2-2_0224 Component of the TRAPP (transport protein particle) complex GO:0006810 YML077W BET5 "Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi" Transport protein particle 18 kDa subunit PAS_2g05605 CAY69693.1 PAS_chr2-2_0223 Hypothetical protein PAS_2g05610 CAY69694.1 PAS_chr2-2_0222 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 PAS_2g05615 CAY69695.1 PAS_chr2-2_0221 Nuclear encoded protein required for translation of COX1 mRNA YLR203C MSS51 Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase "Protein MSS51, mitochondrial " PAS_2g05620 CAY69696.1 PAS_chr2-2_0475 hypothetical protein PAS_2g05625 CAY69697.1 PAS_chr2-2_0220 "Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant" YML028W TSA1 "Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype" Peroxiredoxin TSA1 PAS_2g05630 CAY69698.1 PAS_chr2-2_0219 "Guanylate kinase, converts GMP to GDP" YDR454C GUK1 "Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins" Guanylate kinase PAS_2g05635 CAY69699.1 PAS_chr2-2_0218 One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases YBL057C PTH2 One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth Peptidyl-tRNA hydrolase 2 PAS_2g05640 CAY69700.1 PAS_chr2-2_0217 Hypothetical protein GO:0003723;GO:0004540 PAS_2g05645 CAY69701.1 PAS_chr2-2_0216 Type 2C protein phosphatase YER089C PTC2 Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation Protein phosphatase 2C homolog 3 PAS_2g05650 CAY69702.1 PAS_chr2-2_0215 3'-->5' exonuclease and endonuclease with a possible role in apoptosis GO:0016888 Deoxyribonuclease Tat-D PAS_2g05655 CAY69703.1 PAS_chr2-2_0214 Protein of unknown function involved in rRNA and ribosome biosynthesis YBL054W TOD6 "PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor, similar to Dot6p; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manne" Transcriptional regulatory protein DOT6 PAS_2g05660 CAY69704.1 PAS_chr2-2_0213 "Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in" YBL052C SAS3 "Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality" Histone acetyltransferase SAS3 PAS_2g05665 CAY69705.1 PAS_chr2-2_0212 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family YML005W TRM12 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA tRNA wybutosine-synthesizing protein 2 PAS_2g05670 CAY69706.1 PAS_chr2-2_0211 "Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p" GO:0000166 YBL051C PIN4 "Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage" RNA-binding protein PIN4 PAS_2g05675 CAY69707.1 PAS_chr2-2_0210 Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) YER019C-A SBH2 "Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p" Protein transport protein Sec61 subunit beta PAS_2g05680 CAY69708.1 PAS_chr2-2_0209 Protein with similarity to tRNA synthetases GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YER087W AIM10 Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss "Prolyl-tRNA synthetase, cytoplasmic " PAS_2g05685 CAY69709.1 PAS_chr2-2_0208 Hypothetical protein PAS_2g05690 CAY69710.1 PAS_chr2-2_0207 Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins GO:0005777;GO:0016021;GO:0016560 YLR191W PEX13 "Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p" Peroxisomal membrane protein PEX13 PAS_2g05695 CAY69711.1 PAS_chr2-2_0474 hypothetical protein GO:0005509 PAS_2g05700 CAY69712.1 PAS_chr2-2_0206 Hypothetical protein GO:0005509 Mediator of RNA polymerase II transcription subunit 15 PAS_2g05705 CAY69713.1 PAS_chr2-2_0205 Essential component of the Sorting and Assembly Machinery of the mitochondrial outer membrane GO:0019867 YNL026W SAM50 "Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85" Sorting assembly machinery 50 kDa subunit PAS_2g05710 CAY69714.1 PAS_chr2-2_0204 Putative phosphopantothenoylcysteine synthetase (PPCS) YIL083C CAB2 "Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)" Uncharacterized protein YIL083C PAS_2g05715 CAY69715.1 PAS_chr2-2_0203 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins GO:0004221;GO:0006511 YDL122W UBP1 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains Ubiquitin carboxyl-terminal hydrolase 1 PAS_2g05720 CAY69716.1 PAS_chr2-2_0473 hypothetical protein PAS_2g05725 CAY69717.1 PAS_chr2-2_0202 Transcription factor that activates transcription of genes involved in stress response GO:0003676 YNL027W CRZ1 Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation Transcriptional regulator CRZ1 PAS_2g05730 CAY69718.1 PAS_chr2-2_0472 hypothetical protein YIL084C SDS3 "Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes" Transcriptional regulatory protein SDS3 PAS_2g05735 CAY69719.1 PAS_chr2-2_0201 Putative mannosyltransferase involved in protein glycosylation GO:0004377;GO:0006486;GO:0016020 YNL029C KTR5 Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family Probable mannosyltransferase KTR5 PAS_2g05740 CAY69720.1 PAS_chr2-2_0200 One of two identical histone H4 proteins (see also HHF2) GO:0000786;GO:0003677;GO:0005634;GO:0006334 YBR009C HHF1 "Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity" Histone H4 PAS_2g05745 CAY69721.1 PAS_chr2-2_0199 One of two identical histone H3 proteins (see also HHT2) GO:0003677 YBR010W HHT1 "Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation" Histone H3.1/H3.2 PAS_2g05750 CAY69722.1 PAS_chr2-2_0198 Hypothetical protein YIL087C AIM19 "Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth" Loss of respiratory capacity protein 2 PAS_2g05755 CAY69723.1 PAS_chr2-2_0197 Tyrosine phosphatase that plays a role in actin filament organization and endocytosis YNL032W SIW14 Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm Tyrosine-protein phosphatase SIW14 PAS_2g05760 CAY69724.1 PAS_chr2-2_0196 Protein required for cell viability YIL091C YIL091C Nucleolar protein of unknown function; proposed to function as an RNA helicase based on structure prediction and remote homology searches; essential for viability Uncharacterized protein YIL091C PAS_2g05765 CAY69725.1 PAS_chr2-2_0195 Integral ER membrane protein with type-III transmembrane domains YIL090W ICE2 Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells Protein ICE2 PAS_2g05770 CAY69726.1 PAS_chr2-2_0194 Cyclin-like component of the RNA polymerase II holoenzyme YNL025C SSN8 "Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance" RNA polymerase II holoenzyme cyclin-like subunit PAS_2g05775 CAY69727.1 PAS_chr2-2_0193 Ceramide synthase component Sphingosine N-acyltransferase lag1 PAS_2g05780 CAY69728.1 PAS_chr2-2_0192 "Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole" Vacuolar amino acid transporter 7 PAS_2g05785 CAY69729.1 PAS_chr2-2_0191 Hypothetical protein PAS_2g05790 CAY69730.1 PAS_chr2-2_0190 "Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcri" YNL039W BDP1 "Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs" Transcription factor TFIIIB component B'' PAS_2g05795 CAY69731.1 PAS_chr2-2_0189 Putative protein of unknown function with similarity to proteins containing WD-40 domains YNL035C YNL035C Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene Uncharacterized WD repeat-containing protein YNL035C PAS_2g05800 CAY69732.1 PAS_chr2-2_0188 "Protein involved in pre-mRNA splicing, component of a complex containing Cef1p" GO:0000166 YDL209C CWC2 "Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2" Pre-mRNA-splicing factor CWC2 PAS_2g05805 CAY69733.1 PAS_chr2-2_0187 "RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site" YDR243C PRP28 "RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site" Pre-mRNA-splicing ATP-dependent RNA helicase PRP28 PAS_2g05810 CAY69734.1 PAS_chr2-2_0186 Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) YDR244W PEX5 "Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions" Peroxisomal targeting signal receptor PAS_2g05815 CAY69735.1 PAS_chr2-2_0185 Subunit of a Golgi mannosyltransferase complex GO:0003677;GO:0005622 YDR245W MNN10 "Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family" "Probable alpha-1,6-mannosyltransferase MNN10 " PAS_2g05820 CAY69736.1 PAS_chr2-2_0471 hypothetical protein GO:0003677;GO:0005622 YPL016W SWI1 "Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]" UPF0746 protein DDB_G0281095 PAS_2g05825 CAY69737.1 PAS_chr2-2_0184 Single-stranded DNA endonuclease (with Rad10p) GO:0003677 YPL022W RAD1 "Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein" DNA repair protein rad16 PAS_2g05830 PAS_2g05835 CAY69738.1 PAS_chr2-2_0182 Isozyme of methylenetetrahydrofolate reductase GO:0004489;GO:0006555 YPL023C MET12 Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR Methylenetetrahydrofolate reductase 1 PAS_2g05840 CAY69739.1 PAS_chr2-2_0181 Hypothetical protein YPL024W RMI1 Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing and ssDNA binding activities of Top3p; involved in response to DNA damage; null mutants display increased rates of recombination and delayed S phase RecQ-mediated genome instability protein 1 PAS_2g05845 CAY69740.1 PAS_chr2-2_0180 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi GO:0006810 YDR246W TRS23 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4 Trafficking protein particle complex subunit 4 PAS_2g05850 CAY69741.1 PAS_chr2-2_0179 Cytoplasmic serine/threonine protein kinase GO:0004674;GO:0006468 YDR247W VHS1 "Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p" Serine/threonine-protein kinase VHS1 PAS_2g05855 CAY69742.1 PAS_chr2-2_0178 Hypothetical protein YKR044W UIP5 "Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates" PAS_2g05860 CAY69743.1 PAS_chr2-2_0470 hypothetical protein GO:0006808;GO:0016564 PAS_2g05865 CAY69744.1 PAS_chr2-2_0177 Putative protein of unknown function GO:0006808;GO:0016564 YKR043C YKR043C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Uncharacterized protein YKR043C PAS_2g05870 CAY69745.1 PAS_chr2-2_0176 Hypothetical protein PAS_2g05875 CAY69746.1 PAS_chr2-2_0469 hypothetical protein Cell division control protein 14 PAS_2g05880 CAY69747.1 PAS_chr2-2_0175 Mu2-like subunit of the clathrin associated protein complex (AP-2) GO:0006810 YOL062C APM4 Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport AP-1 complex subunit mu-2 PAS_2g05885 CAY69748.1 PAS_chr2-2_0174 "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP" GO:0000287;GO:0004749;GO:0009156;GO:0044249 YOL061W PRS5 "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes" Ribose-phosphate pyrophosphokinase 5 PAS_2g05890 CAY69749.1 PAS_chr2-2_0468 hypothetical protein GO:0004674;GO:0006468 YDL025C YDL025C "Putative protein kinase, potentially phosphorylated by Cdc28p; YDL025C is not an essential gene" Probable serine/threonine-protein kinase YDL025C PAS_2g05895 CAY69750.1 PAS_chr2-2_0173 "Protein required for normal mitochondrial morphology, has similarity to hemolysins" YOL060C MAM3 "Protein required for normal mitochondrial morphology, has similarity to hemolysins" Protein MAM3 PAS_2g05900 CAY69751.1 PAS_chr2-2_0172 Protein that interacts with mitotic cyclin Clb2p GO:0005634;GO:0006334 YKR048C NAP1 Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2 Nucleosome assembly protein PAS_2g05905 CAY69752.1 PAS_chr2-2_0171 Hypothetical protein GO:0003824;GO:0046872 PAS_2g05910 CAY69753.1 PAS_chr2-2_0170 Mitochondrial ribosomal protein of the small subunit YIL093C RSM25 Mitochondrial ribosomal protein of the small subunit "37S ribosomal protein S25, mitochondrial " PAS_2g05915 CAY69754.1 PAS_chr2-2_0169 Hypothetical protein GO:0003954;GO:0005739;GO:0006118;GO:0008137 PAS_2g05920 CAY69755.1 PAS_chr2-2_0467 hypothetical protein GO:0003676 YNL023C FAP1 "Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1" FKBP12-associated protein 1 PAS_2g05925 CAY69756.1 PAS_chr2-2_0168 "Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme" GO:0003676 YIL094C LYS12 "Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate" "Homoisocitrate dehydrogenase, mitochondrial " PAS_2g05930 CAY69757.1 PAS_chr2-2_0167 Putative protein of unknown function with seven beta-strand methyltransferase motif YNL022C YNL022C "Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis" Uncharacterized protein YNL022C PAS_2g05935 CAY69758.1 PAS_chr2-2_0166 JmjC domain family histone demethylase YJR119C JHD2 JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation Histone demethylase JHD2 PAS_2g05940 CAY69759.1 PAS_chr2-2_0165 Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase GO:0015078;GO:0016469 YJR121W ATP2 "Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated" "ATP synthase subunit beta, mitochondrial " PAS_2g05945 CAY69760.1 PAS_chr2-2_0164 Highly conserved zinc metalloprotease GO:0004222;GO:0006508;GO:0016020 YJR117W STE24 "Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans" CAAX prenyl protease 1 PAS_2g05950 CAY69761.1 PAS_chr2-2_0466 hypothetical protein YER022W SRB4 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Mediator of RNA polymerase II transcription subunit 17 PAS_2g05955 CAY69762.1 PAS_chr2-2_0163 Putative protein of unknown function GO:0003824;GO:0005488;GO:0008152 YDL144C YDL144C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene. Uncharacterized protein YDL144C PAS_2g05960 CAY69763.1 PAS_chr2-2_0162 "Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet)" GO:0004001;GO:0006166 YJR105W ADO1 "Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle" Adenosine kinase PAS_2g05965 CAY69764.1 PAS_chr2-2_0161 Putative protein of unknown function GO:0016021 YJR116W YJR116W Putative protein of unknown function Uncharacterized TLC domain-containing protein YJR116W PAS_2g05970 CAY69765.1 PAS_chr2-2_0160 "Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YER119C AVT6 "Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" Vacuolar amino acid transporter 5 PAS_2g05975 CAY69766.1 PAS_chr2-2_0465 hypothetical protein GO:0003735;GO:0005622;GO:0005840;GO:0006412 YBL090W MRP21 Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences "37S ribosomal protein MRP21, mitochondrial " PAS_2g05980 CAY69767.1 PAS_chr2-2_0159 Methionine aminopeptidase GO:0004239;GO:0006508 YBL091C MAP2 "Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p" Methionine aminopeptidase 2 PAS_2g05985 CAY69768.1 PAS_chr2-2_0463 hypothetical protein GO:0005198 YER120W SCS2 "Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog" Vesicle-associated membrane protein-associated protein SCS2 PAS_2g05990 CAY69769.1 PAS_chr2-2_0158 Putative protein of unknown function YLR104W YLR104W Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate; genetic interactions suggest a role in ER-associated protein degradation (ERAD) Uncharacterized protein YLR104W PAS_2g05995 CAY69770.1 PAS_chr2-2_0157 "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p" GO:0003677;GO:0004518 YLR105C SEN2 "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease" tRNA-splicing endonuclease subunit SEN2 PAS_2g06000 CAY69771.1 PAS_chr2-2_0156 Hypothetical protein PAS_2g06005 CAY69772.1 PAS_chr2-2_0155 Hypothetical protein PAS_2g06010 PAS_2g06015 CAY69773.1 PAS_chr2-2_0153 Major transcriptional repressor of DNA-damage-regulated genes GO:0003677;GO:0006355 YLR176C RFX1 "Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins" Protein sak1 PAS_2g06020 CAY69774.1 PAS_chr2-2_0152 Hypothetical protein GO:0005634 YPL165C SET6 "SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability" SET and MYND domain-containing protein 2 PAS_2g06025 CAY69775.1 PAS_chr2-2_0151 Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p GO:0006457;GO:0031072;GO:0051082 YNL007C SIS1 Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins Protein SIS1 PAS_2g06030 CAY69776.1 PAS_chr2-2_0150 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface YNL006W LST8 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat Target of rapamycin complex subunit LST8 PAS_2g06035 CAY69777.1 PAS_chr2-2_0149 Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles YLR175W CBF5 "Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita" Centromere/microtubule-binding protein CBF5 PAS_2g06040 CAY69778.1 PAS_chr2-2_0148 Cell wall protein that contains a putative GPI-attachment site YBR078W ECM33 "GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p" Cell wall mannoprotein PST1 PAS_2g06045 CAY69779.1 PAS_chr2-2_0147 Hypothetical protein GO:0005737;GO:0017089;GO:0046836;GO:0051861 Pleckstrin homology domain-containing family A member 8 PAS_2g06050 CAY69780.1 PAS_chr2-2_0145 Isozyme of methylenetetrahydrofolate reductase GO:0004489;GO:0006555 YGL125W MET13 "Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway" Methylenetetrahydrofolate reductase 2 PAS_2g06055 CAY69781.1 PAS_chr2-2_0144 Protein involved in bud-site selection GO:0005634 YCR063W BUD31 Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Cell cycle control protein cwf14 PAS_2g06060 CAY69782.1 PAS_chr2-2_0143 Component of the Trk1p-Trk2p potassium transport system GO:0006812;GO:0008324 YKR050W TRK2 Component of the Trk1p-Trk2p potassium transport system Potassium transport protein 2 PAS_2g06065 CAY69783.1 PAS_chr2-2_0142 Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase) GO:0004086;GO:0006807 YJL130C URA2 "Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP" Protein URA1 PAS_2g06070 CAY69784.1 PAS_chr2-2_0141 "Putative histone acetylase, sequence-specific activator of histone genes" YJL127C SPT10 "Putative histone acetylase, sequence-specific activator of histone genes, binds specifically and highly cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box" Protein SPT10 PAS_2g06075 CAY69785.1 PAS_chr2-2_0140 "Putative histone acetylase, sequence-specific activator of histone genes" L-azetidine-2-carboxylic acid acetyltransferase PAS_2g06080 CAY69786.1 PAS_chr2-2_0139 Hypothetical protein PAS_2g06085 CAY69787.1 PAS_chr2-2_0138 One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases GO:0004045;GO:0006412 YHR189W PTH1 "One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium" Peptidyl-tRNA hydrolase PAS_2g06090 CAY69788.1 PAS_chr2-2_0137 "Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine" YGR155W CYS4 "Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria" Cystathionine beta-synthase PAS_2g06095 CAY69789.1 PAS_chr2-2_0136 Hypothetical protein YGL041W-A YGL041W-A "Putative protein of unknown function, conserved in fungi; identified by expression profiling and mass spectrometry" PAS_2g06100 CAY69790.1 PAS_chr2-2_0135 General transcription elongation factor TFIIS GO:0003677;GO:0003702;GO:0003746;GO:0005515;GO:0005634;GO:0006354;GO:0006355 YGL043W DST1 "General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites" Transcription elongation factor S-II PAS_2g06105 CAY69791.1 PAS_chr2-2_0134 Cleavage and polyadenylation factor I (CF I) component GO:0000166 YGL044C RNA15 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p Cleavage stimulation factor subunit 2 PAS_2g06110 CAY69792.1 PAS_chr2-2_0133 Hypothetical protein GO:0000166 PAS_2g06115 CAY69793.1 PAS_chr2-2_0132 t-SNARE protein important for fusion of secretory vesicles with the plasma membrane YGR009C SEC9 t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog Protein transport protein SEC9 PAS_2g06120 CAY69794.1 PAS_chr2-2_0462 hypothetical protein GO:0006118;GO:0010181;GO:0016651;GO:0051287;GO:0051539 "NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial " PAS_2g06125 CAY69795.1 PAS_chr2-2_0131 "Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1" GO:0006118;GO:0010181;GO:0016651;GO:0051287;GO:0051539 YDR256C CTA1 "Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation" Peroxisomal catalase PAS_2g06130 CAY69796.1 PAS_chr2-2_0130 Essential protein involved in maturation of 18S rRNA YER127W LCP5 Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus U3 small nucleolar ribonucleoprotein protein LCP5 PAS_2g06135 CAY69797.1 PAS_chr2-2_0129 "Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA" GO:0005622 YER126C NSA2 "Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA" Ribosome biogenesis protein NSA2 PAS_2g06140 CAY69798.1 PAS_chr2-2_0128 ATPase component of the RSC chromatin remodeling complex GO:0003677;GO:0005524 YIL126W STH1 ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Nuclear protein STH1/NPS1 PAS_2g06145 CAY69799.1 PAS_chr2-2_0127 Mitochondrial cytochrome-c peroxidase GO:0004601;GO:0006118;GO:0006979;GO:0020037 YKR066C CCP1 "Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress" "Cytochrome c peroxidase, mitochondrial " PAS_2g06150 CAY69800.1 PAS_chr2-2_0126 Presequence translocase-associated motor subunit YKR065C PAM17 Constituent of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 complex "Presequence translocated-associated motor subunit PAM17, mitochondrial " PAS_2g06155 CAY69801.1 PAS_chr2-2_0125 "Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p" GO:0016021;GO:0016758 YJL183W MNN11 "Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p" "Probable alpha-1,6-mannosyltransferase MNN11 " PAS_2g06160 CAY69802.1 PAS_chr2-2_0124 Putative protein of unknown function YOL107W YOL107W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein Uncharacterized membrane protein YOL107W PAS_2g06165 CAY69803.1 PAS_chr2-2_0123 Hypothetical protein GO:0005634;GO:0030528;GO:0045449 YOL108C INO4 "Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain" Protein INO4 PAS_2g06170 CAY69804.1 PAS_chr2-2_0122 Mitochondrial matrix protein YJR122W IBA57 Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system "Putative transferase CAF17, mitochondrial " PAS_2g06175 CAY69805.1 PAS_chr2-2_0121 Protein proposed to be involved in the modification of N-linked oligosaccharides YJL184W GON7 "Protein proposed to be involved in the modification of N-linked oligosaccharides, osmotic stress response, telomere uncapping and elongation, transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p" Protein GON7 PAS_2g06180 CAY69806.1 PAS_chr2-2_0120 Hypothetical protein Eukaryotic translation initiation factor 3 subunit M PAS_2g06185 CAY69807.1 PAS_chr2-2_0119 Conserved protein required for assembly of subunits of mitochondrial F1F0 ATP synthase YJL180C ATP12 Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency "Protein ATP12, mitochondrial " PAS_2g06190 CAY69808.1 PAS_chr2-2_0118 Hypothetical protein PAS_2g06195 CAY69809.1 PAS_chr2-2_0117 Hypothetical protein Uncharacterized serine-rich protein C215.13 PAS_2g06200 CAY69810.1 PAS_chr2-2_0116 ER associated glutathione S-transferase capable of homodimerization YIR038C GTT1 "ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p" Glutathione S-transferase 1 PAS_2g06205 CAY69811.1 PAS_chr2-2_0115 Boron efflux transporter of the plasma membrane GO:0006820;GO:0015380;GO:0016021 YNL275W BOR1 "Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1" Boron transporter 1 PAS_2g06210 CAY69812.1 PAS_chr2-2_0114 "Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity" YCR044C PER1 "Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1" Protein PER1 PAS_2g06215 CAY69813.1 PAS_chr2-2_0113 Inositol 1-phosphate synthase GO:0003824;GO:0005488;GO:0008152 YJL153C INO1 "Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element" Inositol-3-phosphate synthase PAS_2g06220 CAY69814.1 PAS_chr2-2_0112 Hypothetical protein GO:0006118;GO:0016491 Xanthine dehydrogenase/oxidase PAS_2g06225 CAY69815.1 PAS_chr2-2_0111 "NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis" GO:0004367;GO:0006072;GO:0009331 YDL022W GPD1 "NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p" Glycerol-3-phosphate dehydrogenase [NAD+] PAS_2g06230 CAY69816.1 PAS_chr2-2_0461 hypothetical protein YJL179W PFD1 "Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin" PAS_2g06235 CAY69817.1 PAS_chr2-2_0110 Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway GO:0005515 YJL178C ATG27 Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site Autophagy-related protein 27 PAS_2g06240 CAY69818.1 PAS_chr2-2_0109 Protein component of the large (60S) ribosomal subunit GO:0003735;GO:0006412;GO:0015934 YJL177W RPL17B "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins" 60S ribosomal protein L17 PAS_2g06245 CAY69819.1 PAS_chr2-2_0108 Hypothetical protein Retrotransposon-like protein 1 PAS_2g06250 CAY69820.1 PAS_chr2-2_0107 Hypothetical protein GO:0006464;GO:0008474 Palmitoyl-protein thioesterase 1 PAS_2g06255 CAY69821.1 PAS_chr2-2_0106 Possible U3 snoRNP protein GO:0003735;GO:0005622;GO:0005840;GO:0006412 YKR060W UTP30 Subunit of U3-containing 90S preribosome complex involved in production of 18S rRNA and assembly of small ribosomal subunit Ribosome biogenesis protein UTP30 PAS_2g06260 CAY69822.1 PAS_chr2-2_0105 Mannosyltransferase involved in N-linked protein glycosylation GO:0004377;GO:0006486;GO:0016020 YKR061W KTR2 Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family Probable mannosyltransferase YUR1 PAS_2g06265 CAY69823.1 PAS_chr2-2_0104 RNA polymerase II subunit B32 GO:0003899;GO:0006350 YJL140W RPB4 RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions DNA-directed RNA polymerase II subunit RPB4 PAS_2g06270 CAY69824.1 PAS_chr2-2_0103 Serine-threonine protein kinase that is part of a glucose-sensing system YJL141C YAK1 Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal Dual specificity protein kinase YAK1 PAS_2g06275 CAY69825.1 PAS_chr2-2_0102 Essential constituent of the mitochondrial inner membrane presequence translocase GO:0005743;GO:0008565;GO:0015031 YJL143W TIM17 "Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex" Mitochondrial import inner membrane translocase subunit TIM17 PAS_2g06280 CAY69826.1 PAS_chr2-2_0101 Protein involved in excretion of putrescine and spermidine GO:0006810;GO:0016020 YKL174C TPO5 Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles Polyamine transporter TPO5 PAS_2g06285 CAY69827.1 PAS_chr2-2_0100 GTPase component of U5 snRNP involved in mRNA splicing via spliceosome YKL173W SNU114 GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2 116 kDa U5 small nuclear ribonucleoprotein component PAS_2g06290 CAY69828.1 PAS_chr2-2_0099 Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly YKL172W EBP2 "Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles" rRNA-processing protein EBP2 PAS_2g06295 CAY69829.1 PAS_chr2-2_0098 Hypothetical protein PAS_2g06300 CAY69830.1 PAS_chr2-2_0097 Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates GO:0006508;GO:0008234 YPL020C ULP1 Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates; specifically required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase Sentrin-specific protease PAS_2g06305 CAY69831.1 PAS_chr2-2_0096 Integral inner mitochondrial membrane protein YMR302C YME2 Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases Mitochondrial escape protein 2 PAS_2g06310 CAY69832.1 PAS_chr2-2_0095 Rho GTPase activating protein (RhoGAP) GO:0005622;GO:0007165 YER155C BEM2 Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence GTPase-activating protein BEM2 PAS_2g06315 CAY69833.1 PAS_chr2-2_0094 Chitin synthase II YBR038W CHS2 Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis Chitin synthase 1 PAS_2g06320 CAY69834.1 PAS_chr2-2_0460 hypothetical protein GO:0003677;GO:0004518 YAR008W SEN34 "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease" tRNA-splicing endonuclease subunit SEN34 PAS_2g06325 CAY69835.1 PAS_chr2-2_0093 Putative protein of unknown function YER156C YER156C "Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1" UPF0160 protein YER156C PAS_2g06330 CAY69836.1 PAS_chr2-2_0092 Chaperone that specifically facilitates the assembly of cytochrome c oxidase YDR079W PET100 "Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme" "Protein PET100, mitochondrial " PAS_2g06335 CAY69837.1 PAS_chr2-2_0091 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p GO:0016021 YDR084C TVP23 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Golgi apparatus membrane protein TVP23 PAS_2g06340 CAY69838.1 PAS_chr2-2_0090 Hypothetical protein PAS_2g06345 CAY69839.1 PAS_chr2-2_0089 Member of the PUF protein family GO:0005488 YGL014W PUF4 "Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors" Pumilio homology domain family member 4 PAS_2g06350 CAY69840.1 PAS_chr2-2_0088 Putative protein of unknown function YGR149W YGR149W Putative protein of unknown function; predicted to be an integal membrane protein Uncharacterized membrane protein YGR149W PAS_2g06355 CAY69841.1 PAS_chr2-2_0087 "ADP-ribosylation factor, GTPase of the Ras superfamily" GO:0005525 YDL192W ARF1 "ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p" ADP-ribosylation factor 1-like 2 PAS_2g06360 CAY69842.1 PAS_chr2-2_0086 Mitochondrial ribosomal protein of the small subunit GO:0003723;GO:0003735;GO:0005622;GO:0005840;GO:0006412 YBR251W MRPS5 Mitochondrial ribosomal protein of the small subunit "37S ribosomal protein S5, mitochondrial " PAS_2g06365 CAY69843.1 PAS_chr2-2_0085 Cytosolic J-domain-containing protein GO:0006457;GO:0031072;GO:0051082 Protein CAJ1 PAS_2g06370 CAY69844.1 PAS_chr2-2_0459 hypothetical protein GO:0004674;GO:0006468 Serine/threonine-protein kinase HAL4/SAT4 PAS_2g06375 CAY69845.1 PAS_chr2-2_0084 "Repressible alkaline phosphatase, a glycoprotein localized to the vacuole" GO:0003824;GO:0008152 YDR481C PHO8 "Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides" Repressible alkaline phosphatase PAS_2g06380 CAY69846.1 PAS_chr2-2_0083 Hypothetical protein YJL148W RPA34 RNA polymerase I subunit A34.5 DNA-directed RNA polymerase I subunit RPA34 PAS_2g06385 CAY69847.1 PAS_chr2-2_0082 Hypothetical protein PAS_2g06390 CAY69848.1 PAS_chr2-2_0081 Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex) YPL063W TIM50 Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel Mitochondrial import inner membrane translocase subunit TIM50 PAS_2g06395 CAY69849.1 PAS_chr2-2_0080 Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimul GO:0016491;GO:0050660 YNR074C AIF1 "Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase" Apoptosis-inducing factor 1 PAS_2g06400 CAY69850.1 PAS_chr2-2_0079 "Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli," GO:0016491;GO:0050660 Apoptosis-inducing factor 1 PAS_2g06405 CAY69851.1 PAS_chr2-2_0078 GTPase of the Ras superfamily required to recruit Arl1p to the Golgi GO:0031177 YPL051W ARL3 GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor ADP-ribosylation factor-like protein 3 PAS_2g06410 CAY69852.1 PAS_chr2-2_0458 hypothetical protein GO:0031177 YER010C YER010C "Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction" Uncharacterized protein YER010C PAS_2g06415 CAY69853.1 PAS_chr2-2_0077 Putative phosphatidylinositol transfer protein (PITP) YJL145W SFH5 "Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p" Phosphatidylinositol transfer protein SFH5 PAS_2g06420 CAY69854.1 PAS_chr2-2_0457 hypothetical protein GO:0006457;GO:0031072;GO:0051082 J protein JJJ2 PAS_2g06425 CAY69855.1 PAS_chr2-2_0076 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis GO:0003824;GO:0008152 YKL165C MCD4 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes GPI ethanolamine phosphate transferase 1 PAS_2g06430 CAY69856.1 PAS_chr2-2_0075 Para-aminobenzoate (PABA) synthase GO:0003824;GO:0009058 YNR033W ABZ1 "Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB" Putative aminodeoxychorismate synthase PAS_2g06435 CAY69857.1 PAS_chr2-2_0074 Mitochondrial ribosomal protein of the small subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YCR071C IMG2 Mitochondrial ribosomal protein of the small subunit "54S ribosomal protein IMG2, mitochondrial " PAS_2g06440 CAY69858.1 PAS_chr2-2_0455 hypothetical protein GO:0005086;GO:0005622;GO:0032012 YBL060W YEL1 Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip Brefeldin A-inhibited guanine nucleotide-exchange protein 2 PAS_2g06445 CAY69859.1 PAS_chr2-2_0073 Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism GO:0004298;GO:0005839;GO:0006511 YER094C PUP3 Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 Proteasome component PUP3 PAS_2g06450 CAY69860.1 PAS_chr2-2_0456 hypothetical protein YBL059C-A CMC2 Protein of the mitochondrial intermembrane space with a role in respiratory chain complex assembly or maintenance; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold Coiled-coil-helix-coiled-coil-helix domain-containing protein YBL059C-A PAS_2g06455 CAY69861.1 PAS_chr2-2_0072 Protein of unknown function that may interact with ribosomes YJL123C MTC1 Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 UPF0615 protein YJL123C PAS_2g06460 CAY69862.1 PAS_chr2-2_0071 Hypothetical protein PAS_2g06465 CAY69863.1 PAS_chr2-2_0070 Nit protein YJL126W NIT2 "Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member" Probable hydrolase NIT2 PAS_2g06470 CAY69864.1 PAS_chr2-2_0068 Nuclear actin-related protein involved in chromatin remodeling GO:0005515 YNL059C ARP5 "Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes" Actin-related protein 5 PAS_2g06475 CAY69865.1 PAS_chr2-2_0067 CAP (cyclase-associated protein) subunit of adenylyl cyclase complex GO:0003779;GO:0007010 YNL138W SRV2 "CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis" Adenylyl cyclase-associated protein PAS_2g06480 CAY69866.1 PAS_chr2-2_0066 Protein chaperone involved in regulation of the HSP90 and HSP70 functions GO:0006457;GO:0031072;GO:0051082 YNL064C YDJ1 Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family Mitochondrial protein import protein MAS5 PAS_2g06485 CAY69867.1 PAS_chr2-2_0065 Plasma membrane multidrug transporter of the major facilitator superfamily YNL065W AQR1 "Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids" Probable transporter AQR1 PAS_2g06490 CAY69868.1 PAS_chr2-2_0454 hypothetical protein PAS_2g06495 CAY69869.1 PAS_chr2-2_0064 "Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication" YNL066W SUN4 "Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family" Septation protein SUN4 PAS_2g06500 CAY69870.1 PAS_chr2-2_0063 NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase GO:0008152;GO:0016491 YIL124W AYR1 "NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones" NADPH-dependent 1-acyldihydroxyacetone phosphate reductase PAS_2g06505 CAY69871.1 PAS_chr2-2_0062 Putative protein of unknown function GO:0016020 YBR187W GDT1 Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis UPF0016 membrane protein YBR187W PAS_2g06510 CAY69872.1 PAS_chr2-2_0061 Essential abundant protein involved in regulation of transcription GO:0003677;GO:0005524 YPL082C MOT1 "Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity" Probable helicase mot1 PAS_2g06515 CAY69873.1 PAS_chr2-2_0060 "6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligib" YIL107C PFK26 "6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A" 6-phosphofructo-2-kinase 1 PAS_2g06520 CAY69874.1 PAS_chr2-2_0059 Nucleoside diphosphate kinase GO:0004550;GO:0005524;GO:0006183;GO:0006228;GO:0006241 YKL067W YNK1 "Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate" Nucleoside diphosphate kinase PAS_2g06525 CAY69875.1 PAS_chr2-2_0058 Eukaryotic initiation factor (eIF) 2A YGR054W YGR054W "Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A" Eukaryotic translation initiation factor 2A PAS_2g06530 CAY69876.1 PAS_chr2-2_0057 Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p GO:0003676;GO:0005622;GO:0008270;n/a YFL044C OTU1 Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family Putative ubiquitin thioesterase otu1 PAS_2g06535 CAY69877.1 PAS_chr2-2_0056 Hypothetical protein YLR073C RFU1 Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes AMSH-like protease sst2 PAS_2g06540 CAY69878.1 PAS_chr2-2_0055 Protein involved in bud-site selection GO:0003676;GO:0005622;GO:0008270 YLR074C BUD20 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Bud site selection protein 20 PAS_2g06545 CAY69879.1 PAS_chr2-2_0054 Protein component of the large (60S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YLR075W RPL10 "Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family" 60S ribosomal protein L10 PAS_2g06550 CAY69880.1 PAS_chr2-2_0053 "Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose" GO:0003824;GO:0008152 YFL045C SEC53 "Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen" Phosphomannomutase PAS_2g06555 CAY69881.1 PAS_chr2-2_0052 Putative protein of unknown function YFL046W FMP32 "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" "Protein FMP32, mitochondrial " PAS_2g06560 CAY69882.1 PAS_chr2-2_0051 Putative protein of unknown function YLR077W FMP25 "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" "Protein FMP25, mitochondrial " PAS_2g06565 CAY69883.1 PAS_chr2-2_0453 hypothetical protein GO:0006886;GO:0016020 YLR078C BOS1 "v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi" Protein transport protein BOS1 PAS_2g06570 CAY69884.1 PAS_chr2-2_0050 Component of the RSC chromatin remodeling complex YGR056W RSC1 "Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook" Chromatin structure-remodeling complex subunit RSC2 PAS_2g06575 CAY69885.1 PAS_chr2-2_0049 NAD(+)-dependent histone deacetylase GO:0003677;GO:0005677;GO:0006342;GO:0006355;GO:0006476;GO:0008270;GO:0017136;GO:0051287 NAD-dependent deacetylase sirtuin-5 PAS_2g06580 CAY69886.1 PAS_chr2-2_0048 Dihydrolipoamide dehydrogenase GO:0006118;GO:0016491 YFL018C LPD1 "Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes" "Dihydrolipoyl dehydrogenase, mitochondrial " PAS_2g06585 CAY69887.1 PAS_chr2-2_0047 Putative protein with similarity to the allantoate permease (Dal5p) subfamily Uncharacterized transporter YIL166C PAS_2g06590 CAY69888.1 PAS_chr2-2_0046 Putative protein of unknown function YGR031W YGR031W "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Uncharacterized abhydrolase domain-containing protein YGR031W PAS_2g06595 CAY69889.1 PAS_chr2-2_0045 "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA" GO:0005488 YJL109C UTP10 "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" U3 small nucleolar RNA-associated protein 10 PAS_2g06600 CAY69890.1 PAS_chr2-2_0044 Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) YBR029C CDS1 "Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids" Phosphatidate cytidylyltransferase PAS_2g06605 CAY69891.1 PAS_chr2-2_0043 Homeobox transcription factor GO:0003677;GO:0045449 YDL106C PHO2 Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p Putative uncharacterized protein DDB_G0271606 PAS_2g06610 CAY69892.1 PAS_chr2-2_0042 Specificity factor required for Rsp5p-dependent ubiquitination YMR171C EAR1 Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p Protein ssh-4 PAS_2g06615 CAY69893.1 PAS_chr2-2_0041 "Serine/threonine protein kinase, subunit of the transcription factor TFIIH" GO:0004674;GO:0006468 YDL108W KIN28 "Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters" Serine/threonine-protein kinase KIN28 PAS_2g06620 CAY69894.1 PAS_chr2-2_0452 hypothetical protein GO:0016491 "L-2-hydroxyglutarate dehydrogenase, mitochondrial " PAS_2g06625 CAY69895.1 PAS_chr2-2_0040 Cell-cycle checkpoint serine-threonine kinase GO:0004672;GO:0005524;GO:0006468 YDL101C DUN1 "Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair" DNA damage response protein kinase DUN1 PAS_2g06630 CAY69896.1 PAS_chr2-2_0451 hypothetical protein YDL117W CYK3 SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis Cytokinesis protein 3 PAS_2g06635 CAY69897.1 PAS_chr2-2_0039 Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis YGL142C GPI10 "Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog" GPI mannosyltransferase 3 PAS_2g06640 CAY69898.1 PAS_chr2-2_0038 Putative serine/threonine protein kinase GO:0004674;GO:0006468 YJR059W PTK2 Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake Serine/threonine-protein kinase PTK2/STK2 PAS_2g06645 CAY69899.1 PAS_chr2-2_0037 AP-1 accessory protein GO:0005488 YJL207C LAA1 AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene AP-1 accessory protein LAA1 PAS_2g06650 CAY69900.1 PAS_chr2-2_0036 "Mannosyltransferase, involved in N-linked glycosylation" YNL219C ALG9 "Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation" Probable mannosyltransferase ALG9 PAS_2g06655 CAY69901.1 PAS_chr2-2_0035 Hypothetical protein NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 PAS_2g06660 CAY69902.1 PAS_chr2-2_0034 Alkaline phosphatase specific for p-nitrophenyl phosphate GO:0008152;GO:0016791 YDL236W PHO13 Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity 4-nitrophenylphosphatase PAS_2g06665 CAY69903.1 PAS_chr2-2_0033 Phosphorelay intermediate protein GO:0004871;GO:0007165 YDL235C YPD1 "Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus" Phosphorelay intermediate protein YPD1 PAS_2g06670 CAY69904.1 PAS_chr2-2_0032 Cytoplasmic protein of unknown function YNL212W VID27 "Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth" Vacuolar import and degradation protein 27 PAS_2g06675 CAY69905.1 PAS_chr2-2_0031 Protein of unknown function YNL213C RRG9 "Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Uncharacterized protein YNL213C PAS_2g06680 CAY69906.1 PAS_chr2-2_0030 Sorting nexin family member GO:0005515;GO:0007154;GO:0035091 YDL113C ATG20 Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate Sorting nexin-41 PAS_2g06685 CAY69907.1 PAS_chr2-2_0029 Subunit of the ARP2/3 complex GO:0005856;GO:0030833 YIL062C ARC15 "Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches" Actin-related protein 2/3 complex subunit 5 PAS_2g06690 CAY69908.1 PAS_chr2-2_0450 hypothetical protein YML108W YML108W Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene Uncharacterized protein YML108W PAS_2g06695 CAY69909.1 PAS_chr2-2_0449 hypothetical protein GO:0000166 YIL061C SNP1 Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein U1 small nuclear ribonucleoprotein 70 kDa homolog PAS_2g06700 CAY69910.1 PAS_chr2-2_0028 "Putative protein, acetyl coenzyme A transporter" YBR220C YBR220C Putative protein of unknown function; YBR220C is not an essential gene Uncharacterized membrane protein YBR220C PAS_2g06705 CAY69911.1 PAS_chr2-2_0027 Hypothetical protein YGL126W SCS3 "Protein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; disputed role in the synthesis of inositol phospholipids from inositol" FIT family protein SCS3 PAS_2g06710 YGL127C SOH1 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits Mediator of RNA polymerase II transcription subunit 31 PAS_2g06715 CAY69912.1 PAS_chr2-2_0025 Hypothetical protein PAS_2g06720 CAY69913.1 PAS_chr2-2_0024 "Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate" GO:0003824;GO:0005524 YBR218C PYC2 "Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis" Pyruvate carboxylase PAS_2g06725 CAY69914.1 PAS_chr2-2_0023 Component of the Rsp5p E3-ubiquitin ligase complex YMR275C BUL1 "Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases" Ubiquitin ligase-binding protein BUL2 PAS_2g06730 CAY69915.1 PAS_chr2-2_0022 "Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p" Bypass of stop codon protein 5 PAS_2g06735 CAY69916.1 PAS_chr2-2_0021 Hypothetical protein GO:0004152;GO:0006222 YKL216W URA1 "Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid" "Dihydroorotate dehydrogenase, mitochondrial " PAS_2g06740 CAY69917.1 PAS_chr2-2_0019 "Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation" GO:0008152;GO:0016491 D-arabinitol 2-dehydrogenase [ribulose-forming] PAS_2g06745 CAY69918.1 PAS_chr2-2_0018 Protein of unknown function YBL086C YBL086C Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Uncharacterized protein YBL086C PAS_2g06750 CAY69919.1 PAS_chr2-2_0017 Apyrase with wide substrate specificity GO:0016787 Guanosine-diphosphatase PAS_2g06755 CAY69920.1 PAS_chr2-2_0448 hypothetical protein GO:0005525;GO:0005622;GO:0007264 YCR027C RHB1 Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins GTP-binding protein rhb1 PAS_2g06760 CAY69921.1 PAS_chr2-2_0016 Histone deacetylase YGL194C HOS2 "Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity" Probable histone deacetylase HOS2 PAS_2g06765 CAY69922.1 PAS_chr2-2_0015 "One of several homologs of bacterial chaperone DnaJ, located in the ER lumen" GO:0031072 DnaJ-like chaperone JEM1 PAS_2g06770 CAY69923.1 PAS_chr2-2_0014 Guanyl-nucleotide exchange factor for the small G-protein Sec4p YNL272C SEC2 "Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles" Rab guanine nucleotide exchange factor SEC2 PAS_2g06775 CAY69924.1 PAS_chr2-2_0013 Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) YNL273W TOF1 "Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase" Topoisomerase 1-associated factor 1 PAS_2g06780 CAY69925.1 PAS_chr2-2_0012 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 Transcription factor PDR1 PAS_2g06785 CAY69927.1 PAS_chr2-2_0010 Hypothetical protein PAS_2g06790 CAY69928.1 PAS_chr2-2_0009 Low-affinity Fe(II) transporter of the plasma membrane YMR319C FET4 Low-affinity Fe(II) transporter of the plasma membrane Low-affinity Fe(2+) transport protein PAS_2g06795 PAS_2g06800 CAY69929.1 PAS_chr2-2_0007 Hypothetical protein PAS_2g06805 CAY69930.1 PAS_chr2-2_0006 Hypothetical protein PAS_2g06810 CAY69931.1 PAS_chr2-2_0005 "Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration" GO:0016020;GO:0030001;GO:0046873 Magnesium transporter ALR1 PAS_2g06815 CAY69932.1 PAS_chr2-2_0004 Hypothetical protein PAS_2g06820 CAY69933.1 PAS_chr2-2_0003 Hypothetical protein PAS_2g06825 PAS_34c00000 CAY67024.1 PAS_c034_0002 contains GLEYA adhesin domain Glycoprotein gp2 PAS_34c00005 CAY67025.1 PAS_c034_0004 hypothetical protein PAS_34c00010 CAY67026.1 PAS_c034_0007 transcriptional regulatory protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 YMR019W STB4 Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters Probable transcriptional regulatory protein STB4 PAS_34c00015 CAY67027.1 PAS_c034_0008 Major faciliator superfamily Probable transporter MCH2 PAS_34c00020 CAY67028.1 PAS_c034_0010 Major faciliator superfamily Uncharacterized transporter YIL166C PAS_34c00025 CAY67029.1 PAS_c034_0011 Alpha-ketoglutarate-dependent sulfonate dioxygenase GO:0006118;GO:0016491 YLL057C JLP1 "Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation" Alpha-ketoglutarate-dependent sulfonate dioxygenase PAS_34c00030 CAY67030.1 PAS_c034_0012 hypothetical protein PAS_34c00035 CAY67031.1 PAS_c034_0013 Cu/Zn superoxide dismutase GO:0006801;GO:0046872 PAS_34c00040 CAY67032.1 PAS_c034_0014 Alpha-ketoglutarate-dependent sulfonate dioxygenase GO:0006118;GO:0016491 Alpha-ketoglutarate-dependent sulfonate dioxygenase PAS_34c00045 CAY67033.1 PAS_c034_0015 transporter Uncharacterized transporter YIL166C PAS_34c00050 CAY67034.1 PAS_c034_0016 Multidrug resistance protein GO:0005524;GO:0006810;GO:0016021;GO:0042626 Multidrug resistance protein 3 PAS_34c00055 CAY67035.1 PAS_c034_0018 Alcohol dehydrogenase GO:0008270;GO:0016491 Protein TOXD PAS_34c00060 CAY67036.1 PAS_c034_0019 Basic amino-acid permease GO:0006810;GO:0016020 Lysine-specific permease PAS_34c00065 CAY67037.1 PAS_c034_0020 Uncharacterized protein YLR154C-H YLR154C-H Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-2 Uncharacterized protein YLR154C-H/YLR156C-A/YLR157C-C/YLR159C-A PAS_34c00070 CAY67038.1 PAS_c034_0021 Major facilitator superfamily Sugar transport protein 11 PAS_34c00075 CAY67039.1 PAS_c034_0022 hypothetical protein with 2OG-Fe(II) oxygenase domain GO:0016491 Gibberellin 3-beta-dioxygenase 1 PAS_34c00080 CAY67040.1 PAS_c034_0023 hypothetical protein PAS_34c00085 CAY67041.1 PAS_c034_0024 Major facilitator superfamily Probable transporter SEO1 PAS_34c00090 CAY67042.1 PAS_c034_0025 Alkaline ceramidase GO:0000139;GO:0005789;GO:0006672;GO:0016021;GO:0016811 Alkaline ceramidase 3 PAS_34c00095 CAY67043.1 PAS_c034_0026 hypothetical protein with Armadillo-like helical domain GO:0005488 PAS_34c00100 CAY67044.1 PAS_c034_0027 lipase GO:0004806;GO:0006629 PAS_34c00105 CAY67045.1 PAS_c034_0028 Serine/threonine protein kinase GO:0004674;GO:0006468 YMR216C SKY1 SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 Serine/threonine-protein kinase SKY1 PAS_34c00110 CAY67046.1 PAS_c034_0029 Heat shock protein YPL106C SSE1 ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm Heat shock protein homolog SSE1 PAS_34c00115 CAY67047.1 PAS_c034_0030 Nuclear protein localization protein YBR170C NPL4 "Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation" Nuclear protein localization protein 4 PAS_34c00120 CAY67048.1 PAS_c034_0031 hypothetical protein YPL107W YPL107W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene "UPF0651 protein YPL107W, mitochondrial " PAS_34c00125 CAY67049.1 PAS_c034_0032 Glycolipid-anchored surface protein YMR215W GAS3 "Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall" "Probable 1,3-beta-glucanosyltransferase GAS3 " PAS_34c00130 CAY67050.1 PAS_c034_0033 hypothetical protein YPL066W YPL066W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source PAS_34c00135 CAY67051.1 PAS_c034_0034 hypothetical protein YBR162C TOS1 "Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C" Protein TOS1 PAS_34c00140 CAY67052.1 PAS_c034_0035 Histone H4 GO:0000786;GO:0003677;GO:0005634;GO:0006334 Histone H4 PAS_34c00145 CAY67053.1 PAS_c034_0036 Histone H3 GO:0003677 Histone H3.1/H3.2 PAS_34c00150 CAY67054.1 PAS_c034_0037 GPI mannosyltransferase GO:0005789;GO:0006506;GO:0016021;GO:0016758 YBR004C GPI18 "Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria" GPI mannosyltransferase 2 PAS_34c00155 CAY67055.1 PAS_c034_0038 26S proteasome non-ATPase regulatory particle subunit YFR052W RPN12 "Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p" 26S proteasome regulatory subunit RPN12 PAS_34c00160 CAY67056.1 PAS_c034_0039 Peptidyl-prolyl isomerase YDR171W HSP42 Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock Heat shock protein 42 PAS_34c00165 CAY67057.1 PAS_c034_0041 hypothetical protein "Myosin light chain kinase, smooth muscle " PAS_3g00000 CAY69934.1 PAS_chr3_0001 Hypothetical protein PAS_3g00005 CAY69935.1 PAS_chr3_0002 Hypothetical protein Cell wall protein DAN4 PAS_3g00010 PAS_3g00015 PAS_3g00020 CAY69936.1 PAS_chr3_0005 Hypothetical protein PAS_3g00025 CAY69937.1 PAS_chr3_0006 NADPH-dependent medium chain alcohol dehydrogenase GO:0008270;GO:0016491 NADP-dependent alcohol dehydrogenase C 1 PAS_3g00030 PAS_3g00035 CAY69938.1 PAS_chr3_0008 Hypothetical protein UNC93-like protein C922.05c PAS_3g00040 CAY69939.1 PAS_chr3_0010 Hypothetical protein GO:0016491 Salicylate hydroxylase PAS_3g00045 CAY69940.1 PAS_chr3_1144 hypothetical protein PAS_3g00050 CAY69941.1 PAS_chr3_0012 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 Regulatory protein CAT8 PAS_3g00055 CAY69942.1 PAS_chr3_0013 "Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation" PAS_3g00060 CAY69943.1 PAS_chr3_1145 hypothetical protein Agglutinin-like protein 2 PAS_3g00065 CAY69944.1 PAS_chr3_0014 Putative dihydrokaempferol 4-reductase GO:0003824;GO:0005488;GO:0008152 Putative uncharacterized oxidoreductase YDR541C PAS_3g00070 CAY69945.1 PAS_chr3_0015 Hypothetical protein Serine-rich adhesin for platelets PAS_3g00075 CAY69946.1 PAS_chr3_0016 Hypothetical protein Cell wall protein DAN4 PAS_3g00080 CAY69947.1 PAS_chr3_0017 Hypothetical protein GO:0003824;GO:0005488;GO:0008152 Putative uncharacterized protein b4286 PAS_3g00085 CAY69948.1 PAS_chr3_0018 "High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regi" GO:0006810;GO:0016020 High-affinity methionine permease PAS_3g00090 CAY69949.1 PAS_chr3_0019 "Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane" GO:0006118;GO:0016491 YHR176W FMO1 "Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins" Thiol-specific monooxygenase PAS_3g00095 CAY69950.1 PAS_chr3_0020 Putative protein of unknown function GO:0016020 YPL279C YPL279C Putative protein of unknown function UPF0695 membrane protein YOR390W PAS_3g00100 PAS_3g00105 CAY69951.1 PAS_chr3_0022 Allantoin permease GO:0015205;GO:0015931;GO:0016020 YIR028W DAL4 "Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation" Allantoin permease PAS_3g00110 CAY69952.1 PAS_chr3_0023 "Putative transporter, member of the sugar porter family" YFL040W YFL040W "Putative transporter, member of the sugar porter family; YFL040W is not an essential gene" High-affinity glucose transporter PAS_3g00115 CAY69953.1 PAS_chr3_0024 "Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen" GO:0005215;GO:0006810;GO:0016020 Probable urea active transporter 1 PAS_3g00120 CAY69954.1 PAS_chr3_0025 Hypothetical protein PAS_3g00125 CAY69955.1 PAS_chr3_0026 Hypothetical protein PAS_3g00130 CAY69956.1 PAS_chr3_0027 Hypothetical protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 Uncharacterized transcriptional regulatory protein C1327.01c PAS_3g00135 CAY69957.1 PAS_chr3_0028 Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitat YIL166C YIL166C Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene Uncharacterized transporter YIL166C PAS_3g00140 CAY69958.1 PAS_chr3_0029 Hypothetical protein PAS_3g00145 CAY69959.1 PAS_chr3_0030 Hypothetical protein Flocculation protein FLO1 PAS_3g00150 Uncharacterized protein YLR154C-H/YLR156C-A/YLR157C-C/YLR159C-A PAS_3g00155 CAY69960.1 PAS_chr3_0032 Hypothetical protein Uncharacterized protein KIAA0754 PAS_3g00160 PAS_3g00165 PAS_3g00170 CAY69961.1 PAS_chr3_0035 Hypothetical protein F-box protein At5g06550 PAS_3g00175 CAY69962.1 PAS_chr3_0036 "S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial ca" GO:0005488;GO:0006810;GO:0016020 YNL003C PET8 "S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth" Putative mitochondrial carrier protein PET8 PAS_3g00180 CAY69963.1 PAS_chr3_0037 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis GO:0003824;GO:0030170 YCL017C NFS1 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria "Cysteine desulfurase, mitochondrial " PAS_3g00185 CAY69964.1 PAS_chr3_0038 Nucleolar protein with similarity to large ribosomal subunit L7 proteins GO:0003735;GO:0005840;GO:0006412 YNL002C RLP7 Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs Ribosome biogenesis protein RLP7 PAS_3g00190 CAY69965.1 PAS_chr3_0039 "Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis path" GO:0008152;GO:0016616 YCL018W LEU2 "Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway" 3-isopropylmalate dehydrogenase PAS_3g00195 CAY69966.1 PAS_chr3_0040 "Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochond" GO:0005215;GO:0005743;GO:0006810 YPL134C ODC1 "Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation" Mitochondrial 2-oxodicarboxylate carrier 2 PAS_3g00200 CAY69967.1 PAS_chr3_0041 Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the o YPR054W SMK1 Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p Sporulation-specific mitogen-activated protein kinase SMK1 PAS_3g00205 CAY69968.1 PAS_chr3_0042 Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting GO:0005488 YBR097W VPS15 Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p Putative serine/threonine-protein kinase VPS15 PAS_3g00210 CAY69969.1 PAS_chr3_0043 peroxisomal integral membrane protein GO:0005515;GO:0008270 YJL210W PEX2 "RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import" Peroxisomal biogenesis factor 2 PAS_3g00215 CAY69970.1 PAS_chr3_1146 hypothetical protein YHR012W VPS29 Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval Vacuolar protein sorting-associated protein 29 PAS_3g00220 CAY69971.1 PAS_chr3_1147 hypothetical protein YDR473C PRP3 "Splicing factor, component of the U4/U6-U5 snRNP complex" Uncharacterized protein C29E6.02 PAS_3g00225 CAY69972.1 PAS_chr3_0044 E3 ubiquitin ligase of the hect-domain class GO:0004842;GO:0005737;GO:0006512;GO:0051028 YDR457W TOM1 E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones E3 ubiquitin-protein ligase TOM1 PAS_3g00230 CAY69973.1 PAS_chr3_0045 Hypothetical protein Putative leucine-rich repeat-containing protein DDB_G0290503 PAS_3g00235 CAY69974.1 PAS_chr3_0046 "Protein required for S phase progression and telomere homeostasis, forms an alternative replication" YOR144C ELG1 "Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair" Telomere length regulation protein ELG1 PAS_3g00240 CAY69975.1 PAS_chr3_0047 "Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling en" GO:0005515 YOR141C ARP8 "Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes" Actin-like protein ARP8 PAS_3g00245 CAY69976.1 PAS_chr3_0048 Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived GO:0005515;GO:0016020;GO:0016192 YDR468C TLG1 Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p T-SNARE affecting a late Golgi compartment protein 1 PAS_3g00250 CAY69977.1 PAS_chr3_0049 Hypothetical protein PAS_3g00255 CAY69978.1 PAS_chr3_0050 Hypothetical protein PAS_3g00260 CAY69979.1 PAS_chr3_0051 "Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to act" GO:0003677 YDR392W SPT3 "Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters" Protein SPT3 PAS_3g00265 CAY69980.1 PAS_chr3_0052 "Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (" GO:0004788;GO:0005524;GO:0009229 YOR143C THI80 "Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)" Thiamine pyrophosphokinase PAS_3g00270 CAY69981.1 PAS_chr3_0053 "C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl grou" GO:0003824;GO:0008152 YGR060W ERG25 "C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol" C-4 methylsterol oxidase PAS_3g00275 CAY69982.1 PAS_chr3_0054 "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similari" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YMR242C RPL20A "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein" 60S ribosomal protein L20 PAS_3g00280 CAY69983.1 PAS_chr3_0055 Hypothetical protein DASH complex subunit ask1 PAS_3g00285 CAY69984.1 PAS_chr3_0056 Mitochondrial intermembrane space cysteine motif protein YKL053C-A MDM35 Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs Mitochondrial distribution and morphology protein 35 PAS_3g00290 CAY69985.1 PAS_chr3_0057 Hypothetical protein YML041C VPS71 "Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting" Uncharacterized zinc finger protein C29A3.05 PAS_3g00295 CAY69986.1 PAS_chr3_0058 "Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron h" GO:0006118 YDR376W ARH1 "Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability" "NADPH:adrenodoxin oxidoreductase, mitochondrial " PAS_3g00300 CAY69987.1 PAS_chr3_0059 "Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily cons" YDR377W ATP17 "Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis" "ATP synthase subunit f, mitochondrial " PAS_3g00305 CAY69988.1 PAS_chr3_0060 Hypothetical protein YDR378C LSM6 "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA" U6 snRNA-associated Sm-like protein LSm6 PAS_3g00310 CAY69989.1 PAS_chr3_0061 "Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane p" YKL034W TUL1 "Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes" Transmembrane E3 ubiquitin-protein ligase 1 PAS_3g00315 CAY69990.1 PAS_chr3_1148 hypothetical protein YKL033W-A YKL033W-A Putative protein of unknown function; similar to uncharacterized proteins from other fungi Putative uncharacterized hydrolase YKL033W-A PAS_3g00320 CAY69991.1 PAS_chr3_0062 "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleot" GO:0000287;GO:0004749;GO:0009156;GO:0044249 YHL011C PRS3 "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes" Ribose-phosphate pyrophosphokinase 1 PAS_3g00325 CAY69992.1 PAS_chr3_0063 "Putative protein of unknown function, contains a zinc finger region and has homology to human BRAP2," YHL010C ETP1 "Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences" RING finger protein ETP1 homolog PAS_3g00330 CAY69993.1 PAS_chr3_0064 Hypothetical protein PAS_3g00335 CAY69994.1 PAS_chr3_0065 RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both YMR229C RRP5 RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome rRNA biogenesis protein RRP5 PAS_3g00340 YOR289W YOR289W Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus AMME syndrome candidate gene 1 protein PAS_3g00345 CAY69995.1 PAS_chr3_0066 "Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues" GO:0016671;GO:0019538 YER042W MXR1 "Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan" Probable peptide methionine sulfoxide reductase PAS_3g00350 CAY69996.1 PAS_chr3_0067 Hypothetical protein PAS_3g00355 CAY69997.1 PAS_chr3_0068 Component of the RSC chromatin remodeling complex YKR008W RSC4 Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling Protein polybromo-1 PAS_3g00360 CAY69998.1 PAS_chr3_0069 "Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated a" GO:0008415 YML042W CAT2 "Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes" "Carnitine O-acetyltransferase, mitochondrial " PAS_3g00365 PAS_3g00370 CAY69999.1 PAS_chr3_0071 Hypothetical protein GO:0003677;GO:0006355 Mastermind-like protein 2 PAS_3g00375 CAY70000.1 PAS_chr3_0072 "Diacylglycerol kinase, localized to the endoplasmic reticulum (ER)" GO:0004605;GO:0008654;GO:0016020 YOR311C DGK1 "Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain" CTP-dependent diacylglycerol kinase 1 PAS_3g00380 CAY70001.1 PAS_chr3_1149 hypothetical protein PAS_3g00385 CAY70002.1 PAS_chr3_1150 hypothetical protein PAS_3g00390 CAY70003.1 PAS_chr3_0073 Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the GO:0008152;GO:0008415 YBL011W SCT1 "Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed" Glycerol-3-phosphate O-acyltransferase 1 PAS_3g00395 CAY70004.1 PAS_chr3_1151 hypothetical protein Uncharacterized protein C8E11.05c PAS_3g00400 CAY70005.1 PAS_chr3_0074 Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylat GO:0003824;GO:0005488;GO:0008152 YPL003W ULA1 "Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation" NEDD8-activating enzyme E1 regulatory subunit PAS_3g00405 CAY70006.1 PAS_chr3_1152 hypothetical protein Uncharacterized RING finger protein C6B12.07c PAS_3g00410 CAY70007.1 PAS_chr3_0075 Protein of unknown function CCR4-NOT transcriptional complex subunit CAF120 PAS_3g00415 CAY70008.1 PAS_chr3_0076 "Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathog" YJL079C PRY1 Protein of unknown function Protein PRY2 PAS_3g00420 CAY70009.1 PAS_chr3_0077 "Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start" GO:0003723;GO:0003743;GO:0005850;GO:0006412 YJR007W SUI2 "Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP" Eukaryotic translation initiation factor 2 subunit alpha PAS_3g00425 CAY70010.1 PAS_chr3_0078 Putative protein of unknown function YJR008W YJR008W Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source. UPF0103 protein C4H3.04c PAS_3g00430 Agglutinin-like protein 2 PAS_3g00435 CAY70011.1 PAS_chr3_0079 "Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2)" GO:0005515;GO:0006461;GO:0006886;GO:0016192;GO:0030117 YJR005W APL1 "Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex" AP-1 complex subunit beta PAS_3g00440 CAY70012.1 PAS_chr3_0080 Putative DNA helicase YDR291W HRQ1 Putative RecQ helicase; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS) Putative ATP-dependent helicase HRQ1 PAS_3g00445 PAS_3g00450 CAY70013.1 PAS_chr3_0082 "Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosph" GO:0000015;GO:0004634;GO:0006096 YGR254W ENO1 "Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose" Enolase PAS_3g00455 CAY70014.1 PAS_chr3_0083 Hypothetical protein Dentin sialophosphoprotein PAS_3g00460 CAY70015.1 PAS_chr3_0084 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 PAS_3g00465 CAY70016.1 PAS_chr3_0085 "Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosyn" YOR128C ADE2 "Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine" Phosphoribosylaminoimidazole carboxylase PAS_3g00470 CAY70017.1 PAS_chr3_0086 "Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation" GO:0008152;GO:0016491 Gluconate 5-dehydrogenase PAS_3g00475 CAY70018.1 PAS_chr3_0087 Protein involved in bud site selection during bipolar budding GO:0004871 YOR301W RAX1 Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily Protein rax1 PAS_3g00480 PAS_3g00485 CAY70019.1 PAS_chr3_0089 Putative protein of unknown function YDL237W AIM6 "Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene" Uncharacterized protein YDL237W PAS_3g00490 CAY70020.1 PAS_chr3_0090 Hypothetical protein UPF0642 protein YBL028C PAS_3g00495 CAY70021.1 PAS_chr3_0091 "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similari" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YBL027W RPL19B "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal" 60S ribosomal protein L19 PAS_3g00500 CAY70022.1 PAS_chr3_0092 "Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid inv" GO:0003700;GO:0005634;GO:0006355 YBR083W TEC1 "Transcription factor required for full Ty1 expression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member" Transcriptional enhancer factor TEF-5 PAS_3g00505 PAS_3g00510 CAY70023.1 PAS_chr3_0094 "Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis" GO:0005488 YDR060W MAK21 "Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein" Ribosome biogenesis protein MAK21 PAS_3g00515 CAY70024.1 PAS_chr3_0095 "Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, whi" GO:0030976 YDR380W ARO10 "Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway" Transaminated amino acid decarboxylase PAS_3g00520 CAY70025.1 PAS_chr3_0096 Hypothetical protein PAS_3g00525 CAY70026.1 PAS_chr3_0097 "Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucle" GO:0000166 YDR381W YRA1 "RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member" RNA annealing protein YRA1 PAS_3g00530 CAY70027.1 PAS_chr3_0098 Hypothetical protein YDR381C-A YDR381C-A "Protein of unknown function, localized to the mitochondrial outer membrane" PAS_3g00535 CAY70028.1 PAS_chr3_0099 "Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YE" GO:0005488;GO:0006810;GO:0016020 Peroxisomal membrane protein PMP47B PAS_3g00540 CAY70029.1 PAS_chr3_0100 "Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as pa" GO:0005488;GO:0006810;GO:0016020 YOR130C ORT1 "Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome" Mitochondrial ornithine carrier protein PAS_3g00545 CAY70030.1 PAS_chr3_0101 Hypothetical protein PAS_3g00550 CAY70031.1 PAS_chr3_0102 Hypothetical protein PAS_3g00555 CAY70032.1 PAS_chr3_0103 Hypothetical protein PAS_3g00560 CAY70033.1 PAS_chr3_0104 Hypothetical protein PAS_3g00565 CAY70034.1 PAS_chr3_0105 Hypothetical protein PAS_3g00570 CAY70035.1 PAS_chr3_0106 "Profilin, actin-and phosphatidylinositol 4,5-bisphosphate-binding protein, involved in cytoskeleton" GO:0003779;GO:0030036 YOR122C PFY1 "Profilin, actin- and phosphatidylinositol 4,5-bisphosphate-binding protein, involved in cytoskeleton organization, required for normal timing of actin polymerization in response to thermal stress; localizes to plasma membrane and cytosol" Profilin PAS_3g00575 CAY70036.1 PAS_chr3_1154 hypothetical protein YOR123C LEO1 "Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition" RNA polymerase-associated protein LEO1 PAS_3g00580 CAY70037.1 PAS_chr3_0107 Sporulation-specific chitinase GO:0003824;GO:0005975;GO:0043169 YDR371W CTS2 Protein similar to Ashbya gossypii sporulation-specific chitinase Sporulation-specific chitinase 2 PAS_3g00585 CAY70038.1 PAS_chr3_0108 Protein required for Golgi localization of glycosyltransferases YDR372C VPS74 Protein required for Golgi localization of glycosyltransferases; binds the cytosolic domains of Golgi glycosyltransferases; functions as a heterotetramer Vacuolar protein sorting-associated protein 74 PAS_3g00590 Uncharacterized trans-sulfuration enzyme YHR112C PAS_3g00595 CAY70039.1 PAS_chr3_0110 Nucleolar protein involved in pre-rRNA processing GO:0005634 YDR365C ESF1 Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels Pre-rRNA-processing protein ESF1 PAS_3g00600 CAY70040.1 PAS_chr3_0111 Putative protein of unknown function YOR118W RTC5 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity Uncharacterized protein YOR118W PAS_3g00605 CAY70041.1 PAS_chr3_0112 Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into m YOR119C RIO1 Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA Serine/threonine-protein kinase RIO1 PAS_3g00610 CAY70042.1 PAS_chr3_0113 Component of the inositol phosphorylceramide synthase YDR367W KEI1 Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene UPF0596 Golgi apparatus membrane protein YDR367W PAS_3g00615 CAY70043.1 PAS_chr3_0114 Hypothetical protein "Complex I intermediate-associated protein 30, mitochondrial " PAS_3g00620 CAY70044.1 PAS_chr3_0115 Transcriptional repressor and activator GO:0003700;GO:0005634;GO:0006355;GO:0043565 YOR140W SFL1 "Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p" UPF0746 protein DDB_G0281095 PAS_3g00625 PAS_3g00630 CAY70046.1 PAS_chr3_0116 "Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required f" YDR375C BCS1 "Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required for the incorporation of the Rip1p and Qcr10p subunits into the cytochrome bc(1) complex; member of the CDC48/PAS1/SEC18 ATPase family" Mitochondrial chaperone BCS1 PAS_3g00635 CAY70048.1 PAS_chr3_0117 "Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins, cleaves at the C ter" GO:0004221;GO:0006511 YOR124C UBP2 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity Ubiquitin carboxyl-terminal hydrolase 2 PAS_3g00640 CAY70049.1 PAS_chr3_0118 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC) YDR362C TFC6 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 Transcription factor tau 91 kDa subunit PAS_3g00645 CAY70051.1 PAS_chr3_0119 Putative protein of unknown function GO:0003824;GO:0030170 YHR112C YHR112C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Uncharacterized trans-sulfuration enzyme YHR112C PAS_3g00650 CAY70053.1 PAS_chr3_0120 "Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall bet" YHR101C BIG1 "Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan" Protein BIG1 PAS_3g00655 CAY70054.1 PAS_chr3_0121 Hypothetical protein PAS_3g00660 CAY70056.1 PAS_chr3_0122 "Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein" GO:0006810 YJL024C APS3 "Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function" AP-3 complex subunit sigma PAS_3g00665 CAY70058.1 PAS_chr3_0123 Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome YGR174C CBP4 Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p Assembly factor CBP4 PAS_3g00670 CAY70059.1 PAS_chr3_0124 "Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene" GO:0016491 YGR175C ERG1 "Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine" Squalene monooxygenase PAS_3g00675 CAY70061.1 PAS_chr3_0125 Putative protein of unknown function YOR378W YOR378W Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene Drug resistance protein YOR378W PAS_3g00680 CAY70063.1 PAS_chr3_0126 Hypothetical protein PAS_3g00685 CAY70065.1 PAS_chr3_0127 Protein kinase with similarityto serine/threonine protein kinase Ypk1p GO:0004672;GO:0005524;GO:0006468 YMR104C YPK2 Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK Serine/threonine-protein kinase YPK1 PAS_3g00690 YKL101W HSL1 "Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p" Serine/threonine-protein kinase GIN4 PAS_3g00695 CAY70067.1 PAS_chr3_0129 SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p GO:0008270 YDR409W SIZ1 SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring E3 SUMO-protein ligase SIZ1 PAS_3g00700 CAY70069.1 PAS_chr3_0130 "Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-termin" GO:0004671;GO:0006481;GO:0016021 YDR410C STE14 "Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane" Protein-S-isoprenylcysteine O-methyltransferase PAS_3g00705 CAY70071.1 PAS_chr3_0131 Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in th YDR339C FCF1 Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p rRNA-processing protein FCF1 PAS_3g00710 CAY70072.1 PAS_chr3_0132 Hypothetical protein YOR138C RUP1 "Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain" PAS_3g00715 CAY70074.1 PAS_chr3_0133 GTP-binding protein of the ras superfamily required for bud site selection Ras-related protein Rap-1b PAS_3g00720 CAY70076.1 PAS_chr3_0134 Hypothetical protein GO:0008152;GO:0016491 Pseudouridine-metabolizing bifunctional protein C1861.05 PAS_3g00725 CAY70078.1 PAS_chr3_0135 "Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of" GO:0003700;GO:0005634;GO:0006355;GO:0043565;GO:0046983 YIL036W CST6 "Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance" ATF/CREB activator 2 PAS_3g00730 CAY70079.1 PAS_chr3_0136 "Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into" GO:0006464;GO:0006512;GO:0015031 YCL008C STP22 "Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype" Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease PAS_3g00735 CAY70081.1 PAS_chr3_0137 Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex GO:0005524;GO:0015991;GO:0016021;GO:0016469;GO:0042626;GO:0046961 YCL005W-A VMA9 Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis V-type proton ATPase subunit e PAS_3g00740 CAY70083.1 PAS_chr3_0138 Hypothetical protein PAS_3g00745 CAY70085.1 PAS_chr3_0139 Hypothetical protein PAS_3g00750 CAY70086.1 PAS_chr3_0140 "ER localized, heme-binding peroxidase involved in the degradation of heme" GO:0004392;GO:0006788 YLR205C HMX1 "ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1" Heme-binding protein HMX1 PAS_3g00755 CAY70088.1 PAS_chr3_1155 hypothetical protein Uncharacterized protein DDB_G0271670 PAS_3g00760 CAY70089.1 PAS_chr3_0141 High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter Inorganic phosphate transporter PHO84 PAS_3g00765 CAY70091.1 PAS_chr3_0142 Putative protein of unknown function YLR063W YLR063W Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene Uncharacterized protein YLR063W PAS_3g00770 CAY70093.1 PAS_chr3_0143 Secretory vesicle-associated Rab GTPase essential for exocytosis GO:0005524;GO:0005622;GO:0006355;GO:0008134 YFL005W SEC4 Secretory vesicle-associated Rab GTPase essential for exocytosis; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane Ras-related protein SEC4 PAS_3g00775 CAY70095.1 PAS_chr3_0144 "Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate ac" GO:0003723;GO:0004826;GO:0006412 YLR060W FRS1 "Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control" Phenylalanyl-tRNA synthetase beta chain PAS_3g00780 YFL034W YFL034W "Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk" Uncharacterized membrane protein YFL034W PAS_3g00785 CAY70096.1 PAS_chr3_0146 Hypothetical protein PAS_3g00790 CAY70098.1 PAS_chr3_0147 "Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for" YGR099W TEL2 "Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect" Telomere length regulation protein TEL2 PAS_3g00795 CAY70100.1 PAS_chr3_0148 Glucose-repressible protein kinase involved in signal transduction during cell proliferation in resp GO:0000156;GO:0000160;GO:0006355 YFL033C RIM15 "Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase" Serine/threonine-protein kinase RIM15 PAS_3g00800 CAY70102.1 PAS_chr3_0149 Hypothetical protein PAS_3g00805 CAY70103.1 PAS_chr3_0150 "GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell pol" GO:0005525;GO:0005622;GO:0007264 YPR165W RHO1 "GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)" GTP-binding protein RHO1 PAS_3g00810 YPR167C MET16 "3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism" Phosphoadenosine phosphosulfate reductase PAS_3g00815 CAY70105.1 PAS_chr3_0152 Subunit of the RNA polymerase II mediator complex YPR168W NUT2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription Mediator of RNA polymerase II transcription subunit 10 PAS_3g00820 CAY70107.1 PAS_chr3_1156 hypothetical protein PAS_3g00825 Lactation elevated protein 1 homolog B PAS_3g00830 CAY70109.1 PAS_chr3_0154 Putative protein of unknown function YHR045W YHR045W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum PAS_3g00835 PAS_3g00840 YBR146W MRPS9 Mitochondrial ribosomal protein of the small subunit "40S ribosomal protein S9, mitochondrial " PAS_3g00845 CAY70110.1 PAS_chr3_0156 Diaminohydroxyphoshoribosylaminopyrimidine deaminase GO:0008703;GO:0009231 YBR153W RIB7 Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway 5-amino-6-(5-phosphoribosylamino)uracil reductase PAS_3g00850 CAY70112.1 PAS_chr3_0157 "RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III" YBR154C RPB5 "RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation" "DNA-directed RNA polymerases I, II, and III subunit RPABC1 " PAS_3g00855 CAY70114.1 PAS_chr3_0158 Putative protein of unknown function YOL087C YOL087C "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid" F-box/WD repeat-containing protein sel-10 PAS_3g00860 CAY70115.1 PAS_chr3_0159 Hypothetical protein GO:0005576 LisH domain-containing protein C1711.05 PAS_3g00865 CAY70117.1 PAS_chr3_0160 "Nucleolar protein, constituent of 66S pre-ribosomal particles" YOL077C BRX1 "Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif" Ribosome biogenesis protein BRX1 PAS_3g00870 CAY70118.1 PAS_chr3_0161 Hypothetical protein YOL077W-A ATP19 "Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase" "ATP synthase subunit K, mitochondrial " PAS_3g00875 CAY70120.1 PAS_chr3_0162 Component of a membrane-bound complex containing the Tor2p kinase and other proteins YOL078W AVO1 "Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth" Stress-activated map kinase-interacting protein 1 PAS_3g00880 YOL081W IRA2 "GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin" Inhibitory regulator protein IRA2 PAS_3g00885 YDR471W RPL27B "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein" 60S ribosomal protein L27 PAS_3g00890 YDR490C PKH1 "Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p" Probable serine/threonine-protein kinase YOL100W PAS_3g00895 CAY70121.1 PAS_chr3_0164 Hypothetical protein PAS_3g00900 CAY70123.1 PAS_chr3_0165 "Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA" GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YOL097C WRS1 "Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA" "Tryptophanyl-tRNA synthetase, cytoplasmic " PAS_3g00905 CAY70124.1 PAS_chr3_0166 Arginyl-tRNA synthetase GO:0004190;GO:0006508 YDR341C YDR341C "Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" "Arginyl-tRNA synthetase, cytoplasmic " PAS_3g00910 CAY70126.1 PAS_chr3_1157 hypothetical protein GO:0004190;GO:0006508 Candidapepsin-1 PAS_3g00915 CAY70128.1 PAS_chr3_0167 "3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis" GO:0008686;GO:0009231 YDR487C RIB3 "3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration" "3,4-dihydroxy-2-butanone 4-phosphate synthase " PAS_3g00920 CAY70130.1 PAS_chr3_0168 Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport GO:0015031 YDR486C VPS60 Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p Charged multivesicular body protein 5 PAS_3g00925 CAY70131.1 PAS_chr3_0169 "O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynth" GO:0006744;GO:0008425 YOL096C COQ3 "O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein" "Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial " PAS_3g00930 CAY70133.1 PAS_chr3_1158 hypothetical protein GO:0003677;GO:0003700;GO:0005634;GO:0045449 YDR485C VPS72 "Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting" Vacuolar protein sorting-associated protein 72 PAS_3g00935 CAY70135.1 PAS_chr3_0170 Co-chaperone that binds to Hsp82p and activates its ATPase activity GO:0001671;GO:0005737;GO:0030189;GO:0051087 Hsp90 co-chaperone HCH1 PAS_3g00940 CAY70136.1 PAS_chr3_0171 Hypothetical protein GO:0016021 PAS_3g00945 CAY70138.1 PAS_chr3_0172 Putative protein of unknown function GO:0005215;GO:0006810;GO:0016020 YHL008C YHL008C "Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole" Uncharacterized transporter YHL008C PAS_3g00950 CAY70140.1 PAS_chr3_0173 Protein required for establishment and maintenance of sister chromatid condensation and cohesion GO:0005488 YMR076C PDS5 "Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis" Sister chromatid cohesion protein PDS5 PAS_3g00955 CAY70142.1 PAS_chr3_0174 Essential subunit of the histone deacetylase Rpd3S complex GO:0008270 YMR075W RCO1 Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p Uncharacterized protein C16C9.05 PAS_3g00960 CAY70144.1 PAS_chr3_0175 Hypothetical protein GO:0006508;GO:0008235 Curved DNA-binding protein PAS_3g00965 CAY70146.1 PAS_chr3_0176 Mitochondrial ornithine acetyltransferase GO:0000228;GO:0006338 YMR062C ARG7 "Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine" "Arginine biosynthesis bifunctional protein ARG7, mitochondrial " PAS_3g00970 CAY70148.1 PAS_chr3_1159 hypothetical protein GO:0000228;GO:0006338 YBR289W SNF5 Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p SWI/SNF chromatin-remodeling complex subunit SNF5 PAS_3g00975 CAY70149.1 PAS_chr3_1160 hypothetical protein YBR290W BSD2 "Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification" Metal homeostatis protein BSD2 PAS_3g00980 CAY70151.1 PAS_chr3_0177 Mitochondrial inner membrane citrate transporter GO:0005488;GO:0006810;GO:0016020 YBR291C CTP1 "Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family" Tricarboxylate transport protein PAS_3g00985 CAY70153.1 PAS_chr3_0178 TFIIE large subunit GO:0003702;GO:0005673;GO:0006367 YKL028W TFA1 "TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening" Transcription initiation factor IIE subunit alpha PAS_3g00990 CAY70155.1 PAS_chr3_0179 Glucosidase II beta subunit GO:0005515 YDR221W GTB1 "Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER" Glucosidase 2 subunit beta PAS_3g00995 CAY70156.1 PAS_chr3_0180 Hypothetical protein PAS_3g01000 CAY70158.1 PAS_chr3_0181 Mitochondrial malic enzyme GO:0003824;GO:0005488;GO:0008152 YKL029C MAE1 "Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids" "NAD-dependent malic enzyme, mitochondrial " PAS_3g01005 CAY70160.1 PAS_chr3_0182 Dicarboxylic amino acid permease GO:0006810;GO:0016020 Dicarboxylic amino acid permease PAS_3g01010 CAY70161.1 PAS_chr3_0183 Hypothetical protein YNL311C YNL311C "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; putative F-box protein; analysis of integrated high-throughput datasets predicts involvement in ubiquitin-dependent protein catabolism" PAS_3g01015 CAY70162.1 PAS_chr3_0184 "1,3-beta-glucanosyltransferase" YOL132W GAS4 "1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall" "1,3-beta-glucanosyltransferase GAS4 " PAS_3g01020 CAY70164.1 PAS_chr3_0185 Hypothetical protein GO:0003676 Krueppel-like factor 2 PAS_3g01025 CAY70166.1 PAS_chr3_0186 D-serine dehydratase (aka D-serine ammonia-lyase) YGL196W DSD1 D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate D-serine dehydratase PAS_3g01030 CAY70167.1 PAS_chr3_0187 Putative protein of unknown function GO:0016020 YJR085C YJR085C "Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" UPF0136 membrane protein YJR085C PAS_3g01035 CAY70169.1 PAS_chr3_0188 Major of three pyruvate decarboxylase isozymes GO:0030976 YLR044C PDC1 "Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism" Pyruvate decarboxylase PAS_3g01040 CAY70171.1 PAS_chr3_0189 Peripheral peroxisomal membrane peroxin YPL112C PEX25 "Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p" Peroxisomal membrane protein PEX25 PAS_3g01045 CAY70173.1 PAS_chr3_0191 Hypothetical protein PAS_3g01050 CAY70174.1 PAS_chr3_0192 Hypothetical protein PAS_3g01055 CAY70176.1 PAS_chr3_0193 Hypothetical protein Cell wall protein DAN4 PAS_3g01060 CAY70178.1 PAS_chr3_0194 "Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to r" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YHR141C RPL42B "Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus" 60S ribosomal protein L44 PAS_3g01065 CAY70180.1 PAS_chr3_0195 Serine/threonine protein kinase GO:0004672;GO:0005524;GO:0006468 YNL161W CBK1 "Serine/threonine protein kinase that regulates cell morphogenesis pathways; involved in cell wall biosynthesis, apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation" Serine/threonine-protein kinase CBK1 PAS_3g01070 CAY70181.1 PAS_chr3_0196 Hypothetical protein PAS_3g01075 CAY70182.1 PAS_chr3_0197 Hypothetical protein YER083C GET2 Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division Golgi to ER traffic protein 2 PAS_3g01080 CAY70184.1 PAS_chr3_0198 Diacylglycerol pyrophosphate (DGPP) phosphatase GO:0003824;GO:0016020 Diacylglycerol pyrophosphate phosphatase 1 PAS_3g01085 CAY70185.1 PAS_chr3_0199 Putative protein of unknown function with similarity to asparagine synthetases GO:0004066;GO:0006529 YML096W YML096W Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10 Asparagine synthetase domain-containing protein YML096W PAS_3g01090 CAY70187.1 PAS_chr3_0200 Sumoylated protein of unknown function YHR134W WSS1 "Sumoylated protein of unknown function, identified based on genetic interactions with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response, processing stalled or collapsed replication forks" DNA damage response protein WSS1 PAS_3g01095 CAY70189.1 PAS_chr3_0202 Protein involved in 5.8S rRNA processing YMR285C NGL2 Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p RNA exonuclease NGL2 PAS_3g01100 CAY70190.1 PAS_chr3_0203 Guanine nucleotide exchange factor YML097C VPS9 A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin Vacuolar protein sorting-associated protein 9a PAS_3g01105 CAY70192.1 PAS_chr3_0204 Protein required for pre-rRNA processing and 40S ribosomal subunit assembly YIL019W FAF1 Protein required for pre-rRNA processing and 40S ribosomal subunit assembly Protein FAF1 PAS_3g01110 CAY70193.1 PAS_chr3_0205 Chromatin-associated protein YPR135W CTF4 "Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion" Minichromosome loss protein 1 PAS_3g01115 CAY70194.1 PAS_chr3_0206 Hypothetical protein YGR120C COG2 "Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" Conserved oligomeric Golgi complex subunit 2 PAS_3g01120 CAY70196.1 PAS_chr3_0207 Protein involved in pre-rRNA processing YPR137W RRP9 "Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein" Ribosomal RNA-processing protein 9 PAS_3g01125 CAY70198.1 PAS_chr3_0208 Hypothetical protein Uncharacterized protein DDB_G0271670 PAS_3g01130 CAY70200.1 PAS_chr3_0209 Cytosolic protein required for sporulation YDR255C RMD5 "Conserved protein that has an E3-like ubiquitin ligase activity necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; also required for sporulation; has a degenerate RING finger domain" Protein RMD5 homolog A PAS_3g01135 CAY70201.1 PAS_chr3_1161 hypothetical protein YPL084W BRO1 Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes Vacuolar protein-sorting protein BRO1 PAS_3g01140 YPL046C ELC1 "Elongin C, involved in transcription elongation as a heterodimer with Ela1p; required for ubiquitin-dependent degradation of Rpo21p; plays a role in global genomic nucleotide excision repair; expression highly upregulated during sporulation" Elongin-C PAS_3g01145 CAY70203.1 PAS_chr3_0210 Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex GO:0005737;GO:0006886 YPL045W VPS16 Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages Probable vacuolar protein sorting-associated protein 16 homolog PAS_3g01150 CAY70205.1 PAS_chr3_0211 Outer kinetochore protein required for chromosome stability YDR254W CHL4 "Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p" Kinetochore protein mis15 PAS_3g01155 CAY70207.1 PAS_chr3_0212 Nucleolar protein GO:0000166 YPL043W NOP4 "Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)" Nucleolar protein 4 PAS_3g01160 CAY70209.1 PAS_chr3_0213 tRNA(Ser) Um(44) 2'-O-methyltransferase YPL030W TRM44 tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene tRNA (uracil-O(2)-)-methyltransferase PAS_3g01165 CAY70210.1 PAS_chr3_0214 Cyclin-dependent kinase GO:0004674;GO:0006468 YPL031C PHO85 "Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle" Negative regulator of the PHO system PAS_3g01170 CAY70212.1 PAS_chr3_0215 "Alpha1,2-mannosyltransferase" GO:0004377;GO:0006486;GO:0016020 Probable mannosyltransferase MNT2 PAS_3g01175 CAY70214.1 PAS_chr3_1162 hypothetical protein GO:0004377;GO:0006486;GO:0016020 YOR099W KTR1 "Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family" Glycolipid 2-alpha-mannosyltransferase PAS_3g01180 CAY70215.1 PAS_chr3_1163 hypothetical protein YBL008W HIR1 "Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores" Protein HIR1 PAS_3g01185 CAY70217.1 PAS_chr3_0216 Arginosuccinate synthetase GO:0004377;GO:0006486;GO:0016020 YOL058W ARG1 "Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate" Argininosuccinate synthase PAS_3g01190 CAY70219.1 PAS_chr3_0217 Type 2A-related serine-threonine phosphatase GO:0016787 YDL047W SIT4 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization Serine/threonine-protein phosphatase PP1-1 PAS_3g01195 CAY70221.1 PAS_chr3_0218 Diacylglycerol acyltransferase YOR245C DGA1 "Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles" Diacylglycerol O-acyltransferase 1 PAS_3g01200 CAY70223.1 PAS_chr3_0219 DNA helicase and DNA-dependent ATPase GO:0003677;GO:0004003;GO:0005524;GO:0006281 YJL092W SRS2 "DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability" ATP-dependent DNA helicase SRS2 PAS_3g01205 CAY70224.1 PAS_chr3_0220 Mitogen-activated protein (MAP) kinase kinase kinase YJL095W BCK1 "Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p" Serine/threonine-protein kinase BCK1/SLK1/SSP31 PAS_3g01210 CAY70226.1 PAS_chr3_0221 Mitochondrial ribosomal protein of the large subunit GO:0008152 YJL096W MRPL49 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L49, mitochondrial " PAS_3g01215 CAY70228.1 PAS_chr3_0222 3-hydroxyacyl-CoA dehydratase YJL097W PHS1 "Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking" 3-hydroxyacyl-CoA dehydratase PHS1 PAS_3g01220 CAY70230.1 PAS_chr3_1164 hypothetical protein GO:0000287;GO:0004427;GO:0005737;GO:0006796 YDL206W YDL206W Putative protein of unknown function; YDL206W is not an essential protein Putative cation exchanger C3A12.06c PAS_3g01225 CAY70231.1 PAS_chr3_0223 non-ATPase regulatory subunit of the 26S proteasome lid GO:0000287;GO:0004427;GO:0005737;GO:0006796 YER021W RPN3 "Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control" Probable 26S proteasome regulatory subunit rpn3 PAS_3g01230 CAY70233.1 PAS_chr3_1165 hypothetical protein YPL002C SNF8 "Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression" Vacuolar-sorting protein dot2 PAS_3g01235 CAY70235.1 PAS_chr3_0224 DNA-dependent ATPase GO:0003677;GO:0005524 YGL163C RAD54 "DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family" DNA repair protein rhp54 PAS_3g01240 CAY70237.1 PAS_chr3_0225 Soluble fumarate reductase GO:0006118;GO:0016491 YEL047C YEL047C "Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies" Putative fumarate reductase PAS_3g01245 CAY70238.1 PAS_chr3_0226 Vacuolar transporter YJR001W AVT1 "Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" Vacuolar amino acid transporter 1 PAS_3g01250 CAY70240.1 PAS_chr3_1166 hypothetical protein YPR007C REC8 Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p PAS_3g01255 CAY70242.1 PAS_chr3_0227 Primary component of eisosomes Sphingolipid long chain base-responsive protein LSP1 PAS_3g01260 CAY70244.1 PAS_chr3_0228 Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex YPL001W HAT1 "Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair" Histone acetyltransferase type B catalytic subunit PAS_3g01265 CAY70246.1 PAS_chr3_0229 Protein of unknown function UPF0121 membrane protein YLR064W PAS_3g01270 CAY70247.1 PAS_chr3_0230 ATPase involved in protein folding and the response to stress GO:0005524;GO:0005622;GO:0006355;GO:0008134 YBL075C SSA3 ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm Heat shock protein 70 1 PAS_3g01275 CAY70249.1 PAS_chr3_1167 hypothetical protein GO:0005524;GO:0005622;GO:0006355;GO:0008134 YFL038C YPT1 "Rab family small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)" GTP-binding protein ypt1 PAS_3g01280 CAY70251.1 PAS_chr3_1168 hypothetical protein YLR065C YLR065C Putative protein of unknown function; YLR065C is not an essential gene Transmembrane protein 208 homolog PAS_3g01285 CAY70252.1 PAS_chr3_1169 hypothetical protein GO:0005515 YFL039C ACT1 "Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions" Actin PAS_3g01290 CAY70253.1 PAS_chr3_0231 Hypothetical protein GO:0016051;GO:0016758 Glucose N-acetyltransferase 1 PAS_3g01295 CAY70255.1 PAS_chr3_0232 Transcriptional activator GO:0003677;GO:0003700;GO:0005507;GO:0005634;GO:0006355 YPR008W HAA1 "Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins; involved in adaptation to weak acid stress" Copper resistance protein CRF1 PAS_3g01300 CAY70256.1 PAS_chr3_0233 Proliferating cell nuclear antigen (PCNA) GO:0003677;GO:0006275;GO:0030337;GO:0043626 YBR088C POL30 "Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair" Proliferating cell nuclear antigen PAS_3g01305 CAY70258.1 PAS_chr3_0234 Catalytic subunit of N-terminal acetyltransferase of the NatC type YPR051W MAK3 Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus "N-alpha-acetyltransferase 30, NatC catalytic subunit " PAS_3g01310 CAY70260.1 PAS_chr3_0235 Zinc-finger protein of unknown function GO:0003676 YLR375W STP3 "Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids" Transcription factor STP2 PAS_3g01315 CAY70261.1 PAS_chr3_0236 Elongase GO:0016021 YLR372W SUR4 "Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis" Elongation of fatty acids protein 3 PAS_3g01320 YLR371W ROM2 "GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP" Rho1 guanine nucleotide exchange factor 1 PAS_3g01325 CAY70263.1 PAS_chr3_0238 Subunit of the ARP2/3 complex GO:0005856;GO:0030833 YLR370C ARC18 "Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches" Actin-related protein 2/3 complex subunit 3 PAS_3g01330 CAY70264.1 PAS_chr3_0239 Putative protein of unknown function YOR352W YOR352W "Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus" Uncharacterized protein YOR352W PAS_3g01335 CAY70266.1 PAS_chr3_1170 hypothetical protein PAS_3g01340 CAY70267.1 PAS_chr3_0240 Essential protein required for biogenesis of 40S (small) ribosomal subunit YLL011W SOF1 Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p Protein SOF1 PAS_3g01345 CAY70269.1 PAS_chr3_0241 Plasma membrane associated protein phosphatase involved in the general stress response YLL010C PSR1 "Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p" Phosphatase PSR1 PAS_3g01350 CAY70271.1 PAS_chr3_0242 Topoisomerase I GO:0003677;GO:0003917;GO:0005694;GO:0006265;GO:0006268 YOL006C TOP1 "Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination" DNA topoisomerase 1 PAS_3g01355 CAY70273.1 PAS_chr3_0243 Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p GO:0004672;GO:0005524;GO:0006468 YMR001C CDC5 "Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate" Cell cycle serine/threonine-protein kinase CDC5/MSD2 PAS_3g01360 CAY70274.1 PAS_chr3_0244 RNA polymerase II subunit B12.5 GO:0003677;GO:0003899;GO:0006350 YOL005C RPB11 RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit DNA-directed RNA polymerase II subunit RPB11 PAS_3g01365 CAY70276.1 PAS_chr3_0245 Component of the Sin3p-Rpd3p histone deacetylase complex GO:0005634;GO:0006355 YOL004W SIN3 "Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity" Transcriptional regulatory protein SIN3 PAS_3g01370 CAY70278.1 PAS_chr3_0246 Palmitoyltransferase with autoacylation activity GO:0008270 YOL003C PFA4 "Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases" Palmitoyltransferase PFA4 PAS_3g01375 CAY70280.1 PAS_chr3_0247 Hypothetical protein YMR265C YMR265C Putative protein of unknown function PAS_3g01380 CAY70281.1 PAS_chr3_0248 Component of the chromatin assembly complex (with Rlf2p and Msi1p) YML102W CAC2 "Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans" Chromatin assembly factor 1 subunit p60 PAS_3g01385 CAY70283.1 PAS_chr3_0249 Hypothetical protein PAS_3g01390 CAY70284.1 PAS_chr3_0250 Subunit of a histone deacetylase complex YMR263W SAP30 "Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance" Transcriptional regulatory protein SAP30 PAS_3g01395 CAY70286.1 PAS_chr3_0251 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) cAMP-independent regulatory protein pac2 PAS_3g01400 CAY70288.1 PAS_chr3_0252 Steryl ester hydrolase YKL140W TGL1 "Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes" Sterol esterase TGL1 PAS_3g01405 CAY70290.1 PAS_chr3_0253 Acetyl-coA hydrolase GO:0003824;GO:0006084 YBL015W ACH1 "Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth" Acetyl-CoA hydrolase PAS_3g01410 PAS_3g01415 CAY70291.1 PAS_chr3_1171 hypothetical protein GO:0005488 Meiotic PUF family protein 1 PAS_3g01420 CAY70292.1 PAS_chr3_0255 Mitochondrial GTP/GDP transporter GO:0005488 YDL198C GGC1 "Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family" Putative mitochondrial carrier protein YHM1/SHM1 PAS_3g01425 CAY70293.1 PAS_chr3_0256 mRNA 3' end processing factor YDR228C PCF11 "mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)" Protein PCF11 PAS_3g01430 CAY70294.1 PAS_chr3_0257 Adenylate kinase GO:0005524;GO:0019201 YDR226W ADK1 "Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence" Adenylate kinase 1-1 PAS_3g01435 CAY70295.1 PAS_chr3_0258 Hypothetical protein PAS_3g01440 CAY70296.1 PAS_chr3_0259 Putative protein of unknown function GO:0003676 YGR067C YGR067C Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p Zinc finger protein YGR067C PAS_3g01445 CAY70297.1 PAS_chr3_0260 Hypothetical protein GO:0003677 PAS_3g01450 CAY70298.1 PAS_chr3_0261 Hypothetical protein GO:0003715;GO:0006353 YEL017W GTT3 "Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery" Histone chaperone ASF1 PAS_3g01455 CAY70299.1 PAS_chr3_0262 Thymidylate and uridylate kinase GO:0031072 YJR057W CDC8 "Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p" Thymidylate kinase PAS_3g01460 CAY70300.1 PAS_chr3_1172 hypothetical protein GO:0031072 Chaperone protein dnaJ PAS_3g01465 CAY70301.1 PAS_chr3_0263 Mitochondrial outer membrane protein YOL009C MDM12 "Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins" Mitochondrial distribution and morphology protein 12 PAS_3g01470 CAY70302.1 PAS_chr3_0264 Ferrochelatase GO:0004325;GO:0006783 YOR176W HEM15 "Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway" "Ferrochelatase, mitochondrial " PAS_3g01475 CAY70303.1 PAS_chr3_0265 Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p) GO:0005488 YLR272C YCS4 "Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus" Condensin complex subunit 1 PAS_3g01480 CAY70304.1 PAS_chr3_0266 Putative protein with similarity to the allantoate permease (Dal5p) Uncharacterized transporter C1002.16c PAS_3g01485 CAY70305.1 PAS_chr3_1173 hypothetical protein YKL095W YJU2 Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ( Protein CWC16 PAS_3g01490 CAY70306.1 PAS_chr3_0267 TFIID subunit (48 kDa) GO:0005669;GO:0006352;GO:0016986 YMR005W TAF4 "TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate" Transcription initiation factor TFIID subunit 4 PAS_3g01495 CAY70307.1 PAS_chr3_0268 RNA terminal phosphate cyclase-like protein GO:0003824 YOL010W RCL1 Subunit of U3-containing 90S preribosome processome complex involved in 18S rRNA biogenesis and small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no activity detected RNA 3'-terminal phosphate cyclase-like protein PAS_3g01500 CAY70308.1 PAS_chr3_0269 Protein required for sorting proteins to the vacuole GO:0005515;GO:0007154;GO:0035091 YMR004W MVP1 Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole Sorting nexin MVP1 PAS_3g01505 CAY70309.1 PAS_chr3_0270 Coenzyme Q (ubiquinone) binding protein "Coenzyme Q-binding protein COQ10, mitochondrial " PAS_3g01510 CAY70310.1 PAS_chr3_0271 Lysophospholipid acyltransferase YOR175C ALE1 "Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids" Lysophospholipid acyltransferase PAS_3g01515 CAY70311.1 PAS_chr3_0272 Hypothetical protein YOR174W MED4 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Mediator of RNA polymerase II transcription subunit 4 PAS_3g01520 CAY70312.1 PAS_chr3_0273 Non-essential hydrolase involved in mRNA decapping GO:0000290;GO:0005515;GO:0016787 YLR270W DCS1 "Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p" Scavenger mRNA-decapping enzyme DcpS PAS_3g01525 CAY70313.1 PAS_chr3_0274 R-SNARE protein GO:0006810 YLR268W SEC22 "R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog" Protein transport protein SEC22 PAS_3g01530 CAY70314.1 PAS_chr3_0275 Protein of unknown function YOR166C SWT1 "RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain" Transcriptional protein SWT1 PAS_3g01535 CAY70315.1 PAS_chr3_0276 Hypothetical protein PAS_3g01540 CAY70316.1 PAS_chr3_0277 6-phosphogluconate dehydrogenase (decarboxylating) YGR256W GND2 "6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone" "6-phosphogluconate dehydrogenase, decarboxylating " PAS_3g01545 CAY70317.1 PAS_chr3_0278 Protein with similarity to monocarboxylate permeases YNL125C ESBP6 "Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane" Uncharacterized transporter ESBP6 PAS_3g01550 CAY70318.1 PAS_chr3_0279 "Protein of unknown function, contains two predicted GTP-binding motifs" YOR165W SEY1 "GTPase with a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; possible functional ortholog of mammalian atlastins, defects in which cause a form of hereditary spastic paraplegia; homolog of Arabidopsis RHD3" Protein SEY1 PAS_3g01555 CAY70319.1 PAS_chr3_0280 Protein of unknown function YOR164C GET4 "Protein of unknown function, highly conserved across species and homologous to human gene C7orf20; interacts with Mdy2p; genetic interactions predict a role in insertion of tail-anchored proteins into the ER membrane" Golgi to ER traffic protein 4 PAS_3g01560 CAY70320.1 PAS_chr3_0281 Polyphosphate phosphatase GO:0016787 YOR163W DDP1 Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases Diphosphoinositol polyphosphate phosphohydrolase DDP1 PAS_3g01565 CAY70321.1 PAS_chr3_1174 hypothetical protein GO:0003735;GO:0005622;GO:0005840;GO:0006412 40S ribosomal protein S28 PAS_3g01570 CAY70322.1 PAS_chr3_0282 Plasma membrane transporter for both urea and polyamines GO:0005215;GO:0006810;GO:0016020 Probable urea active transporter 3 PAS_3g01575 CAY70323.1 PAS_chr3_0283 Putative amidase GO:0016884 YDR242W AMD2 Putative amidase Putative amidase PB8B6.03 PAS_3g01580 CAY70324.1 PAS_chr3_0284 Hypothetical protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 Zinc finger protein grt1 PAS_3g01585 CAY70325.1 PAS_chr3_0285 Glutamine tRNA synthetase GO:0000166;GO:0004819;GO:0005524;GO:0005737;GO:0006412;GO:0006425 YOR168W GLN4 "Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions" Glutaminyl-tRNA synthetase PAS_3g01590 CAY70326.1 PAS_chr3_0286 Hypothetical protein Uncharacterized protein DDB_G0271670 PAS_3g01595 CAY70327.1 PAS_chr3_0287 "Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patch" YDL222C FMP45 Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C SUR7 family protein FMP45 PAS_3g01600 CAY70328.1 PAS_chr3_0288 Hypothetical protein Protein KRE1 (Fragment) PAS_3g01605 CAY70329.1 PAS_chr3_0289 Hypothetical protein PAS_3g01610 CAY70330.1 PAS_chr3_0290 Protein component of the small (40S) ribosomal subunit YLR287C-A RPS30A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein 40S ribosomal protein S30 PAS_3g01615 CAY70331.1 PAS_chr3_0291 Para hydroxybenzoate: polyprenyl transferase GO:0004659;GO:0016021 YNR041C COQ2 "Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis" "Para-hydroxybenzoate--polyprenyltransferase, mitochondrial " PAS_3g01620 CAY70332.1 PAS_chr3_1175 hypothetical protein YDR495C VPS3 "Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase" Vacuolar protein sorting-associated protein 3 PAS_3g01625 CAY70333.1 PAS_chr3_0292 Essential protein possibly involved in secretion GO:0005634;n/a YDR299W BFR2 Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock Protein BFR2 PAS_3g01630 CAY70334.1 PAS_chr3_1176 hypothetical protein YKL143W LTV1 "Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature" Protein LTV1 PAS_3g01635 CAY70335.1 PAS_chr3_0293 Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) YDL008W APC11 "Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition" Anaphase-promoting complex subunit 11 PAS_3g01640 CAY70336.1 PAS_chr3_0294 Gamma-glutamyl kinase GO:0004349;GO:0005737;GO:0006561 YDR300C PRO1 "Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis" Glutamate 5-kinase PAS_3g01645 CAY70337.1 PAS_chr3_0295 Vacuolar transporter YKL146W AVT3 "Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" Vacuolar amino acid transporter 4 PAS_3g01650 Uncharacterized transporter YDR338C PAS_3g01655 YHR034C PIH1 "Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)" Protein interacting with Hsp90 1 PAS_3g01660 CAY70338.1 PAS_chr3_0297 Hypothetical protein YHR159W YHR159W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate PAS_3g01665 CAY70339.1 PAS_chr3_0298 Protein required for proper cell fusion and cell morphology YHR158C KEL1 "Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate" Kelch repeat-containing protein 2 PAS_3g01670 CAY70340.1 PAS_chr3_0299 "Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor" GO:0004194;GO:0006508 Aspartic proteinase 3 PAS_3g01675 CAY70341.1 PAS_chr3_0300 "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p" GO:0005524;GO:0006457;GO:0051082 YJL008C CCT8 "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo" T-complex protein 1 subunit theta PAS_3g01680 CAY70342.1 PAS_chr3_0301 Component of the GARP (Golgi-associated retrograde protein) complex YJL029C VPS53 "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting" Vacuolar protein sorting-associated protein 53 PAS_3g01685 CAY70343.1 PAS_chr3_0302 Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli GO:0016491;GO:0050660 Glycine-rich cell wall structural protein PAS_3g01690 CAY70344.1 PAS_chr3_0303 "Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor" GO:0004190;GO:0006508 Barrierpepsin PAS_3g01695 PAS_3g01700 CAY70345.1 PAS_chr3_0305 Phosphatidyl Glycerol phospholipase C GO:0006071;GO:0008889 YPL206C PGC1 Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs Probable glycerophosphodiester phosphodiesterase YPL206C PAS_3g01705 CAY70346.1 PAS_chr3_0306 "1,3-beta-glucanosyltransferase" YLR343W GAS2 "1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p" "1,3-beta-glucanosyltransferase GAS2 " PAS_3g01710 CAY70347.1 PAS_chr3_0307 Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex) YGR033C TIM21 Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity Mitochondrial import inner membrane translocase subunit TIM21 PAS_3g01715 CAY70348.1 PAS_chr3_0308 Required for a post-incision step in the repair of DNA single and double-strand breaks YMR137C PSO2 Required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation DNA cross-link repair 1 protein PAS_3g01720 CAY70349.1 PAS_chr3_0309 Putative protein of unknown function YDR332W IRC3 Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Putative ATP-dependent helicase IRC3 PAS_3g01725 CAY70350.1 PAS_chr3_0310 UBX (ubiquitin regulatory X) domain-containing protein YDR330W UBX5 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p UBX domain-containing protein 5 PAS_3g01730 CAY70351.1 PAS_chr3_0311 Hypothetical protein PAS_3g01735 CAY70352.1 PAS_chr3_0312 Component of the ESCRT-II complex GO:0005622;GO:0008270 YLR417W VPS36 Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome PAS_3g01740 CAY70353.1 PAS_chr3_0313 Component of the RAM signaling network GO:0005488 YKL189W HYM1 "Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response" Calcium-binding protein 39 PAS_3g01745 CAY70354.1 PAS_chr3_0315 "Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron c" Siderophore iron transporter mirA PAS_3g01750 CAY70355.1 PAS_chr3_0316 Cytoplasmic GTP binding protein GO:0005525;GO:0005634;GO:0005737 YML121W GTR1 "Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB" GTP-binding protein GTR1 PAS_3g01755 CAY70356.1 PAS_chr3_0317 Farnesyl-diphosphate farnesyl transferase (squalene synthase) GO:0009058;GO:0016740 YHR190W ERG9 "Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway" Squalene synthase PAS_3g01760 CAY70357.1 PAS_chr3_0318 Hypothetical protein PAS_3g01765 CAY70358.1 PAS_chr3_0319 Hypothetical protein "Probable methyltransferase DDB_G0287769, mitochondrial " PAS_3g01770 CAY70359.1 PAS_chr3_0320 Tubulin folding factor D GO:0005488 YOR349W CIN1 Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl Tubulin-specific chaperone D PAS_3g01775 CAY70360.1 PAS_chr3_0321 Hypothetical protein PAS_3g01780 CAY70361.1 PAS_chr3_0322 Essential type II topoisomerase GO:0003677;GO:0003918;GO:0005524;GO:0005694;GO:0006265 YNL088W TOP2 "Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis" DNA topoisomerase 2 PAS_3g01785 CAY70362.1 PAS_chr3_0324 Component of the commitment complex GO:0003676;GO:0008270 YLR116W MSL5 "Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA" Branchpoint-bridging protein PAS_3g01790 CAY70363.1 PAS_chr3_0325 Essential splicesome assembly factor YLR117C CLF1 "Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins" Pre-mRNA-splicing factor CLF1 PAS_3g01795 CAY70364.1 PAS_chr3_0326 Hypothetical protein Vacuolar protein sorting/targeting protein pep1 PAS_3g01800 CAY70365.1 PAS_chr3_0327 "Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in" Vacuolar protein sorting/targeting protein PEP1 PAS_3g01805 CAY70366.1 PAS_chr3_0328 Hypothetical protein YPL189C-A COA2 Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p PAS_3g01810 CAY70367.1 PAS_chr3_0329 Subunit of the telomeric Ku complex (Yku70p-Yku80p) GO:0003677;GO:0004003;GO:0005634;GO:0005958;GO:0006303 YMR284W YKU70 "Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair" ATP-dependent DNA helicase II subunit 1 PAS_3g01815 CAY70368.1 PAS_chr3_0330 Trans-aconitate methyltransferase GO:0008152;GO:0008168 YER175C TMT1 "Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle" Putative methyltransferase DDB_G0268948 PAS_3g01820 CAY70369.1 PAS_chr3_0331 Protein involved in bud-site selection and required for axial budding pattern YJR092W BUD4 Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate Bud site selection protein BUD4 PAS_3g01825 CAY70370.1 PAS_chr3_0332 Hypothetical protein GO:0006118;GO:0016491 Putative dioxygenase C576.01c PAS_3g01830 CAY70371.1 PAS_chr3_0333 Subunit of cleavage polyadenylation factor (CPF) YJR093C FIP1 "Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity" Pre-mRNA polyadenylation factor FIP1 PAS_3g01835 CAY70372.1 PAS_chr3_0334 Hypothetical protein PAS_3g01840 CAY70373.1 PAS_chr3_0335 "Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YJR094W-A RPL43B "Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein" 60S ribosomal protein L43 PAS_3g01845 CAY70374.1 PAS_chr3_0336 Hypothetical protein PAS_3g01850 PAS_3g01855 CAY70375.1 PAS_chr3_0337 Hypothetical protein YKL096W CWP1 "Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization; required for propionic acid resistance" PAS_3g01860 CAY70376.1 PAS_chr3_0338 Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen YPR037C ERV2 "Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER" FAD-linked sulfhydryl oxidase ERV2 PAS_3g01865 CAY70377.1 PAS_chr3_0339 "Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2" YPR040W TIP41 "Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway" Type 2A phosphatase activator TIP41 PAS_3g01870 CAY70378.1 PAS_chr3_1177 hypothetical protein GO:0005097;GO:0005622;GO:0032313 YHL029C OCA5 "Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts" Uncharacterized protein YHL029C PAS_3g01875 CAY70379.1 PAS_chr3_0340 Subunit of the core complex of translation initiation factor 3(eIF3) GO:0005097;GO:0005622;GO:0032313 YBR079C RPG1 "eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes" Eukaryotic translation initiation factor 3 subunit A PAS_3g01880 CAY70380.1 PAS_chr3_0341 Hypothetical protein PAS_3g01885 CAY70381.1 PAS_chr3_0342 ATPase required for the release of Sec17p GO:0005524 YBR080C SEC18 ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF Vesicular-fusion protein SEC18 PAS_3g01890 CAY70382.1 PAS_chr3_1178 hypothetical protein PAS_3g01895 CAY70383.1 PAS_chr3_0343 Hypothetical protein PAS_3g01900 CAY70384.1 PAS_chr3_1179 hypothetical protein YLR033W RSC58 "Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance" Chromatin structure-remodeling complex protein RSC58 PAS_3g01905 CAY70385.1 PAS_chr3_0344 Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP YMR128W ECM16 "Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis" Probable ATP-dependent RNA helicase DHR1 PAS_3g01910 CAY70386.1 PAS_chr3_0345 Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p) YMR127C SAS2 "Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family" Histone acetyltransferase SAS2 PAS_3g01915 CAY70387.1 PAS_chr3_0346 DNA helicase YLR032W RAD5 DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p DNA repair protein RAD5 PAS_3g01920 CAY70388.1 PAS_chr3_0347 Serine/threonine protein kinase involved in regulation of exocytosis GO:0004674;GO:0006468 YLR096W KIN2 Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p Serine/threonine protein kinase KIN1 PAS_3g01925 CAY70389.1 PAS_chr3_0348 Hypothetical protein GO:0005634;GO:0030528;GO:0045449 Uncharacterized protein DDB_G0271670 PAS_3g01930 CAY70390.1 PAS_chr3_0349 NADP(+)-dependent dehydrogenase GO:0008152;GO:0016491 YMR226C YMR226C "NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments" Uncharacterized oxidoreductase YMR226C PAS_3g01935 CAY70391.1 PAS_chr3_1180 hypothetical protein YDR125C ECM18 "Protein of unknown function, similar to Rlp24p" 1-acylglycerol-3-phosphate O-acyltransferase ICT1 PAS_3g01940 CAY70392.1 PAS_chr3_0350 Ferric reductase and cupric reductase GO:0005506;GO:0006118;GO:0016021;GO:0016491;GO:0050660 Probable ferric reductase transmembrane component PAS_3g01945 CAY70393.1 PAS_chr3_0351 Putative protein of unknown function YDR124W YDR124W Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor Uncharacterized protein YDR124W PAS_3g01950 CAY70394.1 PAS_chr3_0352 Putative SCF-ubiquitin ligase F-box protein YLR097C HRT3 "Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies" F-box protein HRT3 PAS_3g01955 CAY70395.1 PAS_chr3_0353 Hypothetical protein YBL049W MOH1 "Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase" Protein yippee-like MOH1 PAS_3g01960 CAY70396.1 PAS_chr3_0354 Phosphatidylinositol 3-phosphate [PI(3)P] phosphatase GO:0004437;GO:0046839 YJR110W YMR1 "Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family" Probable phosphoinositide 3-phosphatase PAS_3g01965 CAY70397.1 PAS_chr3_0355 Putative protein of unknown function YJR111C YJR111C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria Uncharacterized protein YJR111C PAS_3g01970 CAY70398.1 PAS_chr3_0356 Hypothetical protein PAS_3g01975 CAY70399.1 PAS_chr3_0357 ceramide glucosyltransferase GO:0005783 Ceramide glucosyltransferase PAS_3g01980 CAY70400.1 PAS_chr3_0358 Hypothetical protein PAS_3g01985 CAY70401.1 PAS_chr3_0359 Ubiquitin-conjugating enzyme (E2) GO:0019787;GO:0043687;GO:0051246 YGL058W RAD6 "Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p" Ubiquitin-conjugating enzyme E2 2 PAS_3g01990 CAY70402.1 PAS_chr3_0360 Mitochondrial protein kinase GO:0005524 YGL059W PKP2 Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p Probable protein kinase YGL059W PAS_3g01995 CAY70403.1 PAS_chr3_0361 Nicotinamidase GO:0003824;GO:0008152 YGL037C PNC1 "Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span" Nicotinamidase PAS_3g02000 CAY70404.1 PAS_chr3_1181 hypothetical protein YJR044C VPS55 Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP) Vacuolar protein sorting-associated protein 55 PAS_3g02005 CAY70405.1 PAS_chr3_0362 Hypothetical protein YJL066C MPM1 "Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches" PAS_3g02010 CAY70406.1 PAS_chr3_0363 Conserved ubiquitin-like modifier GO:0000045;GO:0005737 YBR217W ATG12 Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation Autophagy-related protein 12 PAS_3g02015 CAY70407.1 PAS_chr3_0364 Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p YGL060W YBP2 Central kinetochore associated protein that mediates mitotic progression; interacts with several central kinetochore proteins and the centromeric histone Cse4p; role in resistance to oxidative stress; similarity to Ybp1p and Slk19p YAP1-binding protein 2 PAS_3g02020 CAY70408.1 PAS_chr3_1182 hypothetical protein YBR215W HPC2 "Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes" Histone promoter control protein 2 PAS_3g02025 CAY70409.1 PAS_chr3_0365 Mitochondrial matrix ATPase YJR045C SSC1 "Hsp70 family ATPase, constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease" "Heat shock protein SSC1, mitochondrial " PAS_3g02030 CAY70410.1 PAS_chr3_0366 Hypothetical protein 1-aminocyclopropane-1-carboxylate oxidase 1 PAS_3g02035 CAY70411.1 PAS_chr3_0367 Hypothetical protein YJR046W TAH11 "DNA replication licensing factor, required for pre-replication complex assembly" PAS_3g02040 CAY70412.1 PAS_chr3_0368 "P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis" GO:0004601;GO:0006118;GO:0006979;GO:0020037 YEL031W SPF1 "P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1" Probable cation-transporting ATPase 1 PAS_3g02045 CAY70413.1 PAS_chr3_0369 Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) GO:0005789;GO:0006506;GO:0016021;GO:0016746 YJL091C GWT1 "Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors" GPI-anchored wall transfer protein 1 PAS_3g02050 CAY70414.1 PAS_chr3_0370 "Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose" GO:0003700;GO:0005622;GO:0006355;GO:0043565 YBR015C MNN2 "Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment" Protein TTP1 PAS_3g02055 CAY70415.1 PAS_chr3_0371 Delta(24)-sterol C-methyltransferase GO:0008152;GO:0008168 YML008C ERG6 "Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane" Sterol 24-C-methyltransferase PAS_3g02060 CAY70416.1 PAS_chr3_0372 Putative vacuolar Fe2+/Mn2+ transporter YLR220W CCC1 "Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation" Protein CCC1 PAS_3g02065 PAS_3g02070 CAY70417.1 PAS_chr3_0374 Hypothetical protein GO:0005515 PAS_3g02075 CAY70418.1 PAS_chr3_0375 Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation GO:0004674;GO:0006468 YPR161C SGV1 Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p Serine/threonine-protein kinase BUR1 PAS_3g02080 CAY70419.1 PAS_chr3_1183 hypothetical protein PAS_3g02085 CAY70420.1 PAS_chr3_0376 Cytoplasmic and mitochondrial glycyl-tRNA synthase GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YBR121C GRS1 Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation Glycyl-tRNA synthetase 1 PAS_3g02090 CAY70421.1 PAS_chr3_1184 hypothetical protein GO:0010181;GO:0016491 Probable NADPH dehydrogenase PAS_3g02095 CAY70422.1 PAS_chr3_0377 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) GO:0010181;GO:0016491 YPL171C OYE3 "Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; expression induced in cells treated with the mycotoxin patulin" Probable NADPH dehydrogenase PAS_3g02100 CAY70423.1 PAS_chr3_0378 Peptidyl-prolyl cis-trans isomerase (cyclophilin) YJR032W CPR7 "Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity" Peptidyl-prolyl cis-trans isomerase CYP7 PAS_3g02105 CAY70424.1 PAS_chr3_0379 Hypothetical protein PAS_3g02110 CAY70425.1 PAS_chr3_0380 Hypothetical protein GO:0005488;GO:0006810;GO:0016020 PAS_3g02115 CAY70426.1 PAS_chr3_0381 Orotidine-5'-phosphate (OMP) decarboxylase GO:0004590;GO:0006207 YEL021W URA3 "Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound" Orotidine 5'-phosphate decarboxylase PAS_3g02120 CAY70427.1 PAS_chr3_0382 Mitochondrial intermembrane space protein GO:0006626;GO:0042719;GO:0045039 YEL020W-A TIM9 "Essential protein of the mitochondrial intermembrane space, forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane" Mitochondrial import inner membrane translocase subunit TIM9 PAS_3g02125 CAY70428.1 PAS_chr3_0383 Hypothetical protein Myb-like protein X PAS_3g02130 CAY70429.1 PAS_chr3_0384 Hypothetical protein YEL019C MMS21 SUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination E3 SUMO-protein ligase NSE2 PAS_3g02135 CAY70430.1 PAS_chr3_0385 3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome GO:0003824;GO:0005524;GO:0008152 YGR195W SKI6 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4) Exosome complex component SKI6 PAS_3g02140 CAY70431.1 PAS_chr3_0386 "Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I" YJR013W GPI14 "Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M" GPI mannosyltransferase 1 PAS_3g02145 CAY70432.1 PAS_chr3_1185 hypothetical protein YJR014W TMA22 "Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1" Translation machinery-associated protein 22 PAS_3g02150 CAY70433.1 PAS_chr3_0387 Putative protein of unknown function YPL067C YPL067C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene Uncharacterized protein YPL067C PAS_3g02155 CAY70434.1 PAS_chr3_0388 Methionine aminopeptidase GO:0004239;GO:0006508 YLR244C MAP1 "Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p" Methionine aminopeptidase 1 PAS_3g02160 CAY70435.1 PAS_chr3_0389 Hypothetical protein YDR201W SPC19 "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body" DASH complex subunit SPC19 PAS_3g02165 CAY70436.1 PAS_chr3_0390 "Subunit of RAVE (Rav1p, Rav2p, Skp1p)" YDR202C RAV2 "Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme" PAS_3g02170 CAY70437.1 PAS_chr3_1186 hypothetical protein GO:0005488 YDR180W SCC2 "Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin" Sister chromatid cohesion protein 2 PAS_3g02175 CAY70438.1 PAS_chr3_0391 Catalytic epsilon subunit of the translation initiation factor eIF2B GO:0005488 YDR211W GCD6 "Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression" Translation initiation factor eIF-2B subunit epsilon PAS_3g02180 CAY70439.1 PAS_chr3_0392 Putative nucleotide sugar transporter YML038C YMD8 "Putative nucleotide sugar transporter, has similarity to Vrg4p" Solute carrier family 35 member C2 PAS_3g02185 CAY70440.1 PAS_chr3_0393 Transcription factor GO:0003676;GO:0005622;GO:0008270 YHR006W STP2 "Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes" Transcription factor STP2 PAS_3g02190 CAY70441.1 PAS_chr3_0394 Putative GPI-anchored aspartic protease GO:0004194;GO:0006508 YDR349C YPS7 "Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum" Aspartic proteinase yapsin-7 PAS_3g02195 CAY70442.1 PAS_chr3_0395 Hypothetical protein GO:0005622 YDR217C RAD9 "DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate" DNA repair protein rhp9 PAS_3g02200 CAY70443.1 PAS_chr3_0396 Hypothetical protein PAS_3g02205 CAY70444.1 PAS_chr3_0397 Component of the septin ring of the mother-bud neck that is required for cytokinesis GO:0005525;GO:0007049 Cell division control protein 11 PAS_3g02210 CAY70445.1 PAS_chr3_1187 hypothetical protein YLR226W BUR2 Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II Cyclin pch1 PAS_3g02215 CAY70446.1 PAS_chr3_0398 Translation termination factor eRF3 GO:0003747;GO:0005525;GO:0006415 YDR172W SUP35 "Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype" Eukaryotic peptide chain release factor GTP-binding subunit PAS_3g02220 CAY70447.1 PAS_chr3_0399 Minor sphingoid long-chain base kinase GO:0003824;GO:0005488;GO:0008152 YLR260W LCB5 "Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules" Sphingoid long chain base kinase 5 PAS_3g02225 CAY70448.1 PAS_chr3_1188 hypothetical protein GO:0003824;GO:0005488;GO:0008152 "NADH-ubiquinone oxidoreductase 40 kDa subunit, mitochondrial " PAS_3g02230 CAY70449.1 PAS_chr3_0400 Hypothetical protein YNL253W TEX1 "Protein involved in mRNA export, component of the transcription export (TREX) complex" PAS_3g02235 CAY70450.1 PAS_chr3_0401 Hypothetical protein YBR162W-A YSY6 Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion Protein YSY6 PAS_3g02240 CAY70451.1 PAS_chr3_0402 Mitochondrial matrix ATPase "Heat shock protein SSC1, mitochondrial " PAS_3g02245 CAY70452.1 PAS_chr3_0403 Acetyl-coA synthetase isoform GO:0003824;GO:0008152 YLR153C ACS2 "Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions" Acetyl-coenzyme A synthetase 2 PAS_3g02250 CAY70453.1 PAS_chr3_0404 Putative protein of unknown function YKL069W YKL069W "Methionine-R-sulfoxide reductase, reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress" Free methionine-R-sulfoxide reductase PAS_3g02255 CAY70454.1 PAS_chr3_0405 Hypothetical protein PAS_3g02260 CAY70455.1 PAS_chr3_0406 D-aspartate oxidase GO:0003884 D-amino-acid oxidase PAS_3g02265 CAY70456.1 PAS_chr3_0407 Putative transcription factor containing a zinc finger GO:0003677;GO:0005634;GO:0006350;GO:0008270 YOL089C HAL9 Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression Halotolerance protein 9 PAS_3g02270 CAY70457.1 PAS_chr3_0408 Hypothetical protein GO:0005740;GO:0007585 "Alternative oxidase, mitochondrial " PAS_3g02275 CAY70458.1 PAS_chr3_0409 Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane GO:0006885;GO:0015299;GO:0016021 YLR138W NHA1 Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH Na(+)/H(+) antiporter PAS_3g02280 CAY70459.1 PAS_chr3_0410 L-ornithine transaminase (OTAse) GO:0003824;GO:0030170 YLR438W CAR2 "L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive" Ornithine aminotransferase PAS_3g02285 CAY70460.1 PAS_chr3_0411 Hypothetical protein PAS_3g02290 CAY70461.1 PAS_chr3_0412 Hypothetical protein YLR436C ECM30 Non-essential protein of unknown function UPF0663 protein C17A5.16 PAS_3g02295 CAY70462.1 PAS_chr3_0413 Protein with a potential role in pre-rRNA processing YLR435W TSR2 Protein with a potential role in pre-rRNA processing Pre-rRNA-processing protein TSR2 PAS_3g02300 CAY70463.1 PAS_chr3_0414 Calcineurin A GO:0016787 YML057W CMP2 "Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1" Serine/threonine-protein phosphatase 2B catalytic subunit A1 PAS_3g02305 CAY70464.1 PAS_chr3_0415 Hypothetical protein PAS_3g02310 CAY70465.1 PAS_chr3_0416 Hypothetical protein YKL183W LOT5 Protein of unknown function; gene expression increases in cultures shifted to a lower temperature Protein LOT5 PAS_3g02315 CAY70466.1 PAS_chr3_0417 Ornithine decarboxylase GO:0003824 YKL184W SPE1 "Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation" Ornithine decarboxylase PAS_3g02320 CAY70467.1 PAS_chr3_0418 Zinc-finger inhibitor of HO transcription GO:0003700;GO:0005634;GO:0006355;GO:0008270;GO:0043565 YKL185W ASH1 "Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate" Transcriptional regulatory protein ASH1 PAS_3g02325 CAY70468.1 PAS_chr3_0419 Putative metalloprotease with similarity to the zinc carboxypeptidase family GO:0004182;GO:0006508;GO:0008270 YHR132C ECM14 "Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly" Protein ECM14 PAS_3g02330 CAY70469.1 PAS_chr3_0420 Hypothetical protein YDR138W HPR1 "Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p" Nucleolar protein 58 PAS_3g02335 CAY70470.1 PAS_chr3_0421 Member of an oxysterol-binding protein family with seven members in S. cerevisiae YHR073W OSH3 "Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability" Oxysterol-binding protein homolog 3 PAS_3g02340 CAY70471.1 PAS_chr3_0422 Hypothetical protein PAS_3g02345 CAY70472.1 PAS_chr3_0423 Putative membrane protein of unknown function involved in Mn2+ homeostasis GO:0016787 Cell division control protein 1 PAS_3g02350 CAY70473.1 PAS_chr3_0424 "Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p)" GO:0005506;GO:0005740;GO:0006099;GO:0006118;GO:0016021;GO:0020037 "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial " PAS_3g02355 CAY70474.1 PAS_chr3_1189 hypothetical protein YHR103W SBE22 Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth Protein SBE22 PAS_3g02360 CAY70475.1 PAS_chr3_0425 Sphinganine C4-hydroxylase GO:0003824;GO:0008152 YDR297W SUR2 "Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis" Sphingolipid C4-hydroxylase SUR2 PAS_3g02365 CAY70476.1 PAS_chr3_0426 Protein involved in homologous recombination in mitochondria and in transcription regulation in nucl YDR296W MHR1 Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus; binds to activation domains of acidic activators; required for recombination-dependent mtDNA partitioning Mitochondrial homologous recombination protein 1 PAS_3g02370 CAY70477.1 PAS_chr3_0427 Hypothetical protein YHR078W YHR078W High osmolarity-regulated gene of unknown function GPCR-type G protein 2 PAS_3g02375 CAY70478.1 PAS_chr3_0428 Protein required for cytochrome c oxidase assembly YLL018C-A COX19 "Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs" Cytochrome c oxidase assembly protein COX19 PAS_3g02380 CAY70479.1 PAS_chr3_1190 hypothetical protein GO:0005741;GO:0006886;GO:0015450 YNL070W TOM7 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex Mitochondrial import receptor subunit TOM7 PAS_3g02385 CAY70480.1 PAS_chr3_0429 Protein required for transport of flavin adenine dinucleotide (FAD) GO:0005741;GO:0006886;GO:0015450 YIL134W FLX1 "Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane" Mitochondrial FAD carrier protein FLX1 PAS_3g02390 CAY70481.1 PAS_chr3_0431 Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC) GO:0005198 YGL172W NUP49 "Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes" Nucleoporin NUP49/NSP49 PAS_3g02395 CAY70482.1 PAS_chr3_0432 Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies GO:0003676;GO:0004527;GO:0005622 YGL173C KEM1 "Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance" 5'-3' exoribonuclease 1 PAS_3g02400 CAY70483.1 PAS_chr3_0433 Subunit of the RES complex YGL174W BUD13 "Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern" Pre-mRNA-splicing factor CWC26 PAS_3g02405 CAY70484.1 PAS_chr3_0434 Mitochondrial amino acid transporter GO:0005488;GO:0006810;GO:0016020 YPR021C AGC1 "Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis" Mitochondrial aspartate-glutamate transporter AGC1 PAS_3g02410 CAY70485.1 PAS_chr3_0435 Hypothetical protein YGL175C SAE2 Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents PAS_3g02415 CAY70486.1 PAS_chr3_0436 Putative protein of unknown function GO:0003676;GO:0005622;GO:0008270 YPR022C YPR022C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS Zinc finger protein YPR022C PAS_3g02420 PAS_3g02425 CAY70487.1 PAS_chr3_0438 "Member of the PUF protein family, which is defined by the presence of Pumilio homology domains" GO:0005488 Pumilio domain-containing protein C6G9.14 PAS_3g02430 PAS_3g02435 CAY70488.1 PAS_chr3_0440 Lactate transporter YKL217W JEN1 "Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose" Carboxylic acid transporter protein homolog PAS_3g02440 YJL121C RPE1 "D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress" Ribulose-phosphate 3-epimerase PAS_3g02445 PAS_3g02450 CAY70489.1 PAS_chr3_0442 Lsm (Like Sm) protein GO:0016071;GO:0030529 YJL124C LSM1 "Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs" Sm-like protein LSm1 PAS_3g02455 CAY70490.1 PAS_chr3_0443 Subunit of tRNA (1-methyladenosine) methyltransferase YJL125C GCD14 "Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression" tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61 PAS_3g02460 CAY70491.1 PAS_chr3_0444 Hypothetical protein GO:0003824 UPF0613 protein PB24D3.06c PAS_3g02465 CAY70492.1 PAS_chr3_0445 Hypothetical protein PAS_3g02470 CAY70493.1 PAS_chr3_0446 Putative dihydrokaempferol 4-reductase GO:0003824;GO:0005488;GO:0008152 Putative uncharacterized oxidoreductase YDR541C PAS_3g02475 CAY70494.1 PAS_chr3_0447 Putative dihydrokaempferol 4-reductase GO:0003824;GO:0005488;GO:0008152 Putative uncharacterized oxidoreductase YDR541C PAS_3g02480 CAY70495.1 PAS_chr3_0448 Putative dihydrokaempferol 4-reductase GO:0006808;GO:0016564 Putative uncharacterized oxidoreductase YDR541C PAS_3g02485 CAY70496.1 PAS_chr3_0449 Putative dihydrokaempferol 4-reductase GO:0006808;GO:0016564 Putative uncharacterized oxidoreductase YDR541C PAS_3g02490 CAY70497.1 PAS_chr3_0450 Alpha 4 subunit of the 20S proteasome GO:0004298;GO:0005839;GO:0006511 YOL038W PRE6 Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress Proteasome component PRE6 PAS_3g02495 YIR015W RPR2 "Subunit of nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits" Ribonuclease P protein subunit rpr2 PAS_3g02500 CAY70498.1 PAS_chr3_0451 Mitochondrial outer membrane protein GO:0005741;GO:0006810 YOL026C MIM1 "Mitochondrial outer membrane protein, required for assembly of the translocase of the outer membrane (TOM) complex and thereby for mitochondrial protein import; N terminus is exposed to the cytosol: transmembrane segment is highly conserved" Mitochondrial import protein 1 PAS_3g02505 CAY70499.1 PAS_chr3_0452 Sensor of mitochondrial dysfunction YGL252C RTG2 "Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p" Retrograde regulation protein 2 PAS_3g02510 CAY70500.1 PAS_chr3_0453 Subunit (90 kDa) of TFIID and SAGA complexes GO:0005634;GO:0030528;GO:0045449 YBR198C TAF5 "Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification" Transcription initiation factor TFIID subunit 5 PAS_3g02515 CAY70501.1 PAS_chr3_0454 Hypothetical protein GO:0006506;GO:0016021;GO:0017176 YPL076W GPI2 "Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein" Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit PAS_3g02520 CAY70502.1 PAS_chr3_0455 Hypothetical protein PAS_3g02525 CAY70503.1 PAS_chr3_0456 Glycolytic enzyme phosphoglucose isomerase GO:0004347;GO:0006094;GO:0006096 YBR196C PGI1 "Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation" Glucose-6-phosphate isomerase PAS_3g02530 CAY70504.1 PAS_chr3_1191 hypothetical protein YBR195C MSI1 "Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46" Probable histone-binding protein rbbD PAS_3g02535 CAY70505.1 PAS_chr3_0457 "Essential, non-ATPase regulatory subunit of the 26S proteasome" YPR108W RPN7 "Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits" 26S proteasome regulatory subunit RPN7 PAS_3g02540 CAY70506.1 PAS_chr3_1192 hypothetical protein GO:0004396;GO:0005524;GO:0006096 YGL253W HXK2 Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene Hexokinase PAS_3g02545 CAY70507.1 PAS_chr3_0458 Essential component of the Arp2/3 complex GO:0004396;GO:0005524;GO:0006096 YDL029W ARP2 "Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity" Actin-related protein 2 PAS_3g02550 CAY70508.1 PAS_chr3_0459 Dual-specificity kinase GO:0004674;GO:0006468 YDL028C MPS1 "Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p" Serine/threonine-protein kinase MPS1 PAS_3g02555 CAY70509.1 PAS_chr3_0460 Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase YPL078C ATP4 "Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated" "ATP synthase subunit 4, mitochondrial " PAS_3g02560 CAY70510.1 PAS_chr3_0461 Hypothetical protein YBR194W AIM4 "Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress" PAS_3g02565 CAY70511.1 PAS_chr3_0462 Cytoplasmic alanyl-tRNA synthetase GO:0003676 YOR335C ALA1 "Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog" "Alanyl-tRNA synthetase, cytoplasmic " PAS_3g02570 CAY70512.1 PAS_chr3_0463 Hypothetical protein PAS_3g02575 CAY70513.1 PAS_chr3_0464 Putative protein of unknown function YNR021W YNR021W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene UPF0674 endoplasmic reticulum membrane protein YNR021W PAS_3g02580 CAY70514.1 PAS_chr3_0465 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YCR046C IMG1 "Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome" "54S ribosomal protein IMG1, mitochondrial " PAS_3g02585 CAY70515.1 PAS_chr3_0466 Protein involved in bud-site selection GO:0008152;GO:0008168 YCR047C BUD23 "Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern" Putative methyltransferase BUD23 PAS_3g02590 CAY70516.1 PAS_chr3_0467 "Acyl-CoA:sterol acyltransferase, isozyme of Are1p" YNR019W ARE2 "Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen" Sterol O-acyltransferase 2 PAS_3g02595 CAY70517.1 PAS_chr3_0468 Putative metalloprotease of the mitochondrial inner membrane GO:0006508;GO:0008237;GO:0008270 YNR020C ATP23 "Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex" Mitochondrial inner membrane protease ATP23 PAS_3g02600 CAY70518.1 PAS_chr3_0469 Signal transducing MEK kinase GO:0004672;GO:0005524;GO:0006468 YLR362W STE11 "Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p" Protein kinase byr2 PAS_3g02605 CAY70519.1 PAS_chr3_0470 Hypothetical protein YLR137W YLR137W Putative S-adenosylmethionine-dependent methyltransferase Diaminohydroxyphosphoribosylamino-pyrimidine deaminase PAS_3g02610 CAY70520.1 PAS_chr3_0471 Aspartic beta semi-aldehyde dehydrogenase GO:0004073;GO:0008652;GO:0050661 YDR158W HOM2 "Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis" Aspartate-semialdehyde dehydrogenase PAS_3g02615 CAY70521.1 PAS_chr3_0472 Hypothetical protein Protein PXR1 PAS_3g02620 CAY70522.1 PAS_chr3_0473 Hypothetical protein GO:0003735;GO:0005622;GO:0005840;GO:0006412 YDR115W YDR115W "Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins" "54S ribosomal protein L34, mitochondrial " PAS_3g02625 CAY70523.1 PAS_chr3_0474 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YDR116C MRPL1 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L1, mitochondrial " PAS_3g02630 CAY70524.1 PAS_chr3_0475 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex YDR434W GPI17 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog GPI transamidase component PIG-S homolog PAS_3g02635 CAY70525.1 PAS_chr3_0476 Protein of unknown function that associates with ribosomes GO:0003723 YDR117C TMA64 Protein of unknown function that associates with ribosomes; has a putative RNA binding domain Translation machinery-associated protein 64 PAS_3g02640 CAY70526.1 PAS_chr3_0477 Hypothetical protein YDR118W APC4 "Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition" Anaphase-promoting complex subunit 4 PAS_3g02645 CAY70527.1 PAS_chr3_0478 Hypothetical protein PAS_3g02650 CAY70528.1 PAS_chr3_0479 Hypothetical protein PAS_3g02655 CAY70529.1 PAS_chr3_0480 "Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p" GO:0006457;GO:0031072;GO:0051082 YLR090W XDJ1 "Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" DnaJ homolog subfamily A member 2 PAS_3g02660 CAY70530.1 PAS_chr3_0482 Putative alanine transaminase (glutamic pyruvic transaminase) GO:0003824;GO:0030170 YLR089C ALT1 "Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" "Probable alanine aminotransferase, mitochondrial " PAS_3g02665 CAY70531.1 PAS_chr3_1193 hypothetical protein Serine/threonine-protein kinase PRP4 homolog PAS_3g02670 CAY70532.1 PAS_chr3_0483 Conserved phosphoesterase domain-containing protein GO:0016787 YIL039W TED1 Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Protein TED1 PAS_3g02675 CAY70533.1 PAS_chr3_0484 Putative protein of unknown function GO:0003676;GO:0005622;GO:0008270 Zinc finger protein YPR022C PAS_3g02680 CAY70534.1 PAS_chr3_0485 Cytoplasmic protein required for cytoplasm to vacuole targeting of proteins YDR200C VPS64 Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; localizes to the cytoplasm and endoplasmic reticulum membrane Vacuolar protein sorting-associated protein 64 PAS_3g02685 CAY70535.1 PAS_chr3_0486 Hypothetical protein Glycoprotein gp2 PAS_3g02690 PAS_3g02695 CAY70536.1 PAS_chr3_0488 Bud-specific protein with a potential role in membrane trafficking GO:0003824;GO:0030170 YOR086C TCB1 "Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact" Tricalbin-1 PAS_3g02700 CAY70537.1 PAS_chr3_1194 hypothetical protein GO:0003824;GO:0030170 YLR231C BNA5 "Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p" Kynureninase PAS_3g02705 CAY70538.1 PAS_chr3_0489 High affinity sulfate permease GO:0008271;GO:0008272;GO:0016020 YBR294W SUL1 "High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates" Sulfate permease 2 PAS_3g02710 CAY70539.1 PAS_chr3_0490 Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type GO:0003700;GO:0005634;GO:0006355;GO:0008270 Arginine metabolism regulation protein II PAS_3g02715 PAS_3g02720 CAY70540.1 PAS_chr3_0492 Hypothetical protein PAS_3g02725 CAY70541.1 PAS_chr3_0493 Hypothetical protein GO:0015986;GO:0016020;GO:0016469;GO:0046933;GO:0046961 Proline utilization trans-activator PAS_3g02730 CAY70542.1 PAS_chr3_0494 Hypothetical protein PAS_3g02735 CAY70543.1 PAS_chr3_0495 Low-affinity phosphate transporter of the vacuolar membrane GO:0000287;GO:0004427;GO:0005737;GO:0006796 YNR013C PHO91 "Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth" Uncharacterized transporter C3B8.04c PAS_3g02740 CAY70544.1 PAS_chr3_0496 RNA-dependent ATPase in the DEAH-box family YNR011C PRP2 "RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing" Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein cdc28 PAS_3g02745 CAY70545.1 PAS_chr3_0497 Hypothetical protein GO:0005515 Leucine-rich repeat-containing protein 8B PAS_3g02750 CAY70546.1 PAS_chr3_0498 Actin-associated protein Intersectin-1 PAS_3g02755 CAY70547.1 PAS_chr3_0499 Hypothetical protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 PAS_3g02760 CAY70548.1 PAS_chr3_0500 Hypothetical protein Uncharacterized protein MJ0590 PAS_3g02765 CAY70549.1 PAS_chr3_0501 Hypothetical protein PAS_3g02770 PAS_3g02775 CAY70550.1 PAS_chr3_0503 Zinc finger transcriptional activator of the Zn2Cys6 family GO:0003700;GO:0005634;GO:0006355;GO:0008270 YDR421W ARO80 Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids Transcriptional activator ARO80 PAS_3g02780 CAY70551.1 PAS_chr3_1195 hypothetical protein YOR266W PNT1 "Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine" PAS_3g02785 CAY70552.1 PAS_chr3_0504 Hypothetical protein GO:0008152;GO:0016491 PAS_3g02790 CAY70553.1 PAS_chr3_0505 Putative protein of unknown function YOR338W YOR338W Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen SWIRM domain-containing protein YOR338W PAS_3g02795 CAY70554.1 PAS_chr3_0506 Pentafunctional arom protein GO:0003824 YDR127W ARO1 "Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids" Pentafunctional AROM polypeptide PAS_3g02800 CAY70555.1 PAS_chr3_0507 C-22 sterol desaturase GO:0004497;GO:0005506;GO:0006118;GO:0020037 YMR015C ERG5 "C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs" Cytochrome P450 61 PAS_3g02805 CAY70556.1 PAS_chr3_1196 hypothetical protein PAS_3g02810 CAY70557.1 PAS_chr3_0508 Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins YKL124W SSH4 "Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases" Protein SSH4 PAS_3g02815 CAY70558.1 PAS_chr3_0509 Hypothetical protein PAS_3g02820 CAY70559.1 PAS_chr3_0510 Hypothetical protein "2',3'-cyclic-nucleotide 2'-phosphodiesterase " PAS_3g02825 CAY70560.1 PAS_chr3_0511 Choline/ethanolamine transporter GO:0006810;GO:0016020 YGL077C HNM1 Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol Choline transport protein PAS_3g02830 CAY70561.1 PAS_chr3_0512 Mg<sup>2+</sup>-dependent phosphatidate (PA) phosphatase Nuclear elongation and deformation protein 1 PAS_3g02835 CAY70562.1 PAS_chr3_0513 Hypothetical protein 26S proteasome non-ATPase regulatory subunit 7 PAS_3g02840 CAY70563.1 PAS_chr3_0514 Hypothetical protein Nucleolar and coiled-body phosphoprotein 1 PAS_3g02845 CAY70564.1 PAS_chr3_0515 "Subunit of the alpha-1,6 mannosyltransferase complex" YEL036C ANP1 "Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol" Mannan polymerase II complex ANP1 subunit PAS_3g02850 CAY70565.1 PAS_chr3_0516 High-affinity zinc transporter of the plasma membrane GO:0016020;GO:0030001;GO:0046873 Zinc-regulated transporter 2 PAS_3g02855 CAY70566.1 PAS_chr3_0517 Putative GPI-anchored protein YOL154W ZPS1 "Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH" pH-regulated antigen PRA1 PAS_3g02860 CAY70567.1 PAS_chr3_0518 Predicted cytoskeleton protein YEL043W YEL043W "Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold" Uncharacterized protein YEL043W PAS_3g02865 CAY70568.1 PAS_chr3_0519 Permease of basic amino acids in the vacuolar membrane YBR293W VBA2 Permease of basic amino acids in the vacuolar membrane Multidrug resistance protein fnx1 PAS_3g02870 CAY70569.1 PAS_chr3_0520 Putative mitochondrial ribosomal protein of the small subunit GO:0003723;GO:0003735;GO:0005622;GO:0005840;GO:0006412 YNL081C SWS2 "Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency" "37S ribosomal protein SWS2, mitochondrial " PAS_3g02875 CAY70570.1 PAS_chr3_0521 Protein involved in ubiquitin ligation YNL116W DMA2 "Protein involved in ubiquitination; plays a role in regulating spindle position and orientation; functionally redundant with Dma1p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr" E3 ubiquitin-protein ligase DMA2 PAS_3g02880 CAY70571.1 PAS_chr3_0522 Putative protein of unknown function YNL115C YNL115C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene Uncharacterized vacuolar membrane protein SCY_4679 PAS_3g02885 CAY70572.1 PAS_chr3_0523 Putative protein of unknown function GO:0003824;GO:0008152 YOR093C YOR093C Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents Uncharacterized protein C56F8.02 PAS_3g02890 CAY70573.1 PAS_chr3_0524 Essential component of the nuclear pore complex Dentin sialophosphoprotein PAS_3g02895 CAY70574.1 PAS_chr3_0525 Hypothetical protein PAS_3g02900 CAY70575.1 PAS_chr3_0526 Protein with a role in regulation of Ty1 transposition YNL206C RTT106 "Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition" Histone chaperone RTT106 PAS_3g02905 CAY70576.1 PAS_chr3_0527 Hypothetical protein PAS_3g02910 CAY70577.1 PAS_chr3_0528 "Saccharopine dehydrogenase (NADP+, L-glutamate-forming)" GO:0003824;GO:0005488;GO:0008152 YNR050C LYS9 "Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112" "Saccharopine dehydrogenase [NADP+, L-glutamate-forming] " PAS_3g02915 CAY70578.1 PAS_chr3_0529 Hypothetical protein PAS_3g02920 CAY70579.1 PAS_chr3_0530 Hypothetical protein PAS_3g02925 CAY70580.1 PAS_chr3_0531 GDP dissociation inhibitor GO:0005093;GO:0015031 YER136W GDI1 "GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins" Rab GDP-dissociation inhibitor PAS_3g02930 CAY70581.1 PAS_chr3_0532 Intermediate filament protein GO:0007242 YML104C MDM1 "Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)" Structural protein MDM1 PAS_3g02935 CAY70582.1 PAS_chr3_0533 Hypothetical protein PAS_3g02940 CAY70583.1 PAS_chr3_0534 "Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER" GO:0006614;GO:0008312;GO:0048500 YML105C SEC65 "Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19" Signal recognition particle SEC65 subunit PAS_3g02945 CAY70584.1 PAS_chr3_1197 hypothetical protein GO:0016740 YML106W URA5 "Major orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; minor OPRTase encoded by URA10" Orotate phosphoribosyltransferase 1 PAS_3g02950 CAY70585.1 PAS_chr3_0535 Sphingolipid alpha-hydroxylase GO:0016740 YMR272C SCS7 "Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth" Ceramide very long chain fatty acid hydroxylase SCS7 PAS_3g02955 CAY70586.1 PAS_chr3_0536 Hypothetical protein GO:0005149;GO:0005576;GO:0006955 PAS_3g02960 CAY70587.1 PAS_chr3_0537 Peripheral mitochondrial membrane protein involved in mitochondrial protein import GO:0005744;GO:0006886;GO:0015450 YIL022W TIM44 Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex) Mitochondrial import inner membrane translocase subunit TIM44 PAS_3g02965 CAY70588.1 PAS_chr3_0538 Ubiquitin-protein ligase of the ER/nuclear envelope GO:0008270 YIL030C SSM4 Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation ERAD-associated E3 ubiquitin-protein ligase DOA10 PAS_3g02970 PAS_3g02975 CAY70589.1 PAS_chr3_0540 Subunit of the cohesin complex YIL026C IRR1 "Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability" Cohesin subunit psc3 PAS_3g02980 CAY70590.1 PAS_chr3_0541 Hypothetical protein YIL027C KRE27 "Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance" PAS_3g02985 Uncharacterized protein C1919.03c PAS_3g02990 CAY70591.1 PAS_chr3_0543 Zinc transporter GO:0016020;GO:0030001;GO:0046873 YIL023C YKE4 "Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family" Zinc transporter SLC39A7 PAS_3g02995 CAY70592.1 PAS_chr3_0544 Component of the RSC chromatin remodeling complex GO:0008270 YFR037C RSC8 "Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters" SWI/SNF and RSC complexes subunit ssr1 PAS_3g03000 CAY70593.1 PAS_chr3_0545 Putative ATPase containing the DEAD/H helicase-related sequence motif GO:0003677;GO:0005524 YFR038W IRC5 Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci Uncharacterized ATP-dependent helicase YFR038W PAS_3g03005 CAY70594.1 PAS_chr3_0546 Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) YIL033C BCY1 "Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation" cAMP-dependent protein kinase regulatory subunit PAS_3g03010 CAY70595.1 PAS_chr3_0547 Endoplasmic reticulum membrane protein GO:0016021 YER044C ERG28 "Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p" Ergosterol biosynthetic protein 28 PAS_3g03015 CAY70596.1 PAS_chr3_0548 Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) GO:0003779;GO:0008290;GO:0030036 YIL034C CAP2 Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches F-actin-capping protein subunit beta PAS_3g03020 CAY70597.1 PAS_chr3_0549 Alpha' catalytic subunit of casein kinase 2 Casein kinase II subunit alpha PAS_3g03025 CAY70598.1 PAS_chr3_1198 hypothetical protein PAS_3g03030 CAY70599.1 PAS_chr3_0550 "Meiosis-specific protein of unknown function, required for spore wall formation during sporulation" YER046W SPO73 "Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis" PAS_3g03035 CAY70600.1 PAS_chr3_0551 Vacuolar membrane protein of unknown function YCR023C YCR023C Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene Uncharacterized membrane protein YCR023C PAS_3g03040 CAY70601.1 PAS_chr3_0552 UDP-glucose:dolichyl-phosphate glucosyltransferase YPL227C ALG5 "UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum" Dolichyl-phosphate beta-glucosyltransferase PAS_3g03045 CAY70602.1 PAS_chr3_1199 hypothetical protein NADH-ubiquinone oxidoreductase 21.3 kDa subunit PAS_3g03050 CAY70603.1 PAS_chr3_0553 Hypothetical protein PAS_3g03055 CAY70604.1 PAS_chr3_0554 Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes GO:0003676;n/a YML081W YML081W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene Zinc finger protein ZMS1 PAS_3g03060 PAS_3g03065 CAY70605.1 PAS_chr3_0557 Hypothetical protein Putative leucine-rich repeat-containing protein DDB_G0290503 PAS_3g03070 CAY70606.1 PAS_chr3_0558 Putative protein of unknown function GO:0008168 YJR129C YJR129C Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Uncharacterized protein YJR129C PAS_3g03075 CAY70607.1 PAS_chr3_0559 ADP-ribosylation factor GTPase activating protein (ARF GAP) GO:0008060;GO:0008270;GO:0032312 YER122C GLO3 "ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p" ADP-ribosylation factor GTPase-activating protein GLO3 PAS_3g03080 CAY70608.1 PAS_chr3_0560 "Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway" PAS_3g03085 YOR188W MSB1 "Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4" Morphogenesis-related protein MSB1 PAS_3g03090 CAY70609.1 PAS_chr3_0561 Gamma-glutamyltranspeptidase GO:0003840 YLR299W ECM38 "Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation" Gamma-glutamyltransferase PAS_3g03095 CAY70610.1 PAS_chr3_0562 Mitochondrial translation elongation factor Tu GO:0003924;GO:0005525 YOR187W TUF1 "Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans" "Elongation factor Tu, mitochondrial " PAS_3g03100 CAY70611.1 PAS_chr3_0563 Hypothetical protein PAS_3g03105 CAY70612.1 PAS_chr3_0564 Beta subunit of the translation initiation factor eIF2B GO:0044237 YLR291C GCD7 "Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression" Translation initiation factor eIF-2B subunit beta PAS_3g03110 CAY70613.1 PAS_chr3_0565 Hypothetical protein YLR288C MEC3 "DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1" PAS_3g03115 CAY70614.1 PAS_chr3_0566 3-phosphoserine aminotransferase GO:0003824;GO:0030170 YOR184W SER1 "3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p" Phosphoserine aminotransferase PAS_3g03120 CAY70615.1 PAS_chr3_0567 Peptidyl-prolyl cis-trans isomerase (cyclophilin) YLR216C CPR6 "Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity" Peptidyl-prolyl cis-trans isomerase D PAS_3g03125 CAY70616.1 PAS_chr3_0568 RNA polymerase II largest subunit B220 GO:0003677;GO:0003899;GO:0006350 YDL140C RPO21 "RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime" DNA-directed RNA polymerase II subunit RPB1 PAS_3g03130 CAY70617.1 PAS_chr3_0569 "Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin" GO:0004077;GO:0006464 YDL141W BPL1 "Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation" Biotin--protein ligase PAS_3g03135 CAY70618.1 PAS_chr3_0570 Cardiolipin synthase GO:0008654;GO:0016020;GO:0016780 YDL142C CRD1 "Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis" Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c PAS_3g03140 CAY70619.1 PAS_chr3_0571 "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p" GO:0005524;GO:0006457;GO:0051082 YDL143W CCT4 "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo" T-complex protein 1 subunit delta PAS_3g03145 CAY70620.1 PAS_chr3_0572 Protein involved in nutritional control of the cell cycle YLR215C CDC123 Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein Cell division cycle protein 123 PAS_3g03150 CAY70621.1 PAS_chr3_0573 Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing GO:0006364;GO:0032040 YDL153C SAS10 Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced Something about silencing protein 10 PAS_3g03155 CAY70622.1 PAS_chr3_0574 Hypothetical protein GO:0003677;GO:0003899;GO:0005666;GO:0006383;n/a YDL150W RPC53 RNA polymerase III subunit C53 DNA-directed RNA polymerase III subunit RPC4 PAS_3g03160 CAY70623.1 PAS_chr3_0575 Cyclin associated with protein kinase Kin28p YPR025C CCL1 "Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters" Cyclin CCL1 PAS_3g03165 CAY70624.1 PAS_chr3_0576 Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase GO:0015078;GO:0016469 YBL099W ATP1 "Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated" "ATP synthase subunit alpha, mitochondrial " PAS_3g03170 CAY70625.1 PAS_chr3_0577 Hypothetical protein Uncharacterized protein C167.05 PAS_3g03175 CAY70626.1 PAS_chr3_0578 "Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function" GO:0016787 YLR151C PCD1 "Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids" "Peroxisomal coenzyme A diphosphatase 1, peroxisomal " PAS_3g03180 CAY70627.1 PAS_chr3_0579 Mitochondrial glycerol-3-phosphate dehydrogenase GO:0004368;GO:0006072;GO:0009331 YIL155C GUT2 "Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner" "Glycerol-3-phosphate dehydrogenase, mitochondrial " PAS_3g03185 PAS_3g03190 CAY70628.1 PAS_chr3_0581 3'-5' exoribonuclease involved in rRNA processing GO:0003723 YHR069C RRP4 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) Exosome complex component RRP4 PAS_3g03195 CAY70629.1 PAS_chr3_0582 Zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance YPR094W RDS3 "Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance" Uncharacterized protein At1g07170/At2g30000 PAS_3g03200 CAY70630.1 PAS_chr3_0583 Protein that contains a Phox homology (PX) domain and binds phosphoinositides GO:0005515;GO:0007154;GO:0035091 YPR097W YPR097W "Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" PX domain-containing protein YPR097W PAS_3g03205 CAY70631.1 PAS_chr3_0584 Component of the TOM (translocase of outer membrane) complex YGR082W TOM20 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins Mitochondrial import receptor subunit TOM20 PAS_3g03210 PAS_3g03215 CAY70632.1 PAS_chr3_0585 Hypothetical protein GO:0006120;GO:0008137 "NADH-ubiquinone oxidoreductase 19.3 kDa subunit, mitochondrial " PAS_3g03220 CAY70633.1 PAS_chr3_0586 "Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p" GO:0005084;GO:0006886 YOR370C MRS6 "Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene" Rab proteins geranylgeranyltransferase component A PAS_3g03225 CAY70634.1 PAS_chr3_1200 hypothetical protein YOR369C RPS12 Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12 40S ribosomal protein S12 PAS_3g03230 CAY70635.1 PAS_chr3_0587 "Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints" GO:0003684;GO:0004527;GO:0005634;GO:0006281 YOR368W RAD17 "Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins" DNA damage checkpoint control protein RAD17 PAS_3g03235 CAY70636.1 PAS_chr3_0588 Peroxisome assembly protein 22 Peroxisome assembly protein 22 PAS_3g03240 CAY70637.1 PAS_chr3_0589 Component of yeast cortical actin cytoskeleton YOR367W SCP1 "Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin" Transgelin PAS_3g03245 CAY70638.1 PAS_chr3_0590 Homeodomain-containing transcriptional repressor of PTR2 GO:0003677;GO:0045449 YPL177C CUP9 "Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription" Homeobox protein CUP9 PAS_3g03250 CAY70639.1 PAS_chr3_0591 Cytosolic L-asparaginase GO:0004067;GO:0006528 YDR321W ASP1 "Cytosolic L-asparaginase, involved in asparagine catabolism" L-asparaginase 2 PAS_3g03255 Molybdenum cofactor sulfurase PAS_3g03260 CAY70640.1 PAS_chr3_0593 tRNA methyltransferase YKR056W TRM2 "tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair" tRNA (uracil-5-)-methyltransferase PAS_3g03265 CAY70641.1 PAS_chr3_0594 "F-box protein containing five copies of the WD40 motif, controls cell cycle function" YIL046W MET30 "F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus" F-box protein MET30 PAS_3g03270 CAY70642.1 PAS_chr3_0595 "Translation initiation factor eIF4A, identical to Tif1p" YJL138C TIF2 "Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G" ATP-dependent RNA helicase eIF4A PAS_3g03275 CAY70643.1 PAS_chr3_0596 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YKR057W RPS21A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein 40S ribosomal protein S21 PAS_3g03280 CAY70644.1 PAS_chr3_0597 Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate GO:0003824;GO:0016020 YJL134W LCB3 "Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids" Dihydrosphingosine 1-phosphate phosphatase LCB3 PAS_3g03285 CAY70645.1 PAS_chr3_0598 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins GO:0005525;GO:0005622;GO:0007264 YKR055W RHO4 "Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity" GTP-binding protein rho4 PAS_3g03290 CAY70646.1 PAS_chr3_0599 "Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex" YJL194W CDC6 "Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p" Cell division control protein 6 homolog PAS_3g03295 CAY70647.1 PAS_chr3_0600 Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit YCR033W SNT1 "Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein" Probable DNA-binding protein SNT1 PAS_3g03300 CAY70648.1 PAS_chr3_0601 Hypothetical protein PAS_3g03305 CAY70649.1 PAS_chr3_0602 Fatty acid elongase GO:0016021 YCR034W FEN1 "Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway" Elongation of fatty acids protein 2 PAS_3g03310 CAY70650.1 PAS_chr3_0603 Protein involved in rRNA processing GO:0000175;GO:0003723;GO:0006396 YCR035C RRP43 "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8)" Exosome complex component RRP43 PAS_3g03315 CAY70651.1 PAS_chr3_0604 Putative ribokinase YCR036W RBK1 Putative ribokinase Probable ribokinase PAS_3g03320 CAY70652.1 PAS_chr3_0605 Ubiquitin carboxyl-terminal hydrolase GO:0004221;GO:0006511 YJL197W UBP12 "Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins" Ubiquitin carboxyl-terminal hydrolase 12 PAS_3g03325 CAY70653.1 PAS_chr3_0606 PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins YCR032W BPH1 "PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting" Beige protein homolog 1 PAS_3g03330 CAY70654.1 PAS_chr3_0607 Hypothetical protein GO:0030246 PAS_3g03335 CAY70655.1 PAS_chr3_0608 Protein serine/threonine phosphatase with similarity to human phosphatase PP5 GO:0016787 YGR123C PPT1 Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing Serine/threonine-protein phosphatase T PAS_3g03340 CAY70656.1 PAS_chr3_0609 Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme GO:0004651;GO:0005634;GO:0006370 YPL228W CET1 "Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide" mRNA-capping enzyme subunit beta PAS_3g03345 CAY70657.1 PAS_chr3_0610 Hypothetical protein PAS_3g03350 PAS_3g03355 Cell wall protein DAN4 PAS_3g03360 CAY70658.1 PAS_chr3_0612 "Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p" GO:0005488 YNL189W SRP1 "Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation" Importin subunit alpha PAS_3g03365 CAY70659.1 PAS_chr3_0613 Putative protein of unknown function with similarity to phosphoserine phosphatases YNL010W YNL010W Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation Uncharacterized phosphatase YNL010W PAS_3g03370 CAY70660.1 PAS_chr3_1201 hypothetical protein YKR105C VBA5 Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny Vacuolar basic amino acid transporter 5 PAS_3g03375 CAY70661.1 PAS_chr3_0614 Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat YIL109C SEC24 "Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p" Protein transport protein SEC24 PAS_3g03380 CAY70662.1 PAS_chr3_0615 Subunit Va of cytochrome c oxidase GO:0004129;GO:0006118 YNL052W COX5A "Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth" "Cytochrome c oxidase polypeptide 5A, mitochondrial " PAS_3g03385 CAY70663.1 PAS_chr3_0616 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family YIL110W MNI1 "Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect, enhanced resistance to caspofungin, and is synthetically lethal with MEN mutants" Mitotic exit network interactor 1 PAS_3g03390 CAY70664.1 PAS_chr3_1202 hypothetical protein YNL051W COG5 "Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" Conserved oligomeric Golgi complex subunit 5 PAS_3g03395 YNL050C YNL050C Putative protein of unknown function; YNL050c is not an essential gene Protein PXR1 PAS_3g03400 YIL112W HOS4 "Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate" Ankyrin repeat domain-containing protein 11 PAS_3g03405 CAY70665.1 PAS_chr3_0618 Dual-specificity protein phosphatase GO:0006470;GO:0008138 YNL053W MSG5 "Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p" Tyrosine-protein phosphatase MSG5 PAS_3g03410 CAY70666.1 PAS_chr3_0619 Hypothetical protein GO:0016491;GO:0051536 "NADH-ubiquinone oxidoreductase 23 kDa subunit, mitochondrial " PAS_3g03415 CAY70667.1 PAS_chr3_0620 "Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis" YJR075W HOC1 "Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele" Putative glycosyltransferase HOC1 PAS_3g03420 YNL054W VAC7 Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock Vacuolar segregation protein 7 PAS_3g03425 CAY70668.1 PAS_chr3_0622 "tRNA ligase, required for tRNA splicing" GO:0003972;GO:0005524;GO:0006388 YJL087C TRL1 "tRNA ligase, required for tRNA splicing; composed of three essential domains containing the phosphodiesterase, polynucleotide kinase, and ligase activities required for ligation; localized at the inner membrane of the nuclear envelope" tRNA ligase PAS_3g03430 CAY70669.1 PAS_chr3_0623 Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase) GO:0006323 YJL088W ARG3 "Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine" "Ornithine carbamoyltransferase, mitochondrial " PAS_3g03435 CAY70670.1 PAS_chr3_0624 Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity YJL187C SWE1 Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate Mitosis inhibitor protein kinase SWE1 PAS_3g03440 CAY70671.1 PAS_chr3_0625 Transcriptional repressor involved in response to pH and in cell wall construction GO:0003676 YHL027W RIM101 Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC pH-response transcription factor pacC/RIM101 PAS_3g03445 CAY70672.1 PAS_chr3_0626 ER membrane protein YHL028W WSC4 ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3 Uncharacterized protein DDB_G0271670 PAS_3g03450 CAY70673.1 PAS_chr3_0627 Protein that binds to cruciform DNA structures YHR146W CRP1 Protein that binds to cruciform DNA structures Uncharacterized protein YHR146W PAS_3g03455 CAY70674.1 PAS_chr3_1203 hypothetical protein YFR003C YPI1 "Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen" Type 1 phosphatases regulator YPI1 PAS_3g03460 CAY70675.1 PAS_chr3_0628 Hypothetical protein PAS_3g03465 CAY70676.1 PAS_chr3_1204 hypothetical protein GO:0005643;GO:0006810 YFR002W NIC96 "Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p" Nucleoporin NIC96 PAS_3g03470 CAY70677.1 PAS_chr3_0629 Conserved nuclear protein required to establish sister-chromatid pairing during S-phase GO:0003676;GO:0005524;GO:0006139;GO:0008026;GO:0016818;n/a YPL008W CHL1 "Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p" ATP-dependent RNA helicase CHL1 PAS_3g03475 CAY70678.1 PAS_chr3_0630 Hypothetical protein YDR315C IPK1 "Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable" Inositol-pentakisphosphate 2-kinase PAS_3g03480 CAY70679.1 PAS_chr3_0631 Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis YHR067W HTD2 "Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology" "Hydroxyacyl-thioester dehydratase type 2, mitochondrial " PAS_3g03485 CAY70680.1 PAS_chr3_0632 tRNA(m(1)G37)methyltransferase YHR070W TRM5 "tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya" tRNA (guanine-N(1)-)-methyltransferase PAS_3g03490 CAY70681.1 PAS_chr3_1205 hypothetical protein YOL076W MDM20 "Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly" N-terminal acetyltransferase B complex subunit MDM20 PAS_3g03495 CAY70682.1 PAS_chr3_0633 Putative serine type carboxypeptidase with a role in phytochelatin synthesis GO:0004185;GO:0006508 YBR139W YBR139W "Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner" Putative serine carboxypeptidase YBR139W PAS_3g03500 CAY70683.1 PAS_chr3_0634 Tryptophan synthase involved in tryptophan biosynthesis GO:0003824;GO:0008152;GO:0030170 Tryptophan synthase beta chain 1 PAS_3g03505 CAY70684.1 PAS_chr3_0635 Calpain-like cysteine protease GO:0004198;GO:0005622;GO:0006508 YMR154C RIM13 Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB Calpain-like protease palB/RIM13 PAS_3g03510 CAY70685.1 PAS_chr3_0636 Beta subunit of the CAAX farnesyltransferase (FTase) GO:0003824 YDL090C RAM1 Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit Protein farnesyltransferase subunit beta PAS_3g03515 CAY70686.1 PAS_chr3_0637 Hypothetical protein YPR075C OPY2 Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone PAS_3g03520 CAY70687.1 PAS_chr3_0638 "Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex" GO:0005622;GO:0043565 YOR358W HAP5 "Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex" Transcriptional activator HAP5 PAS_3g03525 CAY70688.1 PAS_chr3_0639 Sorting nexin GO:0005515;GO:0007154;GO:0035091 YOR357C SNX3 Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p Sorting nexin-3 PAS_3g03530 CAY70689.1 PAS_chr3_0640 "Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase" YLR178C TFS1 Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase Carboxypeptidase Y inhibitor PAS_3g03535 CAY70690.1 PAS_chr3_0641 "Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF" YAL043C PTA1 "Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII" Pre-tRNA-processing protein PTA1 PAS_3g03540 CAY70691.1 PAS_chr3_0642 "Subunit of the SF3a splicing factor complex, required for spliceosome assembly" GO:0003676;GO:0005622;GO:0008270 YDL030W PRP9 "Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex" Pre-mRNA-splicing factor PRP9 PAS_3g03545 CAY70692.1 PAS_chr3_0643 "Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1-cotransporter family" GO:0006810;GO:0016020 YBR235W YBR235W "Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene" Uncharacterized membrane protein YBR235W PAS_3g03550 CAY70693.1 PAS_chr3_0644 "RNA helicase in the DEAD-box family, necessary for prespliceosome formation" YBR237W PRP5 "RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA" Pre-mRNA-processing ATP-dependent RNA helicase prp5 PAS_3g03555 YBR236C ABD1 "Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA" mRNA cap guanine-N7 methyltransferase PAS_3g03560 CAY70694.1 PAS_chr3_0646 "Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine" YKR031C SPO14 "Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis" Phospholipase D1 PAS_3g03565 CAY70695.1 PAS_chr3_0647 "Fumarase, converts fumaric acid to L-malic acid in the TCA cycle" GO:0003824 YPL262W FUM1 "Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria" "Fumarate hydratase, mitochondrial " PAS_3g03570 CAY70696.1 PAS_chr3_0648 "Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate" GO:0006118;GO:0016491 YGR144W THI4 "Thiazole synthase, catalyzes formation of a thiazole intermediate during thiamine biosynthesis; required for mitochondrial genome stability in response to DNA damaging agents" "Thiazole biosynthetic enzyme, mitochondrial " PAS_3g03575 CAY70697.1 PAS_chr3_0649 Transporter of thiamine or related compound GO:0015205;GO:0015931;GO:0016020 YOR192C THI72 Transporter of thiamine or related compound; shares sequence similarity with Thi7p Thiamine transporter THI72 PAS_3g03580 CAY70698.1 PAS_chr3_0651 RNA polymerase I subunit A49 GO:0003677;GO:0003899;GO:0005634;GO:0006350 YNL248C RPA49 RNA polymerase I subunit A49 DNA-directed RNA polymerase I subunit RPA49 PAS_3g03585 CAY70699.1 PAS_chr3_0652 NAP family histone chaperone GO:0005634;GO:0006334 YNL246W VPS75 "NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair" Vacuolar protein sorting-associated protein 75 PAS_3g03590 CAY70700.1 PAS_chr3_0653 Type I transmembrane sorting receptor for multiple vacuolar hydrolases GO:0016021 Vacuolar protein sorting/targeting protein PEP1 PAS_3g03595 CAY70701.1 PAS_chr3_0654 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C GO:0005524 YMR078C CTF18 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint Chromosome transmission fidelity protein 18 PAS_3g03600 CAY70702.1 PAS_chr3_0655 Phosphatidylinositol/phosphatidylcholine transfer protein YMR079W SEC14 "Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; functionally homologous to mammalian PITPs" SEC14 cytosolic factor PAS_3g03605 CAY70703.1 PAS_chr3_0656 GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns GO:0005622;GO:0007165 YKL092C BUD2 GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types Inhibitory regulator protein BUD2/CLA2 PAS_3g03610 CAY70704.1 PAS_chr3_0657 "ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for" YMR080C NAM7 ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance ATP-dependent helicase NAM7 PAS_3g03615 CAY70705.1 PAS_chr3_1206 hypothetical protein PAS_3g03620 PAS_3g03625 CAY70706.1 PAS_chr3_0659 Putative mitochondrial aconitase isozyme GO:0008152 YJL200C ACO2 "Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol" Probable aconitate hydratase 2 PAS_3g03630 CAY70707.1 PAS_chr3_0660 GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns GO:0005085;GO:0005622;GO:0007264 YCR038C BUD5 GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types Bud site selection protein 5 PAS_3g03635 CAY70708.1 PAS_chr3_0661 Putative protein of unknown function YPR084W YPR084W Putative protein of unknown function Uncharacterized protein YPR084W PAS_3g03640 CAY70709.1 PAS_chr3_0662 Ferrioxamine B transporter YEL065W SIT1 "Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p" Siderophore iron transporter 1 PAS_3g03645 CAY70710.1 PAS_chr3_0663 Hypothetical protein GO:0000166 U1 small nuclear ribonucleoprotein A PAS_3g03650 CAY70711.1 PAS_chr3_0664 Mitochondrial translational activator of the COB mRNA YBR120C CBP6 Mitochondrial translational activator of the COB mRNA; phosphorylated Cytochrome B pre-mRNA-processing protein 6 PAS_3g03655 CAY70712.1 PAS_chr3_0665 "17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing" YPR082C DIB1 "17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein" Mitosis protein dim1 PAS_3g03660 CAY70713.1 PAS_chr3_0666 Hypothetical protein YBR129C OPY1 "Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Rho GTPase-activating protein 22 PAS_3g03665 CAY70714.1 PAS_chr3_0667 "Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism" GO:0000103;GO:0005524;GO:0016301;GO:0016772 YKL001C MET14 "Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism" Adenylyl-sulfate kinase PAS_3g03670 CAY70715.1 PAS_chr3_1207 hypothetical protein YJR003C YJR003C Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis "Uncharacterized protein YJR003C, mitochondrial " PAS_3g03675 CAY70716.1 PAS_chr3_0668 Putative protein of unknown function Hydantoin utilization protein A PAS_3g03680 CAY70717.1 PAS_chr3_0669 Hypothetical protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 PAS_3g03685 CAY70718.1 PAS_chr3_0670 Cytoplasmic thioredoxin isoenzyme of the thioredoxin system Thioredoxin-like protein R548 PAS_3g03690 CAY70719.1 PAS_chr3_0671 Hypothetical protein YBR130C SHE3 Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance Uncharacterized protein YBR130C PAS_3g03695 CAY70720.1 PAS_chr3_0672 "Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis" YKL078W DHR2 "Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis" Probable ATP-dependent RNA helicase DHR2 PAS_3g03700 CAY70721.1 PAS_chr3_0673 Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway YOR008C SLG1 Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response Uncharacterized protein DDB_G0271670 PAS_3g03705 CAY70722.1 PAS_chr3_0674 "D-lactate dehydrogenase, located in the mitochondrial matrix" GO:0016491;GO:0050660 YDL178W DLD2 "D-lactate dehydrogenase, located in the mitochondrial matrix" "D-lactate dehydrogenase [cytochrome] 2, mitochondrial " PAS_3g03710 CAY70723.1 PAS_chr3_1208 hypothetical protein YPL260W YPL260W Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene UPF0662 protein YPL260W PAS_3g03715 CAY70724.1 PAS_chr3_0675 "Asparagine synthetase, isozyme of Asn1p" GO:0004066;GO:0006529 YGR124W ASN2 "Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway" Asparagine synthetase [glutamine-hydrolyzing] 2 PAS_3g03720 CAY70725.1 PAS_chr3_0676 UDP-N-acetylglucosamine pyrophosphorylase GO:0008152;GO:0016779 YDL103C QRI1 "UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis" UDP-N-acetylglucosamine pyrophosphorylase PAS_3g03725 CAY70726.1 PAS_chr3_0677 Hypothetical protein PAS_3g03730 CAY70727.1 PAS_chr3_0678 Protein that interacts with the karyopherin Srp1p YIR011C STS1 Protein that interacts with the karyopherin Srp1p; may have a role with Srp1p in ubiquitin-mediated protein degradation PAS_3g03735 CAY70728.1 PAS_chr3_0679 Hypothetical protein YBR255C-A YBR255C-A Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase); identified by sequence comparison with hemiascomycetous yeast species Uncharacterized protein YBR255C-A PAS_3g03740 CAY70729.1 PAS_chr3_0680 Hypothetical protein PAS_3g03745 CAY70730.1 PAS_chr3_0681 "RNA exonuclease, required for U4 snRNA maturation" YLR059C REX2 "3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease" "Oligoribonuclease, mitochondrial " PAS_3g03750 CAY70731.1 PAS_chr3_0682 Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae YCR095C OCA4 "Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts" Putative tyrosine-protein phosphatase OCA1 PAS_3g03755 CAY70732.1 PAS_chr3_0683 Essential nucleolar protein that is a component of the SSU (small subunit) processome YOR004W UTP23 "Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function" rRNA-processing protein UTP23 PAS_3g03760 CAY70733.1 PAS_chr3_0684 Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors YLR002C NOC3 Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation Nucleolar complex-associated protein 3 PAS_3g03765 CAY70734.1 PAS_chr3_0685 "Protein with similarity to Emp24p and Erv25p, member of the p24 family" YDL018C ERP3 "Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport" Uncharacterized membrane protein C17A5.08 PAS_3g03770 CAY70735.1 PAS_chr3_0686 Molybdenum cofactor biosynthesis protein GO:0006777 Molybdenum cofactor biosynthesis protein C PAS_3g03775 CAY70736.1 PAS_chr3_0687 Hypothetical protein GO:0003824;GO:0046872;GO:0051539 Molybdenum cofactor biosynthesis protein 1 PAS_3g03780 CAY70737.1 PAS_chr3_0688 E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway YNR007C ATG3 "E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt" Autophagy-related protein 3 PAS_3g03785 CAY70738.1 PAS_chr3_0689 Transcription factor that stimulates expression of proteasome genes GO:0003676;GO:0005622;GO:0008270 YDL020C RPN4 Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses Protein RPN4 PAS_3g03790 CAY70739.1 PAS_chr3_0690 Epsilon-COP subunit of the coatomer GO:0005198;GO:0005515;GO:0006461;GO:0006890;GO:0008565;GO:0030126 YIL076W SEC28 "Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth" Coatomer subunit epsilon PAS_3g03795 CAY70740.1 PAS_chr3_0691 Possible chaperone and cysteine protease with similarity to E. coli Hsp31 YDR533C HSP31 "Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site" Uncharacterized protein C757.03c PAS_3g03800 CAY70741.1 PAS_chr3_0692 Hypothetical protein GO:0003824;GO:0005488;GO:0008152 PAS_3g03805 CAY70742.1 PAS_chr3_0693 Tetrameric phosphoglycerate mutase GO:0006096;GO:0016868 Phosphoglycerate mutase PAS_3g03810 CAY70743.1 PAS_chr3_1209 hypothetical protein GO:0005634;GO:0030528;GO:0045449 Sterol regulatory element-binding protein 1 PAS_3g03815 CAY70744.1 PAS_chr3_0694 Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p YIR006C PAN1 "Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease" Actin cytoskeleton-regulatory complex protein PAN1 PAS_3g03820 PAS_3g03825 CAY70745.1 PAS_chr3_0696 Hypothetical protein Uncharacterized protein DDB_G0271670 PAS_3g03830 CAY70746.1 PAS_chr3_0697 Hypothetical protein Bypass of stop codon protein 1 PAS_3g03835 CAY70747.1 PAS_chr3_0698 Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase GO:0005524;GO:0005622;GO:0006355;GO:0008134 YAL048C GEM1 "Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death" Mitochondrial Rho GTPase 1 PAS_3g03840 CAY70748.1 PAS_chr3_0699 Alpha 7 subunit of the 20S proteasome GO:0004298;GO:0005839;GO:0006511 YOR362C PRE10 Alpha 7 subunit of the 20S proteasome Proteasome component C1 PAS_3g03845 CAY70749.1 PAS_chr3_0700 Hypothetical protein YAL047C SPC72 "Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization" PAS_3g03850 CAY70750.1 PAS_chr3_0701 "Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation" GO:0003723;GO:0003743;GO:0006413 YOR361C PRT1 "eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes" Eukaryotic translation initiation factor 3 subunit B PAS_3g03855 CAY70751.1 PAS_chr3_0702 Putative protein of unknown function YAL046C AIM1 Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss Uncharacterized bolA-like protein YAL046C PAS_3g03860 CAY70752.1 PAS_chr3_1210 hypothetical protein YOR329C SCD5 Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency Protein SCD5 PAS_3g03865 CAY70753.1 PAS_chr3_1211 hypothetical protein PAS_3g03870 CAY70754.1 PAS_chr3_0703 DNA polymerase gamma GO:0003677;GO:0005760;GO:0006260 YOR330C MIP1 "Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; related to human POLG, which has been associated with mitochondrial diseases" DNA polymerase gamma PAS_3g03875 CAY70755.1 PAS_chr3_0704 Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) GO:0016469;GO:0046961 YOR332W VMA4 "Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane" V-type proton ATPase subunit E PAS_3g03880 CAY70756.1 PAS_chr3_0705 Hypothetical protein YAL031C GIP4 Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate Uncharacterized serine/threonine-rich protein PB15E9.01c PAS_3g03885 CAY70757.1 PAS_chr3_0706 Mitochondrial inner membrane Mg(2+) channel GO:0016020;GO:0030001;GO:0046873 YOR334W MRS2 "Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns" Mitochondrial inner membrane magnesium transporter mrs2 PAS_3g03890 CAY70758.1 PAS_chr3_0707 RNA polymerase I subunit A43 GO:0003899;GO:0006350 YOR340C RPA43 RNA polymerase I subunit A43 DNA-directed RNA polymerase I subunit RPA43 PAS_3g03895 CAY70759.1 PAS_chr3_0708 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) GO:0000775;GO:0005634;GO:0007049;GO:0007067 YAL034W-A MTW1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly Kinetochore-associated protein MTW1 PAS_3g03900 CAY70760.1 PAS_chr3_0709 Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C GO:0019787;GO:0043687;GO:0051246 YOR339C UBC11 "Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2" Ubiquitin-conjugating enzyme E2-20 kDa PAS_3g03905 CAY70761.1 PAS_chr3_0710 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal protein GO:0019787;GO:0043687;GO:0051246 YDR059C UBC5 "Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible" Ubiquitin-conjugating enzyme E2 4 PAS_3g03910 YJL050W MTR4 "ATP-dependent 3'-5' RNA helicase, involved in nuclear RNA processing and degredation both as a component of the TRAMP complex and in TRAMP independent processes; member of the Dead-box family of helicases" ATP-dependent RNA helicase DOB1 PAS_3g03915 CAY70762.1 PAS_chr3_0712 Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors GO:0005634;GO:0030528;GO:0045449 YOR032C HMS1 Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant Sterol regulatory element-binding protein 1 PAS_3g03920 CAY70763.1 PAS_chr3_0713 "Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex" YBR081C SPT7 "Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex" Transcriptional activator SPT7 PAS_3g03925 CAY70764.1 PAS_chr3_0714 Putative divalent metal ion transporter involved in iron homeostasis GO:0005215;GO:0006810;GO:0016020 YLR034C SMF3 Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins Manganese transporter SMF2 PAS_3g03930 CAY70765.1 PAS_chr3_0715 Nuclear pore membrane glycoprotein YMR129W POM152 Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase; Nucleoporin POM152 PAS_3g03935 CAY70766.1 PAS_chr3_0716 Putative protein of unknown function GO:0000166 YLR243W YLR243W Putative protein of unknown function; YLR243W is an essential gene GPN-loop GTPase 3 homolog DEHA2G13222g PAS_3g03940 CAY70767.1 PAS_chr3_0717 Hypothetical protein PAS_3g03945 PAS_3g03950 YLR246W ERF2 "Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole" Palmitoyltransferase ERF2 PAS_3g03955 CAY70768.1 PAS_chr3_0721 Putative protein of unknown function that may be involved in intramitochondrial sorting YLR168C UPS2 "Mitochondrial intermembrane space protein involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI" Protein MSF1 PAS_3g03960 CAY70769.1 PAS_chr3_1212 hypothetical protein PAS_3g03965 CAY70770.1 PAS_chr3_0722 Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin GO:0004842;GO:0006512 YLR167W RPS31 Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B Ubiquitin-40S ribosomal protein S27a PAS_3g03970 CAY70771.1 PAS_chr3_1213 hypothetical protein YDR183W PLP1 "Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators" Phosducin-like protein 1 PAS_3g03975 CAY70772.1 PAS_chr3_0723 Hypothetical protein GO:0007242 YDR179W-A YDR179W-A Putative protein of unknown function PAS_3g03980 CAY70773.1 PAS_chr3_0724 Hypothetical protein GO:0001522;GO:0003723;GO:0009982 YLR165C PUS5 "Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability" Pseudouridylate synthase PUS5 PAS_3g03985 CAY70774.1 PAS_chr3_0725 Protein with a role in ubiquinone (Coenzyme Q) biosynthesis YDR204W COQ4 "Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex" "Ubiquinone biosynthesis protein COQ4, mitochondrial " PAS_3g03990 CAY70775.1 PAS_chr3_0726 Cytidine deaminase GO:0004126;GO:0046087 YLR245C CDD1 "Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm" Cytidine deaminase PAS_3g03995 CAY70776.1 PAS_chr3_0727 Hypothetical protein GO:0005515 YOR373W NUD1 "Component of the spindle pole body outer plaque, required for exit from mitosis" Septation initiation network scaffold protein cdc11 PAS_3g04000 CAY70777.1 PAS_chr3_0728 ATP binding cassette family member GO:0000785;GO:0003682;GO:0005634;GO:0006333 YPL226W NEW1 ATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction; homologous to mRNA export factor from S. pombe and similar protein from C. albicans [NU+] prion formation protein 1 PAS_3g04005 CAY70778.1 PAS_chr3_0729 Phosphotyrosine-specific protein phosphatase GO:0004725;GO:0006470 YDL230W PTP1 "Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria" Tyrosine-protein phosphatase non-receptor type 14 PAS_3g04010 CAY70779.1 PAS_chr3_0730 Hypothetical protein GO:0003723 YNL210W MER1 Protein with RNA-binding motifs required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination PAS_3g04015 CAY70780.1 PAS_chr3_0731 Cytoplasmic ATPase that is a ribosome-associated molecular chaperone YNL209W SSB2 "Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1" Heat shock protein SSB1 PAS_3g04020 CAY70781.1 PAS_chr3_0732 DNA ligase required for nonhomologous end-joining (NHEJ) GO:0005622 YOR005C DNL4 "DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth" DNA ligase 4 PAS_3g04025 CAY70782.1 PAS_chr3_0733 Component of serine palmitoyltransferase GO:0003824;GO:0030170 YDR062W LCB2 "Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine" Serine palmitoyltransferase 2 PAS_3g04030 CAY70783.1 PAS_chr3_0734 Hypothetical protein UPF0746 protein DDB_G0281095 PAS_3g04035 CAY70784.1 PAS_chr3_0735 "Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C)" GO:0003824;GO:0016020 YDR072C IPT1 "Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid;, can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin" Inositolphosphotransferase 1 PAS_3g04040 CAY70785.1 PAS_chr3_1214 hypothetical protein PAS_3g04045 CAY70786.1 PAS_chr3_0736 Putative protein of unknown function YLL007C YLL007C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene Uncharacterized protein YLL007C PAS_3g04050 CAY70787.1 PAS_chr3_0737 "TFIIE small subunit, involved in RNA polymerase II transcription initiation" GO:0003702;GO:0005673;GO:0006367 YKR062W TFA2 "TFIIE small subunit, involved in RNA polymerase II transcription initiation" Transcription initiation factor IIE subunit beta PAS_3g04055 CAY70788.1 PAS_chr3_0738 Nucleolar DEAD-box protein required for ribosome assembly and function YLL008W DRS1 "Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles" ATP-dependent RNA helicase DRS1 PAS_3g04060 CAY70789.1 PAS_chr3_0739 Protein involved in DNA mismatch repair and crossing-over during meiotic recombination GO:0005524 YPL164C MLH3 Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability DNA mismatch repair protein pms1 PAS_3g04065 PAS_3g04070 YLR017W MEU1 "Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression" Uncharacterized protein C16C9.02c PAS_3g04075 YLL003W SFI1 "Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C" PAS_3g04080 CAY70790.1 PAS_chr3_0741 Alpha subunit of the oligosaccharyltransferase complex of the ER lumen GO:0004579;GO:0005783;GO:0006486;GO:0016021 YJL002C OST1 "Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins" Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 PAS_3g04085 CAY70791.1 PAS_chr3_0742 Subunit of cleavage factor I (CFI) YOR250C CLP1 "Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation" Protein CLP1 PAS_3g04090 CAY70792.1 PAS_chr3_1215 hypothetical protein YJL004C SYS1 Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation Protein SYS1 PAS_3g04095 CAY70793.1 PAS_chr3_0743 "Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain" GO:0006807;GO:0016810 YLR351C NIT3 "Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member" Probable hydrolase NIT3 PAS_3g04100 CAY70794.1 PAS_chr3_0744 "Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism" GO:0016491 YHR104W GRE3 "Aldose reductase involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway" "NADPH-dependent D-xylose reductase II,III " PAS_3g04105 CAY70795.1 PAS_chr3_0745 Cytochrome c oxidase assembly protein/Cu2+ chaperone GO:0005507;GO:0005758;GO:0006825;GO:0016531 YLL009C COX17 Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Cytochrome c oxidase copper chaperone PAS_3g04110 CAY70796.1 PAS_chr3_0746 Putative protein of unknown function YPL162C YPL162C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology Vacuolar membrane protein YPL162C PAS_3g04115 CAY70797.1 PAS_chr3_0747 Hypothetical protein GO:0003743;GO:0006413 Eukaryotic translation initiation factor 3 subunit D PAS_3g04120 CAY70798.1 PAS_chr3_0748 "Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides" GO:0004298;GO:0005839;GO:0006511 YJL001W PRE3 "Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides" Proteasome component PRE3 PAS_3g04125 CAY70799.1 PAS_chr3_0749 Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase YLL002W RTT109 Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p Histone acetyltransferase RTT109 PAS_3g04130 PAS_3g04135 CAY70800.1 PAS_chr3_0751 Dynamin-related GTPase GO:0005525 YLL001W DNM1 Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance Dynamin-related protein DNM1 PAS_3g04140 CAY70801.1 PAS_chr3_1216 hypothetical protein YGR093W YGR093W Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus CWF19-like protein mug161 PAS_3g04145 CAY70802.1 PAS_chr3_0752 Ser/Thr kinase involved in transcription and stress response GO:0004672;GO:0005524;GO:0006468 YGR092W DBF2 Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis Cell cycle protein kinase DBF2 PAS_3g04150 CAY70803.1 PAS_chr3_0753 Protein involved in rRNA processing GO:0000175;GO:0003723;GO:0006396 YGR095C RRP46 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) Exosome complex component RRP46 PAS_3g04155 CAY70804.1 PAS_chr3_0754 Mitochondrial and cytoplasmic valyl-tRNA synthetase GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YGR094W VAS1 Mitochondrial and cytoplasmic valyl-tRNA synthetase "Valyl-tRNA synthetase, mitochondrial " PAS_3g04160 CAY70805.1 PAS_chr3_0755 "Splicing factor, component of the U4/U6-U5 snRNP complex" YGR091W PRP31 "Splicing factor, component of the U4/U6-U5 snRNP complex" Pre-mRNA-processing factor 31 PAS_3g04165 CAY70806.1 PAS_chr3_0756 Mitochondrial membrane transporter GO:0005488;GO:0006810;GO:0016020 YGR096W TPC1 Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family Mitochondrial thiamine pyrophosphate carrier 1 PAS_3g04170 CAY70807.1 PAS_chr3_0757 "Nucleolar protein, forms a complex with Nop14p" YPR144C NOC4 "Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits" Nucleolar complex protein 4 PAS_3g04175 CAY70808.1 PAS_chr3_0758 Putative GDP/GTP exchange factor required for mitotic exit at low temperatures GO:0005085;GO:0005622;GO:0051056 YAL024C LTE1 Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures Guanine nucleotide exchange factor LTE1 PAS_3g04180 CAY70809.1 PAS_chr3_0759 Zinc-finger transcription factor GO:0003677;GO:0005634;GO:0006350;GO:0008270 YLR451W LEU3 "Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis" Regulatory protein LEU3 PAS_3g04185 CAY70810.1 PAS_chr3_0760 Putative protein of unknown function YJR124C YJR124C Putative protein of unknown function; expression induced under calcium shortage Uncharacterized membrane protein YJR124C PAS_3g04190 CAY70811.1 PAS_chr3_0761 Carnitine acetyltransferase GO:0008415 YER024W YAT2 "Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane" Carnitine O-acetyltransferase YAT2 PAS_3g04195 CAY70812.1 PAS_chr3_0762 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YJR123W RPS5 "Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins" 40S ribosomal protein S5 PAS_3g04200 CAY70813.1 PAS_chr3_0763 Spore-specific water channel that mediates the transport of water across cell membranes GO:0005215;GO:0006810;GO:0016020 YPR192W AQY1 "Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance" Aquaporin-2 PAS_3g04205 CAY70814.1 PAS_chr3_0764 Beta subunit of Type II geranylgeranyltransferase GO:0003824 YPR176C BET2 Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p Geranylgeranyl transferase type-2 subunit beta PAS_3g04210 CAY70815.1 PAS_chr3_0765 Second largest subunit of DNA polymerase II (DNA polymerase epsilon) GO:0003677;GO:0003887;GO:0005634;GO:0006260 YPR175W DPB2 "Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate" DNA polymerase epsilon subunit B PAS_3g04215 CAY70816.1 PAS_chr3_1217 hypothetical protein PAS_3g04220 CAY70817.1 PAS_chr3_0766 "Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex" GO:0003700;GO:0005634;GO:0006355 YGL237C HAP2 "Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding" Transcriptional activator HAP2 PAS_3g04225 CAY70818.1 PAS_chr3_0767 Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p) GO:0006886 YGL238W CSE1 "Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation" Importin alpha re-exporter PAS_3g04230 CAY70819.1 PAS_chr3_1218 hypothetical protein YGL240W DOC1 "Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis" Anaphase-promoting complex subunit 10 PAS_3g04235 CAY70820.1 PAS_chr3_0768 Protein involved in the regulation of cell wall synthesis GO:0042546 KNR4/SMI1 homolog PAS_3g04240 CAY70821.1 PAS_chr3_0769 Putative mitochondrial transport protein GO:0005488;GO:0006810;GO:0016020 YFR045W YFR045W "Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white" Uncharacterized mitochondrial carrier SCRG_05595 PAS_3g04245 CAY70822.1 PAS_chr3_0770 Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway GO:0003824;GO:0005524 YGL234W "ADE5,7" "Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities" Bifunctional purine biosynthetic protein ADE1 PAS_3g04250 CAY70823.1 PAS_chr3_0771 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0043565;GO:0046983 YNL103W MET4 "Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p" Regulatory protein cys-3 PAS_3g04255 CAY70824.1 PAS_chr3_0772 Hypothetical protein Serine-rich adhesin for platelets PAS_3g04260 CAY70825.1 PAS_chr3_0773 Hypothetical protein PAS_3g04265 CAY70826.1 PAS_chr3_0774 Subunit of the eukaryotic translation initiation factor 3 (eIF3) GO:0003743;GO:0005852;GO:0006413 YMR309C NIP1 "eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection" Eukaryotic translation initiation factor 3 subunit C PAS_3g04270 CAY70827.1 PAS_chr3_0775 "Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs" YGL211W NCS6 "Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae" Cytoplasmic tRNA 2-thiolation protein 1 PAS_3g04275 CAY70828.1 PAS_chr3_0776 Proteosome activator subunit GO:0005488 YFL007W BLM10 "Proteasome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200" Proteasome activator BLM10 PAS_3g04280 CAY70829.1 PAS_chr3_0777 Putative protein of unknown function GO:0005506;GO:0006118;GO:0016021;GO:0016491;GO:0050660 YGL160W AIM14 "Putative protein of with similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes; null mutant displays elevated frequency of mitochondrial genome loss" Uncharacterized membrane protein YGL160W PAS_3g04285 CAY70830.1 PAS_chr3_0778 Hypothetical protein GO:0005525;GO:0006614;GO:0008312;GO:0016020 PAS_3g04290 CAY70831.1 PAS_chr3_1219 hypothetical protein PAS_3g04295 CAY70832.1 PAS_chr3_0779 Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis GO:0019787;GO:0043687;GO:0051246 YEL012W UBC8 "Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro" Ubiquitin-conjugating enzyme E2 8 PAS_3g04300 CAY70833.1 PAS_chr3_1220 hypothetical protein PAS_3g04305 CAY70834.1 PAS_chr3_0780 Hypothetical protein PAS_3g04310 CAY70835.1 PAS_chr3_0781 "Glycogen synthase, similar to Gsy1p" GO:0004373;GO:0005978 YLR258W GSY2 "Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase" Glycogen [starch] synthase PAS_3g04315 CAY70836.1 PAS_chr3_1221 hypothetical protein ABC1 family protein C10F6.14c PAS_3g04320 CAY70837.1 PAS_chr3_0782 "Nucleolar protein, component of the small subunit (SSU) processome" GO:0006364;GO:0032040;n/a YLR222C UTP13 "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" U3 small nucleolar RNA-associated protein 13 PAS_3g04325 CAY70838.1 PAS_chr3_0783 Cytoplasmic glyoxalase II GO:0016787 YDR272W GLO2 "Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate" Probable hydroxyacylglutathione hydrolase C824.07 PAS_3g04330 CAY70839.1 PAS_chr3_0784 Hypothetical protein PAS_3g04335 CAY70840.1 PAS_chr3_0785 Putative protein of unknown function YGR251W YGR251W Essential protein required for maturation of 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus Uncharacterized protein YGR251W PAS_3g04340 PAS_3g04345 CAY70841.1 PAS_chr3_0787 "Alpha-1,2-mannosyltransferase" Protein TTP1 PAS_3g04350 CAY70842.1 PAS_chr3_0788 "Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis" GO:0000105;GO:0004424 YOR202W HIS3 "Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p" Imidazoleglycerol-phosphate dehydratase PAS_3g04355 CAY70843.1 PAS_chr3_0789 Ribose methyltransferase GO:0008173;GO:0009451 YOR201C MRM1 "Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA" "rRNA methyltransferase, mitochondrial " PAS_3g04360 CAY70844.1 PAS_chr3_0790 Mitochondrial ribosomal protein of the small subunit YPL118W MRP51 Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences Uncharacterized protein in HIS3 3'region (Fragment) PAS_3g04365 CAY70845.1 PAS_chr3_0791 Protein kinase of the PAK/Ste20 kinase family YHR102W KIC1 "Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body" Serine/threonine-protein kinase KIC1 PAS_3g04370 CAY70846.1 PAS_chr3_0792 "Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase" GO:0005509 "External NADH-ubiquinone oxidoreductase 1, mitochondrial " PAS_3g04375 PAS_3g04380 CAY70847.1 PAS_chr3_0794 Hypothetical protein Putative lipase YOR059C PAS_3g04385 CAY70848.1 PAS_chr3_1222 hypothetical protein GO:0000166 Protein PES4 PAS_3g04390 CAY70849.1 PAS_chr3_0795 Protein involved in the organization of the actin cytoskeleton YHR016C YSC84 Actin-binding protein involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p LAS seventeen-binding protein 3 PAS_3g04395 CAY70850.1 PAS_chr3_0796 Hypothetical protein PAS_3g04400 CAY70851.1 PAS_chr3_0797 DNA polymerase IV GO:0003677;GO:0003887;GO:0006260 YCR014C POL4 "DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta" DNA polymerase lambda PAS_3g04405 CAY70852.1 PAS_chr3_0798 Hypothetical protein PAS_3g04410 CAY70853.1 PAS_chr3_0799 Large subunit of carbamoyl phosphate synthetase GO:0003824;GO:0005524 YJR109C CPA2 "Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor" Carbamoyl-phosphate synthase arginine-specific large chain PAS_3g04415 YER020W GPA2 "Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery" Guanine nucleotide-binding protein alpha-2 subunit PAS_3g04420 YPR117W YPR117W Putative protein of unknown function Uncharacterized protein YPR117W PAS_3g04425 CAY70854.1 PAS_chr3_0801 "Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p" GO:0005097;GO:0005622;GO:0032313 YGR100W MDR1 "Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function" GTPase-activating protein GYP2 PAS_3g04430 CAY70855.1 PAS_chr3_0802 Hypothetical protein Dentin sialophosphoprotein PAS_3g04435 CAY70856.1 PAS_chr3_0803 Vacuolar aminopeptidase GO:0004177;GO:0005773;GO:0006508;GO:0008270 YKL103C LAP4 Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway Vacuolar aminopeptidase 1 PAS_3g04440 CAY70857.1 PAS_chr3_0804 Putative protein of unknown function YDR282C YDR282C Putative protein of unknown function Uncharacterized protein YDR282C PAS_3g04445 CAY70858.1 PAS_chr3_0805 Hypothetical protein PAS_3g04450 CAY70859.1 PAS_chr3_0806 Hypothetical protein Uncharacterized protein DDB_G0271670 PAS_3g04455 CAY70860.1 PAS_chr3_0807 Mitochondrial intermembrane space cysteine motif protein YMR002W MIC17 Mitochondrial intermembrane space protein; contains twin cysteine-x9-cysteine motifs; MIC17 is not an essential gene Mitochondrial intermembrane space cysteine motif-containing protein MIC17 PAS_3g04460 CAY70861.1 PAS_chr3_0808 Hypothetical protein "NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrial " PAS_3g04465 CAY70862.1 PAS_chr3_0809 Hypothetical protein GO:0003676 YMR003W AIM34 Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss PAS_3g04470 CAY70863.1 PAS_chr3_0810 "Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage" YKL114C APN1 "Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine" DNA-(apurinic or apyrimidinic site) lyase 1 PAS_3g04475 CAY70864.1 PAS_chr3_0811 Hypothetical protein PAS_3g04480 CAY70865.1 PAS_chr3_0812 Hypothetical protein YNL193W YNL193W Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis Uncharacterized protein YNL193W PAS_3g04485 PAS_3g04490 CAY70866.1 PAS_chr3_0813 Hypothetical protein YLR135W SLX4 Endonuclease involved in processing DNA during recombination and repair; cleaves branched structures in a complex with Slx1p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing Structure-specific endonuclease subunit SLX4 PAS_3g04495 CAY70867.1 PAS_chr3_0814 Hypothetical protein YPR018W RLF2 Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin DNA ligase 1 PAS_3g04500 CAY70868.1 PAS_chr3_0815 Protein of unknown function involved in vacuolar protein sorting Vacuolar protein sorting-associated protein 70 PAS_3g04505 CAY70869.1 PAS_chr3_0816 Component of the polarisome YLL021W SPA2 "Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate" Protein SPA2 PAS_3g04510 CAY70870.1 PAS_chr3_0817 Mitochondrial ribosomal protein of the large subunit GO:0003723;GO:0004525;GO:0006396 YLR312W-A MRPL15 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L15, mitochondrial " PAS_3g04515 CAY70871.1 PAS_chr3_0818 ATP-dependent RNA helicase of the DEAD box family YGL171W ROK1 ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis ATP-dependent RNA helicase ROK1 PAS_3g04520 CAY70872.1 PAS_chr3_0819 Subunit g of the mitochondrial F1F0 ATP synthase GO:0015986;GO:0016469;GO:0046933;GO:0046961 YPR020W ATP20 Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex "ATP synthase subunit g, mitochondrial " PAS_3g04525 YLR141W RRN5 "Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p" Histone-lysine N-methyltransferase SETD1B PAS_3g04530 CAY70873.1 PAS_chr3_0821 Protein with similarity to human cystinosin YCR075C ERS1 "Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains" Cystine transporter PAS_3g04535 CAY70874.1 PAS_chr3_0822 Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p) GO:0000166;GO:0017111 YPL147W PXA1 "Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins" Peroxisomal long-chain fatty acid import protein 2 PAS_3g04540 CAY70875.1 PAS_chr3_1223 hypothetical protein GO:0003824;GO:0046872 YHR024C MAS2 "Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins" Mitochondrial-processing peptidase subunit alpha PAS_3g04545 CAY70876.1 PAS_chr3_0823 "Type II myosin heavy chain, required for wild-type cytokinesis and cell separation" YHR023W MYO1 "Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively" Myosin-11 PAS_3g04550 CAY70877.1 PAS_chr3_0824 Subunit VI of cytochrome c oxidase GO:0004129;GO:0006118 YHR051W COX6 "Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels" "Cytochrome c oxidase subunit 6, mitochondrial " PAS_3g04555 CAY70878.1 PAS_chr3_1224 hypothetical protein PAS_3g04560 CAY70879.1 PAS_chr3_0825 "Essential component of the nuclear pore complex, which mediates nuclear import and export" GO:0005643;GO:0017056 YJL041W NSP1 "Essential component of the nuclear pore complex, which mediates nuclear import and export, found in both the Nup82 and Nic96 complexes" Nucleoporin NSP1 PAS_3g04565 CAY70880.1 PAS_chr3_0826 Tetrameric phosphoglycerate mutase GO:0006096;GO:0016868 YKL152C GPM1 "Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis" Phosphoglycerate mutase PAS_3g04570 YPL207W TYW1 "Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions" tRNA wybutosine-synthesizing protein 1 PAS_3g04575 PAS_3g04580 CAY70881.1 PAS_chr3_0829 Hypothetical protein L-rhamnose mutarotase PAS_3g04585 PAS_3g04590 CAY70882.1 PAS_chr3_0831 Alpha subunit of succinyl-CoA ligase YOR142W LSC1 "Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated" "Probable succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial " PAS_3g04595 CAY70883.1 PAS_chr3_1225 hypothetical protein YGR150C CCM1 Protein required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport Pentatricopeptide repeat-containing protein C19G7.07c PAS_3g04600 CAY70884.1 PAS_chr3_0832 "Transketolase, similar to Tkl2p" Dihydroxyacetone synthase PAS_3g04605 CAY70885.1 PAS_chr3_0833 Amphiphysin-like lipid raft protein GO:0005515;GO:0005737 Protein hob3 PAS_3g04610 CAY70886.1 PAS_chr3_0834 "Transketolase, similar to Tkl2p" Dihydroxyacetone synthase PAS_3g04615 PAS_3g04620 CAY70887.1 PAS_chr3_0836 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 Zinc finger protein 1 PAS_3g04625 CAY70888.1 PAS_chr3_0837 Hypothetical protein PAS_3g04630 CAY70889.1 PAS_chr3_0838 "Twinfilin, highly conserved actin monomer-sequestering protein" GO:0003779;GO:0005622 YGR080W TWF1 "Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly" Twinfilin PAS_3g04635 CAY70890.1 PAS_chr3_0839 Gamma subunit of the translation initiation factor eIF2 GO:0003924;GO:0005525 YER025W GCD11 "Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met" Eukaryotic translation initiation factor 2 subunit gamma PAS_3g04640 CAY70891.1 PAS_chr3_0840 "GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone" GO:0007242 YLR452C SST2 "GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family" Protein SST2 PAS_3g04645 CAY70892.1 PAS_chr3_0841 "Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA)" GO:0004371;GO:0006071 YFL053W DAK2 "Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation" Dihydroxyacetone kinase PAS_3g04650 CAY70893.1 PAS_chr3_0842 Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities YOL055C THI20 Multifunctional protein with hydroxymethylpyrimidine phosphate (HMP-P) kinase and thiaminase activities; involved in thiamine biosynthesis and degradation; in a gene family with THI21 and THI22; HMP-P kinase activity redundant with Thi21p Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20 PAS_3g04655 CAY70894.1 PAS_chr3_0843 Bifunctional enzyme GO:0004417;GO:0009228 YPL214C THI6 "Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern" Thiamine biosynthetic bifunctional enzyme PAS_3g04660 CAY70895.1 PAS_chr3_0844 Phosphatidylinositol transfer protein (PITP) Phosphatidylinositol transfer protein PDR16 PAS_3g04665 CAY70896.1 PAS_chr3_0845 Lyso-phosphatidylcholine acyltransferase YPR140W TAZ1 "Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome" Lysophosphatidylcholine acyltransferase PAS_3g04670 CAY70897.1 PAS_chr3_0846 "Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism" GO:0003676;GO:0004527;GO:0005622 YOR048C RAT1 "Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination" 5'-3' exoribonuclease 2 PAS_3g04675 CAY70898.1 PAS_chr3_0847 Hypothetical protein YKL162C YKL162C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Protein midA homolog PAS_3g04680 CAY70899.1 PAS_chr3_0848 High affinity polyamine permease GO:0006810;GO:0016020 General amino acid permease AGP2 PAS_3g04685 CAY70900.1 PAS_chr3_0849 "Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing" GO:0000156;GO:0000160;GO:0006355 YLR006C SSK1 "Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate" Osomolarity two-component system protein SSK1 PAS_3g04690 CAY70901.1 PAS_chr3_1226 hypothetical protein YJL020C BBC1 Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches Glutamic acid-rich protein PAS_3g04695 CAY70902.1 PAS_chr3_0850 "Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p)" YDR283C GCN2 "Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control" Serine/threonine-protein kinase GCN2 PAS_3g04700 CAY70903.1 PAS_chr3_0851 Subunit of a complex with Rad50p and Xrs2p (MRX complex) GO:0004519;GO:0005634;GO:0006302;GO:0030145 YMR224C MRE11 "Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved" DNA repair protein rad32 PAS_3g04705 YDR284C DPP1 "Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism" Diacylglycerol pyrophosphate phosphatase 1 PAS_3g04710 CAY70904.1 PAS_chr3_0853 Ubiquitin C-terminal hydrolase GO:0004221;GO:0005622;GO:0006511 YJR099W YUH1 Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p Ubiquitin carboxyl-terminal hydrolase isozyme L3 PAS_3g04715 CAY70905.1 PAS_chr3_1227 hypothetical protein YDR286C YDR286C Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site PAS_3g04720 CAY70906.1 PAS_chr3_0854 Hypothetical protein PAS_3g04725 CAY70907.1 PAS_chr3_0855 Smaller subunit of the mitochondrial processing protease (MPP) GO:0003824;GO:0046872 YLR163C MAS1 "Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins" Mitochondrial-processing peptidase subunit beta PAS_3g04730 CAY70908.1 PAS_chr3_0856 "Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation" GO:0006464;GO:0006512;GO:0008641 YKL210W UBA1 "Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability" Ubiquitin-activating enzyme E1 1 PAS_3g04735 CAY70909.1 PAS_chr3_1228 hypothetical protein YJR074W MOG1 "Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p" Nuclear import protein MOG1 PAS_3g04740 CAY70910.1 PAS_chr3_0857 "Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane" GO:0016491;GO:0050660 Thiol-specific monooxygenase PAS_3g04745 CAY70911.1 PAS_chr3_1229 hypothetical protein GO:0016491 YDR166C SEC5 "Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis" Exocyst complex component SEC5 PAS_3g04750 CAY70912.1 PAS_chr3_0858 Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor GO:0005524;GO:0006810;GO:0016021;GO:0042626 YKL209C STE6 "Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells" ATP-binding cassette sub-family B member 5 PAS_3g04755 CAY70913.1 PAS_chr3_0859 Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase) GO:0006644;GO:0008170 YJR073C OPI3 "Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis" Methylene-fatty-acyl-phospholipid synthase PAS_3g04760 CAY70914.1 PAS_chr3_0860 Hypothetical protein PAS_3g04765 CAY70915.1 PAS_chr3_0861 "Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells" GO:0004932;GO:0007186;GO:0016021 YKL178C STE3 "Receptor for a factor pheromone, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPC" Pheromone a factor receptor PAS_3g04770 CAY70916.1 PAS_chr3_0862 Single-stranded DNA-binding protein essential for mitochondrial genome maintenance GO:0003697 YCR028C-A RIM1 Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication "Single-stranded DNA-binding protein RIM1, mitochondrial " PAS_3g04775 PAS_3g04780 CAY70917.1 PAS_chr3_1230 ATG30 PAS_3g04785 CAY70918.1 PAS_chr3_0864 Hypothetical protein GO:0004497;GO:0005506;GO:0006118;GO:0020037 Cytochrome P450 2C70 PAS_3g04790 CAY70919.1 PAS_chr3_0865 Protein with a potential role in actin cytoskeletal organization YCR030C SYP1 Protein of unknown function that may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization Suppressor of yeast profilin deletion PAS_3g04795 CAY70920.1 PAS_chr3_0866 "Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor" GO:0004190;GO:0006508 Candidapepsin-2 PAS_3g04800 CAY70921.1 PAS_chr3_0867 Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase YJL068C YJL068C "Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D" S-formylglutathione hydrolase PAS_3g04805 CAY70922.1 PAS_chr3_1231 hypothetical protein PAS_3g04810 CAY70923.1 PAS_chr3_1232 hypothetical protein YMR295C YMR295C Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene Uncharacterized protein YMR295C PAS_3g04815 CAY70924.1 PAS_chr3_0868 "Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway" GO:0005975;GO:0042578 YLR377C FBP1 "Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p" "Fructose-1,6-bisphosphatase " PAS_3g04820 CAY70925.1 PAS_chr3_0869 Hypothetical protein PAS_3g04825 CAY70926.1 PAS_chr3_0870 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) GO:0009058;GO:0016779 YDL055C PSA1 "GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure" Mannose-1-phosphate guanyltransferase PAS_3g04830 CAY70927.1 PAS_chr3_1233 hypothetical protein YIL115C NUP159 "Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, member of the Nup82 subcomplex, required for mRNA export" Uncharacterized protein DDB_G0271670 PAS_3g04835 CAY70928.1 PAS_chr3_0871 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 Sterol uptake control protein 2 PAS_3g04840 CAY70929.1 PAS_chr3_0872 Hypothetical protein PAS_3g04845 CAY70930.1 PAS_chr3_0873 Serine-threonine protein kinase that is part of a glucose-sensing system GO:0004674;GO:0006468 Dual specificity protein kinase pom1 PAS_3g04850 CAY70931.1 PAS_chr3_0874 Peroxisomal integral membrane peroxin YHR150W PEX28 "Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p" PAS_3g04855 CAY70932.1 PAS_chr3_0875 "Protein localized to COPII-coated vesicles, forms a complex with Erv46p" YML067C ERV41 "Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein" ER-derived vesicles protein ERV41 PAS_3g04860 CAY70933.1 PAS_chr3_0876 S-adenosylmethionine synthetase GO:0004478;GO:0005524;GO:0006730 YDR502C SAM2 "S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)" S-adenosylmethionine synthase PAS_3g04865 CAY70934.1 PAS_chr3_0877 "Protein with a potential role in cell survival pathways, required for the diauxic growth shift" GO:0016491;n/a YHR009C YHR009C Putative protein of unknown function; not an essential gene UPF0673 membrane protein YHR009C PAS_3g04870 CAY70935.1 PAS_chr3_1234 hypothetical protein YDR346C SVF1 "Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis" Survival factor 1 PAS_3g04875 YDR469W SDC1 "Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30" PAS_3g04880 CAY70936.1 PAS_chr3_0878 Protein of unknown function GO:0005488;GO:0006810;GO:0016020 YDR470C UGO1 Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion Mitochondrial fusion and transport protein UGO1 PAS_3g04885 YOR145C PNO1 "Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain" Pre-rRNA-processing protein PNO1 PAS_3g04890 CAY70937.1 PAS_chr3_0880 Mitochondrial inner membrane protein required for normal mitochondrial morphology YDR393W SHE9 "Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex" "Sensitive to high expression protein 9 homolog, mitochondrial " PAS_3g04895 CAY70938.1 PAS_chr3_0881 One of six ATPases of the 19S regulatory particle of the 26S proteasome GO:0005634;GO:0005737;GO:0016787;GO:0030163 YDR394W RPT3 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B 26S protease regulatory subunit 6B homolog PAS_3g04900 CAY70939.1 PAS_chr3_0882 "Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis" YOR149C SMP3 "Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure" GPI mannosyltransferase 4 PAS_3g04905 CAY70940.1 PAS_chr3_0883 Nuclear transport factor (karyopherin) GO:0005488 YDR395W SXM1 "Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1" Importin beta SMX1 PAS_3g04910 CAY70941.1 PAS_chr3_0884 Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p GO:0003677 YDR397C NCB2 Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta Negative cofactor 2 complex subunit beta PAS_3g04915 CAY70942.1 PAS_chr3_0885 "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA" YDR398W UTP5 Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit U3 small nucleolar RNA-associated protein 5 PAS_3g04920 CAY70943.1 PAS_chr3_0886 Hypothetical protein PAS_3g04925 CAY70944.1 PAS_chr3_0887 Dimeric hypoxanthine-guanine phosphoribosyltransferase YDR399W HPT1 "Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome" Hypoxanthine-guanine phosphoribosyltransferase PAS_3g04930 CAY70945.1 PAS_chr3_0888 "Putative transporter, member of the sugar porter family" Probable metabolite transport protein YBR241C PAS_3g04935 CAY70946.1 PAS_chr3_0889 Hypothetical protein PAS_3g04940 CAY70947.1 PAS_chr3_0890 S-adenosyl-L-homocysteine hydrolase YER043C SAH1 "S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor" Adenosylhomocysteinase PAS_3g04945 CAY70948.1 PAS_chr3_0891 Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoprotein GO:0004571;GO:0005509;GO:0016020 YHR204W MNL1 Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides ER degradation-enhancing alpha-mannosidase-like protein 1 PAS_3g04950 CAY70949.1 PAS_chr3_0893 Protein kinase involved in transcriptional activation of osmostress-responsive genes YHR205W SCH9 "Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB" Serine/threonine-protein kinase SCH9 PAS_3g04955 CAY70950.1 PAS_chr3_1235 hypothetical protein GO:0000156;GO:0000160;GO:0003700;GO:0005634;GO:0006355;GO:0006950 YHR206W SKN7 "Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation" Transcription factor SKN7 PAS_3g04960 CAY70951.1 PAS_chr3_0894 Zinc-finger protein of unknown function GO:0005634 YHR207C SET5 "Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus" Potential protein lysine methyltransferase SET5 PAS_3g04965 CAY70952.1 PAS_chr3_0895 Serine/threonine MAP kinase GO:0004672;GO:0005524;GO:0006468 YHR030C SLT2 Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway Mitogen-activated protein kinase SLT2/MPK1 PAS_3g04970 CAY70953.1 PAS_chr3_0896 "Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor" GO:0004274;GO:0006508;GO:0016020 YHR028C DAP2 "Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p" Dipeptidyl aminopeptidase B PAS_3g04975 CAY70954.1 PAS_chr3_0897 Hypothetical protein PAS_3g04980 CAY70955.1 PAS_chr3_0898 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome YHR027C RPN1 "Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions" 26S proteasome non-ATPase regulatory subunit 2 PAS_3g04985 CAY70956.1 PAS_chr3_1236 hypothetical protein GO:0005524;GO:0016021;GO:0016469;GO:0042626;GO:0046961 YHR026W PPA1 "Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain" V-type proton ATPase subunit c'' PAS_3g04990 CAY70957.1 PAS_chr3_0899 "Homoserine kinase, conserved protein required for threonine biosynthesis" YHR025W THR1 "Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway" Homoserine kinase PAS_3g04995 CAY70958.1 PAS_chr3_0900 Putative protein of unknown function YOR238W YOR238W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Uncharacterized protein C57A10.07 PAS_3g05000 CAY70959.1 PAS_chr3_0901 Hypothetical protein PAS_3g05005 CAY70960.1 PAS_chr3_0902 Hypothetical protein PAS_3g05010 CAY70961.1 PAS_chr3_0903 Nucleolar protein YPL146C NOP53 Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired Ribosome biogenesis protein NOP53 PAS_3g05015 CAY70962.1 PAS_chr3_1237 hypothetical protein PAS_3g05020 CAY70963.1 PAS_chr3_0904 "Strand exchange protein, forms a helical filament with DNA that searches for homology" GO:0003684;GO:0005524;GO:0006281;GO:0008094 YER095W RAD51 "Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein" DNA repair protein RAD51 PAS_3g05025 CAY70964.1 PAS_chr3_0905 "Putative transcription factor, has homolog in Kluyveromyces lactis" GO:0003677;GO:0005634;GO:0006350;GO:0008270 YBL066C SEF1 "Putative transcription factor, has homolog in Kluyveromyces lactis" Putative transcription factor SEF1 PAS_3g05030 CAY70965.1 PAS_chr3_0906 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity YBL064C PRX1 "Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated" Mitochondrial peroxiredoxin PRX1 PAS_3g05035 CAY70966.1 PAS_chr3_0907 Hypothetical protein PAS_3g05040 CAY70967.1 PAS_chr3_0908 "Mitochondrial protein, forms a heterodimer complex with Mss1p" YGL236C MTO1 "Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants" tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG PAS_3g05045 CAY70968.1 PAS_chr3_0909 Hypothetical protein GO:0003677;n/a PAS_3g05050 CAY70969.1 PAS_chr3_0910 Putative protein of unknown function that may participate in DNA replication YLR003C CMS1 Subunit of U3-containing 90S preribosome processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; overexpression rescues supressor mutant of mcm10; null mutant is viable Protein CMS1 PAS_3g05055 CAY70970.1 PAS_chr3_0911 Hypothetical protein PAS_3g05060 CAY70971.1 PAS_chr3_0912 Mitochondrial ribosomal protein of the large subunit GO:0003723;GO:0004525;GO:0006396 YMR024W MRPL3 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L3, mitochondrial " PAS_3g05065 CAY70972.1 PAS_chr3_0913 Component of the mitotic spindle that binds to interpolar microtubules GO:0003824;GO:0046872 YBL034C STU1 Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles Protein STU1 PAS_3g05070 CAY70973.1 PAS_chr3_0914 Acetyltransferase required for the establishment of sister chromatid cohesion GO:0006281 YFR027W ECO1 Acetytransferase required for sister chromatid cohesion; modifies Smc3p at DNA replication forks during S-phase; modifies Mcd1p in response to double-strand DNA breaks during G2/M; acetylation of cohesin subunits antagonizes Rad61p N-acetyltransferase ECO1 PAS_3g05075 CAY70974.1 PAS_chr3_0915 Quinolinate phosphoribosyl transferase GO:0004514;GO:0009435 YFR047C BNA6 "Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p" Nicotinate-nucleotide pyrophosphorylase [carboxylating] PAS_3g05080 CAY70975.1 PAS_chr3_0916 Golgi GDP-mannose transporter GO:0005338;GO:0015780;GO:0016021 YGL225W VRG4 Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi GDP-mannose transporter PAS_3g05085 CAY70976.1 PAS_chr3_0917 Hypothetical protein PAS_3g05090 CAY70977.1 PAS_chr3_0918 ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis GO:0016020 YER036C ARB1 "ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p" ABC transporter ATP-binding protein ARB1 PAS_3g05095 CAY70978.1 PAS_chr3_1238 hypothetical protein GO:0016020 YOL018C TLG2 "Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation" T-SNARE affecting a late Golgi compartment protein 2 PAS_3g05100 CAY70979.1 PAS_chr3_0919 Protein of unknown function GO:0006508;GO:0009268;GO:0016020;GO:0051090 YOL019W YOL019W Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole Meiotically up-regulated gene 33 protein PAS_3g05105 YFR019W FAB1 "1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis" 1-phosphatidylinositol-3-phosphate 5-kinase FAB1 PAS_3g05110 YPR089W YPR089W Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p Dilute domain-containing protein YPR089W PAS_3g05115 CAY70980.1 PAS_chr3_0922 "Polyamine oxidase, converts spermine to spermidine" GO:0006118;GO:0016491 YMR020W FMS1 "Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis" Corticosteroid-binding protein PAS_3g05120 CAY70981.1 PAS_chr3_0923 Copper-sensing transcription factor GO:0003677;GO:0003700;GO:0005507;GO:0005634;GO:0006355 YMR021C MAC1 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Metal-binding activator 1 PAS_3g05125 CAY70982.1 PAS_chr3_0924 "Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway" GO:0019787;GO:0043687;GO:0051246 YMR022W UBC7 "Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly" Ubiquitin-conjugating enzyme E2 7 PAS_3g05130 CAY70983.1 PAS_chr3_0925 eIF3 component of unknown function YMR012W CLU1 "eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant" Protein TIF31 homolog PAS_3g05135 CAY70984.1 PAS_chr3_0926 Hypothetical protein GO:0003676 Staphylococcal nuclease domain-containing protein 1 PAS_3g05140 CAY70985.1 PAS_chr3_1239 hypothetical protein YHR118C ORC6 "Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p" PAS_3g05145 CAY70986.1 PAS_chr3_0927 "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursor" GO:0004540;GO:0008033 YAL033W POP5 "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends" Ribonucleases P/MRP protein subunit POP5 PAS_3g05150 CAY70987.1 PAS_chr3_1240 hypothetical protein GO:0005634 YAL032C PRP45 Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene SNW domain-containing protein 1 PAS_3g05155 CAY70988.1 PAS_chr3_0928 "Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function" GO:0005634 YBR227C MCX1 Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins Mitochondrial clpX-like chaperone MCX1 PAS_3g05160 CAY70989.1 PAS_chr3_0929 "Protein required for beta-1,6 glucan biosynthesis" GO:0003980;GO:0006486 YOR336W KRE5 "Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects" UDP-glucose:glycoprotein glucosyltransferase PAS_3g05165 CAY70990.1 PAS_chr3_0930 Membrane protein YOR018W ROD1 "Membrane protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene,zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins" Protein ROG3 PAS_3g05170 CAY70991.1 PAS_chr3_0931 Phosphoinositide binding protein required for vesicle formation in autophagy YFR021W ATG18 "Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein" Autophagy-related protein 18 PAS_3g05175 CAY70992.1 PAS_chr3_0932 "NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate" GO:0003824;GO:0005488;GO:0008152 YOR388C FDH1 "NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate" Formate dehydrogenase PAS_3g05180 CAY70993.1 PAS_chr3_1241 hypothetical protein YBR057C MUM2 "Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex" Protein MUM2 PAS_3g05185 CAY70994.1 PAS_chr3_0933 Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains GO:0004221;GO:0006511 YBR058C UBP14 "Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T" Ubiquitin carboxyl-terminal hydrolase 14 PAS_3g05190 CAY70995.1 PAS_chr3_0934 Hypothetical protein GO:0016021 Rhomboid family member 1 PAS_3g05195 CAY70996.1 PAS_chr3_0935 Putative ATP-dependent permease of the ABC transporter family of proteins YCR011C ADP1 Putative ATP-dependent permease of the ABC transporter family of proteins Probable ATP-dependent permease PAS_3g05200 CAY70997.1 PAS_chr3_0936 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase GO:0003849;GO:0009073 YDR035W ARO3 "3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan" "Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited " PAS_3g05205 CAY70998.1 PAS_chr3_0937 "3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases" GO:0003824;GO:0008152 YDR036C EHD3 "3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis" "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial " PAS_3g05210 PAS_3g05215 CAY70999.1 PAS_chr3_0939 delta 4-(E)-sphingolipid desaturase GO:0016491 Dihydroceramide delta(4)-desaturase PAS_3g05220 CAY71000.1 PAS_chr3_0940 "Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family" GO:0004674;GO:0006468 YBR059C AKL1 "Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization" Serine/threonine-protein kinase AKL1 PAS_3g05225 CAY71001.1 PAS_chr3_0941 "Subunit of the origin recognition complex, which directs DNA replication" GO:0000808;GO:0005634;GO:0006260 YBR060C ORC2 "Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p" Origin recognition complex subunit 2 PAS_3g05230 CAY71002.1 PAS_chr3_0942 RNA polymerase III subunit C11 GO:0003676;GO:0008270;GO:0030528;GO:0045449 YDR045C RPC11 RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS DNA-directed RNA polymerase III subunit RPC10 PAS_3g05235 CAY71003.1 PAS_chr3_0943 "Coproporphyrinogen III oxidase, an oxygen requiring enzyme" GO:0003676 YDR044W HEM13 "Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)" Coproporphyrinogen-III oxidase PAS_3g05240 CAY71004.1 PAS_chr3_1242 hypothetical protein GO:0003676 YDR043C NRG1 Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response Transcriptional regulator NRG1 PAS_3g05245 CAY71005.1 PAS_chr3_0944 Component of UDP-GlcNAc transferase YBR070C ALG14 Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases UDP-N-acetylglucosamine transferase subunit ALG14 PAS_3g05250 CAY71006.1 PAS_chr3_0945 Hypothetical protein YBR062C YBR062C Hypothetical protein Uncharacterized RING finger protein YBR062C PAS_3g05255 CAY71007.1 PAS_chr3_0946 Mitochondrial ribosomal protein of the small subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YDR041W RSM10 "Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins" "30S ribosomal protein S10, mitochondrial " PAS_3g05260 CAY71008.1 PAS_chr3_0947 "2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides" YBR061C TRM7 "2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop" tRNA (uridine-2'-O-)-methyltransferase TRM7 PAS_3g05265 CAY71009.1 PAS_chr3_0948 Hypothetical protein Eukaryotic translation initiation factor 3 subunit H PAS_3g05270 CAY71010.1 PAS_chr3_0949 Lysyl-tRNA synthetase GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YDR037W KRS1 Lysyl-tRNA synthetase "Lysyl-tRNA synthetase, cytoplasmic " PAS_3g05275 CAY71011.1 PAS_chr3_0950 Protein of unknown function GO:0003824;GO:0008152 YDR051C DET1 Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel Putative phosphoglycerate mutase DET1 PAS_3g05280 CAY71012.1 PAS_chr3_0951 "Triose phosphate isomerase, abundant glycolytic enzyme" GO:0004807;GO:0008152 YDR050C TPI1 "Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region" Triosephosphate isomerase PAS_3g05285 CAY71013.1 PAS_chr3_0952 Hypothetical protein PAS_3g05290 CAY71014.1 PAS_chr3_0953 Putative metalloprotease GO:0006508;GO:0008233 YBR074W YBR074W Putative metalloprotease Uncharacterized zinc metalloprotease YBR074W PAS_3g05295 CAY71015.1 PAS_chr3_0954 Uroporphyrinogen decarboxylase GO:0004853;GO:0006779 YDR047W HEM12 "Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda" Uroporphyrinogen decarboxylase PAS_3g05300 CAY71016.1 PAS_chr3_0955 Hypothetical protein Uncharacterized protein C16G5.07c PAS_3g05305 CAY71017.1 PAS_chr3_0956 Protein involved in rRNA processing GO:0000175;GO:0003723;GO:0006396 YDR280W RRP45 "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9)" Exosome complex component RRP45 PAS_3g05310 CAY71018.1 PAS_chr3_0957 "Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol" GO:0004497;GO:0005506;GO:0006118;GO:0020037 YHR007C ERG11 "Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family" Lanosterol 14-alpha demethylase PAS_3g05315 CAY71019.1 PAS_chr3_0958 Hypothetical protein YKL167C MRP49 "Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation" "54S ribosomal protein MRP49, mitochondrial " PAS_3g05320 CAY71020.1 PAS_chr3_0959 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YKL170W MRPL38 Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels "54S ribosomal protein L38, mitochondrial " PAS_3g05325 CAY71021.1 PAS_chr3_0960 Glycoprotein involved in cell wall beta-glucan assembly GO:0005576;GO:0042546 YJL174W KRE9 "Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects" Cell wall synthesis protein KRE9 PAS_3g05330 CAY71022.1 PAS_chr3_0961 Hypothetical protein Replication factor A protein 3 PAS_3g05335 CAY71023.1 PAS_chr3_0962 Bifunctional enzyme exhibiting indole-3-glycerol-phosphate synthase and anthranilate synthase activi GO:0003824;GO:0009058 YKL211C TRP3 "Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p" Anthranilate synthase component 2 PAS_3g05340 CAY71024.1 PAS_chr3_0963 Hypothetical protein PAS_3g05345 CAY71025.1 PAS_chr3_0964 cAMP-dependent protein kinase catalytic subunit GO:0004674;GO:0006468 cAMP-dependent protein kinase type 2 PAS_3g05350 CAY71026.1 PAS_chr3_1243 hypothetical protein PAS_3g05355 CAY71027.1 PAS_chr3_0965 "Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA)" GO:0003824;GO:0030170 YMR250W GAD1 "Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress" Glutamate decarboxylase PAS_3g05360 CAY71028.1 PAS_chr3_0966 Vacuolar membrane zinc transporter GO:0016020;GO:0030001;GO:0046873 YKL175W ZRT3 "Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency" Zinc-regulated transporter 3 PAS_3g05365 CAY71029.1 PAS_chr3_0967 Component of the septin ring of the mother-bud neck that is required for cytokinesis GO:0005525;GO:0007049 YJR076C CDC11 "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM" Cell division control protein 11 PAS_3g05370 CAY71030.1 PAS_chr3_1244 hypothetical protein PAS_3g05375 CAY71031.1 PAS_chr3_1245 hypothetical protein YMR044W IOC4 "Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif" PAS_3g05380 CAY71032.1 PAS_chr3_0968 Transcription factor involved in cell-type-specific transcription and pheromone response GO:0003700;GO:0005634;GO:0006355;GO:0043565;n/a YMR043W MCM1 Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes Pheromone receptor transcription factor PAS_3g05385 CAY71033.1 PAS_chr3_0969 "tRNase Z, involved in RNA processing" YKR079C TRZ1 tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2 Ribonuclease Z PAS_3g05390 CAY71034.1 PAS_chr3_0970 Hypothetical protein GO:0005515;GO:0008270 PAS_3g05395 PAS_3g05400 CAY71035.1 PAS_chr3_0971 Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals GO:0005215;GO:0006810;GO:0016020 YOL122C SMF1 Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins Manganese transporter SMF2 PAS_3g05405 CAY71036.1 PAS_chr3_0972 Cytoplasmic mRNA cap binding protein GO:0015078;GO:0016469 YOL139C CDC33 Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p) Eukaryotic translation initiation factor 4E PAS_3g05410 CAY71037.1 PAS_chr3_0973 Hypothetical protein Integumentary mucin C.1 (Fragment) PAS_3g05415 CAY71038.1 PAS_chr3_0974 "ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport" GO:0008060;GO:0008270;GO:0032312 YDL226C GCS1 "ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p" ADP-ribosylation factor GTPase-activating protein GCS1 PAS_3g05420 CAY71039.1 PAS_chr3_0975 "Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation" GO:0008152;GO:0016491 YNL202W SPS19 "Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate" "Peroxisomal 2,4-dienoyl-CoA reductase SPS19 " PAS_3g05425 CAY71040.1 PAS_chr3_0976 Putative protein of unknown function YNL200C YNL200C "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Meiotically up-regulated gene 182 protein PAS_3g05430 CAY71041.1 PAS_chr3_0977 "One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p)" GO:0005525;GO:0007049 YDL225W SHS1 "One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis" Cell division control protein 11 PAS_3g05435 CAY71042.1 PAS_chr3_0978 RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci GO:0000166 YDL224C WHI4 Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division "Adenylate cyclase, terminal-differentiation specific " PAS_3g05440 CAY71043.1 PAS_chr3_0979 Hypothetical protein GO:0006508;GO:0008462 ATP-dependent Clp protease proteolytic subunit PAS_3g05445 CAY71044.1 PAS_chr3_0980 Putative serine/threonine protein kinase with unknown cellular role GO:0004674;GO:0006468 Probable serine/threonine-protein kinase HAL5-like PAS_3g05450 PAS_3g05455 CAY71045.1 PAS_chr3_0982 Ferric reductase and cupric reductase GO:0005506;GO:0006118;GO:0016021;GO:0016491;GO:0050660 YLR214W FRE1 "Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels" Ferric/cupric reductase transmembrane component 1 PAS_3g05460 CAY71046.1 PAS_chr3_0983 "Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p)" Reduced viability upon starvation protein 167 PAS_3g05465 CAY71047.1 PAS_chr3_0984 "Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin" YDL115C IWR1 Protein involved in transcription from polymerase II promoters; interacts with with most of the polymerase II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to the K1 killer toxin Putative transcription factor IWR1 PAS_3g05470 CAY71048.1 PAS_chr3_0985 Putative protein of unknown function with similarity to acyl-carrier-protein reductases GO:0008152;GO:0016491 YDL114W YDL114W Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene Uncharacterized oxidoreductase YDL114W PAS_3g05475 CAY71049.1 PAS_chr3_0986 Serine hydrolase with sequence similarity to monoglyceride lipase (MGL) YKL094W YJU3 "Serine hydrolase with sequence similarity to monoglyceride lipase (MGL), localizes to lipid particles" Serine hydrolase YJU3 PAS_3g05480 CAY71050.1 PAS_chr3_0987 Mitochondrial aldehyde dehydrogenase GO:0008152;GO:0016491 Aldehyde dehydrogenase PAS_3g05485 YKR084C HBS1 "GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components" HBS1-like protein PAS_3g05490 CAY71051.1 PAS_chr3_0989 t-SNARE required for ER membrane fusion and vesicular traffic YOR075W UFE1 "t-SNARE required for ER membrane fusion and vesicular traffic, integral membrane protein that constitutes with Sec20p and Use1p the trimeric acceptor for R/v-SNAREs on Golgi-derived vesicles at the ER" Syntaxin ufe1 PAS_3g05495 CAY71052.1 PAS_chr3_0990 Nexin-1 homolog required for localizing membrane proteins GO:0005515;GO:0007154;GO:0035091 YOR069W VPS5 Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p Vacuolar protein sorting-associated protein 5 PAS_3g05500 CAY71053.1 PAS_chr3_0991 Essential protein involved in the processing of pre-rRNA and the assembly of 60S ribosomal subunit YKR081C RPF2 Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles Ribosome biogenesis protein RPF2 PAS_3g05505 CAY71054.1 PAS_chr3_0992 Protein involved in pre-mRNA splicing GO:0003676;GO:0005634 YML049C RSE1 Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport Pre-mRNA-splicing factor rse-1 PAS_3g05510 CAY71055.1 PAS_chr3_0993 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) GO:0005643;GO:0006913;GO:0050658 YKR082W NUP133 "Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p" Nucleoporin NUP133 PAS_3g05515 CAY71056.1 PAS_chr3_0994 Hypothetical protein YKR083C DAD2 "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" DASH complex subunit DAD2 PAS_3g05520 CAY71057.1 PAS_chr3_0995 Hypothetical protein Shugoshin PAS_3g05525 CAY71058.1 PAS_chr3_0996 "Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides" GO:0004799;GO:0006231 YOR074C CDC21 "Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S" Thymidylate synthase PAS_3g05530 CAY71059.1 PAS_chr3_0997 "Cytochrome c1, component of the mitochondrial respiratory chain" GO:0005506;GO:0006118;GO:0009055;GO:0020037 YOR065W CYT1 "Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex" "Cytochrome c1, heme protein, mitochondrial " PAS_3g05535 CAY71060.1 PAS_chr3_0998 Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A GO:0008270 Chromatin modification-related protein YNG2 PAS_3g05540 CAY71061.1 PAS_chr3_0999 "Glucosyl transferase, involved in N-linked glycosylation" YOR067C ALG8 "Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p" "Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase " PAS_3g05545 CAY71062.1 PAS_chr3_1000 Hypothetical protein PAS_3g05550 CAY71063.1 PAS_chr3_1001 "General repressor of transcription, forms complex with Cyc8p" YCR084C TUP1 "General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes" Transcriptional repressor TUP1 PAS_3g05555 CAY71064.1 PAS_chr3_1002 Putative nicotinamide N-methyltransferase YLR285W NNT1 "Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination" Putative nicotinamide N-methyltransferase PAS_3g05560 YLR286C CTS1 "Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p" Endochitinase PAS_3g05565 CAY71065.1 PAS_chr3_1004 Hypothetical protein PAS_3g05570 CAY71066.1 PAS_chr3_1005 Hypothetical protein Meiotically up-regulated gene 157 protein PAS_3g05575 CAY71067.1 PAS_chr3_1006 "Essential, conserved, cytoplasmic ATPase" GO:0000166 YJR072C NPA3 "Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex" GTPase NPA3 PAS_3g05580 CAY71068.1 PAS_chr3_1007 "Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate" GO:0008299 YPL069C BTS1 "Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic" Geranylgeranyl pyrophosphate synthase PAS_3g05585 CAY71069.1 PAS_chr3_1008 Hypothetical protein PAS_3g05590 CAY71070.1 PAS_chr3_1009 Hypothetical protein PAS_3g05595 CAY71071.1 PAS_chr3_1010 Putative protein of unknown function YLR149C YLR149C Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene Uncharacterized protein YLR149C PAS_3g05600 CAY71072.1 PAS_chr3_1011 Cytosolic and mitochondrial glutathione oxidoreductase GO:0006118;GO:0016491 YPL091W GLR1 "Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia" Glutathione reductase PAS_3g05605 CAY71073.1 PAS_chr3_1012 "Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis" GO:0003864;GO:0015940 YBR176W ECM31 "Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate" 3-methyl-2-oxobutanoate hydroxymethyltransferase PAS_3g05610 CAY71074.1 PAS_chr3_1013 Putative protein of unknown function YPL103C FMP30 Protein of unknown function proposed to be involved in N-acylethanolamine metabolism; related to human NAPE-selective phospholipase D enzyme; native protein is detected in highly purified mitochondria in high-throughput studies "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, mitochondrial " PAS_3g05615 CAY71075.1 PAS_chr3_1014 "Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p)" GO:0008565;GO:0015031;GO:0016021 YPL094C SEC62 "Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER" Translocation protein SEC62 PAS_3g05620 CAY71076.1 PAS_chr3_1015 Protein required for growth of cells lacking the mitochondrial genome YPL098C MGR2 Protein required for growth of cells lacking the mitochondrial genome Protein MGR2 PAS_3g05625 CAY71077.1 PAS_chr3_1016 Phosphoinositide binding protein Autophagy-related protein 18 PAS_3g05630 CAY71078.1 PAS_chr3_1017 Putative protein of unknown function YGR068C ART5 Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane Arrestin-related trafficking adapter 5 PAS_3g05635 CAY71079.1 PAS_chr3_1018 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation YLR207W HRD3 "Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events" ERAD-associated E3 ubiquitin-protein ligase component HRD3 PAS_3g05640 CAY71080.1 PAS_chr3_1019 Hypothetical protein GO:0008270 PAS_3g05645 CAY71081.1 PAS_chr3_1246 hypothetical protein PAS_3g05650 CAY71082.1 PAS_chr3_1020 Hypothetical protein GO:0005515 PAS_3g05655 CAY71083.1 PAS_chr3_1021 "D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent" GO:0016491;GO:0050660 YDL174C DLD1 "D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane" "D-lactate dehydrogenase [cytochrome], mitochondrial " PAS_3g05660 CAY71084.1 PAS_chr3_1022 Dual function protein GO:0031177 YLR192C HCR1 Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA Eukaryotic translation initiation factor 3 subunit J PAS_3g05665 CAY71085.1 PAS_chr3_1023 Hypothetical protein YDL173W PAR32 Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene PAS_3g05670 CAY71086.1 PAS_chr3_1024 NAD(+)-dependent glutamate synthase (GOGAT) GO:0006537;GO:0015930 YDL171C GLT1 "NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source" Putative glutamate synthase [NADPH] PAS_3g05675 CAY71087.1 PAS_chr3_1247 hypothetical protein YLR196W PWP1 Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily Periodic tryptophan protein 1 PAS_3g05680 CAY71088.1 PAS_chr3_1025 N-myristoyl transferase YLR195C NMT1 "N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction" Glycylpeptide N-tetradecanoyltransferase PAS_3g05685 CAY71089.1 PAS_chr3_1026 "Putative protein of unknown function, may be involved in detoxification" GO:0016020 Uncharacterized membrane protein YLR241W PAS_3g05690 CAY71090.1 PAS_chr3_1027 "Protein of unknown function, rich in asparagine residues" GO:0005622;GO:0008270 YDL167C NRP1 Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis Asparagine-rich protein PAS_3g05695 CAY71091.1 PAS_chr3_1028 S-(hydroxymethyl)glutathione dehydrogenase YDL168W SFA1 "Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p" S-(hydroxymethyl)glutathione dehydrogenase PAS_3g05700 CAY71092.1 PAS_chr3_1029 Hypothetical protein YOL063C CRT10 Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat PAS_3g05705 CAY71093.1 PAS_chr3_1030 Hypothetical protein PAS_3g05710 CAY71094.1 PAS_chr3_1031 Negative regulatory subunit of the protein phosphatase 1 Ppz1p GO:0003824 YKR072C SIS2 "Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis" Protein SIS2 PAS_3g05715 CAY71095.1 PAS_chr3_1032 Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits YOR056C NOB1 Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA 20S-pre-rRNA D-site endonuclease NOB1 PAS_3g05720 CAY71096.1 PAS_chr3_1033 Hypothetical protein GO:0003824;GO:0005488;GO:0008152 D-amino-acid oxidase PAS_3g05725 CAY71097.1 PAS_chr3_1034 Hypothetical protein Coiled-coil domain-containing protein 124 homolog PAS_3g05730 CAY71098.1 PAS_chr3_1035 Component of the Paf1p complex YOL145C CTR9 "Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; contains TPR repeats" Tetratricopeptide repeat protein 1 PAS_3g05735 CAY71099.1 PAS_chr3_1036 Nucleolar protein required for 60S ribosomal subunit biogenesis YOL144W NOP8 Nucleolar protein required for 60S ribosomal subunit biogenesis 60S ribosome subunit biogenesis protein NOP8 PAS_3g05740 CAY71100.1 PAS_chr3_1037 "Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase)" GO:0004746;GO:0009231;GO:0009349 YOL143C RIB4 "Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin" "6,7-dimethyl-8-ribityllumazine synthase " PAS_3g05745 CAY71101.1 PAS_chr3_1038 Hypothetical protein Dentin sialophosphoprotein PAS_3g05750 CAY71102.1 PAS_chr3_1039 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) YJR042W NUP85 "Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking" Nucleoporin NUP85 PAS_3g05755 CAY71103.1 PAS_chr3_1040 Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector GO:0005524;GO:0016021;GO:0016469;GO:0042626;GO:0046961 YEL027W CUP5 Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis V-type proton ATPase 16 kDa proteolipid subunit PAS_3g05760 CAY71104.1 PAS_chr3_1041 RNA binding protein GO:0030529;GO:0042254 YEL026W SNU13 "RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein" 13 kDa ribonucleoprotein-associated protein PAS_3g05765 CAY71105.1 PAS_chr3_1042 "Catalytic component of the exosome, involved in RNA processing and degradation" GO:0003723;GO:0004540 YOL021C DIS3 Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3 Exosome complex exonuclease DIS3 PAS_3g05770 CAY71106.1 PAS_chr3_1043 Hypothetical protein YBR156C SLI15 "Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly" PAS_3g05775 CAY71107.1 PAS_chr3_1044 "Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p" GO:0005524;GO:0016887 YFR009W GCN20 "Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA" Protein GCN20 PAS_3g05780 CAY71108.1 PAS_chr3_1045 Peroxisome biosynthesis protein PAS1 GO:0005524 YKL197C PEX1 AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis Peroxisome biosynthesis protein PAS1 PAS_3g05785 CAY71109.1 PAS_chr3_1047 Small subunit of the clathrin-associated adaptor complex AP-2 GO:0006810 YJR058C APS2 "Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex" AP-2 complex subunit sigma PAS_3g05790 CAY71110.1 PAS_chr3_1048 "Translation initiation factor eIF-5A, promotes formation of the first peptide bond" YJR047C ANB1 "Translation elongation factor eIF-5A, previously thought to function in translation initiation; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions" Eukaryotic translation initiation factor 5A PAS_3g05795 CAY71111.1 PAS_chr3_1049 Hypothetical protein PAS_3g05800 CAY71112.1 PAS_chr3_1050 Hypothetical protein PAS_3g05805 CAY71113.1 PAS_chr3_1051 RNA polymerase III subunit C17 GO:0000166;GO:0003824;GO:0044237 YJL011C RPC17 "RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex" DNA-directed RNA polymerase III subunit RPC9 PAS_3g05810 CAY71114.1 PAS_chr3_1052 Putative protein of unknown function YLR455W YLR455W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Ribosomal L1 domain-containing protein CG13096 PAS_3g05815 CAY71115.1 PAS_chr3_1053 Hypothetical protein E3 ubiquitin-protein ligase RNF13 PAS_3g05820 CAY71116.1 PAS_chr3_1054 "Translation initiation factor eIF-4B, has RNA annealing activity" GO:0000166 YPR163C TIF3 "Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA" Eukaryotic translation initiation factor 4B PAS_3g05825 CAY71117.1 PAS_chr3_1055 Putative protein of unknown function YLR454W FMP27 "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" "Protein FMP27, mitochondrial " PAS_3g05830 CAY71118.1 PAS_chr3_1056 Subunit of the RNA polymerase II mediator complex YBL093C ROX3 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme Mediator of RNA polymerase II transcription subunit 19 PAS_3g05835 CAY71119.1 PAS_chr3_1057 "Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YBL092W RPL32 "Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing" 60S ribosomal protein L32 PAS_3g05840 CAY71120.1 PAS_chr3_1058 Putative integral membrane protein YML052W SUR7 "Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants" Protein SUR7 PAS_3g05845 CAY71121.1 PAS_chr3_1059 Hypothetical protein YJR056C YJR056C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus PAS_3g05850 CAY71122.1 PAS_chr3_1060 Hypothetical protein PAS_3g05855 CAY71123.1 PAS_chr3_1061 Protein kinase of the Mitotic Exit Network GO:0004674;GO:0006468 YAR019C CDC15 Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II Cell division control protein 15 PAS_3g05860 CAY71124.1 PAS_chr3_1062 Membrane protein of the plasma membrane and ER GO:0016020 YNL323W LEM3 "Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane" Alkylphosphocholine resistance protein LEM3 PAS_3g05865 CAY71125.1 PAS_chr3_1063 Hypothetical protein Uncharacterized protein YNL144C PAS_3g05870 CAY71126.1 PAS_chr3_1248 hypothetical protein YGL145W TIP20 Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p RAD50-interacting protein 1 PAS_3g05875 CAY71127.1 PAS_chr3_1064 Protein with putative serine active lipase domain YGL144C ROG1 Protein with putative serine active lipase domain Putative lipase ROG1 PAS_3g05880 CAY71128.1 PAS_chr3_1065 Putative protein of unknown function Uncharacterized protein YML020W PAS_3g05885 YDL112W TRM3 "2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs" tRNA guanosine-2'-O-methyltransferase TRM3 PAS_3g05890 CAY71129.1 PAS_chr3_1067 Protein involved in rRNA processing GO:0000175;GO:0003723;GO:0006396 YDL111C RRP42 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7) Exosome complex component RRP42 PAS_3g05895 CAY71130.1 PAS_chr3_1068 Protein of unknown function that associates with ribosomes YDL110C TMA17 Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion Translation machinery-associated protein 17 PAS_3g05900 CAY71131.1 PAS_chr3_1249 hypothetical protein YGL143C MRF1 "Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability" "Peptide chain release factor 1, mitochondrial " PAS_3g05905 CAY71132.1 PAS_chr3_1069 "Essential, non-ATPase regulatory subunit of the 26S proteasome lid" YDL097C RPN6 "Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion" Probable 26S proteasome regulatory subunit rpn6 PAS_3g05910 CAY71133.1 PAS_chr3_1070 Subunit of the nuclear pore complex (NPC) GO:0005643;GO:0006810 YDL116W NUP84 "Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis" Nucleoporin NUP84 PAS_3g05915 CAY71134.1 PAS_chr3_1071 Translation elongation factor EF-1 gamma Elongation factor 1-gamma 1 PAS_3g05920 CAY71135.1 PAS_chr3_1072 Hypothetical protein YHR081W LRP1 "Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination" Exosome complex protein LRP1 PAS_3g05925 CAY71136.1 PAS_chr3_1073 Peroxisomal membrane protein (PMP) GO:0005779;GO:0007031 YDR329C PEX3 Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p Peroxisomal biogenesis factor 3 PAS_3g05930 CAY71137.1 PAS_chr3_1074 Hypothetical protein PAS_3g05935 CAY71138.1 PAS_chr3_1075 Hypothetical protein YLR094C GIS3 Protein of unknown function PAS_3g05940 CAY71139.1 PAS_chr3_1250 hypothetical protein GO:0016021 Putative fatty acid elongation protein 4 PAS_3g05945 CAY71140.1 PAS_chr3_1076 Glycerol proton symporter of the plasma membrane High-affinity glucose transporter PAS_3g05950 CAY71141.1 PAS_chr3_1251 hypothetical protein Zinc finger C3H1 domain-containing protein PAS_3g05955 CAY71142.1 PAS_chr3_1077 "Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing" GO:0000398;GO:0005681 YHR165C PRP8 "Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing; mutations of human Prp8 cause retinitis pigmentosa" Pre-mRNA-splicing factor 8 PAS_3g05960 CAY71143.1 PAS_chr3_1078 Subunit of the anaphase-promoting complex/cyclosome (APC/C) YHR166C CDC23 "Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition" Anaphase-promoting complex subunit 8 PAS_3g05965 CAY71144.1 PAS_chr3_1079 Hypothetical protein Histone H3.v1 PAS_3g05970 CAY71145.1 PAS_chr3_1080 Hypothetical protein GO:0005351;GO:0006810;GO:0009401;GO:0016020 PAS_3g05975 CAY71146.1 PAS_chr3_1081 Putative protein of unknown function YGR243W FMP43 "Putative protein of unknown function; expression regulated by osmotic and alkaline stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" UPF0041 protein FMP43 PAS_3g05980 YJR135W-A TIM8 "Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome" Mitochondrial import inner membrane translocase subunit TIM8 PAS_3g05985 CAY71147.1 PAS_chr3_1252 hypothetical protein GO:0000166 YOR319W HSH49 U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) Protein HSH49 PAS_3g05990 CAY71148.1 PAS_chr3_1253 hypothetical protein PAS_3g05995 CAY71149.1 PAS_chr3_1082 U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49 PAS_3g06000 CAY71150.1 PAS_chr3_1083 Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome YHR200W RPN10 Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein 26S proteasome regulatory subunit RPN10 PAS_3g06005 CAY71151.1 PAS_chr3_1084 "Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by meth" GO:0003824;GO:0008152 YJR137C MET5 "Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine" Sulfite reductase [NADPH] subunit beta PAS_3g06010 CAY71152.1 PAS_chr3_1085 Protein involved in cis-Golgi membrane traffic GO:0006886;GO:0016020 YMR197C VTI1 "Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways" t-SNARE VTI1 PAS_3g06015 CAY71153.1 PAS_chr3_1086 Putative protein of unknown function GO:0003824 YMR196W YMR196W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene Uncharacterized protein YMR196W PAS_3g06020 CAY71154.1 PAS_chr3_1087 Vacuolar aspartyl protease (proteinase A) GO:0004190;GO:0006508 YPL154C PEP4 "Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates" Saccharopepsin PAS_3g06025 CAY71155.1 PAS_chr3_1254 hypothetical protein GO:0004672;GO:0005524;GO:0006468 YPL153C RAD53 "Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication" Serine/threonine-protein kinase RAD53 PAS_3g06030 CAY71156.1 PAS_chr3_1088 Pseudouridine synthase GO:0001522;GO:0003723;GO:0004730 YOR243C PUS7 "Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria" Multisubstrate pseudouridine synthase 7 PAS_3g06035 CAY71157.1 PAS_chr3_1089 Sporulation specific protein that localizes to the spore wall YOR242C SSP2 Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis Sporulation-specific protein 2 PAS_3g06040 PAS_3g06045 CAY71158.1 PAS_chr3_1091 Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p GO:0004674;GO:0006468 YOR267C HRK1 Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis Serine/threonine-protein kinase HRK1 PAS_3g06050 CAY71159.1 PAS_chr3_1092 "Protein involved in nuclear migration, part of the dynein/dynactin pathway" YOR269W PAC1 "Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1" Nuclear distribution protein PAC1 PAS_3g06055 CAY71160.1 PAS_chr3_1093 "Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p)" GO:0015992;GO:0016020 YOR270C VPH1 "Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes" "V-type proton ATPase subunit a, vacuolar isoform " PAS_3g06060 CAY71161.1 PAS_chr3_1095 "Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p" GO:0016021 YKL039W PTM1 "Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p" Membrane protein PTM1 PAS_3g06065 YDR430C CYM1 "Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology" Mitochondrial presequence protease PAS_3g06070 CAY71162.1 PAS_chr3_1097 Phosphoesterase involved in downregulation of the unfolded protein response GO:0016787 YLR361C DCR2 "Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START" Phosphatase DCR2 PAS_3g06075 CAY71163.1 PAS_chr3_1098 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi YOR115C TRS33 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic Trafficking protein particle complex subunit 6B PAS_3g06080 CAY71164.1 PAS_chr3_1255 hypothetical protein GO:0016787 YJR069C HAM1 "Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine" Protein ham1 PAS_3g06085 CAY71165.1 PAS_chr3_1099 "Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation" Sugar transporter STL1 PAS_3g06090 CAY71166.1 PAS_chr3_1100 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p GO:0008168 YDL201W TRM8 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA tRNA (guanine-N(7)-)-methyltransferase PAS_3g06095 CAY71167.1 PAS_chr3_1101 Mitochondrial ribosomal protein of the large subunit YDL202W MRPL11 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L11, mitochondrial " PAS_3g06100 CAY71168.1 PAS_chr3_1102 Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins GO:0016021 YDR414C ERD1 "Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)" Xenotropic and polytropic retrovirus receptor 1 PAS_3g06105 CAY71169.1 PAS_chr3_1103 Component of the pre-60S pre-ribosomal particle YDR412W RRP17 Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions Ribosomal RNA-processing protein 17 PAS_3g06110 CAY71170.1 PAS_chr3_1104 Serine-threonine kinase and endoribonuclease YHR079C IRE1 Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress Serine/threonine-protein kinase/endoribonuclease IRE1 PAS_3g06115 CAY71171.1 PAS_chr3_1105 Uracil-DNA glycosylase YML021C UNG1 "Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus" Uracil-DNA glycosylase PAS_3g06120 CAY71172.1 PAS_chr3_1106 Putative protein of unknown function YML020W YML020W Putative protein of unknown function Uncharacterized protein YML020W PAS_3g06125 CAY71173.1 PAS_chr3_1256 hypothetical protein YJL059W YHC3 Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) Protein BTN1 PAS_3g06130 CAY71174.1 PAS_chr3_1107 Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole YGL124C MON1 "Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate" Vacuolar fusion protein MON1 PAS_3g06135 CAY71175.1 PAS_chr3_1108 Plasma membrane protein involved in zinc metabolism and osmotin-induced apoptosis GO:0016021 YOL002C IZH2 "Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc" ADIPOR-like receptor IZH2 PAS_3g06140 CAY71176.1 PAS_chr3_1109 Protein that localizes to the nucleus and is involved in transcription regulation GO:0008060;GO:0008270;GO:0032312 YGL181W GTS1 Protein that localizes to the nucleus and is involved in transcription regulation; also localizes to actin patches and plays a role in endocytosis; N-terminus contains an ARF-GAP domain and C-terminus contains a Gln-rich domain Protein GTS1 PAS_3g06145 CAY71177.1 PAS_chr3_1110 Mitochondrial tyrosyl-tRNA synthetase GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YPL097W MSY1 Mitochondrial tyrosyl-tRNA synthetase "Tyrosyl-tRNA synthetase, mitochondrial " PAS_3g06150 CAY71178.1 PAS_chr3_1111 "Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p)" GO:0006099;GO:0006118;GO:0016491 YLL041C SDH2 "Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone" "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial " PAS_3g06155 CAY71179.1 PAS_chr3_1112 DNA ligase found in the nucleus and mitochondria GO:0003910;GO:0005524;GO:0006260;GO:0006281;GO:0006310 YDL164C CDC9 "DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination" DNA ligase 1 PAS_3g06160 CAY71180.1 PAS_chr3_1113 Hypothetical protein PAS_3g06165 CAY71181.1 PAS_chr3_1114 "Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore" GO:0005622;GO:0006810 YER009W NTF2 "Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport" Nuclear transport factor 2 PAS_3g06170 CAY71182.1 PAS_chr3_1115 "Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P" YER003C PMI40 "Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation" Mannose-6-phosphate isomerase PAS_3g06175 CAY71183.1 PAS_chr3_1116 Hypothetical protein PAS_3g06180 CAY71184.1 PAS_chr3_1117 Mitochondrial ribosomal protein of the small subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YNR037C RSM19 "Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein" "37S ribosomal protein S19, mitochondrial " PAS_3g06185 CAY71185.1 PAS_chr3_1118 Essential protein involved in ribosome biogenesis YNR038W DBP6 Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family ATP-dependent RNA helicase DBP6 PAS_3g06190 CAY71186.1 PAS_chr3_1119 "Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate" YKL192C ACP1 "Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p" "Acyl carrier protein, mitochondrial " PAS_3g06195 CAY71187.1 PAS_chr3_1120 Mitochondrial protein GO:0003735;GO:0006412;GO:0015935 YNR036C MRPS12 Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins "37S ribosomal protein S12, mitochondrial " PAS_3g06200 CAY71188.1 PAS_chr3_1121 Subunit of the ARP2/3 complex GO:0005856;GO:0030833 YNR035C ARC35 "Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin" Actin-related protein 2/3 complex subunit 2 PAS_3g06205 CAY71189.1 PAS_chr3_1122 Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p GO:0003743;GO:0006446 YNL062C GCD10 "Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression" tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6 PAS_3g06210 CAY71190.1 PAS_chr3_1257 hypothetical protein GO:0006479;GO:0008276 YNL063W MTQ1 S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene Mitochondrial N(5)-glutamine methyltransferase MTQ1 PAS_3g06215 CAY71191.1 PAS_chr3_1123 Protein with similarity to mammalian developmentally regulated GTP-binding protein GO:0005525 YGR173W RBG2 Protein with similarity to mammalian developmentally regulated GTP-binding protein Uncharacterized GTP-binding protein YGR173W PAS_3g06220 CAY71192.1 PAS_chr3_1124 "Protein of unknown function, predicted to contain a single transmembrane domain" YGR266W YGR266W "Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane" Uncharacterized protein YGR266W PAS_3g06225 CAY71193.1 PAS_chr3_1126 "6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway" GO:0006098;GO:0017057 YHR163W SOL3 "6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p" Probable 6-phosphogluconolactonase PAS_3g06230 CAY71194.1 PAS_chr3_1127 Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes GO:0004609;GO:0008654 YGR170W PSD2 "Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine" Phosphatidylserine decarboxylase proenzyme 2 PAS_3g06235 CAY71195.1 PAS_chr3_1128 "Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3" YGR252W GCN5 "Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily" Histone acetyltransferase GCN5 PAS_3g06240 CAY71196.1 PAS_chr3_1129 Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism GO:0004298;GO:0005839;GO:0006511 YGR253C PUP2 Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta Proteasome component PUP2 PAS_3g06245 CAY71197.1 PAS_chr3_1130 Hypothetical protein PAS_3g06250 CAY71198.1 PAS_chr3_1258 hypothetical protein GO:0006511 YDR328C SKP1 "Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase" Suppressor of kinetochore protein 1 PAS_3g06255 CAY71199.1 PAS_chr3_1131 Protein involved in programmed cell death GO:0006511 YDR326C YSP2 Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification Uncharacterized protein YHR080C PAS_3g06260 CAY71200.1 PAS_chr3_1132 "Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine" GO:0003824;GO:0030170 YJL060W BNA3 "Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate" Probable kynurenine--oxoglutarate transaminase BNA3 PAS_3g06265 CAY71201.1 PAS_chr3_1133 "Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes" YDR440W DOT1 "Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response" "Histone-lysine N-methyltransferase, H3 lysine-79 specific " PAS_3g06270 CAY71202.1 PAS_chr3_1134 Subunit of the RNA polymerase II mediator complex YDR443C SSN2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation Mediator of RNA polymerase II transcription subunit 13 PAS_3g06275 CAY71203.1 PAS_chr3_1135 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YML009C MRPL39 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L39, mitochondrial " PAS_3g06280 CAY71204.1 PAS_chr3_1136 Protein that forms a complex with Spt4p YML010W SPT5 Protein involved in regulating Pol I and Pol II transcription and pre-mRNA processing; forms a complex with Spt4p; contains a C-terminal repeat domain that is a target for phosphorylation by Sgv1p Transcription elongation factor SPT5 PAS_3g06285 CAY71205.1 PAS_chr3_1259 hypothetical protein YML012W ERV25 "Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport" Endoplasmic reticulum vesicle protein 25 PAS_3g06290 CAY71206.1 PAS_chr3_1137 Hypothetical protein YML011C RAD33 Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus DNA repair protein RAD33 PAS_3g06295 CAY71207.1 PAS_chr3_1138 "Adenine phosphoribosyltransferase, catalyzes the formation of AMP" GO:0016740 YML022W APT1 "Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis" Adenine phosphoribosyltransferase PAS_3g06300 CAY71208.1 PAS_chr3_1139 Sorting nexin GO:0005515;GO:0007154;GO:0035091 YDR425W SNX41 "Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p" Sorting nexin-41 PAS_3g06305 CAY71209.1 PAS_chr3_1140 "Cytoplasmic light chain dynein, microtubule motor protein" GO:0003777;GO:0005875;GO:0007017 YDR424C DYN2 "Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex" "Dynein light chain 1, cytoplasmic " PAS_3g06310 CAY71210.1 PAS_chr3_1141 Hypothetical protein PAS_3g06315 CAY71211.1 PAS_chr3_1142 Subunit of the oligosaccharyltransferase complex of the ER lumen YML019W OST6 "Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p" Uncharacterized protein PB17E12.11 PAS_3g06320 CAY71212.1 PAS_chr3_1143 Putative protein of unknown function YML018C YML018C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene Thiamine-repressible mitochondrial transport protein THI74 PAS_3g06325 CAY71213.1 PAS_c131_0001 Hypothetical protein GO:0006457 YDR519W FPR2 "Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking" FK506-binding protein 2 PAS_3g06330 CAY71214.1 PAS_c131_0002 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 YDR520C URC2 Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism Uracil catabolism protein 2 PAS_3g06335 CAY71215.1 PAS_c131_0003 Hypothetical protein YCL048W SPS22 "Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall" Sporulation-specific protein 22 PAS_3g06340 CAY71216.1 PAS_c131_0004 Hypothetical protein YHL007C STE20 "Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response, pseudohyphal/invasive growth, and vacuole inheritance; GBB motif (found in noncatalytic domains of PAKs) binds Ste4p" Serine/threonine-protein kinase ste20 PAS_3g06345 CAY71217.1 PAS_c131_0005 Hypothetical protein GO:0003735;GO:0006412;GO:0015935 YHL004W MRP4 Mitochondrial ribosomal protein of the small subunit "37S ribosomal protein MRP4, mitochondrial " PAS_3g06350 CAY71218.1 PAS_c131_0006 Hypothetical protein GO:0003779;GO:0008290;GO:0030036 YKL007W CAP1 Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches F-actin-capping protein subunit alpha PAS_3g06355 CAY71219.1 PAS_c131_0007 Hypothetical protein YHL002W HSE1 "Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes" Class E vacuolar protein-sorting machinery protein HSE1 PAS_3g06360 CAY71220.1 PAS_c131_0008 Hypothetical protein YBR122C MRPL36 Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region "54S ribosomal protein L36, mitochondrial " PAS_3g06365 CAY71221.1 PAS_c131_0009 Hypothetical protein YBR123C TFC1 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63 Transcription factor tau subunit sfc1 PAS_3g06370 CAY71222.1 PAS_c131_0010 Hypothetical protein GO:0008270 YKL005C BYE1 "Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit" Transcription factor BYE1 PAS_3g06375 CAY71223.1 PAS_c131_0011 Hypothetical protein GO:0003735;GO:0005622;GO:0005840;GO:0006412 YHL001W RPL14B "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein" 60S ribosomal protein L14-B PAS_3g06380 CAY71224.1 PAS_c131_0012 Hypothetical protein PAS_3g06385 CAY71225.1 PAS_c131_0013 Hypothetical protein GO:0015031 YKL002W DID4 "Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis" DOA4-independent degradation protein 4 PAS_3g06390 CAY71226.1 PAS_c131_0014 Hypothetical protein GO:0003735;GO:0005622;GO:0005840;GO:0006412 YKL003C MRP17 "Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator" "37S ribosomal protein MRP17, mitochondrial " PAS_3g06395 CAY71227.1 PAS_c131_0015 Hypothetical protein YPR083W MDM36 Protein required for normal mitochondrial morphology and inheritance PAS_3g06400 CAY71228.1 PAS_c131_0016 Hypothetical protein YBR125C PTC4 Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity Protein phosphatase 2C homolog 4 PAS_3g06405 CAY71229.1 PAS_c131_0017 Hypothetical protein GO:0003824;GO:0005992 YBR126C TPS1 "Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway" "Alpha,alpha-trehalose-phosphate synthase [UDP-forming] " PAS_3g06410 CAY71230.1 PAS_c131_0021 vacuolar ATP synthase subunit B GO:0015986;GO:0016820;GO:0033180 YBR127C VMA2 "Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm" V-type proton ATPase subunit B PAS_3g06415 CAY71231.1 PAS_c131_0019 Hypothetical protein GO:0003824;GO:0046872 PAS_3g06420 CAY71232.1 PAS_c131_0020 Hypothetical protein PAS_4g00000 PAS_4g00005 CAY71233.1 PAS_chr4_0003 Hypothetical protein PAS_4g00010 PAS_4g00015 CAY71234.1 PAS_chr4_0005 Proton-coupled oligopeptide transporter of the plasma membrane YJL212C OPT1 Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family Oligopeptide transporter 1 PAS_4g00020 CAY71235.1 PAS_chr4_0006 High affinity nicotinic acid plasma membrane permease 1-aminocyclopropane-1-carboxylate oxidase 1 PAS_4g00025 CAY71236.1 PAS_chr4_0911 hypothetical protein Uncharacterized transporter C1039.04 PAS_4g00030 PAS_4g00035 CAY71237.1 PAS_chr4_0008 Low-affinity Fe(II) transporter of the plasma membrane Low-affinity Fe(2+) transport protein PAS_4g00040 CAY71238.1 PAS_chr4_0009 Hypothetical protein PAS_4g00045 CAY71239.1 PAS_chr4_0010 Hypothetical protein PAS_4g00050 CAY71240.1 PAS_chr4_0011 "Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter)" YBR298C MAL31 "Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C" General alpha-glucoside permease PAS_4g00055 CAY71241.1 PAS_chr4_0012 Hypothetical protein GO:0003824 PAS_4g00060 CAY71242.1 PAS_chr4_0013 Hypothetical protein Probable beta-glucosidase I PAS_4g00065 CAY71243.1 PAS_chr4_0014 Hypothetical protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 PAS_4g00070 Agglutinin-like protein 3 PAS_4g00075 PAS_4g00080 PAS_4g00085 CAY71244.1 PAS_chr4_0018 "Cytochrome c, isoform 1" GO:0005506;GO:0006118;GO:0009055;GO:0020037 YJR048W CYC1 "Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration" Cytochrome c PAS_4g00090 CAY71245.1 PAS_chr4_0019 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) GO:0006810;GO:0016020 YDR160W SSY1 "Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes" SPS-sensor component SSY1 PAS_4g00095 CAY71246.1 PAS_chr4_0020 Component of the spliceosome complex involved in pre-mRNA splicing YJR050W ISY1 "Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles" Pre-mRNA-splicing factor ISY1 PAS_4g00100 CAY71247.1 PAS_chr4_0021 Guanosine diphosphatase located in the Golgi GO:0016787 YEL042W GDA1 "Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate" Guanosine-diphosphatase PAS_4g00105 CAY71248.1 PAS_chr4_0912 hypothetical protein GO:0003951;GO:0008152 YJR049C UTR1 ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p) Uncharacterized kinase C24B10.02c PAS_4g00110 CAY71249.1 PAS_chr4_0022 Ubiquitin-specific protease that may play a role in ubiquitin precursor processing GO:0003951;GO:0008152 YMR304W UBP15 Ubiquitin-specific protease that may play a role in ubiquitin precursor processing Ubiquitin carboxyl-terminal hydrolase 15 PAS_4g00115 CAY71250.1 PAS_chr4_0023 Putative pantetheine-phosphate adenylyltransferase (PPAT) GO:0009058;GO:0016779 YGR277C CAB4 "Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved" Uncharacterized protein YGR277C PAS_4g00120 CAY71251.1 PAS_chr4_0024 Hypothetical protein YDR016C DAD1 "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" DASH complex subunit DAD1 PAS_4g00125 YDR017C KCS1 "Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance" Inositol hexakisphosphate kinase 1 PAS_4g00130 CAY71252.1 PAS_chr4_0026 hypothetical protein GO:0003993 PAS_4g00135 CAY71253.1 PAS_chr4_0027 Hypothetical protein Putative methyltransferase C27D7.08c PAS_4g00140 CAY71254.1 PAS_chr4_0028 "Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p)" YDR013W PSF1 "Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery" DNA replication complex GINS protein PSF1 PAS_4g00145 CAY71255.1 PAS_chr4_0029 Hypothetical protein PAS_4g00150 CAY71256.1 PAS_chr4_0030 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis YKR024C DBP7 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions ATP-dependent RNA helicase DBP7 PAS_4g00155 CAY71257.1 PAS_chr4_0031 RNA polymerase III subunit C37 YKR025W RPC37 RNA polymerase III subunit C37 PAS_4g00160 CAY71258.1 PAS_chr4_0032 Alpha subunit of the translation initiation factor eIF2B GO:0044237 YKR026C GCN3 "Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression" Translation initiation factor eIF-2B subunit alpha PAS_4g00165 CAY71259.1 PAS_chr4_0033 Mitochondrial elongation factor involved in translational elongation YJL102W MEF2 Mitochondrial elongation factor involved in translational elongation "Ribosome-releasing factor 2, mitochondrial " PAS_4g00170 CAY71260.1 PAS_chr4_0034 Subunit of heterotrimeric Replication Protein A (RPA) GO:0003676 YNL312W RFA2 "Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination" Replication factor A protein 2 PAS_4g00175 CAY71261.1 PAS_chr4_0035 Putative helicase GO:0003677;GO:0005524 YLR247C IRC20 Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci Uncharacterized ATP-dependent helicase YLR247C PAS_4g00180 PAS_4g00185 CAY71262.1 PAS_chr4_0037 Protein kinase involved in the response to oxidative and osmotic stress YLR248W RCK2 Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations Serine/threonine-protein kinase srk1 PAS_4g00190 CAY71263.1 PAS_chr4_0913 hypothetical protein GO:0004177;GO:0005773;GO:0006508;GO:0008270 YHR113W YHR113W Cytoplasmic aspartyl aminopeptidase; cleaves unblocked N-terminal acidic amino acid residues from peptide substrates; forms a 12 subunit homo-oligomeric complex; M18 metalloprotease family member; may interact with ribosomes Putative aspartyl aminopeptidase PAS_4g00195 CAY71264.1 PAS_chr4_0038 "Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes" GO:0004177;GO:0005773;GO:0006508;GO:0008270 YLR249W YEF3 "Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP" Elongation factor 3 PAS_4g00200 CAY71265.1 PAS_chr4_0039 Meiosis-specific protein with similarity to phospholipase B GO:0004620;GO:0009395 YNL012W SPO1 Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B Putative meiotic phospholipase SPO1 PAS_4g00205 CAY71266.1 PAS_chr4_0040 Protein of unknown function GO:0005509 YLR250W SSP120 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Protein SSP120 PAS_4g00210 CAY71267.1 PAS_chr4_0914 hypothetical protein PAS_4g00215 CAY71268.1 PAS_chr4_0041 Protein component of the large (60S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YLR061W RPL22A "Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein" 60S ribosomal protein L22-A PAS_4g00220 CAY71269.1 PAS_chr4_0915 hypothetical protein Glycoprotein gp2 PAS_4g00225 CAY71270.1 PAS_chr4_0042 Hypothetical protein PAS_4g00230 CAY71271.1 PAS_chr4_0043 Mitochondrial aldehyde dehydrogenase GO:0008152;GO:0016491 Aldehyde dehydrogenase PAS_4g00235 CAY71272.1 PAS_chr4_0044 Hypothetical protein Rhamnogalacturonate lyase PAS_4g00240 CAY71273.1 PAS_chr4_0045 Hypothetical protein YDL139C SCM3 "Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p" Protein SCM3 PAS_4g00245 CAY71274.1 PAS_chr4_0046 Mitochondrial outer membrane and cell wall localized SUN family member YKR042W UTH1 "Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death" Protein UTH1 PAS_4g00250 CAY71275.1 PAS_chr4_0047 Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles YBR105C VID24 "Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase" Uncharacterized protein C17orf39 PAS_4g00255 CAY71276.1 PAS_chr4_0048 "Intracellular beta-1,3-endoglucanase, expression is induced during sporulation" "Endo-1,3(4)-beta-glucanase 2 " PAS_4g00260 CAY71277.1 PAS_chr4_0049 "Mitochondrial protein, putative inner membrane transporter" GO:0005488;GO:0006810;GO:0016020 YPR058W YMC1 "Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p" "Carrier protein YMC1, mitochondrial " PAS_4g00265 CAY71278.1 PAS_chr4_0050 "Chorismate mutase, catalyzes the conversion of chorismate to prephenate" GO:0004106;GO:0009073 YPR060C ARO7 "Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis" Chorismate mutase PAS_4g00270 CAY71279.1 PAS_chr4_0051 "Probable Hsp40p co-chaperone, has a DnaJ-like domain" GO:0031072 YPR061C JID1 "Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae" PAS_4g00275 CAY71280.1 PAS_chr4_0052 Hypothetical protein GO:0016491 Delta(12) fatty acid desaturase PAS_4g00280 PAS_4g00285 CAY71281.1 PAS_chr4_0054 Hypothetical protein YKL057C NUP120 "Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p" Nucleoporin NUP120 PAS_4g00290 CAY71282.1 PAS_chr4_0055 Protoporphyrinogen oxidase GO:0004729;GO:0006118;GO:0006779 YER014W HEM14 "Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides" Protoporphyrinogen oxidase PAS_4g00295 PAS_4g00300 PAS_4g00305 CAY71283.1 PAS_chr4_0058 Hypothetical protein PAS_4g00310 CAY71284.1 PAS_chr4_0059 Hypothetical protein PAS_4g00315 CAY71285.1 PAS_chr4_0060 Evolutionarily conserved glucosamine-6-phosphate acetyltransferase YFL017C GNA1 "Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA" Glucosamine 6-phosphate N-acetyltransferase PAS_4g00320 CAY71286.1 PAS_chr4_0916 hypothetical protein GO:0005801;GO:0006886;GO:0016020 YER157W COG3 "Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" Conserved oligomeric Golgi complex subunit 3 PAS_4g00325 CAY71287.1 PAS_chr4_0061 Component of the RNA polymerase II general transcription and DNA repair factor TFIIH GO:0003677;GO:0006289 YDR079C-A TFB5 Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair RNA polymerase II transcription factor B subunit 5 PAS_4g00330 CAY71288.1 PAS_chr4_0062 Vacuolar membrane protein GO:0005515;GO:0006886;GO:0016192 YDR080W VPS41 Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport Vacuolar protein sorting-associated protein 41 PAS_4g00335 CAY71289.1 PAS_chr4_0063 "C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis" GO:0016020 YGL012W ERG4 "C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol" Delta(24(24(1)))-sterol reductase PAS_4g00340 CAY71290.1 PAS_chr4_0064 Hypothetical protein PAS_4g00345 CAY71291.1 PAS_chr4_0065 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP) YDL244W THI13 "Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13" Pyrimidine precursor biosynthesis enzyme THI13 PAS_4g00350 CAY71292.1 PAS_chr4_0066 Alpha 1 subunit of the 20S core complex of the 26S proteasome GO:0004298;GO:0005839;GO:0006511 YGL011C SCL1 Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria Proteasome component C7-alpha PAS_4g00355 CAY71293.1 PAS_chr4_0067 Mitochondrial ribosomal protein of the small subunit YKL155C RSM22 Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase "37S ribosomal protein S22, mitochondrial " PAS_4g00360 CAY71294.1 PAS_chr4_0068 Hypothetical protein PAS_4g00365 CAY71295.1 PAS_chr4_0069 "Nucleosome assembly factor, involved in chromatin assembly and disassembly" GO:0005634;GO:0006333 YJL115W ASF1 "Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition" Histone chaperone ASF1 PAS_4g00370 CAY71296.1 PAS_chr4_0070 Hypothetical protein YNL042W BOP3 "Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury" PAS_4g00375 YIL104C SHQ1 "Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones" Protein SHQ1 PAS_4g00380 CAY71297.1 PAS_chr4_0072 "Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide" YIL103W DPH1 "Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p" Diphthamide biosynthesis protein 1 PAS_4g00385 CAY71298.1 PAS_chr4_0073 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) YNL041C COG6 "Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" Conserved oligomeric Golgi complex subunit 6 PAS_4g00390 CAY71299.1 PAS_chr4_0917 hypothetical protein GO:0016021 YBR287W YBR287W Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene Uncharacterized transporter C5D6.04 PAS_4g00395 CAY71300.1 PAS_chr4_0074 Vacuolar protein sorting protein GO:0016021 YJL053W PEP8 "Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport" Vacuolar protein sorting-associated protein 26 PAS_4g00400 CAY71301.1 PAS_chr4_0075 Hypothetical protein PAS_4g00405 CAY71302.1 PAS_chr4_0076 One of two (see also PSK1) PAS domain containing S/T protein kinases GO:0004674;GO:0006468 YOL045W PSK2 "One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation)" Probable serine/threonine-protein kinase YOL045W PAS_4g00410 CAY71303.1 PAS_chr4_0077 Hypothetical protein GO:0005634;GO:0030528;GO:0045449 PAS_4g00415 CAY71304.1 PAS_chr4_0078 Essential protein with dual roles in spliceosome assembly and exocytosis YBR102C EXO84 "Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis" Exocyst complex component EXO84 PAS_4g00420 CAY71305.1 PAS_chr4_0079 Hypothetical protein YMR159C ATG16 "Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy" Autophagy protein 16 PAS_4g00425 CAY71306.1 PAS_chr4_0080 Hypothetical protein GO:0005509 PAS_4g00430 CAY71307.1 PAS_chr4_0081 Riboflavin synthase YBR256C RIB5 Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway Riboflavin synthase alpha chain PAS_4g00435 CAY71308.1 PAS_chr4_0082 Essential protein involved in a late step of 60S ribosomal subunit assembly or modification YIR012W SQT1 Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay Ribosome assembly protein SQT1 PAS_4g00440 CAY71309.1 PAS_chr4_0083 Splicing factor that is found in the Cef1p subcomplex of the spliceosome YPL151C PRP46 "Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs" Pre-mRNA-splicing factor PRP46 PAS_4g00445 CAY71310.1 PAS_chr4_0084 Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) YOR244W ESA1 Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression and transcriptional silencing at the rDNA locus Histone acetyltransferase ESA1 PAS_4g00450 CAY71311.1 PAS_chr4_0085 "Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase" GO:0019211 YPL152W RRD2 "Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex" Serine/threonine-protein phosphatase 2A activator 2 PAS_4g00455 CAY71312.1 PAS_chr4_0918 hypothetical protein PAS_4g00460 CAY71313.1 PAS_chr4_0086 Putative acyltransferase with similarity to Eeb1p and Eht1p YMR210W YMR210W "Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification" Putative esterase YMR210W PAS_4g00465 CAY71314.1 PAS_chr4_0087 Protein involved in the repair of double-strand breaks in DNA during vegetative growth GO:0006281;GO:0006310 YDL059C RAD59 Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p DNA repair and recombination protein RAD52 PAS_4g00470 CAY71315.1 PAS_chr4_0088 Essential protein involved in intracellular protein transport GO:0000139;GO:0005737;GO:0006886;GO:0048280 YDL058W USO1 "Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex" Intracellular protein transport protein USO1 PAS_4g00475 CAY71316.1 PAS_chr4_0089 Hypothetical protein Uncharacterized protein YPL158C PAS_4g00480 CAY71317.1 PAS_chr4_0090 "Trimethyl guanosine synthase, conserved nucleolar methyl transferase" YPL157W TGS1 "Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphology" Trimethylguanosine synthase PAS_4g00485 CAY71318.1 PAS_chr4_0091 Kinesin-related motor protein involved in mitotic spindle positioning GO:0003777;GO:0005524;GO:0005875;GO:0007018 YPL155C KIP2 "Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle" Kinesin-like protein KIP2 PAS_4g00490 CAY71319.1 PAS_chr4_0092 Putative protein of unknown function YDR352W YDR352W Putative protein of unknown function Vacuolar integral membrane protein YDR352W PAS_4g00495 CAY71320.1 PAS_chr4_0093 Putative transcription factor involved in regulating the response to osmotic stress GO:0003700;GO:0005634;GO:0006355;GO:0043565 YBR182C SMP1 Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors Transcription factor RLM1 PAS_4g00500 CAY71321.1 PAS_chr4_0094 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005840;GO:0006412 40S ribosomal protein S6 PAS_4g00505 CAY71322.1 PAS_chr4_0095 "Subunit of the SF3a splicing factor complex, required for spliceosome assembly" GO:0003723;GO:0006396 YJL203W PRP21 "Subunit of the SF3a splicing factor complex, required for spliceosome assembly" Pre-mRNA-splicing factor sap114 PAS_4g00510 CAY71323.1 PAS_chr4_0096 Hypothetical protein PAS_4g00515 YPL085W SEC16 "COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p" COPII coat assembly protein SEC16 PAS_4g00520 CAY71324.1 PAS_chr4_0098 "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA" YPL086C ELP3 "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin" Elongator complex protein 3 PAS_4g00525 CAY71325.1 PAS_chr4_0099 Hypothetical protein PAS_4g00530 CAY71326.1 PAS_chr4_0100 "Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex" YFL024C EPL1 "Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb" Enhancer of polycomb-like protein 1 PAS_4g00535 CAY71327.1 PAS_chr4_0101 "Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA" GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YPL104W MSD1 "Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene" "Aspartyl-tRNA synthetase, mitochondrial " PAS_4g00540 CAY71328.1 PAS_chr4_0102 Nuclear protein required for transcription of MXR1 YPL048W CAM1 Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma Elongation factor 1-gamma 2 PAS_4g00545 CAY71329.1 PAS_chr4_0103 "Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p" YPL050C MNN9 "Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation" Mannan polymerase complex subunit MNN9 PAS_4g00550 CAY71330.1 PAS_chr4_0104 Zinc-finger protein of unknown function GO:0003676;GO:0008270 YPL054W LEE1 Zinc-finger protein of unknown function Protein cps3 PAS_4g00555 CAY71331.1 PAS_chr4_0105 Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus YPL093W NOG1 Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins Nucleolar GTP-binding protein 1 PAS_4g00560 CAY71332.1 PAS_chr4_0106 Hypothetical protein PAS_4g00565 CAY71333.1 PAS_chr4_0107 Protein component of the large (60S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YFR031C-A RPL2A "Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins" 60S ribosomal protein L2 PAS_4g00570 CAY71334.1 PAS_chr4_0108 Hypothetical protein PAS_4g00575 CAY71335.1 PAS_chr4_0109 "Component of the condensin complex, essential SMC chromosomal ATPase family member" GO:0005524;GO:0005694;GO:0006259 YFR031C SMC2 Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus Structural maintenance of chromosomes protein 2 PAS_4g00580 CAY71336.1 PAS_chr4_0111 "Low affinity methionine permease, similar to Mup1p" GO:0006865;GO:0015171;GO:0016020 Low-affinity methionine permease PAS_4g00585 CAY71337.1 PAS_chr4_0112 Threonine aldolase GO:0003824;GO:0030170 YEL046C GLY1 "Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis" Threonine aldolase PAS_4g00590 CAY71338.1 PAS_chr4_0113 Protein that associates with ribosomes GO:0006508;GO:0008237;GO:0008270 YIL137C TMA108 Protein that associates with ribosomes; putative metalloprotease Protein TMA108 PAS_4g00595 CAY71339.1 PAS_chr4_0114 Hypothetical protein PAS_4g00600 CAY71341.1 PAS_chr4_0115 "Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments" YIL138C TPM2 "Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p" Tropomyosin-2 PAS_4g00605 CAY71342.1 PAS_chr4_0116 Protein involved in N-glycosylation YNL080C EOS1 Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene N-glycosylation protein EOS1 PAS_4g00610 CAY71343.1 PAS_chr4_0117 Hypothetical protein YIL127C RRT14 Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Uncharacterized protein YIL127C PAS_4g00615 CAY71344.1 PAS_chr4_0118 DNA repair and TFIIH regulator GO:0005488 YIL128W MET18 "DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance" DNA repair/transcription protein MET18/MMS19 PAS_4g00620 CAY71345.1 PAS_chr4_0119 "Protein involved in cell morphogenesis and proliferation, associated with protein kinase Cbk1p" GO:0005509 YIL129C TAO3 "Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p" Cell morphogenesis protein PAG1 PAS_4g00625 YNL084C END3 "EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p" Actin cytoskeleton-regulatory complex protein END3 PAS_4g00630 CAY71347.1 PAS_chr4_0120 Hypothetical protein GO:0006120;GO:0008137 "Probable NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial " PAS_4g00635 CAY71348.1 PAS_chr4_0121 "Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p" GO:0005524;GO:0006457;GO:0051082 YIL142W CCT2 "Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo" T-complex protein 1 subunit beta PAS_4g00640 CAY71349.1 PAS_chr4_0122 "Probable transporter, member of the Ca2+-binding subfamily of the mitochondrial carrier family" GO:0005509 YNL083W SAL1 "ADP/ATP transporter; member of the Ca2+-binding subfamily of the mitochondrial carrier family, with two EF-hand motifs; Pet9p and Sal1p have an overlapping function critical for viability; polymorphic in different S. cerevisiae strains" Calcium-binding mitochondrial carrier SAL1 PAS_4g00645 CAY71350.1 PAS_chr4_0123 Receptor for alpha-factor pheromone GO:0004932;GO:0016020 YFL026W STE2 Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells Pheromone alpha factor receptor PAS_4g00650 CAY71351.1 PAS_chr4_0124 ATP-binding protein required for mismatch repair in mitosis and meiosis GO:0005524 YNL082W PMS1 "ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL" DNA mismatch repair protein PMS1 PAS_4g00655 CAY71352.1 PAS_chr4_0125 Hypothetical protein GO:0007067 YIL139C REV7 "Processivity subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage" PAS_4g00660 CAY71353.1 PAS_chr4_0126 Hypothetical protein YOR308C SNU66 Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; has homology to human SART-1 and to an S. pombe protein; snu66 null mutation confers cold-sensitivity but is not lethal at normal growth temperatures 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component PAS_4g00665 CAY71354.1 PAS_chr4_0127 RNAase III GO:0003723;GO:0004525;GO:0006396 YMR239C RNT1 RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; involved in polyadenylation-independent transcription termination Ribonuclease 3 PAS_4g00670 CAY71355.1 PAS_chr4_0128 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes YOR304W ISW2 "ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth" ISWI chromatin-remodeling complex ATPase ISW2 PAS_4g00675 CAY71356.1 PAS_chr4_0129 Hypothetical protein YGR113W DAM1 "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments" DASH complex subunit DAM1 PAS_4g00680 CAY71357.1 PAS_chr4_0130 Putative protein of unknown function GO:0005515 YDR132C YDR132C Putative protein of unknown function BTB/POZ domain-containing protein YLR108C PAS_4g00685 CAY71358.1 PAS_chr4_0131 Protein component of the large (60S) ribosomal subunit YLR448W RPL6B "Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA" 60S ribosomal protein L6-B PAS_4g00690 CAY71359.1 PAS_chr4_0132 Putative protein of unknown function YLR143W YLR143W Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene Meiotically up-regulated gene 71 protein PAS_4g00695 CAY71360.1 PAS_chr4_0133 Hypothetical protein Formin-like protein 3 PAS_4g00700 CAY71361.1 PAS_chr4_0134 Sm-like protein involved in docking and fusion of exocytic vesicles GO:0006904;GO:0016192 YDR164C SEC1 Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function Protein transport protein SEC1 PAS_4g00705 YLR144C ACF2 "Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly" "Endo-1,3(4)-beta-glucanase 2 " PAS_4g00710 CAY71362.1 PAS_chr4_0136 Subunit of the histone deacetylase Rpd3L complex YBR095C RXT2 Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth Transcriptional regulatory protein RXT2 PAS_4g00715 CAY71363.1 PAS_chr4_0137 Putative tubulin tyrosine ligase associated with P-bodies GO:0004835;GO:0006464 YBR094W PBY1 Putative tubulin tyrosine ligase associated with P-bodies TTL domain-containing protein YBR094W PAS_4g00720 CAY71364.1 PAS_chr4_0138 Small subunit of carbamoyl phosphate synthetase YOR303W CPA1 "Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader" Carbamoyl-phosphate synthase arginine-specific small chain PAS_4g00725 CAY71365.1 PAS_chr4_0139 Protein component of the large (60S) ribosomal subunit YOR063W RPL3 "Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus" 60S ribosomal protein L3 PAS_4g00730 CAY71366.1 PAS_chr4_0140 ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase YOR204W DED1 "ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility" ATP-dependent RNA helicase DED1 PAS_4g00735 CAY71367.1 PAS_chr4_0141 "RNA binding protein, component of the U1 snRNP protein" GO:0000166 Protein NAM8 PAS_4g00740 CAY71368.1 PAS_chr4_0142 Hypothetical protein GO:0003954;GO:0005739;GO:0006118;GO:0008137 "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial " PAS_4g00745 CAY71369.1 PAS_chr4_0143 Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex GO:0003677;GO:0005524 YDR334W SWR1 "Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A" Helicase SWR1 PAS_4g00750 YER048W-A ISD11 Protein required for mitochondrial iron-sulfur cluster biosynthesis Protein ISD11 PAS_4g00755 CAY71370.1 PAS_chr4_0145 Hypothetical protein PAS_4g00760 CAY71371.1 PAS_chr4_0146 Hypothetical protein GO:0003824;GO:0030170 Uncharacterized aminotransferase C660.12c PAS_4g00765 CAY71372.1 PAS_chr4_0147 Aromatic aminotransferase II GO:0003824;GO:0030170 YHR137W ARO9 "Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism" Aromatic amino acid aminotransferase 2 PAS_4g00770 CAY71373.1 PAS_chr4_0148 Gamma-tubulin GO:0003924;GO:0005525;GO:0043234;GO:0051258 YLR212C TUB4 "Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body" Tubulin gamma chain PAS_4g00775 CAY71374.1 PAS_chr4_0149 Microsomal cytochrome b reductase GO:0006118;GO:0016491 YIL043C CBR1 "Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia" NADH-cytochrome b5 reductase 1 PAS_4g00780 CAY71375.1 PAS_chr4_0150 Aspartate kinase (L-aspartate 4-P-transferase) GO:0004072;GO:0008652 YER052C HOM3 Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis Aspartokinase PAS_4g00785 CAY71376.1 PAS_chr4_0151 Hypothetical protein Endoglucanase PAS_4g00790 CAY71377.1 PAS_chr4_0152 Hypothetical protein GO:0016614 Alcohol oxidase PAS_4g00795 CAY71378.1 PAS_chr4_0153 Phospholipase B (lysophospholipase) involved in phospholipid metabolism GO:0004620;GO:0009395 YOL011W PLB3 Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro Lysophospholipase PAS_4g00800 CAY71379.1 PAS_chr4_0154 Hypothetical protein YML043C RRN11 "Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p" RNA polymerase I-specific transcription initiation factor rrn11 PAS_4g00805 CAY71380.1 PAS_chr4_0155 Hypothetical protein OPA3-like protein PAS_4g00810 CAY71381.1 PAS_chr4_0156 Ubiquitin-protein ligase YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger E3 ubiquitin-protein ligase hrd-1 PAS_4g00815 CAY71382.1 PAS_chr4_0157 "Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex" GO:0003677 YOL012C HTZ1 "Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin" Histone H2A.Z PAS_4g00820 CAY71383.1 PAS_chr4_0158 Tetradecameric mitochondrial chaperonin GO:0005524;GO:0006457;GO:0051082 YLR259C HSP60 Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated "Heat shock protein 60, mitochondrial " PAS_4g00825 CAY71384.1 PAS_chr4_0159 Protein with a possible role in regulating expression of nitrogen permeases YEL062W NPR2 "Component, with Npr3p, of an evolutionarily conserved complex that mediates downregulation of TOR Complex 1 activity in response to amino acid limitation; transcription is induced in response to proline and urea" Nitrogen permease regulator 2 PAS_4g00830 CAY71385.1 PAS_chr4_0160 Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation GO:0003777;GO:0005524;GO:0005875;GO:0007018 YBL063W KIP1 "Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions" Kinesin-like protein bimC PAS_4g00835 CAY71386.1 PAS_chr4_0161 Hypothetical protein PAS_4g00840 CAY71387.1 PAS_chr4_0162 Hypothetical protein PAS_4g00845 CAY71388.1 PAS_chr4_0921 hypothetical protein H(+)/Cl(-) exchange transporter 5 PAS_4g00850 CAY71389.1 PAS_chr4_0163 Abundant subunit of the nuclear pore complex (NPC) GO:0005643;GO:0006913;GO:0017056;n/a YBL079W NUP170 "Subunit of the nuclear pore complex (NPC), required for NPC localization of specific nucleoporins; involved in nuclear envelope permeability and chromosome segregation; has similar to Nup157p; essential role, with Nup157p, in NPC assembly" Nucleoporin NUP157 PAS_4g00855 CAY71390.1 PAS_chr4_0164 Hypothetical protein Translation machinery-associated protein 7 PAS_4g00860 CAY71391.1 PAS_chr4_0165 "GTPase, Ras-like GTP binding protein involved in the secretory pathway" GO:0005525;GO:0007264;GO:0015031 YLR262C YPT6 "GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6" GTP-binding protein YPT6 PAS_4g00865 CAY71392.1 PAS_chr4_0166 Putative transcription factor containing a C2H2 zinc finger GO:0003676;GO:0005622;GO:0008270 YPL230W USV1 "Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis" Nutrient and stress factor 1 PAS_4g00870 CAY71393.1 PAS_chr4_0167 UDP-glucose:sterol glucosyltransferase (Sterol 3-beta-glucosyltransferase) YLR189C ATG26 "UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy" Sterol 3-beta-glucosyltransferase PAS_4g00875 YDL240W LRG1 "Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis" Rho-GTPase-activating protein LRG1 PAS_4g00880 YMR074C YMR074C "Protein with homology to human PDCD5, which is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene" Uncharacterized protein YMR074C PAS_4g00885 CAY71394.1 PAS_chr4_0169 Transcription factor that controls expression of many ribosome biogenesis genes GO:0003676;GO:0005622;GO:0008270 YLR403W SFP1 "Transcription factor that controls expression of ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, modulates cell size; regulated by TORC1 and Mrs6p" Zinc finger protein SFP1 PAS_4g00890 CAY71395.1 PAS_chr4_0170 Hypothetical protein PAS_4g00895 CAY71396.1 PAS_chr4_0171 Hypothetical protein GO:0015078;GO:0016469 YDL073W YDL073W Putative protein of unknown function; YDL073W is not an essential gene Uncharacterized serine-rich protein C215.13 PAS_4g00900 CAY71397.1 PAS_chr4_0172 E3 ubiquitin ligase for Rad6p YDL074C BRE1 "E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control" E3 ubiquitin-protein ligase BRE1 PAS_4g00905 CAY71398.1 PAS_chr4_0173 "Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities" YBR208C "DUR1,2" "Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation" Urea amidolyase PAS_4g00910 CAY71399.1 PAS_chr4_0174 Deubiquitinating enzyme anchored to the outer mitochondrial membrane GO:0004221;GO:0006511 YPL072W UBP16 "Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria" Ubiquitin carboxyl-terminal hydrolase 16 PAS_4g00915 CAY71400.1 PAS_chr4_0175 Putative protein of unknown function GO:0020037;GO:0046914 YMR073C IRC21 Putative protein of unknown function; proposed to be involved in resistance to carboplatin and cisplatin; shares similarity to a human cytochrome oxidoreductase; null mutant displays increased levels of spontaneous Rad52p foci Cytochrome b5 reductase 4 PAS_4g00920 CAY71401.1 PAS_chr4_0176 Hypothetical protein PAS_4g00925 CAY71402.1 PAS_chr4_0922 hypothetical protein YOR126C IAH1 "Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing" Isoamyl acetate-hydrolyzing esterase PAS_4g00930 CAY71403.1 PAS_chr4_0177 Non-essential protein of unknown function GO:0016021 Protein ECM3 PAS_4g00935 CAY71404.1 PAS_chr4_0178 Dihydrouridine synthase GO:0008033;GO:0017150;GO:0050660 YLR401C DUS3 "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region" tRNA-dihydrouridine synthase 3 PAS_4g00940 CAY71405.1 PAS_chr4_0179 Dihydrouridine synthase GO:0008033;GO:0017150;GO:0050660 YLR405W DUS4 "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p" tRNA-dihydrouridine synthase 4 PAS_4g00945 CAY71406.1 PAS_chr4_0180 Protein component of the large (60S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YLR406C RPL31B "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality" 60S ribosomal protein L31-B PAS_4g00950 CAY71407.1 PAS_chr4_0923 hypothetical protein YDL076C RXT3 Subunit of the RPD3L complex; involved in histone deacetylation PAS_4g00955 CAY71408.1 PAS_chr4_0181 High-affinity copper transporter of the plasma membrane GO:0005375;GO:0006825;GO:0016021;n/a YPR124W CTR1 "High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels" Copper transport protein CTR1 PAS_4g00960 CAY71409.1 PAS_chr4_0182 BAR domain-containing protein that localizes to both early and late Golgi vesicles GO:0005515;GO:0005737 YIL041W GVP36 "BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis" Protein GVP36 PAS_4g00965 Uncharacterized protein DDB_G0271670 PAS_4g00970 CAY71410.1 PAS_chr4_0184 Protein of unknown function YGL045W RIM8 Protein involved in proteolytic activation of Rim101p in response to alkaline pH; similar to A. nidulans PalF; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family pH-response regulator protein palF/RIM8 PAS_4g00975 CAY71411.1 PAS_chr4_0185 Nucleolar protein that binds nuclear localization sequences GO:0000166 YGR159C NSR1 "Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis" Nuclear localization sequence-binding protein PAS_4g00980 CAY71412.1 PAS_chr4_0186 Plasma membrane ATP-binding cassette (ABC) transporter GO:0005524;GO:0006810;GO:0016021;GO:0042626 YGR281W YOR1 "Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR)" Oligomycin resistance ATP-dependent permease YOR1 PAS_4g00985 PAS_4g00990 CAY71413.1 PAS_chr4_0188 Plasma membrane ATP-binding cassette (ABC) transporter GO:0005524;GO:0006810;GO:0016021;GO:0042626 Oligomycin resistance ATP-dependent permease YOR1 PAS_4g00995 CAY71414.1 PAS_chr4_0189 Cyclin-like protein that interacts with Pho85p YGL215W CLG1 Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2 Meiotically up-regulated gene 80 protein PAS_4g01000 CAY71415.1 PAS_chr4_0190 Hypothetical protein PAS_4g01005 CAY71416.1 PAS_chr4_0191 Malate synthase GO:0004474;GO:0006097 YIR031C DAL7 "Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation" "Malate synthase, glyoxysomal " PAS_4g01010 CAY71417.1 PAS_chr4_0192 Flavin-containing monooxygenase GO:0016491;GO:0050660 Thiol-specific monooxygenase PAS_4g01015 CAY71418.1 PAS_chr4_0193 Hypothetical protein PAS_4g01020 CAY71419.1 PAS_chr4_0194 Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex GO:0016787 YNL118C DCP2 "Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family" mRNA-decapping enzyme subunit 2 PAS_4g01025 CAY71420.1 PAS_chr4_0195 Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA YNL207W RIO2 Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p Serine/threonine-protein kinase RIO2 PAS_4g01030 CAY71421.1 PAS_chr4_0924 hypothetical protein GO:0008083 YDR063W AIM7 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and displays elevated frequency of mitochondrial genome loss Protein AIM7 PAS_4g01035 CAY71422.1 PAS_chr4_0196 "Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes" GO:0004326;GO:0005524;GO:0009396 YOR241W MET7 "Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA" Folylpolyglutamate synthase PAS_4g01040 CAY71423.1 PAS_chr4_0197 Small subunit of the ribonucleotide-diphosphate reductase (RNR) complex GO:0016491;GO:0046914 YJL026W RNR2 "Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits" Ribonucleoside-diphosphate reductase small chain 1 PAS_4g01045 CAY71424.1 PAS_chr4_0198 C-8 sterol isomerase GO:0000247;GO:0005783;GO:0006696 YMR202W ERG2 "C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis" C-8 sterol isomerase PAS_4g01050 CAY71425.1 PAS_chr4_0200 Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway GO:0005488 YOR112W CEX1 "Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p" Probable inactive serine/threonine-protein kinase scy1 PAS_4g01055 CAY71426.1 PAS_chr4_0201 Essential ATP-dependent RNA helicase of the DEAD-box protein family GO:0003677;GO:0003899;GO:0006350 YNL112W DBP2 "Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing" ATP-dependent RNA helicase DBP2 PAS_4g01060 CAY71427.1 PAS_chr4_0925 hypothetical protein GO:0003677;GO:0003899;GO:0006350 YNL113W RPC19 "RNA polymerase subunit, common to RNA polymerases I and III" DNA-directed RNA polymerases I and III subunit RPAC2 PAS_4g01065 CAY71428.1 PAS_chr4_0202 Zinc-finger transcription factor GO:0003676 YOR113W AZF1 "Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance" Asparagine-rich zinc finger protein AZF1 PAS_4g01070 CAY71429.1 PAS_chr4_0203 "Proposed transcriptional activator, member of the Gal4p family of zinc cluster proteins" GO:0003677;GO:0005634;GO:0006350;GO:0008270 YIL130W ASG1 "Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance" Activator of stress genes 1 PAS_4g01075 CAY71430.1 PAS_chr4_0204 Subunit of TFIIH and nucleotide excision repair factor 3 complexes GO:0005634;GO:0007049 YDR460W TFB3 "Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit" RNA polymerase II transcription factor B subunit 3 PAS_4g01080 CAY71431.1 PAS_chr4_0205 Forkhead family transcription factor with a major role in the expression of G2/M phase genes YNL068C FKH2 Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase Fork head protein homolog 2 PAS_4g01085 CAY71432.1 PAS_chr4_0206 Hypothetical protein PAS_4g01090 CAY71433.1 PAS_chr4_0207 Hypothetical protein PAS_4g01095 CAY71434.1 PAS_chr4_0208 "N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA" GO:0003735;GO:0006412;GO:0015934 YIL133C RPL16A "N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p" 60S ribosomal protein L16-A PAS_4g01100 PAS_4g01105 CAY71435.1 PAS_chr4_0210 Major ADP/ATP carrier of the mitochondrial inner membrane GO:0005215;GO:0005743;GO:0006810 YBL030C PET9 "Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene" "ADP,ATP carrier protein " PAS_4g01110 CAY71436.1 PAS_chr4_0926 hypothetical protein PAS_4g01115 CAY71437.1 PAS_chr4_0211 "Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YOR096W RPS7A "Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins" 40S ribosomal protein S7-A PAS_4g01120 CAY71438.1 PAS_chr4_0212 Ribose-5-phosphate ketol-isomerase Ribose-5-phosphate isomerase PAS_4g01125 CAY71439.1 PAS_chr4_0213 Ribose-5-phosphate ketol-isomerase GO:0004751;GO:0009052 YOR095C RKI1 "Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis" Ribose-5-phosphate isomerase PAS_4g01130 CAY71440.1 PAS_chr4_0214 Glucose-repressible ADP-ribosylation factor GO:0005525 Probable ADP-ribosylation factor PAS_4g01135 CAY71441.1 PAS_chr4_0215 SH3 domain protein implicated in the regulation of actin polymerization YHR114W BZZ1 "SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins" Protein BZZ1 PAS_4g01140 CAY71442.1 PAS_chr4_0216 Non-essential protein of unknown function GO:0016021 YOR092W ECM3 Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation Uncharacterized transporter YNL095C PAS_4g01145 CAY71443.1 PAS_chr4_0927 hypothetical protein YNL094W APP1 "Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization" Actin patch protein 1 PAS_4g01150 CAY71444.1 PAS_chr4_0217 Protein of unknown function that associates with ribosomes GO:0003676;GO:0008270 YOR091W TMA46 Protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1p Translation machinery-associated protein 46 PAS_4g01155 CAY71445.1 PAS_chr4_0218 Mitochondrial type 2C protein phosphatase involved in regulation of pyruvate dehydrogenase activity YOR090C PTC5 Mitochondrial type 2C protein phosphatase involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p Protein phosphatase 2C homolog 5 PAS_4g01160 CAY71446.1 PAS_chr4_0219 GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases GO:0005525;GO:0007264;GO:0015031;n/a YOR089C VPS21 GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog Vacuolar protein sorting-associated protein 21 PAS_4g01165 CAY71447.1 PAS_chr4_0928 hypothetical protein YNL092W YNL092W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene UPF0586 protein YNL092W PAS_4g01170 CAY71448.1 PAS_chr4_0220 Vacuolar cation channel GO:0005216;GO:0006811;GO:0016020 YOR087W YVC1 "Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock" Calcium channel YVC1 PAS_4g01175 CAY71449.1 PAS_chr4_0221 Hypothetical protein Stress response protein NST1 PAS_4g01180 CAY71450.1 PAS_chr4_0222 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins GO:0005525;GO:0005622;GO:0007264 YNL090W RHO2 "Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly" GTP-binding protein rho2 PAS_4g01185 CAY71451.1 PAS_chr4_0223 Protein involved in DNA replication GO:0003677;GO:0005524;GO:0005634;GO:0006270 YBL023C MCM2 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex DNA replication licensing factor MCM2 PAS_4g01190 CAY71452.1 PAS_chr4_0224 Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation GO:0005488 YNL288W CAF40 "Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p" Cell differentiation protein rcd1 PAS_4g01195 CAY71453.1 PAS_chr4_0225 "Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat" GO:0005515;GO:0006461;GO:0006886;GO:0008565;GO:0016192;GO:0030117 YNL287W SEC21 "Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo" Probable coatomer subunit gamma PAS_4g01200 CAY71454.1 PAS_chr4_0929 hypothetical protein GO:0000166 YNL286W CUS2 "Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)" Splicing factor U2AF-associated protein 2 PAS_4g01205 CAY71455.1 PAS_chr4_0226 P-loop ATPase with similarity to human OLA1 and bacterial YchF YBR025C OLA1 P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide Uncharacterized GTP-binding protein OLA1 PAS_4g01210 CAY71456.1 PAS_chr4_0227 Copper-binding protein of the mitochondrial inner membrane YBR037C SCO1 "Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins" "Protein SCO1, mitochondrial " PAS_4g01215 CAY71457.1 PAS_chr4_0930 hypothetical protein YOR206W NOC2 "Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors" Nucleolar complex protein 2 PAS_4g01220 CAY71458.1 PAS_chr4_0228 "Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis" GO:0030976 YMR108W ILV2 "Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control" "Acetolactate synthase catalytic subunit, mitochondrial " PAS_4g01225 CAY71459.1 PAS_chr4_0229 Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p) YOL115W PAP2 "Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p" Poly(A) RNA polymerase protein 1 PAS_4g01230 CAY71460.1 PAS_chr4_0931 hypothetical protein PAS_4g01235 CAY71461.1 PAS_chr4_0230 Hypothetical protein YLR016C PML1 "Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p" Pre-mRNA leakage protein 1 PAS_4g01240 CAY71462.1 PAS_chr4_0231 Putative nucleolar DEAD box RNA helicase YJL033W HCA4 Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis ATP-dependent RNA helicase DBP4 PAS_4g01245 CAY71463.1 PAS_chr4_0232 Protein with carboxyl methyl esterase activity GO:0003824 YHR075C PPE1 Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein Protein phosphatase methylesterase 1 PAS_4g01250 CAY71464.1 PAS_chr4_0233 Glutamine-dependent NAD(+) synthetase YHR074W QNS1 "Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide" Glutamine-dependent NAD(+) synthetase PAS_4g01255 CAY71465.1 PAS_chr4_0234 Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum YHR181W SVP26 "Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment" Protein SVP26 PAS_4g01260 CAY71466.1 PAS_chr4_0235 Hypothetical protein GO:0007242 PAS_4g01265 "C-1-tetrahydrofolate synthase, mitochondrial " PAS_4g01270 CAY71467.1 PAS_chr4_0238 Subunit of TFIIH and nucleotide excision repair factor 3 complexes GO:0003702;GO:0005634;GO:0006281;GO:0006355 YPL122C TFB2 "Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH" RNA polymerase II transcription factor B subunit 2 PAS_4g01275 CAY71468.1 PAS_chr4_0239 Second-largest subunit of RNA polymerase III GO:0003677;GO:0003899;GO:0006350 YOR207C RET1 "Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs" DNA-directed RNA polymerase III subunit RPC2 PAS_4g01280 CAY71469.1 PAS_chr4_0240 "Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters" GO:0005506;GO:0006118;GO:0016021;GO:0016491;GO:0050660 YOR381W FRE3 "Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" Ferric reductase transmembrane component 3 PAS_4g01285 CAY71470.1 PAS_chr4_0241 Putative ATPase of the AAA family YER047C SAP1 "Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system" Protein SAP1 PAS_4g01290 CAY71471.1 PAS_chr4_0242 Nuclear type II J heat shock protein of the E. coli dnaJ family GO:0006457;GO:0031072;GO:0051082 YER048C CAJ1 "Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly" Protein CAJ1 PAS_4g01295 CAY71472.1 PAS_chr4_0243 Protein of unknown function YER049W TPA1 "Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate" PKHD-type hydroxylase TPA1 PAS_4g01300 CAY71473.1 PAS_chr4_0244 Hypothetical protein GO:0005634;GO:0006974;GO:0007049;GO:0048478 YMR048W CSM3 Protein required for accurate chromosome segregation during meiosis Chromosome segregation in meiosis protein 3 PAS_4g01305 CAY71474.1 PAS_chr4_0245 Hypothetical protein PAS_4g01310 CAY71475.1 PAS_chr4_0932 hypothetical protein GO:0009166;GO:0016787 YHR202W YHR202W "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization" Uncharacterized protein YHR202W PAS_4g01315 CAY71476.1 PAS_chr4_0246 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412;n/a YHR203C RPS4B Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein 40S ribosomal protein S4 PAS_4g01320 CAY71477.1 PAS_chr4_0933 hypothetical protein YER182W FMP10 "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Uncharacterized mitochondrial membrane protein FMP10 PAS_4g01325 CAY71478.1 PAS_chr4_0247 "5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis" GO:0005524;GO:0009396;GO:0030272 YER183C FAU1 "5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis" 5-formyltetrahydrofolate cyclo-ligase PAS_4g01330 CAY71479.1 PAS_chr4_0248 "Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39" GO:0004084;GO:0009081 YHR208W BAT1 "Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase" "Branched-chain-amino-acid aminotransferase, mitochondrial " PAS_4g01335 CAY71480.1 PAS_chr4_0249 Proposed transcription factor YKR095W-A PCC1 "Proposed transcription factor involved in the expression of genes regulated by alpha-factor and galactose; component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; related to human cancer-testis antigens" Polarized growth chromatin-associated controller 1 PAS_4g01340 CAY71481.1 PAS_chr4_0250 DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns YDR194C MSS116 DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing "ATP-dependent RNA helicase MSS116, mitochondrial " PAS_4g01345 CAY71482.1 PAS_chr4_0251 "Hydrophilic protein, involved in vesicle trafficking between the ER and Golgi" GO:0006904;GO:0016192 YDR189W SLY1 Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex Protein sly1 PAS_4g01350 CAY71483.1 PAS_chr4_0252 Hypothetical protein GO:0003700;GO:0005634;GO:0006355 Zinc finger protein 1 PAS_4g01355 CAY71484.1 PAS_chr4_0253 Mitochondrial ribosome recycling factor GO:0006412 YHR038W RRF1 "Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria" "Ribosome-recycling factor, mitochondrial " PAS_4g01360 CAY71485.1 PAS_chr4_0254 Protein of unknown function GO:0003700;GO:0005622;GO:0006355;GO:0043565 YHR039C MSC7 "Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids" Putative aldehyde dehydrogenase-like protein YHR039C PAS_4g01365 CAY71486.1 PAS_chr4_0255 Hypothetical protein YHR039C-A VMA10 "Subunit G of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification" V-type proton ATPase subunit G PAS_4g01370 CAY71487.1 PAS_chr4_0256 Essential protein required for the accumulation of box C/D snoRNA YHR040W BCD1 Essential protein required for the accumulation of box C/D snoRNA Box C/D snoRNA protein 1 PAS_4g01375 CAY71488.1 PAS_chr4_0257 Putative protein of unknown function YDR333C YDR333C Putative protein of unknown function Uncharacterized protein YDR333C PAS_4g01380 CAY71489.1 PAS_chr4_0258 Essential component of the Rix1 complex (with Rix1p and Ipi3p) GO:0005488 YHR085W IPI1 Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles Pre-rRNA-processing protein IPI1 PAS_4g01385 CAY71490.1 PAS_chr4_0934 hypothetical protein YHR036W BRL1 "Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export" Nucleus export protein BRL1 PAS_4g01390 CAY71491.1 PAS_chr4_0259 Delta(9) fatty acid desaturase GO:0020037;GO:0046914 Acyl-CoA desaturase PAS_4g01395 CAY71492.1 PAS_chr4_0936 hypothetical protein YHR083W SAM35 "Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane" Sorting assembly machinery 35 kDa subunit PAS_4g01400 CAY71493.1 PAS_chr4_0937 hypothetical protein GO:0003700;GO:0005634;GO:0006355 YHR084W STE12 "Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth" Protein STE12 PAS_4g01405 CAY71494.1 PAS_chr4_0260 Nonessential putative serine/threonine protein kinase of unknown cellular role GO:0004674;GO:0006468;n/a YHR082C KSP1 "Ser/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10" Serine/threonine-protein kinase KSP1 PAS_4g01410 CAY71495.1 PAS_chr4_0261 ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex GO:0001509;GO:0004197;GO:0006508 YDR331W GPI8 ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog GPI-anchor transamidase PAS_4g01415 CAY71496.1 PAS_chr4_0262 GTP-binding protein involved in beta-tubulin (Tub2p) folding GO:0005525 YMR138W CIN4 "GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog" Probable ADP-ribosylation factor At2g18390 PAS_4g01420 CAY71497.1 PAS_chr4_0263 "Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p)" GO:0005488 YLR347C KAP95 "Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p" Importin subunit beta-1 PAS_4g01425 CAY71498.1 PAS_chr4_0264 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER GO:0003824;GO:0016020 YGR036C CAX4 "Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation" Dolichyldiphosphatase PAS_4g01430 CAY71499.1 PAS_chr4_0265 Putative protein of unknown function identified by fungal homology comparisons and RT-PCR Uncharacterized protein YLR154C-H/YLR156C-A/YLR157C-C/YLR159C-A PAS_4g01435 CAY71500.1 PAS_chr4_0266 "Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes" YLR345W YLR345W "Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene" "Putative 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase YLR345W " PAS_4g01440 CAY71501.1 PAS_chr4_0267 Protein component of the large (60S) ribosomal subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YGR034W RPL26B "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA" 60S ribosomal protein L26-A PAS_4g01445 CAY71502.1 PAS_chr4_0268 Hypothetical protein PAS_4g01450 CAY71503.1 PAS_chr4_0269 Essential nuclear protein with a possible role in the osmoregulatory glycerol response GO:0005515;GO:0016070 YLR336C SGD1 Essential nuclear protein with a possible role in the osmoregulatory glycerol response; interacts with phospholipase C (Plc1p); putative homolog of human NOM1 which is implicated in acute myeloid leukemia Suppressor of glycerol defect protein 1 PAS_4g01455 CAY71504.1 PAS_chr4_0270 Mitochondrial protein involved in sorting of proteins in the mitochondria GO:0005524 YGR028W MSP1 Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase Protein MSP1 PAS_4g01460 CAY71505.1 PAS_chr4_0271 Protein containing GATA family zinc finger motifs GO:0003700;GO:0005634;GO:0006355;GO:0008270;GO:0043565 YMR136W GAT2 Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine Protein GAT2 PAS_4g01465 CAY71506.1 PAS_chr4_0272 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase) GO:0020037;GO:0046914 YML054C CYB2 "Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions" "Cytochrome b2, mitochondrial " PAS_4g01470 CAY71507.1 PAS_chr4_0273 Hypothetical protein PAS_4g01475 CAY71508.1 PAS_chr4_0274 Essential nucleolar protein involved in the early steps of 35S rRNA processing YLR051C FCF2 Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon rRNA-processing protein FCF2 PAS_4g01480 CAY71509.1 PAS_chr4_0275 Hypothetical protein GO:0003676 Zinc finger protein C144.02 PAS_4g01485 CAY71510.1 PAS_chr4_0276 Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YFL022C FRS2 "Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar" Phenylalanyl-tRNA synthetase alpha chain PAS_4g01490 CAY71511.1 PAS_chr4_0277 Protein that interacts with Sin3p in a two-hybrid assay YMR053C STB2 Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p Protein STB6 PAS_4g01495 CAY71512.1 PAS_chr4_0278 "Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis" YOR310C NOP58 "Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA" Nucleolar protein 58 PAS_4g01500 CAY71513.1 PAS_chr4_0279 Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase YHR164C DNA2 "Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization" DNA replication ATP-dependent helicase dna2 PAS_4g01505 CAY71514.1 PAS_chr4_0280 Putative methylthio-ribulose-1-phosphate dehydratase YJR024C MDE1 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant Methylthioribulose-1-phosphate dehydratase PAS_4g01510 CAY71515.1 PAS_chr4_0281 Hypothetical protein U6 snRNA-associated Sm-like protein LSm8 PAS_4g01515 PAS_4g01520 CAY71516.1 PAS_chr4_0938 hypothetical protein YGR205W YGR205W ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases Uncharacterized kinase mug58 PAS_4g01525 CAY71517.1 PAS_chr4_0939 hypothetical protein YGR207C YGR207C "Protein that interacts with frataxin (Yfh1p); putative homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Probable electron transfer flavoprotein subunit beta PAS_4g01530 CAY71518.1 PAS_chr4_0282 Microtubule-associated protein (MAP) of the XMAP215/Dis1 family GO:0005488 YLR045C STU2 Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p Spindle pole body component alp14 PAS_4g01535 CAY71519.1 PAS_chr4_0283 Hypothetical protein NADH-ubiquinone oxidoreductase 21 kDa subunit PAS_4g01540 CAY71520.1 PAS_chr4_0284 Cytoplasmic thioredoxin isoenzyme of the thioredoxin system YLR043C TRX1 "Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance" Thioredoxin-1 PAS_4g01545 CAY71521.1 PAS_chr4_0940 hypothetical protein GO:0003824;GO:0008152 YMR289W ABZ2 "Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis" Aminodeoxychorismate lyase PAS_4g01550 CAY71522.1 PAS_chr4_0285 "Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthes" GO:0005524;GO:0006810;GO:0015662;GO:0016020 YGR208W SER2 "Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source" Phosphoserine phosphatase PAS_4g01555 CAY71523.1 PAS_chr4_0286 Protein involved in the transcription of 35S rRNA genes by RNA polymerase I GO:0003700;GO:0005634;GO:0006355;GO:0043565 YJL025W RRN7 "Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p" RNA polymerase I-specific transcription initiation factor RRN7 PAS_4g01560 CAY71524.1 PAS_chr4_0287 Dicarboxylic amino acid permease GO:0006810;GO:0016020 YPL265W DIP5 "Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly" Dicarboxylic amino acid permease PAS_4g01565 CAY71525.1 PAS_chr4_0288 Protein interacting with poly(A)-binding protein Pab1p YGR178C PBP1 "Component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation" PAB1-binding protein 1 PAS_4g01570 CAY71526.1 PAS_chr4_0289 Hypothetical protein YER071C YER071C Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern PAS_4g01575 CAY71527.1 PAS_chr4_0290 Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins YER072W VTC1 "Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion" Vacuolar transporter chaperone 1 PAS_4g01580 CAY71528.1 PAS_chr4_0291 Hypothetical protein PAS_4g01585 CAY71529.1 PAS_chr4_0292 Protein component of the small (40S) ribosomal subunit GO:0000166 YER074W RPS24A Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein 40S ribosomal protein S24 PAS_4g01590 CAY71530.1 PAS_chr4_0293 Component of the septin ring of the mother-bud neck that is required for cytokinesis GO:0005525;GO:0007049 YHR107C CDC12 "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM" Septin homolog spn4 PAS_4g01595 CAY71531.1 PAS_chr4_0294 Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway GO:0008152;GO:0016757 YDR354W TRP4 "Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis" Anthranilate phosphoribosyltransferase PAS_4g01600 CAY71532.1 PAS_chr4_0295 Hypothetical protein Myosin-2 heavy chain PAS_4g01605 CAY71533.1 PAS_chr4_0296 Hypothetical protein YDR357C YDR357C Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern PAS_4g01610 CAY71534.1 PAS_chr4_0297 Golgi-localized protein with homology to gamma-adaptin YHR108W GGA2 "Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi" ADP-ribosylation factor-binding protein GGA2 PAS_4g01615 CAY71535.1 PAS_chr4_0298 Component of the NuA4 histone acetyltransferase complex YDR359C EAF1 "Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1" Chromatin modification-related protein VID21 PAS_4g01620 CAY71536.1 PAS_chr4_0941 hypothetical protein Peroxisomal membrane protein PEX30 PAS_4g01625 CAY71537.1 PAS_chr4_0299 Hypothetical protein PAS_4g01630 CAY71538.1 PAS_chr4_0300 One of six ATPases of the 19S regulatory particle of the 26S proteasome GO:0005634;GO:0005737;GO:0016787;GO:0030163 YOR117W RPT5 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription 26S protease regulatory subunit 6A PAS_4g01635 CAY71539.1 PAS_chr4_0301 Essential protein involved in nuclear export of Mss4p YDR361C BCP1 "Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport" Protein BCP1 PAS_4g01640 CAY71540.1 PAS_chr4_0942 hypothetical protein YDR364C CDC40 "Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats" Pre-mRNA-processing factor 17 PAS_4g01645 CAY71541.1 PAS_chr4_0302 "RNA polymerase III subunit C160, part of core enzyme" GO:0003677;GO:0003899;GO:0006350;n/a YOR116C RPO31 "RNA polymerase III subunit C160, part of core enzyme; similar to bacterial beta-prime subunit" DNA-directed RNA polymerase III subunit RPC1 PAS_4g01650 CAY71542.1 PAS_chr4_0303 Putative protein of unknown function YDR262W YDR262W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment FAS1 domain-containing protein AER383W PAS_4g01655 CAY71543.1 PAS_chr4_0304 Hypothetical protein PAS_4g01660 CAY71544.1 PAS_chr4_0305 O-glycosylated protein required for cell wall stability Cell wall mannoprotein PIR3 PAS_4g01665 CAY71545.1 PAS_chr4_0306 Hypothetical protein GO:0006855;GO:0015238;GO:0015297;GO:0016020 YDR338C YDR338C Putative protein of unknown function Uncharacterized transporter YDR338C PAS_4g01670 CAY71546.1 PAS_chr4_0307 Putative protein of unknown function YMR244W YMR244W Putative protein of unknown function Uncharacterized protein YMR244W PAS_4g01675 CAY71547.1 PAS_chr4_0308 Transcription elongation factor GO:0003723 YGR116W SPT6 Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region Transcription elongation factor SPT6 PAS_4g01680 CAY71548.1 PAS_chr4_0309 Hypothetical protein Pre-mRNA-splicing factor SYF2 PAS_4g01685 CAY71549.1 PAS_chr4_0943 hypothetical protein PAS_4g01690 CAY71550.1 PAS_chr4_0310 Putative protein of unknown function GO:0003824 YPR147C YPR147C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS Uncharacterized protein YPR147C PAS_4g01695 CAY71551.1 PAS_chr4_0311 "2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family" GO:0008270;GO:0016491 YBR026C ETR1 "2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis" "Probable trans-2-enoyl-CoA reductase, mitochondrial " PAS_4g01700 CAY71552.1 PAS_chr4_0944 hypothetical protein YDR493W AIM8 Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss; detected in mitochondria in high-throughput studies "Protein FMP36, mitochondrial " PAS_4g01705 CAY71553.1 PAS_chr4_0312 tRNA 2'-phosphotransferase GO:0006388;GO:0016772 YOL102C TPT1 "tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide" tRNA 2'-phosphotransferase PAS_4g01710 CAY71554.1 PAS_chr4_0313 Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p YNL298W CLA4 "Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, which also includes Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, and cytokinesis; phosphorylates septins Cdc3p and Cdc10p" Serine/threonine-protein kinase CLA4 PAS_4g01715 CAY71555.1 PAS_chr4_0314 "Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde" GO:0030976 Pyruvate decarboxylase PAS_4g01720 CAY71556.1 PAS_chr4_0945 hypothetical protein PAS_4g01725 CAY71557.1 PAS_chr4_0315 Histidine kinase osmosensor that regulates a MAP kinase cascade GO:0016310;GO:0016772 YIL147C SLN1 "Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators" Osmosensing histidine protein kinase SLN1 PAS_4g01730 CAY71558.1 PAS_chr4_0316 Myosin-like protein associated with the nuclear envelope YKR095W MLP1 "Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs" Protein MLP1 PAS_4g01735 CAY71559.1 PAS_chr4_0946 hypothetical protein YIL150C MCM10 Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins Minichromosome maintenance protein 10 PAS_4g01740 CAY71560.1 PAS_chr4_0317 Hypothetical protein PAS_4g01745 CAY71561.1 PAS_chr4_0318 "Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7)" YEL064C AVT2 "Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" Vacuolar amino acid transporter 2 PAS_4g01750 CAY71562.1 PAS_chr4_0319 "N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1)" YGR212W SLI1 "N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin" PAS_4g01755 CAY71563.1 PAS_chr4_0320 Hypothetical protein Uncharacterized abhydrolase domain-containing protein DDB_G0269086 PAS_4g01760 CAY71564.1 PAS_chr4_0321 Putative protein of unknown function GO:0003824;GO:0005975;GO:0043169 YIR007W YIR007W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene Uncharacterized glycosyl hydrolase YIR007W PAS_4g01765 CAY71565.1 PAS_chr4_0322 Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) GO:0005525;GO:0006614;GO:0008312;GO:0016020 YPR088C SRP54 "Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain" Signal recognition particle 54 kDa protein homolog PAS_4g01770 CAY71566.1 PAS_chr4_0323 "Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair" YIR008C PRI1 "Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair" DNA primase small subunit PAS_4g01775 CAY71567.1 PAS_chr4_0324 Hypothetical protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 PAS_4g01780 CAY71568.1 PAS_chr4_0325 Protein with an N-terminal kelch-like domain YGL197W MDS3 "Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions" Negative regulator of sporulation MDS3 PAS_4g01785 CAY71569.1 PAS_chr4_0326 Transcriptional activator that enhances pseudohyphal growth Putative transcription factor PHD1 PAS_4g01790 CAY71570.1 PAS_chr4_0327 "Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p" GO:0005488 YGL195W GCN1 "Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA" Translational activator GCN1 PAS_4g01795 PAS_4g01800 CAY71571.1 PAS_chr4_0329 Member of the CCCH zinc finger family GO:0003676;GO:0008270 YDR151C CTH1 "Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis" mRNA decay factor CTH1 PAS_4g01805 CAY71572.1 PAS_chr4_0330 Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase) GO:0003824;GO:0030170 YLR303W MET17 "Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis" Protein MET17 PAS_4g01810 CAY71573.1 PAS_chr4_0331 Hypothetical protein PAS_4g01815 CAY71574.1 PAS_chr4_0332 Hypothetical protein Mucin-2 PAS_4g01820 CAY71575.1 PAS_chr4_0333 Hypothetical protein PAS_4g01825 CAY71576.1 PAS_chr4_0334 Transcription factor involved in glucose repression GO:0003676 YGL035C MIG1 Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase DNA-binding protein creA PAS_4g01830 CAY71577.1 PAS_chr4_0335 Hypothetical protein 4-hydroxyphenylpyruvate dioxygenase PAS_4g01835 CAY71578.1 PAS_chr4_0336 Putative dihydrokaempferol 4-reductase GO:0003824;GO:0005488;GO:0008152 YDR541C YDR541C Putative dihydrokaempferol 4-reductase Putative uncharacterized oxidoreductase YDR541C PAS_4g01840 CAY71579.1 PAS_chr4_0947 hypothetical protein GO:0006118 PAS_4g01845 CAY71580.1 PAS_chr4_0337 High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter GO:0006118 YML123C PHO84 High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p Inorganic phosphate transporter PHO84 PAS_4g01850 CAY71581.1 PAS_chr4_0338 "Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation" GO:0008152;GO:0016491 Glucose 1-dehydrogenase A PAS_4g01855 CAY71582.1 PAS_chr4_0339 Hypothetical protein GO:0003824;GO:0008152 PAS_4g01860 CAY71583.1 PAS_chr4_0340 Hypothetical protein GO:0003677;GO:0005634;GO:0006350;GO:0008270 PAS_4g01865 CAY71584.1 PAS_chr4_0341 Hypothetical protein GO:0008152;GO:0016829 Dihydrodipicolinate synthase-like protein AN1503 PAS_4g01870 CAY71585.1 PAS_chr4_0342 Acid trehalase required for utilization of extracellular trehalose GO:0003824 YPR026W ATH1 Acid trehalase required for utilization of extracellular trehalose Vacuolar acid trehalase PAS_4g01875 CAY71586.1 PAS_chr4_0343 Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase GO:0000105;GO:0003949 YIL020C HIS6 "Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts" 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase PAS_4g01880 CAY71587.1 PAS_chr4_0344 "RNA polymerase II third largest subunit B44, part of central core" GO:0003899;GO:0006350 YIL021W RPB3 "RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit" DNA-directed RNA polymerase II subunit RPB3 PAS_4g01885 CAY71588.1 PAS_chr4_0345 "Protein containing an Lsm domain, may bind RNA and have a role in RNA processing" YPR129W SCD6 "Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin" Protein sum2 PAS_4g01890 CAY71589.1 PAS_chr4_0346 Catalytic subunit of the NatB N-terminal acetyltransferase YPR131C NAT3 "Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met" N-terminal acetyltransferase B complex catalytic subunit NAT3 PAS_4g01895 CAY71590.1 PAS_chr4_0347 Peroxisomal adenine nucleotide transporter GO:0005488;GO:0006810;GO:0016020;n/a YPR128C ANT1 Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Peroxisomal adenine nucleotide transporter 1 PAS_4g01900 CAY71591.1 PAS_chr4_0948 hypothetical protein YGR117C YGR117C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Uncharacterized protein YGR117C PAS_4g01905 CAY71592.1 PAS_chr4_0348 Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit YGR118W RPS23A "Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal" 40S ribosomal protein S23 PAS_4g01910 CAY71593.1 PAS_chr4_0349 Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II YPR133C SPN1 "Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II, probable transcriptional elongation factor; metazoan homologs contain an acidic N terminus; mutations in the gene confer an Spt- phenotype" Transcription factor IWS1 PAS_4g01915 CAY71594.1 PAS_chr4_0350 Hypothetical protein YPR133W-A TOM5 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore Mitochondrial import receptor subunit TOM5 PAS_4g01920 CAY71595.1 PAS_chr4_0351 Hypothetical protein PAS_4g01925 CAY71596.1 PAS_chr4_0352 Long chain fatty acyl-CoA synthetase GO:0003824;GO:0008152 YER015W FAA2 "Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids" Long-chain-fatty-acid--CoA ligase 2 PAS_4g01930 CAY71597.1 PAS_chr4_0353 Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria GO:0006457;GO:0051087 YGL018C JAC1 "Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix" "J-type co-chaperone JAC1, mitochondrial " PAS_4g01935 CAY71598.1 PAS_chr4_0354 "Nucleoporin, essential subunit of the nuclear pore complex (NPC)" YGR119C NUP57 "Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p" Nucleoporin NUP57 PAS_4g01940 CAY71599.1 PAS_chr4_0355 Hypothetical protein NADH-ubiquinone oxidoreductase 20.8 kDa subunit PAS_4g01945 CAY71600.1 PAS_chr4_0356 "Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling" YJL005W CYR1 "Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation" Adenylate cyclase PAS_4g01950 CAY71601.1 PAS_chr4_0357 Hypothetical protein Endoglucanase PAS_4g01955 CAY71602.1 PAS_chr4_0358 Hypothetical protein Serine-aspartate repeat-containing protein C PAS_4g01960 CAY71603.1 PAS_chr4_0359 Hypothetical protein PAS_4g01965 CAY71604.1 PAS_chr4_0360 Hypothetical protein "Keratin, type I cytoskeletal 10 " PAS_4g01970 CAY71605.1 PAS_chr4_0361 Hypothetical protein Glycine-rich cell wall structural protein PAS_4g01975 CAY71606.1 PAS_chr4_0363 Hypothetical protein Putative cell agglutination protein C1289.15 PAS_4g01980 PAS_4g01985 CAY71607.1 PAS_chr4_0365 Hypothetical protein PAS_4g01990 CAY71608.1 PAS_chr4_0949 hypothetical protein PAS_4g01995 CAY71609.1 PAS_chr4_0366 "Protein required for daughter cell separation, multiple mitotic checkpoints and chromosome stability" GO:0005515 YBR158W AMN1 "Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)" Antagonist of mitotic exit network protein 1 PAS_4g02000 CAY71610.1 PAS_chr4_0367 Hypothetical protein Pre-mRNA-processing ATP-dependent RNA helicase PRP5 PAS_4g02005 CAY71611.1 PAS_chr4_0368 Microsomal beta-keto-reductase GO:0008152;GO:0016491 YBR159W IFA38 "Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides" 3-ketoacyl-CoA reductase PAS_4g02010 CAY71612.1 PAS_chr4_0950 hypothetical protein YBR160W CDC28 Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates Cell division control protein 28 PAS_4g02015 CAY71613.1 PAS_chr4_0369 Subunit alpha of assimilatory sulfite reductase GO:0006118;GO:0016491 YFR030W MET10 "Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide" Sulfite reductase [NADPH] flavoprotein component PAS_4g02020 CAY71614.1 PAS_chr4_0951 hypothetical protein GO:0003824;GO:0030170 Molybdenum cofactor sulfurase PAS_4g02025 CAY71615.1 PAS_chr4_0370 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions YEL044W IES6 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes Chromatin-remodeling complex subunit IES6 PAS_4g02030 CAY71616.1 PAS_chr4_0371 Hypothetical protein GO:0006810 YEL048C TCA17 Protein that interacts with subunits of the TRAPP complex and may play a role its assembly or stability; mutation is synthetically lethal with gcs1 deletion; Sedlin_N family member; human Sedlin mutations cause the skeletal disorder SEDT TRAPP-associated protein TCA17 PAS_4g02035 CAY71617.1 PAS_chr4_0372 Putative protein of unknown function Protein RTC2 PAS_4g02040 YLL045C RPL8B "Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits" 60S ribosomal protein L8-A PAS_4g02045 CAY71618.1 PAS_chr4_0374 Hypothetical protein GO:0003735;GO:0005622;GO:0005840;GO:0006412 YFR032C-A RPL29 "Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate" 60S ribosomal protein L29 PAS_4g02050 CAY71619.1 PAS_chr4_0375 Hypothetical protein PAS_4g02055 CAY71620.1 PAS_chr4_0376 Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex GO:0005634;GO:0006355 YNL107W YAF9 "Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain" Protein AF-9 homolog PAS_4g02060 CAY71621.1 PAS_chr4_0377 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC) YOR110W TFC7 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes Uncharacterized protein YNL108C PAS_4g02065 CAY71622.1 PAS_chr4_0378 Putative protein of unknown function YOR111W YOR111W Putative protein of unknown function Maf-like protein C3G6.03c PAS_4g02070 CAY71623.1 PAS_chr4_0952 hypothetical protein GO:0000166 YNL110C NOP15 "Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm" Uncharacterized RNA-binding protein C1827.05c PAS_4g02075 CAY71624.1 PAS_chr4_0953 hypothetical protein GO:0020037;GO:0046914 YNL111C CYB5 "Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation" Cytochrome b5 PAS_4g02080 CAY71625.1 PAS_chr4_0379 Probable type-III integral membrane protein of unknown function GO:0005622;GO:0008270 UPF0652 protein PAS_4g02085 CAY71626.1 PAS_chr4_0954 hypothetical protein YNL237W YTP1 "Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins" Protein YTP1 PAS_4g02090 CAY71627.1 PAS_chr4_0955 hypothetical protein GO:0005488 YER093C TSC11 "Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain" Target of rapamycin complex 2 subunit TSC11 PAS_4g02095 CAY71628.1 PAS_chr4_0380 Hypothetical protein PAS_4g02100 CAY71629.1 PAS_chr4_0381 Putative protein of unknown function YER093C-A AIM11 Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron Uncharacterized protein YER093C-A PAS_4g02105 CAY71630.1 PAS_chr4_0382 Mitochondrial protein of unknown function YBR163W DEM1 Mitochondrial protein of unknown function; null mutant has defects in cell morphology and in response to air drying; may be regulated by the transcription factor Ace2 "Defects in morphology protein 1, mitochondrial " PAS_4g02110 CAY71631.1 PAS_chr4_0383 Hypothetical protein PAS_4g02115 CAY71632.1 PAS_chr4_0384 Hypothetical protein Glycoprotein gp2 PAS_4g02120 CAY71633.1 PAS_chr4_0385 Hypothetical protein PAS_4g02125 CAY71634.1 PAS_chr4_0386 Gamma subunit of the translation initiation factor eIF2B GO:0009058;GO:0016779 YOR260W GCD1 "Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression" Translation initiation factor eIF-2B subunit gamma PAS_4g02130 CAY71635.1 PAS_chr4_0387 One of six ATPases of the 19S regulatory particle of the 26S proteasome GO:0005634;GO:0005737;GO:0016787;GO:0030163 YOR259C RPT4 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle 26S protease subunit RPT4 PAS_4g02135 CAY71636.1 PAS_chr4_0956 hypothetical protein YPL173W MRPL40 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L40, mitochondrial " PAS_4g02140 CAY71637.1 PAS_chr4_0388 Mitochondrial ribosomal protein of the large subunit GO:0005509 YOR257W CDC31 "Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation" Cell division control protein 31 PAS_4g02145 CAY71638.1 PAS_chr4_0389 Large subunit of the dynactin complex YPL174C NIP100 "Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)" Protein NIP100 PAS_4g02150 CAY71639.1 PAS_chr4_0390 Hypothetical protein Dentin sialophosphoprotein PAS_4g02155 CAY71640.1 PAS_chr4_0391 Component of the TOM (translocase of outer membrane) complex GO:0005741;GO:0006820;GO:0008308 YMR203W TOM40 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Mitochondrial import receptor subunit TOM40 PAS_4g02160 CAY71641.1 PAS_chr4_0957 hypothetical protein PAS_4g02165 CAY71642.1 PAS_chr4_0392 "Protein with similarity to oxidoreductases, found in lipid particles" GO:0008152;GO:0016491 YOR246C YOR246C "Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts" Uncharacterized oxidoreductase YOR246C PAS_4g02170 CAY71643.1 PAS_chr4_0393 "Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA" GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YPL160W CDC60 "Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA" "Leucyl-tRNA synthetase, cytoplasmic " PAS_4g02175 CAY71644.1 PAS_chr4_0394 Poly(A)RNA binding protein involved in nuclear mRNA export YPL169C MEX67 "Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP" mRNA export factor MEX67 PAS_4g02180 CAY71645.1 PAS_chr4_0395 "Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p)" GO:0031072 YOR254C SEC63 "Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER" Protein translocation protein SEC63 PAS_4g02185 YOR253W NAT5 "Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing" PAS_4g02190 CAY71646.1 PAS_chr4_0396 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p GO:0020037;GO:0046914 YPL170W DAP1 "Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis" Damage response protein 1 PAS_4g02195 CAY71647.1 PAS_chr4_0397 Protein of unknown function YJR118C ILM1 Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth Protein ILM1 PAS_4g02200 CAY71648.1 PAS_chr4_0398 "Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis" GO:0004735;GO:0006561 YER023W PRO3 "Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis" Pyrroline-5-carboxylate reductase PAS_4g02205 CAY71649.1 PAS_chr4_0399 Ferric reductase and cupric reductase GO:0005506;GO:0006118;GO:0016021;GO:0016491;GO:0050660 Probable ferric reductase transmembrane component PAS_4g02210 PAS_4g02215 CAY71650.1 PAS_chr4_0401 Arginyl-tRNA-protein transferase GO:0004057;GO:0016598;GO:0042176 YGL017W ATE1 "Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway" Arginyl-tRNA--protein transferase 1 PAS_4g02220 CAY71651.1 PAS_chr4_0402 "Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase" GO:0005956;GO:0008605 YGL019W CKB1 "Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases" Probable casein kinase II subunit beta-2 PAS_4g02225 CAY71652.1 PAS_chr4_0403 Hypothetical protein YGL020C GET1 Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance Golgi to ER traffic protein 1 PAS_4g02230 CAY71653.1 PAS_chr4_0404 Protein kinase YBL009W ALK2 Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins Serine/threonine-protein kinase haspin homolog C23C4.03 PAS_4g02235 CAY71654.1 PAS_chr4_0405 Guanine nucleotide exchange factor for Gpa1p GO:0005524;GO:0006820;GO:0016020 YDL100C GET3 "Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity" ATPase GET3 PAS_4g02240 CAY71655.1 PAS_chr4_0406 Hypothetical protein PAS_4g02245 CAY71656.1 PAS_chr4_0407 Protein of unknown function that associates with ribosomes YLR327C TMA10 Protein of unknown function that associates with ribosomes Translation machinery-associated protein 10 PAS_4g02250 CAY71657.1 PAS_chr4_0408 Choline phosphate cytidylyltransferase GO:0009058;GO:0016779 YGR007W MUQ1 "Choline phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases" Ethanolamine-phosphate cytidylyltransferase PAS_4g02255 CAY71658.1 PAS_chr4_0409 Hypothetical protein YLR326W YLR326W "Putative protein of unknown function, predicted to be palmitoylated" Uncharacterized membrane protein YLR326W PAS_4g02260 CAY71659.1 PAS_chr4_0410 Hypothetical protein PAS_4g02265 CAY71660.1 PAS_chr4_0411 Protein of unknown function YMR140W SIP5 Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase Protein SIP5 PAS_4g02270 CAY71661.1 PAS_chr4_0412 Ribosomal stalk protein P1 alpha GO:0003735;GO:0005622;GO:0005840;GO:0006414 YDL081C RPP1A "Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component" 60S acidic ribosomal protein P1-A PAS_4g02275 CAY71662.1 PAS_chr4_0413 "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YDL082W RPL13A "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein" 60S ribosomal protein L13 PAS_4g02280 CAY71663.1 PAS_chr4_0414 Protein component of the small (40S) ribosomal subunit YDL083C RPS16B Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins 40S ribosomal protein S16 PAS_4g02285 CAY71664.1 PAS_chr4_0415 Cytosolic serine hydroxymethyltransferase GO:0004372;GO:0006544;GO:0006563 YLR058C SHM2 "Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis" "Serine hydroxymethyltransferase, cytosolic " PAS_4g02290 CAY71665.1 PAS_chr4_0416 "Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate" GO:0003824;GO:0030170 YFL030W AGX1 "Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases" Alanine--glyoxylate aminotransferase 1 PAS_4g02295 CAY71666.1 PAS_chr4_0417 Hypothetical protein GO:0031072 Uncharacterized J domain-containing protein C4H3.01 PAS_4g02300 CAY71667.1 PAS_chr4_0418 "Delta-aminolevulinate dehydratase, a homo-octameric enzyme" GO:0004655;GO:0033014;GO:0046872 YGL040C HEM2 "Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus" Delta-aminolevulinic acid dehydratase PAS_4g02305 CAY71668.1 PAS_chr4_0419 Putative ATPase of the AAA family GO:0005524 YLL034C RIX7 "Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions" Ribosome biogenesis ATPase RIX7 PAS_4g02310 CAY71669.1 PAS_chr4_0420 Myristoylated subunit of ESCRTIII GO:0015031 YMR077C VPS20 "Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes" Charged multivesicular body protein 6 PAS_4g02315 CAY71670.1 PAS_chr4_0421 "Protein of unknown function, required for cell growth and possibly involved in rRNA processing" YLL035W GRC3 "Protein of unknown function, required for cell growth and possibly involved in rRNA processing; mRNA is cell cycle regulated" Protein GRC3 PAS_4g02320 CAY71671.1 PAS_chr4_0422 Subunit VIb of cytochrome c oxidase GO:0004129;GO:0005739;GO:0006118 YLR038C COX12 "Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated" Cytochrome c oxidase subunit 6B PAS_4g02325 CAY71672.1 PAS_chr4_0958 hypothetical protein PAS_4g02330 CAY71673.1 PAS_chr4_0959 hypothetical protein PAS_4g02335 CAY71674.1 PAS_chr4_0423 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus YNR053C NOG2 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation Nucleolar GTP-binding protein 2 PAS_4g02340 CAY71675.1 PAS_chr4_0424 Hypothetical protein UPF0424 protein C1orf128 PAS_4g02345 CAY71676.1 PAS_chr4_0425 Hypothetical protein E3 ubiquitin-protein ligase RNF149 PAS_4g02350 CAY71677.1 PAS_chr4_0426 Hypothetical protein PAS_4g02355 CAY71678.1 PAS_chr4_0960 hypothetical protein PAS_4g02360 CAY71679.1 PAS_chr4_0427 Evolutionarily conserved protein with similarity to Orm2p GO:0016021 YGR038W ORM1 "Evolutionarily conserved protein with similarity to Orm2p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum" Protein ORM1 PAS_4g02365 YNR052C POP2 "RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation" Poly(A) ribonuclease POP2 PAS_4g02370 CAY71680.1 PAS_chr4_0429 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal protein YDR177W UBC1 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response Ubiquitin-conjugating enzyme E2 1 PAS_4g02375 CAY71681.1 PAS_chr4_0430 "Endosomal protein that regulates cell polarity, controls polarized growth" GO:0000287;GO:0004427;GO:0005737;GO:0006796 YCR094W CDC50 Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Ynr048wp and Lem3p Cell division control protein 50 PAS_4g02380 CAY71682.1 PAS_chr4_0431 "Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels" GO:0005351;GO:0009401 YCR093W CDC39 "Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor" General negative regulator of transcription subunit 1 PAS_4g02385 CAY71683.1 PAS_chr4_0432 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles YFL048C EMP47 "Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport" Protein EMP47 PAS_4g02390 CAY71684.1 PAS_chr4_0433 NADPH-dependent alpha-keto amide reductase GO:0016491 YDL124W YDL124W "NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family" NADPH-dependent alpha-keto amide reductase PAS_4g02395 CAY71685.1 PAS_chr4_0434 Subunit of the core complex of translation initiation factor 3(eIF3) GO:0000166 YDR429C TIF35 "eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation" Eukaryotic translation initiation factor 3 subunit G PAS_4g02400 CAY71686.1 PAS_chr4_0435 Subunit of the RNA polymerase II mediator complex GO:0003713;GO:0005634;GO:0045941 YOL135C MED7 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Mediator of RNA polymerase II transcription subunit 7 PAS_4g02405 CAY71687.1 PAS_chr4_0436 RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF) YOL133W HRT1 "RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF" RING-box protein 1 PAS_4g02410 CAY71688.1 PAS_chr4_0437 "Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate" GO:0004664;GO:0009094 YNL316C PHA2 "Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway" Prephenate dehydratase PAS_4g02415 CAY71689.1 PAS_chr4_0961 hypothetical protein PAS_4g02420 CAY71690.1 PAS_chr4_0438 Heat shock protein with a zinc finger motif YNL310C ZIM17 Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix Mitochondrial protein import protein ZIM17 PAS_4g02425 CAY71691.1 PAS_chr4_0439 Plasma membrane transporter for both urea and polyamines GO:0005215;GO:0006810;GO:0016020 Probable urea active transporter 1 PAS_4g02430 CAY71692.1 PAS_chr4_0962 hypothetical protein PAS_4g02435 CAY71693.1 PAS_chr4_0440 Hypothetical protein GO:0004842;GO:0006512;GO:0008270 Protein mlo2 PAS_4g02440 CAY71694.1 PAS_chr4_0441 "ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria" GO:0004176;GO:0004252;GO:0006508 YBL022C PIM1 "ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria" "Lon protease homolog, mitochondrial " PAS_4g02445 CAY71695.1 PAS_chr4_0442 "Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex" GO:0005634;GO:0006355;GO:0043565 YBL021C HAP3 "Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding" Transcriptional activator HAP3 PAS_4g02450 CAY71696.1 PAS_chr4_0443 "Flippase, essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-D" GO:0005319;GO:0006869;GO:0016021 YBL020W RFT1 Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein Oligosaccharide translocation protein RFT1 PAS_4g02455 CAY71697.1 PAS_chr4_0444 Ubiquitin-protein ligase E3 ubiquitin-protein ligase synoviolin PAS_4g02460 CAY71698.1 PAS_chr4_0445 S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase YBL024W NCL1 "S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120" tRNA (cytosine-5-)-methyltransferase NCL1 PAS_4g02465 CAY71699.1 PAS_chr4_0446 Hypothetical protein YBL025W RRN10 "Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I" PAS_4g02470 CAY71700.1 PAS_chr4_0447 Hypothetical protein GO:0003676;GO:0008270 Uncharacterized protein YEL137C PAS_4g02475 CAY71701.1 PAS_chr4_0448 Lsm (Like Sm) protein GO:0016071;GO:0030529 YBL026W LSM2 "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA" U6 snRNA-associated Sm-like protein LSm2 PAS_4g02480 CAY71702.1 PAS_chr4_0449 Protein required for the hydroxylation of heme O to form heme A GO:0006461;GO:0016020 YER141W COX15 "Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase" Cytochrome c oxidase assembly protein COX15 PAS_4g02485 CAY71703.1 PAS_chr4_0450 Hypothetical protein Protein MNN4 PAS_4g02490 CAY71704.1 PAS_chr4_0451 Hypothetical protein DNA ligase 1 PAS_4g02495 CAY71705.1 PAS_chr4_0452 Putative protein of unknown function YER140W YER140W "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; genetic interactions suggest a role in folding of ER membrane proteins" Protein TAPT1 homolog PAS_4g02500 CAY71706.1 PAS_chr4_0453 Protein with a role in transcription YER139C RTR1 CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm RNA polymerase II subunit B1 CTD phosphatase RTR1 PAS_4g02505 CAY71707.1 PAS_chr4_0454 Hypothetical protein PAS_4g02510 CAY71708.1 PAS_chr4_0455 Hypothetical protein PAS_4g02515 CAY71709.1 PAS_chr4_0456 Protein component of the small (40S) ribosomal subunit YDR064W RPS13 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins 40S ribosomal protein S13 PAS_4g02520 CAY71710.1 PAS_chr4_0457 Putative protein kinase of unknown cellular role YPL150W YPL150W Putative protein kinase of unknown cellular role Putative serine/threonine-protein kinase YPL150W PAS_4g02525 CAY71711.1 PAS_chr4_0963 hypothetical protein Protein SGT1 homolog At5g65490 PAS_4g02530 CAY71712.1 PAS_chr4_0459 Conserved protein involved in autophagy and the Cvt pathway GO:0005737;GO:0006914 YPL149W ATG5 Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation Autophagy protein 5 PAS_4g02535 CAY71713.1 PAS_chr4_0460 Nonessential protein that binds actin filaments and localizes to actin patches and cables YOR239W ABP140 "Nonessential protein that binds actin filaments and localizes to actin patches and cables, has similarity to S-adenosylmethionine (AdoMet)-dependent methyltransferases" Uncharacterized methyltransferase ABP140 PAS_4g02540 CAY71714.1 PAS_chr4_0461 Hypothetical protein PAS_4g02545 CAY71715.1 PAS_chr4_0462 Hypothetical protein PAS_4g02550 CAY71716.1 PAS_chr4_0463 Hypothetical protein YCL052C PBN1 "Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X" Protein PBN1 PAS_4g02555 CAY71717.1 PAS_chr4_0464 AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation YCL054W SPB1 "AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants" AdoMet-dependent rRNA methyltransferase SPB1 PAS_4g02560 CAY71718.1 PAS_chr4_0465 Hypothetical protein GO:0008610;GO:0008825 Uncharacterized methyltransferase in lpd-3 5'region PAS_4g02565 H(+)/Cl(-) exchange transporter 3 PAS_4g02570 CAY71719.1 PAS_chr4_0467 Hypothetical protein PAS_4g02575 CAY71720.1 PAS_chr4_0468 Transcription factor required for gene regulation in repsonse to pheromones GO:0005634;GO:0006139;GO:0008168 YCL055W KAR4 "Transcription factor required for gene regulation in repsonse to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone" Karyogamy protein KAR4 PAS_4g02580 CAY71721.1 PAS_chr4_0469 Hypothetical protein PAS_4g02585 CAY71722.1 PAS_chr4_0470 Mitochondrial aldehyde dehydrogenase GO:0008152;GO:0016491 "Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial " PAS_4g02590 CAY71723.1 PAS_chr4_0471 Hypothetical protein PAS_4g02595 CAY71724.1 PAS_chr4_0472 Conserved protein involved in exocytic transport from the Golgi GO:0006812;GO:0008324;GO:0016020 Putative metal tolerance protein C3 PAS_4g02600 CAY71725.1 PAS_chr4_0964 hypothetical protein YLR114C AVL9 Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms Late secretory pathway protein AVL9 PAS_4g02605 CAY71726.1 PAS_chr4_0965 hypothetical protein GO:0003824;GO:0005488;GO:0008152 YLR290C YLR290C "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene" "Uncharacterized protein YLR290C, mitochondrial " PAS_4g02610 CAY71727.1 PAS_chr4_0966 hypothetical protein YLR276C DBP9 ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit ATP-dependent RNA helicase DBP9 PAS_4g02615 CAY71728.1 PAS_chr4_0473 Mitochondrial inner membrane ATP-binding cassette (ABC) transporter GO:0006812;GO:0008324;GO:0016020 YMR301C ATM1 "Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol" "Iron-sulfur clusters transporter ATM1, mitochondrial " PAS_4g02620 CAY71729.1 PAS_chr4_0967 hypothetical protein GO:0006812;GO:0008324;GO:0016020 YDR205W MSC2 "Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids" Zinc transporter 5 PAS_4g02625 CAY71730.1 PAS_chr4_0474 Member of the Sir2 family of NAD(+)-dependent protein deacetylases GO:0003677;GO:0005677;GO:0006342;GO:0006355;GO:0006476;GO:0008270;GO:0017136;GO:0051287 YDR191W HST4 "Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism" NAD-dependent histone deacetylase HST4 PAS_4g02630 CAY71731.1 PAS_chr4_0475 Essential protein involved in transcription regulation GO:0003824;GO:0005488;GO:0008152 YDR190C RVB1 Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as pontin; member of the RUVB-like protein family RuvB-like helicase 1 PAS_4g02635 CAY71732.1 PAS_chr4_0968 hypothetical protein GO:0003824;GO:0005488;GO:0008152 YHR063C PAN5 "2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE" Probable 2-dehydropantoate 2-reductase PAS_4g02640 CAY71733.1 PAS_chr4_0476 Ribosomal protein lysine methyltransferase YDR198C RKM2 "Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp" Ribosomal N-lysine methyltransferase set11 PAS_4g02645 CAY71734.1 PAS_chr4_0477 Putative dephospho-CoA kinase (DPCK) that catalyzes the final step in Coenzyme A biosynthesis GO:0005524 YDR196C CAB5 Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies Dephospho-CoA kinase CAB5 PAS_4g02650 CAY71735.1 PAS_chr4_0478 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate GO:0016303;GO:0046854;GO:0048015 YLR240W VPS34 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p Phosphatidylinositol 3-kinase VPS34 PAS_4g02655 CAY71736.1 PAS_chr4_0479 Hypothetical protein "Adenylate cyclase, terminal-differentiation specific " PAS_4g02660 CAY71737.1 PAS_chr4_0480 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 Transcriptional regulatory protein pro-1 PAS_4g02665 CAY71738.1 PAS_chr4_0481 Protein involved in inhibition of translation and nonsense-mediated decay YDR206W EBS1 Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors PAS_4g02670 CAY71739.1 PAS_chr4_0482 "Putative protein of unknown function, may be involved in detoxification" GO:0016020 YLR241W YLR241W "Putative protein of unknown function, may be involved in detoxification" Uncharacterized membrane protein YLR241W PAS_4g02675 CAY71740.1 PAS_chr4_0483 Protein required for normal intracellular sterol distribution and for sphingolipid metabolism YLR242C ARV1 Protein functioning in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein Protein ARV1 PAS_4g02680 CAY71741.1 PAS_chr4_0484 Member of the Sec24p family YHR098C SFB3 "Member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate" SED5-binding protein 3 PAS_4g02685 YOR033C EXO1 "5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains" Exodeoxyribonuclease 1 PAS_4g02690 CAY71742.1 PAS_chr4_0486 Hypothetical protein Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 PAS_4g02695 CAY71743.1 PAS_chr4_0487 Carbon source-responsive zinc-finger transcription factor GO:0003676 YDR216W ADR1 "Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization" Regulatory protein ADR1 PAS_4g02700 CAY71744.1 PAS_chr4_0488 "Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria" GO:0005488;GO:0006810;GO:0016020 YER053C PIC2 "Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature" Mitochondrial phosphate carrier protein 2 PAS_4g02705 CAY71745.1 PAS_chr4_0489 Hypothetical protein Uncharacterized protein YGL108C PAS_4g02710 CAY71746.1 PAS_chr4_0490 Component of the CCR4-NOT transcriptional complex YAL021C CCR4 "Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening" Glucose-repressible alcohol dehydrogenase transcriptional effector PAS_4g02715 Glucose-repressible alcohol dehydrogenase transcriptional effector PAS_4g02720 CAY71747.1 PAS_chr4_0492 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair GO:0006284 YOL043C NTG2 "DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus; sumoylated" Endonuclease III homolog PAS_4g02725 CAY71748.1 PAS_chr4_0493 "Putative phosphomutase, contains a region homologous to the active site of phosphomutases" GO:0003824;GO:0008152 YKL128C PMU1 "Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant" Uncharacterized protein YKL128C PAS_4g02730 CAY71749.1 PAS_chr4_0494 Regulatory subunit A of the heterotrimeric protein phosphatase 2A GO:0005488 YAL016W TPD3 "Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A), which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III" Protein phosphatase PP2A regulatory subunit A PAS_4g02735 CAY71750.1 PAS_chr4_0495 Hypothetical protein PAS_4g02740 CAY71751.1 PAS_chr4_0496 Peroxisomal ubiquitin conjugating enzyme GO:0019787;GO:0043687;GO:0051246 YGR133W PEX4 Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis Ubiquitin-conjugating enzyme E2-24 kDa PAS_4g02745 CAY71752.1 PAS_chr4_0497 Hypothetical protein PAS_4g02750 CAY71753.1 PAS_chr4_0969 hypothetical protein YER054C GIP2 "Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p" PAS_4g02755 CAY71754.1 PAS_chr4_0498 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation GO:0006950;GO:0016021 YOR049C RSB1 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane Sphingoid long-chain base transporter RSB1 PAS_4g02760 CAY71755.1 PAS_chr4_0499 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex YGR134W CAF130 "Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation" Protein CAF130 PAS_4g02765 CAY71756.1 PAS_chr4_0500 Protein that induces appearance of [PIN+] prion when overproduced YPR154W PIN3 Protein that induces appearance of [PIN+] prion when overproduced [PSI+] inducibility protein 3 PAS_4g02770 CAY71757.1 PAS_chr4_0501 Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) YPR155C NCA2 Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p Nuclear control of ATPase protein 2 PAS_4g02775 CAY71758.1 PAS_chr4_0502 Putative protein of unknown function YPR153W YPR153W Putative protein of unknown function Uncharacterized protein YPR153W PAS_4g02780 CAY71759.1 PAS_chr4_0503 Hypothetical protein GO:0006508;GO:0008234 NEDD8-specific protease 1 PAS_4g02785 CAY71760.1 PAS_chr4_0504 Protein of unknown function YPR149W NCE102 Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs) Non-classical export protein 2 PAS_4g02790 CAY71761.1 PAS_chr4_0505 Subunit of the prohibitin complex (Phb1p-Phb2p) YGR132C PHB1 "Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation" Prohibitin-1 PAS_4g02795 CAY71762.1 PAS_chr4_0506 "Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit" GO:0004298;GO:0005839;GO:0006511 YGR135W PRE9 "Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform" Proteasome component Y13 PAS_4g02800 CAY71763.1 PAS_chr4_0507 Hypothetical protein GO:0005515 YPR152C URN1 Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase Transcription elongation regulator 1-like protein PAS_4g02805 CAY71764.1 PAS_chr4_0508 "Protein required for beta-1,6 glucan biosynthesis" YPR159W KRE6 "Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p" Beta-glucan synthesis-associated protein KRE6 PAS_4g02810 PAS_4g02815 CAY71765.1 PAS_chr4_0510 Transmembrane protein involved in formation of Cvt and autophagic vesicles YDL149W ATG9 "Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS" Autophagy-related protein 9 PAS_4g02820 CAY71766.1 PAS_chr4_0511 Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis GO:0003824;GO:0008152 YER061C CEM1 Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial " PAS_4g02825 CAY71767.1 PAS_chr4_0512 "Nucleolar protein, forms a complex with Noc4p" YDL148C NOP14 "Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA" Probable nucleolar complex protein 14 PAS_4g02830 CAY71768.1 PAS_chr4_0513 Subunit of the cytosolic chaperonin Cct ring complex GO:0005524;GO:0006457;GO:0051082 YDR188W CCT6 "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif" T-complex protein 1 subunit zeta PAS_4g02835 CAY71769.1 PAS_chr4_0970 hypothetical protein PAS_4g02840 CAY71770.1 PAS_chr4_0514 Purine-cytosine permease GO:0015205;GO:0015931;GO:0016020 YER056C FCY2 "Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation" Purine-cytosine permease FCY2 PAS_4g02845 PAS_4g02850 CAY71771.1 PAS_chr4_0516 Low-affinity zinc transporter of the plasma membrane GO:0016020;GO:0030001;GO:0046873 YLR130C ZRT2 Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor Zinc-regulated transporter 2 PAS_4g02855 CAY71772.1 PAS_chr4_0517 Putative protein of unknown function YLL014W EMC6 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response Uncharacterized membrane protein C1020.11c PAS_4g02860 CAY71773.1 PAS_chr4_0518 TFIIF (Transcription Factor II) largest subunit GO:0003702;GO:0003824;GO:0006367 YGR186W TFG1 TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 Transcription initiation factor IIF subunit alpha PAS_4g02865 CAY71774.1 PAS_chr4_0519 Nonessential protein of unknown function YGR187C HGH1 Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16) Protein HGH1 PAS_4g02870 CAY71775.1 PAS_chr4_0520 Hypothetical protein GO:0005740;GO:0006122;GO:0008121 YGR183C QCR9 "Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex" Cytochrome b-c1 complex subunit 9 PAS_4g02875 CAY71776.1 PAS_chr4_0521 Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p GO:0004842;GO:0006512;GO:0008270 E3 ubiquitin-protein ligase UBR2 PAS_4g02880 CAY71777.1 PAS_chr4_0522 "Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase" GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YGR185C TYS1 "Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies" "Tyrosyl-tRNA synthetase, cytoplasmic " PAS_4g02885 YLR432W IMD3 "Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed" Probable inosine-5'-monophosphate dehydrogenase PAS_4g02890 CAY71778.1 PAS_chr4_0524 Ribosomal protein 10 (rp10) of the small (40S) subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YLR441C RPS1A Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein 40S ribosomal protein S1 PAS_4g02895 CAY71779.1 PAS_chr4_0525 GTP-binding protein of the ras superfamily involved in termination of M-phase GO:0005525;GO:0005622;GO:0007264 YML064C TEM1 GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis Septum-promoting GTP-binding protein 1 PAS_4g02900 CAY71780.1 PAS_chr4_0526 Largest subunit of the origin recognition complex GO:0003677 YML065W ORC1 "Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity" Origin recognition complex subunit 1 PAS_4g02905 CAY71781.1 PAS_chr4_0527 Non-essential putative integral membrane protein YLR443W ECM7 Non-essential putative integral membrane protein; mutant has cell wall defects; transcription is induced under conditions of zinc deficiency Protein ECM7 PAS_4g02910 CAY71782.1 PAS_chr4_0971 hypothetical protein YML066C SMA2 Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation Spore membrane assembly protein 2 PAS_4g02915 CAY71783.1 PAS_chr4_0528 "mRNA transport regulator, essential nuclear protein" GO:0006950 YKL186C MTR2 "mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA" mRNA transport regulator MTR2 PAS_4g02920 CAY71784.1 PAS_chr4_0972 hypothetical protein GO:0006950 Temperature shock-inducible protein 1 PAS_4g02925 CAY71785.1 PAS_chr4_0529 Hypothetical protein YMR134W YMR134W Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes PAS_4g02930 CAY71786.1 PAS_chr4_0973 hypothetical protein YMR135C GID8 "Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START" Protein C20orf11 homolog PAS_4g02935 CAY71787.1 PAS_chr4_0974 hypothetical protein GO:0003824;GO:0030170 YLR027C AAT2 "Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells" "Aspartate aminotransferase, cytoplasmic " PAS_4g02940 CAY71788.1 PAS_chr4_0975 hypothetical protein PAS_4g02945 CAY71789.1 PAS_chr4_0530 "Cytosolic aspartate aminotransferase, involved in nitrogen metabolism" GO:0003824;GO:0030170 Mitogen-activated protein kinase PAS_4g02950 CAY71790.1 PAS_chr4_0531 Putative protein of unknown function with similarity to F-box proteins GO:0005515 YLR352W YLR352W Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene F-box protein YLR352W PAS_4g02955 CAY71791.1 PAS_chr4_0976 hypothetical protein YMR119W ASI1 Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals Protein ASI1 PAS_4g02960 CAY71792.1 PAS_chr4_0532 Permease of basic amino acids in the vacuolar membrane Uncharacterized MFS-type transporter C3E7.06c PAS_4g02965 CAY71793.1 PAS_chr4_0533 Beta-tubulin GO:0003924;GO:0005525;GO:0043234;GO:0051258 YFL037W TUB2 "Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules" Tubulin beta chain PAS_4g02970 CAY71794.1 PAS_chr4_0534 Hypothetical protein YLR039C RIC1 Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes PAS_4g02975 CAY71795.1 PAS_chr4_0535 Hypothetical protein NADH-ubiquinone oxidoreductase 14.8 kDa subunit PAS_4g02980 CAY71796.1 PAS_chr4_0536 Hypothetical protein Uncharacterized protein C4C5.03 PAS_4g02985 CAY71797.1 PAS_chr4_0537 Essential nuclear protein involved in early steps of ribosome biogenesis YMR131C RRB1 Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p Ribosome assembly protein RRB1 PAS_4g02990 CAY71798.1 PAS_chr4_0538 "Splicing factor, component of the U4/U6-U5 snRNP complex" YBR055C PRP6 "Splicing factor, component of the U4/U6-U5 snRNP complex" Pre-mRNA-splicing factor prp1 PAS_4g02995 CAY71799.1 PAS_chr4_0539 Hypothetical protein PAS_4g03000 CAY71800.1 PAS_chr4_0540 Zinc cluster transcriptional activator GO:0003700;GO:0005634;GO:0006355;GO:0008270 Regulatory protein CAT8 PAS_4g03005 CAY71801.1 PAS_chr4_0541 Protein that forms a complex with the Sit4p protein phosphatase and is required for its function YKR028W SAP190 "Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p" SIT4-associating protein SAP190 PAS_4g03010 CAY71802.1 PAS_chr4_0542 "Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p)" YKR027W BCH2 "Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane" Uncharacterized protein C31F10.16 PAS_4g03015 CAY71803.1 PAS_chr4_0543 "Putative protein of unknown function, deletion confers reduced fitness in saline" YNR029C YNR029C "Putative protein of unknown function, deletion confers reduced fitness in saline" Uncharacterized protein YNR029C PAS_4g03020 CAY71804.1 PAS_chr4_0544 "Alpha-1,6-mannosyltransferase localized to the ER" YNR030W ALG12 "Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation" "Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase " PAS_4g03025 CAY71805.1 PAS_chr4_0545 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum GO:0003755;GO:0006457 Peptidyl-prolyl cis-trans isomerase B PAS_4g03030 CAY71806.1 PAS_chr4_0546 Putative metalloprotease GO:0003824;GO:0046872 YOL098C YOL098C Putative metalloprotease Uncharacterized protein YOL098C PAS_4g03035 CAY71807.1 PAS_chr4_0547 Hypothetical protein Serrate RNA effector molecule homolog PAS_4g03040 CAY71808.1 PAS_chr4_0548 Component of the septin ring of the mother-bud neck that is required for cytokinesis GO:0005525;GO:0007049 YLR314C CDC3 "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM" Cell division control protein 3 PAS_4g03045 CAY71809.1 PAS_chr4_0549 Hypothetical protein Immediate-early protein PAS_4g03050 CAY71810.1 PAS_chr4_0550 Putative protein of unknown function GO:0016491 YPR127W YPR127W "Protein of unknown function, differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" Pyridoxal reductase PAS_4g03055 CAY71811.1 PAS_chr4_0551 Protein of unknown function YLL023C YLL023C "Protein of unknown function; highly conserved across species and orthologous to human TMEM33; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the endoplasmic reticulum" UPF0121 membrane protein YLL023C PAS_4g03060 CAY71812.1 PAS_chr4_0552 ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport Heat shock protein SSA2 PAS_4g03065 CAY71813.1 PAS_chr4_0553 Hypothetical protein PAS_4g03070 CAY71814.1 PAS_chr4_0554 Hypothetical protein YGR203W YCH1 "Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" Uncharacterized protein YGR203W PAS_4g03075 CAY71815.1 PAS_chr4_0555 "Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair" GO:0004518;GO:0006281 YGR258C RAD2 "Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein" DNA repair protein rad13 PAS_4g03080 CAY71816.1 PAS_chr4_0556 Hypothetical protein PAS_4g03085 CAY71817.1 PAS_chr4_0557 "Mitochondrial outer membrane protein, component of the Mdm10-Mdm12-Mmm1 complex" YLL006W MMM1 "ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth" Maintenance of mitochondrial morphology protein 1 PAS_4g03090 CAY71818.1 PAS_chr4_0558 "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA" YHR187W IKI1 "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin" Elongator complex protein 5 PAS_4g03095 CAY71819.1 PAS_chr4_0559 "Putative chitin transglycosidase, cell wall protein" GO:0004553;GO:0005975 YGR189C CRH1 Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress Probable glycosidase CRH1 PAS_4g03100 CAY71820.1 PAS_chr4_0560 "Meiosis-specific protein of unknown function, required for spore wall formation during sporulation" GO:0016020 YLL005C SPO75 "Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis" Sporulation-specific protein 75 PAS_4g03105 CAY71821.1 PAS_chr4_0561 "Mitochondrial intermembrane space protein, forms a complex with TIm8p" GO:0006626;GO:0042719;GO:0045039 YGR181W TIM13 "Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane" Mitochondrial import inner membrane translocase subunit TIM13 PAS_4g03110 CAY71822.1 PAS_chr4_0562 Similar to globins and has a functional heme-binding domain GO:0005506;GO:0015671;GO:0019825;GO:0020037 YNL234W YNL234W Protein of unknown function with similarity to globins; has a functional heme-binding domain; transcription is induced by hypoxia and other stress conditions; proposed to be involved in glucose signaling or metabolism; regulated by Rgt1p Uncharacterized globin-like protein YNL234W PAS_4g03115 CAY71823.1 PAS_chr4_0977 hypothetical protein YNL233W BNI4 "Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p" Protein BNI4 PAS_4g03120 PAS_4g03125 CAY71824.1 PAS_chr4_0563 "Subunit of the exosome, which is an essential complex present in both nucleus and cytoplasm" GO:0003723 YNL232W CSL4 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) Exosome complex component CSL4 PAS_4g03130 CAY71825.1 PAS_chr4_0564 Phosphatidylinositol transfer protein (PITP) YNL231C PDR16 "Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p" Phosphatidylinositol transfer protein PDR16 PAS_4g03135 CAY71826.1 PAS_chr4_0565 Hypothetical protein GO:0005634;GO:0016021;GO:0045449 YNL230C ELA1 "Elongin A, F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21; subunit of the Elongin-Cullin-Socs (ECS) ligase complex" PAS_4g03140 CAY71827.1 PAS_chr4_0566 Subunit of both RNase MRP and nuclear RNase P GO:0004540;GO:0008033 YHR062C RPP1 "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends" Ribonuclease P/MRP protein subunit RPP1 PAS_4g03145 CAY71828.1 PAS_chr4_0567 "Putative protein of unknown function, contains DHHC domain" GO:0008270 YNL155W YNL155W "Putative protein of unknown function, contains DHHC domain, also predicted to have thiol-disulfide oxidoreductase active site" AN1-type zinc finger protein YNL155W PAS_4g03150 CAY71829.1 PAS_chr4_0568 "Palmitoylated, plasma membrane-bound casein kinase I isoform" YNL154C YCK2 "Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p" Casein kinase I homolog 1 PAS_4g03155 PAS_4g03160 CAY71830.1 PAS_chr4_0570 Endoplasmic reticulum (ER) resident protein YJL117W PHO86 "Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles" Inorganic phosphate transporter PHO86 PAS_4g03165 CAY71831.1 PAS_chr4_0571 "Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation" Sugar transporter STL1 PAS_4g03170 CAY71832.1 PAS_chr4_0978 hypothetical protein GO:0003824;GO:0005488;GO:0008152 Putative uncharacterized oxidoreductase C513.07 PAS_4g03175 CAY71833.1 PAS_chr4_0572 Hypothetical protein Mitochondrial enolase superfamily member 1 PAS_4g03180 Uncharacterized protein YLR154C-H/YLR156C-A/YLR157C-C/YLR159C-A PAS_4g03185 PAS_4g03190 CAY71834.1 PAS_chr4_0575 Hypothetical protein PAS_4g03195 CAY71835.1 PAS_chr4_0576 NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity GO:0008270;GO:0016491 YMR318C ADH6 NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance NADP-dependent alcohol dehydrogenase 6 PAS_4g03200 CAY71836.1 PAS_chr4_0577 Hypothetical protein GO:0008152;GO:0016829 Dihydrodipicolinate synthase-like protein AN1503 PAS_4g03205 CAY71837.1 PAS_chr4_0578 Carbonic anhydrase GO:0004089;GO:0008270;GO:0015976 YNL036W NCE103 Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway Carbonic anhydrase PAS_4g03210 CAY71838.1 PAS_chr4_0579 Intracellular sporulation-specific glucoamylase involved in glycogen degradation GO:0004339;GO:0005976 YIL099W SGA1 "Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation" Glucoamylase GLU1 PAS_4g03215 CAY71839.1 PAS_chr4_0580 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase GO:0004449;GO:0005739;GO:0006099 YNL037C IDH1 "Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle" "Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial " PAS_4g03220 CAY71840.1 PAS_chr4_0581 "Protein of unknown function, required for survival upon exposure to K1 killer toxin" YIL097W FYV10 "Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of FBPase; contains CTLH domain; plays role in anti-apoptosis" Protein FYV10 PAS_4g03225 CAY71841.1 PAS_chr4_0582 Putative protein of unknown function YIL096C YIL096C Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis UPF0617 protein YIL096C PAS_4g03230 CAY71842.1 PAS_chr4_0583 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 PAS_4g03235 CAY71843.1 PAS_chr4_0584 "Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor" GO:0004190;GO:0006508 YLR120C YPS1 "Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor" Aspartic proteinase 3 PAS_4g03240 CAY71844.1 PAS_chr4_0979 hypothetical protein YDR143C SAN1 "Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins" Protein SAN1 PAS_4g03245 CAY71845.1 PAS_chr4_0585 Serine/threonine kinase and DNA damage checkpoint effector YBR274W CHK1 "Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase" Serine/threonine-protein kinase chk1 PAS_4g03250 CAY71846.1 PAS_chr4_0586 Hypothetical protein PAS_4g03255 CAY71847.1 PAS_chr4_0587 Mitochondrial serine hydroxymethyltransferase GO:0004372;GO:0006544;GO:0006563 YBR263W SHM1 "Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine" "Serine hydroxymethyltransferase, mitochondrial " PAS_4g03260 CAY71848.1 PAS_chr4_0588 Hypothetical protein YOR107W RGS2 Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p PAS_4g03265 CAY71849.1 PAS_chr4_0589 Hypothetical protein PAS_4g03270 CAY71850.1 PAS_chr4_0590 Hypothetical protein Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A PAS_4g03275 CAY71851.1 PAS_chr4_0591 Hypothetical protein UPF0618 protein C8C9.19 PAS_4g03280 CAY71852.1 PAS_chr4_0592 Mitochondrial iron transporter of the mitochondrial carrier family (MCF) GO:0005488;GO:0006810;GO:0016020 YKR052C MRS4 "Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs3p; active under low-iron conditions; may transport other cations" Mitoferrin PAS_4g03285 CAY71853.1 PAS_chr4_0593 Glyoxylate reductase GO:0003824;GO:0005488;GO:0008152 YNL274C GOR1 "Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Putative 2-hydroxyacid dehydrogenase YNL274C PAS_4g03290 CAY71854.1 PAS_chr4_0594 Putative protein of unknown function YJL131C AIM23 "Putative protein of unknown function; the authentic non-tagged protein is detected in highly purified mitochondria; null mutant is viable, displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss" Uncharacterized protein YJL131C PAS_4g03295 CAY71855.1 PAS_chr4_0595 Putative protein of unknown function YJL132W YJL132W Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene Uncharacterized protein YJL132W PAS_4g03300 CAY71856.1 PAS_chr4_0596 Putative protein of unknown function YKR051W YKR051W Putative protein of unknown function Transmembrane protein 184 homolog C30D11.06c PAS_4g03305 CAY71857.1 PAS_chr4_0597 Hypothetical protein YPL075W GCR1 Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p Glycolytic genes transcriptional activator GCR1 PAS_4g03310 CAY71858.1 PAS_chr4_0598 Dihydrosphingosine phosphate lyase GO:0003824;GO:0030170 YDR294C DPL1 "Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate" Sphingosine-1-phosphate lyase PAS_4g03315 CAY71859.1 PAS_chr4_0599 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex YDR295C HDA2 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance HDA1 complex subunit 2 PAS_4g03320 CAY71860.1 PAS_chr4_0600 GTPase-activating protein Protein transport protein SEC23 PAS_4g03325 CAY71861.1 PAS_chr4_0601 Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance GO:0003700;GO:0005634;GO:0006355;GO:0043565;GO:0046983 YML007W YAP1 Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium AP-1-like transcription factor PAS_4g03330 CAY71862.1 PAS_chr4_0602 Hypothetical protein GO:0005488 Acyl-CoA-binding protein PAS_4g03335 CAY71863.1 PAS_chr4_0603 Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation GO:0005759 YIL070C MAM33 Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R Mitochondrial acidic protein MAM33 PAS_4g03340 CAY71864.1 PAS_chr4_0604 B-type cyclin involved in cell cycle progression YLR210W CLB4 "B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation" G2/mitotic-specific cyclin-4 PAS_4g03345 CAY71865.1 PAS_chr4_0605 Putative protein of unknown function YCR051W YCR051W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene Ankyrin repeat-containing protein YCR051W PAS_4g03350 CAY71866.1 PAS_chr4_0606 Guanine nucleotide exchange factor (GEF) YNR026C SEC12 "Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p" Putative guanine nucleotide-exchange factor SED4 PAS_4g03355 CAY71867.1 PAS_chr4_0607 "Putative protein of unknown function, conserved in fungi" YPR170W-B YPR170W-B "Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C" Uncharacterized protein YPR170W-B PAS_4g03360 CAY71868.1 PAS_chr4_0608 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) GO:0003677;GO:0005524 Uncharacterized ATP-dependent helicase C582.10c PAS_4g03365 CAY71869.1 PAS_chr4_0609 Protein that forms a complex with Pbp1p GO:0004518;GO:0006281 YNL085W MKT1 Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO endonuclease; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability Protein MKT1 PAS_4g03370 CAY71870.1 PAS_chr4_0610 "Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-l" YOR085W OST3 "Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins" Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3 PAS_4g03375 CAY71871.1 PAS_chr4_0611 Hypothetical protein PAS_4g03380 CAY71872.1 PAS_chr4_0612 Peripherally bound inner membrane protein of the mitochondrial matrix YDL107W MSS2 "Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p" "Protein MSS2, mitochondrial " PAS_4g03385 CAY71873.1 PAS_chr4_0613 Adenylosuccinate synthase GO:0004019;GO:0005525;GO:0006164 YNL220W ADE12 "Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence" Adenylosuccinate synthetase PAS_4g03390 CAY71874.1 PAS_chr4_0614 Hypothetical protein PAS_4g03395 CAY71875.1 PAS_chr4_0615 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family GO:0008152;GO:0008168 YIL064W SEE1 Protein with a role in intracellular transport; has sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family Uncharacterized methyltransferase YIL064W PAS_4g03400 CAY71876.1 PAS_chr4_0616 Hypothetical protein YIL063C YRB2 "Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential" Ran-specific GTPase-activating protein 2 PAS_4g03405 CAY71877.1 PAS_chr4_0617 Hypothetical protein GO:0003777;GO:0005524;GO:0005875;GO:0007018 Intracellular protein transport protein USO1 PAS_4g03410 CAY71878.1 PAS_chr4_0618 One of two type I myosins GO:0003774;GO:0005524;GO:0016459 YMR109W MYO5 "One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization" Myosin-1 PAS_4g03415 CAY71879.1 PAS_chr4_0619 Putative high affinity iron transporter involved in transport of intravacuolar stores of iron GO:0016020 Iron transporter FTH1 PAS_4g03420 CAY71880.1 PAS_chr4_0620 Hypothetical protein YPL034W YPL034W Putative protein of unknown function; YPL034W is not essential gene PAS_4g03425 CAY71881.1 PAS_chr4_0621 Hypothetical protein GO:0005507;GO:0008131;GO:0009308;GO:0048038 Amiloride-sensitive amine oxidase [copper-containing] PAS_4g03430 CAY71882.1 PAS_chr4_0622 Hypothetical protein PAS_4g03435 CAY71883.1 PAS_chr4_0623 Alpha-tubulin GO:0003924;GO:0005525;GO:0043234;GO:0051258 Tubulin alpha-1 chain PAS_4g03440 CAY71884.1 PAS_chr4_0624 Non-essential protein of unknown function required for transcriptional induction GO:0004396;GO:0005524;GO:0006096 YDR516C EMI2 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p Glucokinase-1 PAS_4g03445 CAY71885.1 PAS_chr4_0625 Hypothetical protein GO:0005215;GO:0006810 YLR054C OSW2 Protein of unknown function proposed to be involved in the assembly of the spore wall PAS_4g03450 CAY71886.1 PAS_chr4_0626 Transcriptional activator of genes involved in nitrogen catabolite repression GO:0003700;GO:0005634;GO:0006355;GO:0008270;GO:0043565 YFL021W GAT1 Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p Transcriptional regulatory protein GAT1 PAS_4g03455 CAY71887.1 PAS_chr4_0627 Plasma membrane localized protein that protects membranes from desiccation GO:0006950 YFL014W HSP12 "Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways" 12 kDa heat shock protein PAS_4g03460 CAY71888.1 PAS_chr4_0628 Hypothetical protein PAS_4g03465 CAY71889.1 PAS_chr4_0629 GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p GO:0005622;GO:0007165 YFL047W RGD2 GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p Rho-GTPase-activating protein RGD2 PAS_4g03470 CAY71890.1 PAS_chr4_0630 Hypothetical protein GO:0008430;GO:0045454 PAS_4g03475 PAS_4g03480 CAY71891.1 PAS_chr4_0631 Hypothetical protein PAS_4g03485 CAY71892.1 PAS_chr4_0632 Hypothetical protein YCL027W FUS1 "Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate" PAS_4g03490 CAY71893.1 PAS_chr4_0633 Protein of unknown function YLR187W SKG3 "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p" CCR4-NOT transcriptional complex subunit CAF120 PAS_4g03495 CAY71894.1 PAS_chr4_0634 "Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p" YLR182W SWI6 "Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate" Regulatory protein SWI6 PAS_4g03500 CAY71895.1 PAS_chr4_0635 Hypothetical protein YLR181C VTA1 "Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain" Vacuolar protein sorting-associated protein VTA1 PAS_4g03505 CAY71896.1 PAS_chr4_0636 "Formin, nucleates the formation of linear actin filaments" YNL271C BNI1 "Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1" Protein BNI1 PAS_4g03510 CAY71897.1 PAS_chr4_0637 Hypothetical protein YPR093C ASR1 Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein Uncharacterized RING finger protein C4G3.12c PAS_4g03515 CAY71898.1 PAS_chr4_0638 "Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex" GO:0003677 Nuclear transcription factor Y subunit B-7 PAS_4g03520 PAS_4g03525 CAY71899.1 PAS_chr4_0640 Hypothetical protein PAS_4g03530 CAY71900.1 PAS_chr4_0641 Essential protein required for sister chromatid cohesion in mitosis and meiosis YDL003W MCD1 Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase Cohesin subunit rad21 PAS_4g03535 CAY71901.1 PAS_chr4_0642 Putative protein of unknown function GO:0016787;n/a YNL320W YNL320W "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Uncharacterized membrane protein YNL320W PAS_4g03540 CAY71902.1 PAS_chr4_0643 Hypothetical protein GO:0005975;GO:0008810 Putative endoglucanase type K PAS_4g03545 CAY71903.1 PAS_chr4_0644 Mitochondrial ribosomal protein of the large subunit YGR076C MRPL25 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L25, mitochondrial " PAS_4g03550 CAY71904.1 PAS_chr4_0645 Acetylornithine aminotransferase GO:0003824;GO:0030170 YOL140W ARG8 "Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine" "Acetylornithine aminotransferase, mitochondrial " PAS_4g03555 CAY71905.1 PAS_chr4_0647 Low affinity vacuolar membrane localized monovalent cation/H+ antiporter GO:0016021 YNL321W VNX1 Low affinity vacuolar membrane localized monovalent cation/H+ antiporter; member of the calcium exchanger (CAX) family; potential Cdc28p substrate Low affinity vacuolar monovalent cation/H(+) antiporter PAS_4g03560 CAY71906.1 PAS_chr4_0648 "Spermine synthase, required for the biosynthesis of spermine" GO:0003824 YLR146C SPE4 "Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid" Spermine synthase PAS_4g03565 CAY71907.1 PAS_chr4_0649 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p YDL091C UBX3 "UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern" UBX domain-containing protein 3 PAS_4g03570 CAY71908.1 PAS_chr4_0650 Hypothetical protein PAS_4g03575 CAY71909.1 PAS_chr4_0651 Hypothetical protein PAS_4g03580 CAY71910.1 PAS_chr4_0652 ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly GO:0005789;GO:0006506;GO:0016021 YDR302W GPI11 ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog Glycosylphosphatidylinositol anchor biosynthesis protein 11 PAS_4g03585 CAY71911.1 PAS_chr4_0653 Protein integral to the mitochondrial membrane GO:0008152;GO:0008168 YDR316W OMS1 Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations "Methyltransferase OMS1, mitochondrial " PAS_4g03590 CAY71912.1 PAS_chr4_0654 Karyopherin involved in nuclear import and export GO:0005488 YDR335W MSN5 "Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP" Protein MSN5 PAS_4g03595 CAY71913.1 PAS_chr4_0655 Hypothetical protein YDR288W NSE3 Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growth PAS_4g03600 CAY71914.1 PAS_chr4_0656 Putative protein of unknown function Uncharacterized membrane protein YMR155W PAS_4g03605 CAY71915.1 PAS_chr4_0657 "Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p" YDL088C ASM4 "Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p" Nucleoporin NUP53 PAS_4g03610 CAY71916.1 PAS_chr4_0658 Hypothetical protein YDL089W NUR1 "Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate" Meiotically up-regulated gene 154 protein PAS_4g03615 CAY71917.1 PAS_chr4_0659 Subunit of the RNA polymerase II mediator complex YHR041C SRB2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance Mediator of RNA polymerase II transcription subunit 20 PAS_4g03620 CAY71918.1 PAS_chr4_0660 Hypothetical protein Histone-lysine N-methyltransferase MLL2 PAS_4g03625 CAY71919.1 PAS_chr4_0661 "Essential nuclear protein, constituent of 66S pre-ribosomal particles" YAL025C MAK16 "Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus" Protein MAK16 PAS_4g03630 CAY71920.1 PAS_chr4_0662 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secre GO:0005524;GO:0006810;GO:0015662;GO:0016020 YAL026C DRS2 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease Probable phospholipid-transporting ATPase DRS2 PAS_4g03635 CAY71921.1 PAS_chr4_0663 Hypothetical protein PAS_4g03640 CAY71922.1 PAS_chr4_0664 S-adenosylmethionine-homocysteine methyltransferase GO:0008898 YPL273W SAM4 "S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio" Homocysteine S-methyltransferase 2 PAS_4g03645 CAY71923.1 PAS_chr4_0665 "Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis" GO:0008152;GO:0016491 YOR323C PRO2 "Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis" Gamma-glutamyl phosphate reductase PAS_4g03650 CAY71924.1 PAS_chr4_0666 "Predicted protein kinase, overexpression causes sensitivity to staurosporine" YPR106W ISR1 "Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C" Putative serine/threonine-protein kinase L673 PAS_4g03655 CAY71925.1 PAS_chr4_0667 "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA" GO:0006364;GO:0032040 YML093W UTP14 Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit U3 small nucleolar RNA-associated protein 14 PAS_4g03660 CAY71926.1 PAS_chr4_0980 hypothetical protein YPR104C FHL1 Transcriptional activator with similarity to DNA-binding domain of Drosophila forkhead but unable to bind DNA in vitro; required for rRNA processing; isolated as a suppressor of splicing factor prp4 Pre-rRNA-processing protein FHL1 PAS_4g03665 CAY71927.1 PAS_chr4_0668 "Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome" GO:0004298;GO:0005839;GO:0006511 YPR103W PRE2 "Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome" Proteasome component PRE2 PAS_4g03670 CAY71928.1 PAS_chr4_0669 "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp" GO:0003735;GO:0005622;GO:0005840;GO:0006412 YPR102C RPL11A "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11" 60S ribosomal protein L11 PAS_4g03675 CAY71929.1 PAS_chr4_0670 Hypothetical protein PAS_4g03680 CAY71930.1 PAS_chr4_0671 "Putative transporter, member of the mitochondrial carrier family" GO:0005215;GO:0005743;GO:0006810 YPR011C YPR011C "Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Uncharacterized mitochondrial carrier YPR011C PAS_4g03685 CAY71931.1 PAS_chr4_0672 Hypothetical protein YPR010C-A YPR010C-A Putative protein of unknown function; conserved among Saccharomyces sensu stricto species UPF0495 protein YPR010C-A PAS_4g03690 CAY71932.1 PAS_chr4_0673 Putative protein of unknown function YGR021W YGR021W "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" UPF0082 protein SYNAS_07390 PAS_4g03695 CAY71933.1 PAS_chr4_0674 Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) GO:0015986;GO:0016469;GO:0046933;GO:0046961 YGR020C VMA7 "Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane" V-type proton ATPase subunit F PAS_4g03700 CAY71934.1 PAS_chr4_0675 "Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p" GO:0005622 YLR330W CHS5 "Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane" Chitin biosynthesis protein CHS5 PAS_4g03705 CAY71935.1 PAS_chr4_0676 Hypothetical protein PAS_4g03710 CAY71936.1 PAS_chr4_0677 Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) GO:0003824;GO:0030170 YGR019W UGA1 Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization 4-aminobutyrate aminotransferase PAS_4g03715 CAY71937.1 PAS_chr4_0981 hypothetical protein YGR017W YGR017W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm Uncharacterized protein YGR017W PAS_4g03720 CAY71938.1 PAS_chr4_0678 Putative protein of unknown function YDL203C ACK1 Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria Chitin synthase regulatory factor 3 PAS_4g03725 CAY71939.1 PAS_chr4_0679 Probable component of the Rpd3 histone deacetylase complex GO:0008270 YNL097C PHO23 "Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3" Transcriptional regulatory protein PHO23 PAS_4g03730 CAY71940.1 PAS_chr4_0680 GTP-binding protein GO:0005525;GO:0005622;GO:0007264 YOR101W RAS1 "GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes" Ras-like protein 1 PAS_4g03735 CAY71941.1 PAS_chr4_0681 GTPase-activating protein (RhoGAP) for Rho3p and Rho4p GO:0005622;GO:0007165 YBR260C RGD1 "GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization" RHO GTPase-activating protein RGD1 PAS_4g03740 CAY71942.1 PAS_chr4_0682 Protein kinase that stabilizes several plasma membrane amino acid transporters Nitrogen permease reactivator protein PAS_4g03745 CAY71943.1 PAS_chr4_0683 Hypothetical protein PAS_4g03750 CAY71944.1 PAS_chr4_0684 "Arginase, responsible for arginine degradation" GO:0004053;GO:0006527 Arginase PAS_4g03755 PAS_4g03760 CAY71945.1 PAS_chr4_0686 Vacuolar carboxypeptidase yscS GO:0016787;GO:0046983 YJL172W CPS1 Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Carboxypeptidase S PAS_4g03765 CAY71946.1 PAS_chr4_0687 Hypothetical protein Dentin sialophosphoprotein PAS_4g03770 CAY71947.1 PAS_chr4_0688 Mitochondrial succinate-fumarate transporter GO:0005488;GO:0006810;GO:0016020 YJR095W SFC1 "Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization" Succinate/fumarate mitochondrial transporter PAS_4g03775 CAY71948.1 PAS_chr4_0982 hypothetical protein GO:0003735;GO:0005622;GO:0005840;GO:0006414 YDL130W RPP1B "Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component" 60S acidic ribosomal protein P1-B PAS_4g03780 CAY71949.1 PAS_chr4_0689 SET-domain lysine-N-methyltransferase GO:0005634 YPL208W RKM1 "SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B)" Ribosomal N-lysine methyltransferase 1 PAS_4g03785 CAY71950.1 PAS_chr4_0983 hypothetical protein PAS_4g03790 CAY71951.1 PAS_chr4_0690 Hypothetical protein GO:0000172;GO:0003723;GO:0004540;GO:0006364;GO:0006379;GO:0008033;GO:0030677 YBR257W POP4 "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P" PAS_4g03795 CAY71952.1 PAS_chr4_0691 Putative lipoate-protein ligase A family member YJL046W AIM22 "Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss" Putative lipoate-protein ligase A PAS_4g03800 CAY71953.1 PAS_chr4_0692 "Sporulation-specific exo-1,3-beta-glucanase" GO:0003824;GO:0005975;GO:0043169 "Glucan 1,3-beta-glucosidase " PAS_4g03805 CAY71954.1 PAS_chr4_0693 Hypothetical protein YKR020W VPS51 "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p" PAS_4g03810 CAY71955.1 PAS_chr4_0694 Cytoplasmic protein of unknown function that interacts with the cyclin Pcl7p YJL084C ALY2 "Protein proposed to regulate the endocytosis of plasma membrane proteins; interacts with the cyclin Pcl7p and ubiquitin ligase Rsp5p; phosphorylated by the cyclin-CDK complex, Pcl7p-Pho85p; mRNA is cell cycle regulated, peaking in M phase" UPF0675 protein YKR021W PAS_4g03815 CAY71956.1 PAS_chr4_0695 Essential 70kDa subunit of the exocyst complex GO:0000145;GO:0006887 YJL085W EXO70 "Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis; acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding" Exocyst complex component EXO70 PAS_4g03820 CAY71957.1 PAS_chr4_0696 Hypothetical protein PAS_4g03825 CAY71958.1 PAS_chr4_0984 hypothetical protein PAS_4g03830 CAY71959.1 PAS_chr4_0697 RNA polymerase III subunit C34 GO:0003677;GO:0003899;GO:0005634;GO:0006350 YNR003C RPC34 RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex DNA-directed RNA polymerase III subunit RPC6 PAS_4g03835 CAY71960.1 PAS_chr4_0698 Hypothetical protein PAS_4g03840 CAY71961.1 PAS_chr4_0699 Hypothetical protein PAS_4g03845 CAY71962.1 PAS_chr4_0700 Phospholipase C GO:0004435;GO:0006629;GO:0007165;GO:0007242 YPL268W PLC1 "Phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes" "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase 1 " PAS_4g03850 CAY71963.1 PAS_chr4_0701 Protein associated with U3 and U14 snoRNAs YBR247C ENP1 "Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus" Uncharacterized protein C13G1.09 PAS_4g03855 CAY71964.1 PAS_chr4_0702 "Nucleotide exchange factor for Gsp1p, localizes to the nucleus" YGL097W SRM1 "Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p" Regulator of chromosome condensation PAS_4g03860 CAY71965.1 PAS_chr4_0703 Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase) YBR248C HIS7 "Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor" Imidazole glycerol phosphate synthase hisHF PAS_4g03865 CAY71966.1 PAS_chr4_0704 Conserved protein that is a component of autophagosomes and Cvt vesicles YBL078C ATG8 "Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation" Autophagy-related protein 8 PAS_4g03870 CAY71967.1 PAS_chr4_0705 Protein required for mitochondrial translation GO:0006412;GO:0016874 YBL080C PET112 Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial " PAS_4g03875 CAY71968.1 PAS_chr4_0706 Hypothetical protein YBL074C AAR2 "Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron" PAS_4g03880 CAY71969.1 PAS_chr4_0708 Hypothetical protein tRNA(Ile)-lysidine synthase PAS_4g03885 CAY71970.1 PAS_chr4_0709 "Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A" GO:0000166;GO:0004812;GO:0005524;GO:0005737;GO:0006412;GO:0006418 YBL076C ILS1 "Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A" "Isoleucyl-tRNA synthetase, cytoplasmic " PAS_4g03890 CAY71971.1 PAS_chr4_0710 Component of the nuclear pore complex YER107C GLE2 Component of the Nup82 subcomplex of the nuclear pore complex; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p Nucleoporin GLE2 PAS_4g03895 CAY71972.1 PAS_chr4_0711 Hypothetical protein YER109C FLO8 "Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene" Putative uncharacterized protein DDB_G0271606 PAS_4g03900 CAY71973.1 PAS_chr4_0712 Dolichol-P-Man dependent alpha(1-3) mannosyltransferase GO:0000030;GO:0005783;GO:0016021 YBL082C ALG3 "Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins" Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase PAS_4g03905 CAY71974.1 PAS_chr4_0713 Hypothetical protein YGR104C SRB5 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance Mediator of RNA polymerase II transcription subunit 18 PAS_4g03910 CAY71975.1 PAS_chr4_0714 Mitochondrial serine protease GO:0016021 YGR101W PCP1 Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases "Rhomboid protein 1, mitochondrial " PAS_4g03915 CAY71976.1 PAS_chr4_0715 Putative protein of unknown function YGR102C YGR102C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria PAS_4g03920 CAY71977.1 PAS_chr4_0716 Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis GO:0005622 Pescadillo homolog PAS_4g03925 CAY71978.1 PAS_chr4_0717 Essential conserved protein that is part of the 90S preribosome GO:0000166 YPR112C MRD1 Essential conserved protein that is part of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains Multiple RNA-binding domain-containing protein 1 PAS_4g03930 CAY71979.1 PAS_chr4_0718 Hypothetical protein GO:0008152;GO:0008415 YOR298W MUM3 Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases PAS_4g03935 CAY71980.1 PAS_chr4_0719 "GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport" GO:0005515 YMR235C RNA1 "GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport" Ran GTPase-activating protein 1 PAS_4g03940 CAY71981.1 PAS_chr4_0720 Transcriptional coactivator GO:0043565 YOR298C-A MBF1 Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations Multiprotein-bridging factor 1 PAS_4g03945 CAY71982.1 PAS_chr4_0721 Hypothetical protein GO:0015078;GO:0016469 PAS_4g03950 CAY71983.1 PAS_chr4_0722 Hypothetical protein GO:0000166 RNA-binding protein 42 PAS_4g03955 CAY71984.1 PAS_chr4_0723 Hypothetical protein PAS_4g03960 CAY71985.1 PAS_chr4_0724 Hypothetical protein PAS_4g03965 CAY71986.1 PAS_chr4_0725 Cytoplasmic thioredoxin isoenzyme of the thioredoxin system Thioredoxin PAS_4g03970 CAY71987.1 PAS_chr4_0726 Putative protein of unknown function YNL305C YNL305C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene Uncharacterized membrane protein C576.04 PAS_4g03975 CAY71988.1 PAS_chr4_0985 hypothetical protein PAS_4g03980 CAY71989.1 PAS_chr4_0727 Polypeptide release factor involved in translation termination GO:0005737;GO:0006415;GO:0016149 YBR143C SUP45 Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin Eukaryotic peptide chain release factor subunit 1 PAS_4g03985 CAY71990.1 PAS_chr4_0728 "Essential nucleolar protein, putative DEAD-box RNA helicase" YBR142W MAK5 "Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits" ATP-dependent RNA helicase MAK5 PAS_4g03990 CAY71991.1 PAS_chr4_0729 Putative protein of unknown function YBR141C YBR141C Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene UPF0657 nucleolar protein YBR141C PAS_4g03995 CAY71992.1 PAS_chr4_0730 "Inositol monophosphatase, involved in biosynthesis of inositol" GO:0004437 YDR287W INM2 "Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy" Inositol monophosphatase 2 PAS_4g04000 CAY71993.1 PAS_chr4_0731 One of six ATPases of the 19S regulatory particle of the 26S proteasome GO:0005634;GO:0005737;GO:0016787;GO:0030163;n/a YDL007W RPT2 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle 26S protease regulatory subunit 4 homolog PAS_4g04005 CAY71994.1 PAS_chr4_0986 hypothetical protein YDL006W PTC1 "Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation" Protein phosphatase 2C homolog 1 PAS_4g04010 CAY71995.1 PAS_chr4_0732 "Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytos" GO:0015662;GO:0016021;GO:0030001 Copper-transporting ATPase RAN1 PAS_4g04015 CAY71996.1 PAS_chr4_0733 "Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p)" YKL148C SDH1 "Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone" "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial " PAS_4g04020 YDR496C PUF6 "Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA" Pumilio homology domain family member 6 PAS_4g04025 CAY71997.1 PAS_chr4_0735 "RNA polymerase III subunit C25, required for transcription initiation" YKL144C RPC25 "RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p" DNA-directed RNA polymerase III subunit RPC8 PAS_4g04030 CAY71998.1 PAS_chr4_0736 One of six ATPases of the 19S regulatory particle of the 26S proteasome GO:0005634;GO:0005737;GO:0016787;GO:0030163 YKL145W RPT1 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p 26S protease regulatory subunit 7 homolog PAS_4g04035 CAY71999.1 PAS_chr4_0987 hypothetical protein GO:0016787 YKL149C DBR1 "RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition" Lariat debranching enzyme PAS_4g04040 CAY72000.1 PAS_chr4_0737 "Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis" GO:0006118;GO:0016491 YKL150W MCR1 "Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis" NADH-cytochrome b5 reductase 2 PAS_4g04045 CAY72001.1 PAS_chr4_0738 Putative protein of unknown function YKL151C YKL151C Putative protein of unknown function; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Uncharacterized protein YKL151C PAS_4g04050 CAY72002.1 PAS_chr4_0739 "Putative mitochondrial ribosomal protein, has similarity to E. coli ribosomal protein S2" YKL142W MRP8 Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; originally thought to be a mitochondrial ribosomal protein based on sequence analysis Uncharacterized protein MRP8 PAS_4g04055 YJL006C CTK2 "Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity" CTD kinase subunit beta PAS_4g04060 CAY72003.1 PAS_chr4_0741 Alpha subunit of Type II geranylgeranyltransferase GO:0008318;GO:0018346 YJL031C BET4 Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p Geranylgeranyl transferase type-2 subunit alpha PAS_4g04065 CAY72004.1 PAS_chr4_0742 Essential component of pre-40S ribosomes GO:0005488 YJL010C NOP9 Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain Pumilio domain-containing protein YJL010C PAS_4g04070 CAY72005.1 PAS_chr4_0743 Hypothetical protein GO:0016491 Delta(12) fatty acid desaturase PAS_4g04075 CAY72006.1 PAS_chr4_0744 Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex YIL157C COA1 Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly Cytochrome oxidase assembly protein 1 PAS_4g04080 CAY72007.1 PAS_chr4_0745 Subunit of TFIIH and nucleotide excision repair factor 3 complexes YDR311W TFB1 "Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators" RNA polymerase II transcription factor B subunit 1 PAS_4g04085 CAY72008.1 PAS_chr4_0746 Auxilin-like protein involved in vesicular transport YDR320C SWA2 Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles Auxilin-like clathrin uncoating factor SWA2 PAS_4g04090 CAY72009.1 PAS_chr4_0747 Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs YHR072W-A NOP10 "Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA" H/ACA ribonucleoprotein complex subunit 3 PAS_4g04095 CAY72010.1 PAS_chr4_0748 Hypothetical protein YDR320C-A DAD4 "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" DASH complex subunit dad4 PAS_4g04100 CAY72011.1 PAS_chr4_0749 Golgi membrane protein involved in manganese homeostasis GO:0016020;GO:0030001;GO:0046873 YOR079C ATX2 "Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation" Zinc transporter ZIP9 PAS_4g04105 CAY72012.1 PAS_chr4_0750 Hypothetical protein DNA ligase 1 PAS_4g04110 CAY72013.1 PAS_chr4_0751 "Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance" GO:0005488;GO:0005634 YMR106C YKU80 "Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair" ATP-dependent DNA helicase II subunit 2 PAS_4g04115 CAY72014.1 PAS_chr4_0752 Hypothetical protein YKL108W SLD2 "Protein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrate" DNA replication regulator SLD2 PAS_4g04120 CAY72015.1 PAS_chr4_0753 Hypothetical protein PAS_4g04125 CAY72016.1 PAS_chr4_0754 "Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation" GO:0008152;GO:0016491 Sorbose reductase SOU1 PAS_4g04130 CAY72017.1 PAS_chr4_0988 hypothetical protein GO:0008152;GO:0016491 Sorbose reductase SOU1 PAS_4g04135 CAY72018.1 PAS_chr4_0755 Hypothetical protein PAS_4g04140 CAY72019.1 PAS_chr4_0756 Mitochondrial protein kinase GO:0016310;GO:0016772 "[Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial " PAS_4g04145 CAY72020.1 PAS_chr4_0757 Putative protein of unknown function with similarity to dehydrogenases from other model organisms GO:0008270;GO:0016491;n/a Uncharacterized protein YNL134C PAS_4g04150 CAY72021.1 PAS_chr4_0989 hypothetical protein GO:0008270 YKR090W PXL1 "LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin" Paxillin-like protein 1 PAS_4g04155 CAY72022.1 PAS_chr4_0758 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p YKR088C TVP38 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern Golgi apparatus membrane protein TVP38 PAS_4g04160 CAY72023.1 PAS_chr4_0759 C3HC4-type RING-finger peroxisomal membrane peroxin YMR026C PEX12 C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorders Peroxisome assembly protein 12 PAS_4g04165 CAY72024.1 PAS_chr4_0760 Protein required for transcription of rDNA by RNA polymerase I YKL125W RRN3 Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA RNA polymerase I-specific transcription initiation factor RRN3 PAS_4g04170 CAY72025.1 PAS_chr4_0761 Major component of the proteasome GO:0005488 YHL030W ECM29 "Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome" Proteasome component ECM29 PAS_4g04175 CAY72026.1 PAS_chr4_0762 Ubiquitin GO:0006464 YLL039C UBI4 "Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats" Polyubiquitin PAS_4g04180 CAY72027.1 PAS_chr4_0763 Protein containing an N-terminal epsin-like domain Epsin-4 PAS_4g04185 CAY72028.1 PAS_chr4_0764 Splicing factor associated with the spliceosome YLL036C PRP19 "Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases" Cell cycle control protein cwf8 PAS_4g04190 CAY72029.1 PAS_chr4_0765 Putative protein of unknown function YJR088C EMC2 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response PAS_4g04195 CAY72030.1 PAS_chr4_0766 Hypothetical protein YJR086W STE18 "G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling" Guanine nucleotide-binding protein subunit gamma PAS_4g04200 CAY72031.1 PAS_chr4_0767 Hypothetical protein PAS_4g04205 YJR091C JSN1 "Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl" Protein JSN1 PAS_4g04210 CAY72032.1 PAS_chr4_0769 F-box protein component of the SCF ubiquitin-ligase complex YJR090C GRR1 "F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification" SCF E3 ubiquitin ligase complex F-box protein GRR1 PAS_4g04215 CAY72033.1 PAS_chr4_0770 Hypothetical protein GO:0005622;GO:0006916 Baculoviral IAP repeat-containing protein 5.2 PAS_4g04220 CAY72034.1 PAS_chr4_0990 hypothetical protein GO:0005488 YPR036W VMA13 "Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase" V-type proton ATPase subunit H PAS_4g04225 CAY72035.1 PAS_chr4_0771 Translation initiation factor eIF-5 GO:0005488 YPR041W TIF5 Translation initiation factor eIF-5; N-terminal domain functions as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP; C-terminal domain is the core of ribosomal preinitiation complex formation Eukaryotic translation initiation factor 5 PAS_4g04230 CAY72036.1 PAS_chr4_0772 Subunit of the Cop9 signalosome YJR084W CSN12 "Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in mRNA splicing and adaptation to pheromone signaling" Protein CSN12 homolog PAS_4g04235 CAY72037.1 PAS_chr4_0773 Hypothetical protein PAS_4g04240 CAY72038.1 PAS_chr4_0774 Hypothetical protein PAS_4g04245 CAY72039.1 PAS_chr4_0991 hypothetical protein Protein disulfide-isomerase PAS_4g04250 CAY72040.1 PAS_chr4_0775 "HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins" GO:0006621;GO:0016021;GO:0046923 YBL040C ERD2 "HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins" ER lumen protein retaining receptor PAS_4g04255 CAY72041.1 PAS_chr4_0776 Beta 6 subunit of the 20S proteasome GO:0004298;GO:0005839;GO:0006511 YBL041W PRE7 Beta 6 subunit of the 20S proteasome Proteasome component C5 PAS_4g04260 CAY72042.1 PAS_chr4_0777 "Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose" GO:0016020 YGR199W PMT6 "Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases" Dolichyl-phosphate-mannose--protein mannosyltransferase 6 PAS_4g04265 CAY72043.1 PAS_chr4_0778 "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA" YGR200C ELP2 "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin" Elongator complex protein 2 PAS_4g04270 CAY72044.1 PAS_chr4_0992 hypothetical protein PAS_4g04275 CAY72045.1 PAS_chr4_0779 Putative protein of unknown function YOR389W YOR389W Putative protein of unknown function; expression regulated by copper levels Uncharacterized protein YPL277C PAS_4g04280 CAY72046.1 PAS_chr4_0780 Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation GO:0005737;GO:0006629;GO:0016021;GO:0016627 YDL015C TSC13 "Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p" "Trans-2,3-enoyl-CoA reductase " PAS_4g04285 CAY72047.1 PAS_chr4_0781 Hypothetical protein GO:0016071;GO:0030529 YGR074W SMD1 "Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1" Probable small nuclear ribonucleoprotein Sm D1 PAS_4g04290 CAY72048.1 PAS_chr4_0782 Hypothetical protein Pre-mRNA-splicing factor 38 PAS_4g04295 CAY72049.1 PAS_chr4_0783 "Glycerol kinase, converts glycerol to glycerol-3-phosphate" GO:0005975 YHL032C GUT1 "Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p" Glycerol kinase PAS_4g04300 CAY72050.1 PAS_chr4_0784 Putative channel-like protein GO:0005215;GO:0006810;GO:0016020 YFL054C YFL054C Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol Uncharacterized membrane protein C977.17 PAS_4g04305 CAY72051.1 PAS_chr4_0785 "Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia" GO:0003824 YPR035W GLN1 "Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation" Glutamine synthetase PAS_4g04310 CAY72052.1 PAS_chr4_0786 Cytosolic superoxide dismutase GO:0006801;GO:0046872 YJR104C SOD1 Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans Superoxide dismutase [Cu-Zn] PAS_4g04315 CAY72053.1 PAS_chr4_0787 Putative protein of unknown function YJR100C AIM25 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss Phospholipid scramblase family protein C343.06c PAS_4g04320 CAY72054.1 PAS_chr4_0788 Mitochondrial ribosomal protein of the small subunit GO:0004784;GO:0006801;GO:0046872 YJR101W RSM26 Mitochondrial ribosomal protein of the small subunit "37S ribosomal protein S26, mitochondrial " PAS_4g04325 CAY72055.1 PAS_chr4_0789 Hypothetical protein PAS_4g04330 CAY72056.1 PAS_chr4_0993 hypothetical protein YJR102C VPS25 "Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome" Vacuolar protein-sorting-associated protein 25 PAS_4g04335 CAY72057.1 PAS_chr4_0994 hypothetical protein YBL039C URA7 "Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis" CTP synthase PAS_4g04340 CAY72058.1 PAS_chr4_0995 hypothetical protein PAS_4g04345 CAY72059.1 PAS_chr4_0790 "Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation" GO:0004559;GO:0005975;n/a YGL156W AMS1 "Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway" Alpha-mannosidase PAS_4g04350 CAY72060.1 PAS_chr4_0791 Beta subunit of geranylgeranyltransferase type I GO:0003824 YGL155W CDC43 "Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis" Geranylgeranyl transferase type-1 subunit beta PAS_4g04355 CAY72061.1 PAS_chr4_0792 Putative mitochondrial transport protein GO:0005488;GO:0006810;GO:0016020 YDL119C YDL119C "Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria" Solute carrier family 25 member 38 homolog PAS_4g04360 CAY72062.1 PAS_chr4_0793 Hypothetical protein GO:0000287;GO:0008897;GO:0009059 YGL154C LYS5 Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine PAS_4g04365 CAY72063.1 PAS_chr4_0794 Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery GO:0005777;GO:0016020 YGL153W PEX14 "Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p" Peroxisomal membrane protein PEX14 PAS_4g04370 CAY72064.1 PAS_chr4_0795 "Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lys" GO:0008152 YDR234W LYS4 "Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway" "Homoaconitase, mitochondrial " PAS_4g04375 CAY72065.1 PAS_chr4_0796 Nuclear protein related to mammalian high mobility group (HMG) proteins GO:0030529;GO:0042254 YDL208W NHP2 "Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing" H/ACA ribonucleoprotein complex subunit 2 PAS_4g04380 CAY72066.1 PAS_chr4_0797 Hypothetical protein Uncharacterized protein DDB_G0271670 PAS_4g04385 CAY72067.1 PAS_chr4_0798 Essential beta-coat protein of the COPI coatomer GO:0005515;GO:0006461;GO:0006886;GO:0016192;GO:0030117 YDR238C SEC26 "Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)" Coatomer subunit beta PAS_4g04390 CAY72068.1 PAS_chr4_0799 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YDR237W MRPL7 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L7, mitochondrial " PAS_4g04395 CAY72069.1 PAS_chr4_0800 Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import GO:0008531;GO:0009231 YDL207W GLE1 Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal Nucleoporin GLE1 PAS_4g04400 CAY72070.1 PAS_chr4_0996 hypothetical protein GO:0008531;GO:0009231 YDR236C FMN1 "Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane" Riboflavin kinase PAS_4g04405 CAY72071.1 PAS_chr4_0801 Putative protein of unknown function GO:0016021 YPR114W YPR114W Putative protein of unknown function Uncharacterized TLC domain-containing protein YPR114W PAS_4g04410 CAY72072.1 PAS_chr4_0802 Putative protein of unknown function GO:0016021 Putative cation exchanger C3A12.06c PAS_4g04415 CAY72073.1 PAS_chr4_0803 Nucleolar protein involved in the assembly of the large ribosomal subunit YHR088W RPF1 "Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA" Ribosome production factor 1 PAS_4g04420 CAY72074.1 PAS_chr4_0804 Hypothetical protein YIL098C FMC1 "Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p" "ATP synthase assembly factor FMC1, mitochondrial " PAS_4g04425 CAY72075.1 PAS_chr4_0805 "U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis" GO:0005622;GO:0006396 YDR235W PRP42 "U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats" U1 small nuclear ribonucleoprotein component PRP42 PAS_4g04430 CAY72076.1 PAS_chr4_0806 NADP-cytochrome P450 reductase GO:0006118;GO:0016491 YHR042W NCP1 NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p NADPH--cytochrome P450 reductase PAS_4g04435 CAY72077.1 PAS_chr4_0807 Hypothetical protein GO:0016021 PAS_4g04440 CAY72078.1 PAS_chr4_0808 "Nucleolar protein, component of the small subunit processome complex, which is required for processi" GO:0003723;GO:0005634;GO:0006364 YDL014W NOP1 "Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin" rRNA 2'-O-methyltransferase fibrillarin PAS_4g04445 CAY72079.1 PAS_chr4_0997 hypothetical protein GO:0005515;GO:0008270 YDL013W SLX5 "Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers" E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 PAS_4g04450 CAY72080.1 PAS_chr4_0809 Hypothetical protein PAS_4g04455 CAY72081.1 PAS_chr4_0810 Hypothetical protein GO:0016020 Uncharacterized protein C12G12.12 PAS_4g04460 CAY72082.1 PAS_chr4_0811 Vacuolar membrane protein of unknown function involved in vacuolar protein sorting YOL129W VPS68 Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria UPF0220 protein C8D2.02c PAS_4g04465 CAY72083.1 PAS_chr4_0812 Protein serine/threonine/tyrosine (dual-specificity) kinase YNL307C MCK1 Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family Protein kinase MCK1 PAS_4g04470 CAY72084.1 PAS_chr4_0813 Mitochondrial ribosomal protein of the small subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YNL306W MRPS18 "Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins" "37S ribosomal protein S18, mitochondrial " PAS_4g04475 CAY72085.1 PAS_chr4_0814 Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit YOL127W RPL25 "Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif" 60S ribosomal protein L25 PAS_4g04480 CAY72086.1 PAS_chr4_0815 "Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate" GO:0003824;GO:0005975 "Malate dehydrogenase, mitochondrial " PAS_4g04485 CAY72087.1 PAS_chr4_0816 "Neutral trehalase, degrades trehalose" GO:0003824 YDR001C NTH1 "Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p" Neutral trehalase PAS_4g04490 CAY72088.1 PAS_chr4_0817 Ran GTPase binding protein YDR002W YRB1 "Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1" Ran-specific GTPase-activating protein 1 PAS_4g04495 CAY72089.1 PAS_chr4_0818 Cis-prenyltransferase involved in dolichol synthesis GO:0008152;GO:0016740 YBR002C RER2 Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Dehydrodolichyl diphosphate synthase PAS_4g04500 CAY72090.1 PAS_chr4_0819 Hexaprenyl pyrophosphate synthetase GO:0008299 YBR003W COQ1 "Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis" "Hexaprenyl pyrophosphate synthase, mitochondrial " PAS_4g04505 CAY72091.1 PAS_chr4_0820 Putative protein of unknown function GO:0003676 YDR514C YDR514C Putative protein of unknown function Uncharacterized protein YDR514C PAS_4g04510 CAY72092.1 PAS_chr4_0821 Alcohol oxidase GO:0016614 Alcohol oxidase PAS_4g04515 PAS_4g04520 CAY72093.1 PAS_chr4_0823 "Polyamine oxidase, converts spermine to spermidine" GO:0006118;GO:0016491 Probable polyamine oxidase 4 PAS_4g04525 CAY72094.1 PAS_chr4_0824 Protein required for resistance to the antifungal drug ciclopirox olamine YBR203W COS111 "Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" F-box protein COS111 PAS_4g04530 PAS_4g04535 YPR109W YPR109W Predicted membrane protein; dipoid deletion strain has high budding index PAS_4g04540 CAY72095.1 PAS_chr4_0826 "RNA polymerase subunit, common to RNA polymerase I and III" GO:0003677;GO:0003899;GO:0006350 YPR110C RPC40 "RNA polymerase subunit, common to RNA polymerase I and III" DNA-directed RNA polymerases I and III subunit RPAC1 PAS_4g04545 CAY72096.1 PAS_chr4_0827 Hypothetical protein PAS_4g04550 CAY72097.1 PAS_chr4_0828 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p Putative polyol transporter 2 PAS_4g04555 CAY72098.1 PAS_chr4_0829 Putative protein of unknown function YBL095W YBL095W "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" Uncharacterized protein in WHS11 5'region (Fragment) PAS_4g04560 CAY72099.1 PAS_chr4_0830 Kynurenine 3-mono oxygenase GO:0008152;GO:0016491 YBL098W BNA4 "Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease" Kynurenine 3-monooxygenase PAS_4g04565 CAY72100.1 PAS_chr4_0831 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA YGR090W UTP22 "Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data" U3 small nucleolar RNA-associated protein 22 PAS_4g04570 CAY72101.1 PAS_chr4_0832 Plasma membrane ATP-binding cassette (ABC) transporter YPL058C PDR12 "Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity" ATP-dependent permease PDR12 PAS_4g04575 CAY72102.1 PAS_chr4_0998 hypothetical protein YPR125W YLH47 "Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome" "LETM1 domain-containing protein YLH47, mitochondrial " PAS_4g04580 CAY72103.1 PAS_chr4_0833 Protein that interacts with silencing proteins at the telomere YML109W ZDS2 "Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; implicated in the mitotic exit network through regulation of Cdc14p localization; paralog of Zds1p" Protein ZDS2 PAS_4g04585 CAY72104.1 PAS_chr4_0834 Hypothetical protein YMR274C RCE1 Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone CAAX prenyl protease 2 PAS_4g04590 CAY72105.1 PAS_chr4_0835 Protein required for respiratory growth and stability of the mitochondrial genome PAS_4g04595 CAY72106.1 PAS_chr4_0836 "Polyamine transport protein, recognizes spermine, putrescine, and spermidine" YOR273C TPO4 "Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily" Polyamine transporter 4 PAS_4g04600 CAY72107.1 PAS_chr4_0837 Hypothetical protein UPF0549 protein C20orf43 homolog PAS_4g04605 CAY72108.1 PAS_chr4_0838 Hypothetical protein YML129C COX14 "Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes" Cytochrome c oxidase assembly protein COX14 PAS_4g04610 YBR019C GAL10 "UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers" Bifunctional protein GAL10 PAS_4g04615 CAY72109.1 PAS_chr4_0840 "Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase" YDR513W GRX2 "Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress" Glutaredoxin PAS_4g04620 CAY72110.1 PAS_chr4_0841 Protein of unknown function YCL034W LSB5 "Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat" LAS seventeen-binding protein 5 PAS_4g04625 CAY72111.1 PAS_chr4_0842 Monomeric glyoxalase I YML004C GLO1 "Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress" Lactoylglutathione lyase PAS_4g04630 CAY72112.1 PAS_chr4_0843 Putative protein-methionine-R-oxide reductase Peptide methionine sulfoxide reductase B3 PAS_4g04635 CAY72113.1 PAS_chr4_0844 "Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen" YCL043C PDI1 "Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds" Protein disulfide-isomerase PAS_4g04640 CAY72114.1 PAS_chr4_0845 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0006412;GO:0015934 YCR003W MRPL32 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L32, mitochondrial " PAS_4g04645 CAY72115.1 PAS_chr4_0846 Component of the septin ring of the mother-bud neck that is required for cytokinesis GO:0005525;GO:0007049 YCR002C CDC10 "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM" Cell division control protein 10 PAS_4g04650 CAY72116.1 PAS_chr4_0847 "Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside" GO:0016051;GO:0016758 YKR058W GLG1 "Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin" Glycogenin-1 PAS_4g04655 PAS_4g04660 CAY72117.1 PAS_chr4_0849 "Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1" YCL039W GID7 "Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions" WD repeat-containing protein 26 PAS_4g04665 CAY72118.1 PAS_chr4_0850 Hypothetical protein YKL090W CUE2 "Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination" Ubiquitin-binding protein CUE2 PAS_4g04670 CAY72119.1 PAS_chr4_0851 Hypothetical protein PAS_4g04675 CAY72120.1 PAS_chr4_0852 Mu1-like medium subunit of the clathrin-associated protein complex (AP-1) GO:0006810 YPL259C APM1 Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting AP-1 complex subunit mu-1 PAS_4g04680 CAY72121.1 PAS_chr4_0853 Hypothetical protein GO:0003677;GO:0006355 TOX high mobility group box family member 3 PAS_4g04685 CAY72122.1 PAS_chr4_0854 Hypothetical protein PAS_4g04690 CAY72123.1 PAS_chr4_0855 Hypothetical protein GO:0003676;GO:0005622;GO:0008270 PAS_4g04695 CAY72124.1 PAS_chr4_0999 hypothetical protein GO:0008017 YER016W BIM1 Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally Protein BIM1 PAS_4g04700 CAY72125.1 PAS_chr4_0856 "Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease" GO:0008017 YER017C AFG3 "Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes" Mitochondrial respiratory chain complexes assembly protein AFG3 PAS_4g04705 CAY72126.1 PAS_chr4_0857 Hypothetical protein GO:0003700;GO:0005634;GO:0006355;GO:0008270 Putative transcription factor SEF1 PAS_4g04710 CAY72127.1 PAS_chr4_0858 Hypothetical protein Mediator of RNA polymerase II transcription subunit 5 PAS_4g04715 CAY72128.1 PAS_chr4_0859 Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter GO:0005524;GO:0006810;GO:0016021;GO:0042626 "ATP-dependent permease MDL1, mitochondrial " PAS_4g04720 CAY72129.1 PAS_chr4_0860 Hypothetical protein PAS_4g04725 CAY72130.1 PAS_chr4_1000 hypothetical protein PAS_4g04730 CAY72131.1 PAS_chr4_0861 F-box protein involved in recycling plasma membrane proteins internalized by endocytosis YJL204C RCY1 F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth Recyclin-1 PAS_4g04735 CAY72132.1 PAS_chr4_0862 Hypothetical protein YJL201W ECM25 Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p PAS_4g04740 CAY72133.1 PAS_chr4_0863 Hypothetical protein YJL209W CBP1 Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p PAS_4g04745 CAY72134.1 PAS_chr4_0864 "Major mitochondrial nuclease, has RNAse and DNA endo-and exonucleolytic activities" GO:0003676;GO:0004519 YJL208C NUC1 "Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy" Mitochondrial nuclease PAS_4g04750 CAY72135.1 PAS_chr4_0865 "L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine" YNL277W MET2 "L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway" Homoserine O-acetyltransferase PAS_4g04755 CAY72136.1 PAS_chr4_0866 Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C YER019W ISC1 "Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance" Inositol phosphosphingolipids phospholipase C PAS_4g04760 CAY72137.1 PAS_chr4_0867 Hypothetical protein Kinetochore protein spc25 PAS_4g04765 CAY72138.1 PAS_chr4_0868 "Acetylated, cis-golgi localized protein involved in ER to Golgi transport" YDR517W GRH1 "Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes" GRASP65 homolog protein 1 PAS_4g04770 CAY72139.1 PAS_chr4_0869 Non-essential protein of unknown function YDR512C EMI1 "Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs" Early meiotic induction protein 1 PAS_4g04775 CAY72140.1 PAS_chr4_0870 Hypothetical protein YGL161C YIP5 "Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport" Protein YIP5 PAS_4g04780 CAY72141.1 PAS_chr4_0871 Hypothetical protein PAS_4g04785 CAY72142.1 PAS_chr4_0872 Hypothetical protein rRNA-processing protein FYV7 PAS_4g04790 CAY72143.1 PAS_chr4_0873 Specific translational activator for the COX1 mRNA YLR067C PET309 "Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)" "Pentatricopeptide repeat-containing protein PET309, mitochondrial " PAS_4g04795 CAY72144.1 PAS_chr4_0874 "Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p)" GO:0005787;GO:0006465;GO:0009003;GO:0016021 YLR066W SPC3 "Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23" Microsomal signal peptidase subunit 3 PAS_4g04800 CAY72145.1 PAS_chr4_0875 Putative protein of unknown function YPR085C ASA1 "Putative protein of unknown function; subunit of the ASTRA complex (Rvb1p, Rvb2p, Tra1p, Tti1p, Tti2, Asa1p and Tra1p) which is part of the chromatin remodeling machinery" PAS_4g04805 CAY72146.1 PAS_chr4_0876 Hypothetical protein PAS_4g04810 CAY72147.1 PAS_chr4_0877 "Mitochondrial dicarboxylate carrier, integral membrane protein" GO:0005488;GO:0006810;GO:0016020 YLR348C DIC1 "Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix" Mitochondrial dicarboxylate transporter PAS_4g04815 CAY72148.1 PAS_chr4_0878 Silenced copy of ALPHA2 at HML GO:0003677;GO:0045449 YCL067C HMLALPHA2 Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression Putative mating-type protein A2 PAS_4g04820 CAY72149.1 PAS_chr4_1001 hypothetical protein YCL066W HMLALPHA1 "Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression" Mating-type protein ALPHA1 PAS_4g04825 CAY72150.1 PAS_chr4_0879 Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization YNL243W SLA2 Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo Endocytosis protein end4 PAS_4g04830 CAY72151.1 PAS_chr4_0880 Translation initiation factor eIF1 GO:0003743;GO:0006412 YNL244C SUI1 Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase Eukaryotic translation initiation factor eIF-1 PAS_4g04835 CAY72152.1 PAS_chr4_0881 Hypothetical protein YNL245C CWC25 Heat-stable protein required for the first step of pre-mRNA splicing; component of a complex containing Cef1p; has similarity to S. pombe Cwf25p Pre-mRNA-splicing factor CWC25 PAS_4g04840 PAS_4g04845 CAY72153.1 PAS_chr4_0883 Hypothetical protein Uncharacterized protein YDR524C-B PAS_4g04850 CAY72154.1 PAS_chr4_0884 hypothetical protein GO:0016021 YDR525W-A SNA2 "Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern" Protein SNA2 PAS_4g04855 CAY72155.1 PAS_chr4_0885 RNA polymerase II-associated protein YDR527W RBA50 "Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1" RNA polymerase II-associated protein RBA50 PAS_4g04860 Heat shock protein SSB1 PAS_4g04865 CAY72156.1 PAS_chr4_0887 transcription factor GO:0003700;GO:0005634;GO:0006355;GO:0043565;GO:0046983 Putative transcription factor kapC PAS_4g04870 CAY72157.1 PAS_chr4_0935 hypothetical protein PAS_4g04875 CAY72158.1 PAS_chr4_0888 pH-response regulator protein YOR030W DFG16 "Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p" pH-response regulator protein palH/RIM21 PAS_4g04880 CAY72159.1 PAS_chr4_0889 hypothetical protein GO:0004222;GO:0005524;GO:0006508 YPR024W YME1 "Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover" Protein YME1 PAS_4g04885 CAY72160.1 PAS_chr4_0890 Hypothetical protein GO:0005529;GO:0005975 Uncharacterized protein HP_1429 PAS_4g04890 CAY72161.1 PAS_chr4_0891 DNA replication licensing factor GO:0003677;GO:0005524;GO:0005634;GO:0006270 YBR202W MCM7 "Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase" DNA replication licensing factor CDC47 PAS_4g04895 CAY72162.1 PAS_chr4_0892 mitochondrial ATP synthase GO:0015986;GO:0016469;GO:0046933;GO:0046961 YDR322C-A TIM11 "Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase" "ATP synthase subunit e, mitochondrial " PAS_4g04900 CAY72163.1 PAS_chr4_0893 Mitochondria protein phosphatase GO:0003824 YHR076W PTC7 Type 2C protein phosphatase; YHR076W is alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope "Protein phosphatase 2C homolog 7, mitochondrial " PAS_4g04905 CAY72164.1 PAS_chr4_0894 Nonsense-mediated mRNA decay protein 2 GO:0005515;GO:0016070 YHR077C NMD2 Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance Nonsense-mediated mRNA decay protein 2 PAS_4g04910 CAY72165.1 PAS_chr4_0895 "54S ribosomal protein L35, mitochondrial" YDR322W MRPL35 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L35, mitochondrial " PAS_4g04915 CAY72166.1 PAS_chr4_0896 Zinc/cadmium resistance protein GO:0006812;GO:0008324;GO:0016020 YMR243C ZRC1 "Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm" Zinc/cadmium resistance protein PAS_4g04920 CAY72167.1 PAS_chr4_0897 hypothetical protein Uncharacterized protein in WHS11 5'region (Fragment) PAS_4g04925 CAY72168.1 PAS_chr4_0898 Cyclin YOL001W PHO80 "Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling" PHO85 cyclin PHO80 PAS_4g04930 CAY72169.1 PAS_chr4_0899 GTP-binding protein GO:0005524;GO:0005622;GO:0006355;GO:0008134 YML001W YPT7 "GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7" Probable Ras-related protein Rab7 PAS_4g04935 CAY72170.1 PAS_chr4_0900 Kinesin-like protein GO:0003777;GO:0005524;GO:0005875;GO:0007018 YPR141C KAR3 "Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate" Kinesin-like protein klp-3 PAS_4g04940 CAY72171.1 PAS_chr4_0901 Ribosomal RNA-processing protein YPR143W RRP15 "Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs" Ribosomal RNA-processing protein 15 PAS_4g04945 CAY72172.1 PAS_chr4_0902 RNAP II-associated protein YBR279W PAF1 "Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; homolog of human PD2/hPAF1" RNA polymerase II-associated protein 1 PAS_4g04950 CAY72173.1 PAS_chr4_0903 DNA Polymerase II Epsilon complex with BRCT domain GO:0005622 YJL090C DPB11 Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1 S-M checkpoint control protein rad4 PAS_4g04955 CAY72174.1 PAS_chr4_0904 Mitochondrial ribosomal protein of the large subunit YBR268W MRPL37 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L37, mitochondrial " PAS_4g04960 CAY72175.1 PAS_chr4_0905 Mitochondrial ribosomal protein of the large subunit GO:0003735;GO:0005622;GO:0005840;GO:0006412 YOR150W MRPL23 Mitochondrial ribosomal protein of the large subunit "54S ribosomal protein L23, mitochondrial " PAS_4g04965 CAY72176.1 PAS_chr4_0906 RNA polymerase II subunit GO:0003899;GO:0006350 YDR404C RPB7 RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p DNA-directed RNA polymerase II subunit rpb7 PAS_4g04970 CAY72177.1 PAS_chr4_0907 1-phosphatidylinositol phosphodiesterase GO:0004629;GO:0007165;GO:0007242 1-phosphatidylinositol phosphodiesterase PAS_4g04975 CAY72178.1 PAS_chr4_0908 Mitochondrial distribution and morphology protein GO:0005743;GO:0007005 YOR147W MDM32 "Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34" Mitochondrial distribution and morphology protein 32 PAS_4g04980 PAS_4g04985 PAS_4g04990 YBR106W PHO88 "Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations" Inorganic phosphate transport protein PHO88 PAS_4g04995 YMR029C FAR8 "Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p" Factor arrest protein 8 PAS_4g05000 PAS_4g05005 YFR011C AIM13 "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria; null mutant displays reduced respiratory growth and reduced frequency of mitochondrial genome loss" UPF0726 protein YFR011C PAS_4g05010 YFR010W UBP6 "Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to polyubiquitin elongation activity of Hul5p" Ubiquitin carboxyl-terminal hydrolase 6 PAS_4g05015 YJL062W LAS21 Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity GPI ethanolamine phosphate transferase 2 PAS_4g05020 YBR269C FMP21 "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" "Protein FMP21, mitochondrial " PAS_4g05025 YJL061W NUP82 "Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Gle2p, Nup159p, Nsp1p, and Nup116p and is required for proper localization of Nup116p in the NPC" Nucleoporin NUP82 PAS_4g05030 YBL104C YBL104C "Putative protein of unknown function, promoter contains multiple GCN4 binding sites" WD repeat-containing protein YBL104C PAS_4g05035 CAY72179.1 PAS_FragD_0029 Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3 GO:0008270 YPR031W NTO1 Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3 NuA3 HAT complex component NTO1 PAS_4g05040 YBL103C RTG3 "Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways" Retrograde regulation protein 3 PAS_4g05045 CAY72180.1 PAS_FragD_0027 Adenosine 5'-monophosphoramidase GO:0003824 YDL125C HNT1 "Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint" Hit family protein 1 PAS_4g05050 CAY72181.1 PAS_FragD_0026 "ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97" GO:0016787 YDL126C CDC48 "ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome" Cell division control protein 48 PAS_4g05055 CAY72182.1 PAS_FragD_0025 "G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk)" YDL127W PCL2 "Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth" PHO85 cyclin-2 PAS_4g05060 CAY72183.1 PAS_FragD_0031 hypothetical protein Uncharacterized protein YOR389W PAS_4g05065 CAY72184.1 PAS_FragD_0024 Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration GO:0006812;GO:0008324;GO:0016021 YDL128W VCX1 "Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter" Vacuolar calcium ion transporter PAS_4g05070 CAY72185.1 PAS_FragD_0023 Hypothetical protein PAS_4g05075 CAY72186.1 PAS_FragD_0022 Deletion mutant is synthetically lethal with MEN mutants YPR045C YPR045C Protein of unknown function; involvement in splicing based on pre-mRNA accumulation defect for many intron-containing genes; contains a SAC3 domain; physically interacts with Csn12p; YRP045C is not an essential gene UPF0666 protein C2A9.11c PAS_4g05080 CAY72187.1 PAS_FragD_0021 Hypothetical protein PAS_4g05085 CAY72188.1 PAS_FragD_0020 Hypothetical protein PAS_4g05090 CAY72189.1 PAS_FragD_0019 Putative protein of unknown function GO:0005524;GO:0006810;GO:0015662;GO:0016020 YOR291W YPK9 "Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor?Rakeb syndrome" Probable cation-transporting ATPase C1672.11c PAS_4g05095 CAY72190.1 PAS_FragD_0018 Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation GO:0003677;GO:0005524 YOR290C SNF2 Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p Transcription regulatory protein SNF2 PAS_4g05100 CAY72191.1 PAS_FragD_0017 Hypothetical protein PAS_4g05105 CAY72192.1 PAS_FragD_0016 "TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation" GO:0005669;GO:0016251;GO:0045449 YMR227C TAF7 "TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation" Transcription initiation factor TFIID subunit 7 PAS_4g05110 CAY72193.1 PAS_FragD_0015 Mitochondrial RNA polymerase specificity factor GO:0000154;GO:0000179;GO:0008649 YMR228W MTF1 "Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p" Mitochondrial transcription factor 1 PAS_4g05115 CAY72194.1 PAS_FragD_0014 Protein component of the small (40S) ribosomal subunit GO:0003735;GO:0005840;GO:0006412 YBR181C RPS6B Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein 40S ribosomal protein S6 PAS_4g05120 CAY72195.1 PAS_FragD_0013 Protein component of the small (40S) ribosomal subunit YOR293W RPS10A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10 40S ribosomal protein S10-A PAS_4g05125 CAY72196.1 PAS_FragD_0012 Putative protein of unknown function GO:0016021 YOR292C YOR292C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene Vacuolar membrane protein YOR292C PAS_4g05130 CAY72197.1 PAS_FragD_0011 Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes GO:0005525;GO:0007049 YGR059W SPR3 Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI Sporulation-regulated protein 3 PAS_4g05135 CAY72198.1 PAS_FragD_0010 Hypothetical protein PAS_4g05140 CAY72199.1 PAS_FragD_0009 Hypothetical protein YOR315W SFG1 "Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate" PAS_4g05145 PAS_4g05150 CAY72200.1 PAS_FragD_0007 Hypothetical protein YGL198W YIP4 "Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport" Protein YIPF6 PAS_4g05155 PAS_4g05160 CAY72201.1 PAS_FragD_0005 Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins YGR141W VPS62 Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins Vacuolar protein sorting-associated protein 62 PAS_4g05165 PAS_4g05170 CAY72202.1 PAS_FragD_0003 Subunit of the CCR4-NOT complex GO:0005634;GO:0030528;GO:0045449 YIL038C NOT3 "Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation" General negative regulator of transcription subunit 3 PAS_4g05175 CAY72203.1 PAS_FragD_0002 "ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p" YIR033W MGA2 "ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting" Protein MGA2