InterPro domains associated with a binding site

Binding site
Motif_166
Name
RAP2.2
Description
Transcription factor RAP2.2 and its interacting partner SINAT2: stable elements in the carotenogenesis of Arabidopsis leaves
#Associated genes
265
#Associated InterPro terms
307

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InterPro Description #Associated genes ath bra cme egr gma ptr ppe sly stu vvi
IPR001128Cytochrome P45013 (4.91%)1101430201
IPR002401Cytochrome P450, E-class, group I12 (4.53%)1101330201
IPR017972Cytochrome P450, conserved site11 (4.15%)1101230201
IPR000719Protein kinase domain11 (4.15%)2110321100
IPR011009Protein kinase-like domain11 (4.15%)2110321100
IPR008271Serine/threonine-protein kinase, active site10 (3.77%)2110311100
IPR002290Serine/threonine- / dual specificity protein kinase, catalytic domain9 (3.40%)2100311100
IPR009057Homeodomain-like7 (2.64%)1000310101
IPR017441Protein kinase, ATP binding site7 (2.64%)1110201100
IPR001810F-box domain6 (2.26%)1010200101
IPR012677Nucleotide-binding, alpha-beta plait6 (2.26%)0000122001
IPR007271Nucleotide-sugar transporter6 (2.26%)0101100111
IPR000504RNA recognition motif domain6 (2.26%)0000122001
IPR004689UDP-galactose transporter6 (2.26%)0101100111
IPR011006CheY-like superfamily5 (1.89%)0110030000
IPR013320Concanavalin A-like lectin/glucanase, subgroup5 (1.89%)0110110100
IPR002109Glutaredoxin5 (1.89%)0002002010
IPR011905Glutaredoxin-like, plant II5 (1.89%)0002002010
IPR027417P-loop containing nucleoside triphosphate hydrolase5 (1.89%)0200021000
IPR001789Signal transduction response regulator, receiver domain5 (1.89%)0110030000
IPR012336Thioredoxin-like fold5 (1.89%)0002002010
IPR011333BTB/POZ fold4 (1.51%)0200200000
IPR016140Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain4 (1.51%)0000100120
IPR016175Cytochrome b/b64 (1.51%)0000040000
IPR005797Cytochrome b/b6, N-terminal4 (1.51%)0000040000
IPR027387Cytochrome b/b6-like domain4 (1.51%)0000040000
IPR016174Di-haem cytochrome, transmembrane4 (1.51%)0000040000
IPR001356Homeobox domain4 (1.51%)0000210001
IPR008709Neurochondrin4 (1.51%)0001210000
IPR001568Ribonuclease T2-like4 (1.51%)0110010010
IPR011991Winged helix-turn-helix DNA-binding domain4 (1.51%)0101100001
IPR001841Zinc finger, RING-type4 (1.51%)2010100000
IPR013083Zinc finger, RING/FYVE/PHD-type4 (1.51%)2010100000
IPR016024Armadillo-type fold3 (1.13%)0001020000
IPR013069BTB/POZ3 (1.13%)0100200000
IPR000210BTB/POZ-like3 (1.13%)0100200000
IPR010402CCT domain3 (1.13%)1100010000
IPR001199Cytochrome b5-like heme/steroid binding domain3 (1.13%)0001200000
IPR020946Flavin monooxygenase-like3 (1.13%)0000101010
IPR014025Glutaredoxin subgroup3 (1.13%)0001001010
IPR027923Hydrophobic seed protein3 (1.13%)0000000120
IPR001611Leucine-rich repeat3 (1.13%)1000001100
IPR006553Leucine-rich repeat, cysteine-containing subtype3 (1.13%)1010000100
IPR006447Myb domain, plants3 (1.13%)1000100100
IPR018188Ribonuclease T2, active site3 (1.13%)0110010000
IPR005299SAM dependent carboxyl methyltransferase3 (1.13%)1000000110
IPR001005SANT/Myb domain3 (1.13%)1000100100
IPR001680WD40 repeat3 (1.13%)1010100000
IPR017986WD40-repeat-containing domain3 (1.13%)1010100000
IPR015943WD40/YVTN repeat-like-containing domain3 (1.13%)1010100000
IPR017907Zinc finger, RING-type, conserved site3 (1.13%)1010100000
IPR0025623'-5' exonuclease domain2 (0.75%)2000000000
IPR024034ATPase, F1 complex beta subunit/V1 complex, C-terminal2 (0.75%)0000010001
IPR000793ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal2 (0.75%)0000010001
IPR027450Alpha-ketoglutarate-dependent dioxygenase AlkB-like2 (0.75%)0000101000
IPR002110Ankyrin repeat2 (0.75%)0100000001
IPR020683Ankyrin repeat-containing domain2 (0.75%)0100000001
IPR006189CHASE2 (0.75%)0000020000
IPR008972Cupredoxin2 (0.75%)0100010000
IPR023530Cytochrome b6, PetB2 (0.75%)0000020000
IPR011545DNA/RNA helicase, DEAD/DEAH box type, N-terminal2 (0.75%)0200000000
IPR004314Domain of unknown function DUF2392 (0.75%)2000000000
IPR024228Domain of unknown function DUF34202 (0.75%)0100000001
IPR025486Domain of unknown function DUF43782 (0.75%)1000010000
IPR025521Domain of unknown function DUF44092 (0.75%)2000000000
IPR008546Domain of unknown function DUF8282 (0.75%)2000000000
IPR018247EF-Hand 1, calcium-binding site2 (0.75%)0000101000
IPR002048EF-hand domain2 (0.75%)0000101000
IPR011992EF-hand domain pair2 (0.75%)0000101000
IPR019378GDP-fucose protein O-fucosyltransferase2 (0.75%)0010010000
IPR012562GUCT2 (0.75%)0200000000
IPR003607HD/PDEase domain2 (0.75%)1010000000
IPR002121HRDC domain2 (0.75%)2000000000
IPR010997HRDC-like2 (0.75%)2000000000
IPR006636Heat shock chaperonin-binding2 (0.75%)0200000000
IPR001650Helicase, C-terminal2 (0.75%)0200000000
IPR014001Helicase, superfamily 1/2, ATP-binding domain2 (0.75%)0200000000
IPR003594Histidine kinase-like ATPase, ATP-binding domain2 (0.75%)0000020000
IPR013783Immunoglobulin-like fold2 (0.75%)0100001000
IPR004864Late embryogenesis abundant protein, LEA-142 (0.75%)0000001010
IPR003386Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase2 (0.75%)0000000110
IPR013210Leucine-rich repeat-containing N-terminal, type 22 (0.75%)0000001100
IPR017930Myb domain2 (0.75%)1000000100
IPR001750NADH:ubiquinone/plastoquinone oxidoreductase2 (0.75%)0000100001
IPR027356NPH3 domain2 (0.75%)0000200000
IPR005123Oxoglutarate/iron-dependent dioxygenase2 (0.75%)0000101000
IPR006501Pectinesterase inhibitor domain2 (0.75%)1000010000
IPR002885Pentatricopeptide repeat2 (0.75%)0001000001
IPR013666Pleckstrin-like, plant2 (0.75%)2000000000
IPR012878Protein of unknown function DUF16802 (0.75%)1000000100
IPR007650Protein of unknown function DUF5812 (0.75%)0000001001
IPR015655Protein phosphatase 2C2 (0.75%)0000010001
IPR001932Protein phosphatase 2C (PP2C)-like domain2 (0.75%)0000010001
IPR014014RNA helicase, DEAD-box type, Q motif2 (0.75%)0200000000
IPR007685RelA/SpoT2 (0.75%)1010000000
IPR012337Ribonuclease H-like domain2 (0.75%)2000000000
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain2 (0.75%)0000020000
IPR003661Signal transduction histidine kinase EnvZ-like, dimerisation/phosphoacceptor domain2 (0.75%)0000020000
IPR005467Signal transduction histidine kinase, core2 (0.75%)0000020000
IPR009082Signal transduction histidine kinase, homodimeric domain2 (0.75%)0000020000
IPR004358Signal transduction histidine kinase-related protein, C-terminal2 (0.75%)0000020000
IPR012341Six-hairpin glycosidase2 (0.75%)1000000100
IPR008928Six-hairpin glycosidase-like2 (0.75%)1000000100
IPR011990Tetratricopeptide-like helical2 (0.75%)0000100001
IPR005202Transcription factor GRAS2 (0.75%)0000110000
IPR025422Transcription factor TGA like domain2 (0.75%)0000020000
IPR002100Transcription factor, MADS-box2 (0.75%)0100100000
IPR009060UBA-like2 (0.75%)0200000000
IPR004806UV excision repair protein Rad232 (0.75%)0200000000
IPR000626Ubiquitin domain2 (0.75%)0200000000
IPR000449Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal2 (0.75%)0200000000
IPR015940Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote2 (0.75%)0200000000
IPR000608Ubiquitin-conjugating enzyme, E22 (0.75%)0000100001
IPR016135Ubiquitin-conjugating enzyme/RWD-like2 (0.75%)0000100001
IPR015360XPC-binding domain2 (0.75%)0200000000
IPR001878Zinc finger, CCHC-type2 (0.75%)0200000000
IPR0268991,3-beta-glucan synthase subunit FKS1-like, domain-11 (0.38%)0000000001
IPR01958526S proteasome, regulatory subunit Rpn71 (0.38%)0000000001
IPR001471AP2/ERF domain1 (0.38%)1000000000
IPR013815ATP-grasp fold, subdomain 11 (0.38%)0100000000
IPR013816ATP-grasp fold, subdomain 21 (0.38%)0100000000
IPR013093ATPase, AAA-21 (0.38%)0000010000
IPR004100ATPase, F1 complex alpha/beta subunit, N-terminal domain1 (0.38%)0000010000
IPR008389ATPase, V0 complex, subunit e1/e21 (0.38%)0100000000
IPR000438Acetyl-CoA carboxylase carboxyl transferase, beta subunit1 (0.38%)0000000100
IPR011762Acetyl-coenzyme A carboxyltransferase, N-terminal1 (0.38%)0000000100
IPR013785Aldolase-type TIM barrel1 (0.38%)0000000001
IPR007934Alpha-L-arabinofuranosidase B1 (0.38%)0000000100
IPR012133Alpha-hydroxy acid dehydrogenase, FMN-dependent1 (0.38%)0000000001
IPR001905Ammonium transporter1 (0.38%)0000010000
IPR024041Ammonium transporter AmtB-like domain1 (0.38%)0000010000
IPR018047Ammonium transporter, conserved site1 (0.38%)0000010000
IPR000225Armadillo1 (0.38%)0000010000
IPR011989Armadillo-like helical1 (0.38%)0000010000
IPR001461Aspartic peptidase1 (0.38%)0010000000
IPR021109Aspartic peptidase domain1 (0.38%)0010000000
IPR004827Basic-leucine zipper domain1 (0.38%)0000010000
IPR000916Bet v I domain1 (0.38%)0100000000
IPR011424C1-like1 (0.38%)0000010000
IPR018362CCAAT-binding factor, conserved site1 (0.38%)0000010000
IPR001289CCAAT-binding transcription factor, subunit B1 (0.38%)0000010000
IPR001251CRAL-TRIO domain1 (0.38%)0000100000
IPR011074CRAL/TRIO, N-terminal domain1 (0.38%)0000100000
IPR026953Callose synthase1 (0.38%)0000000001
IPR002044Carbohydrate binding module family 201 (0.38%)0100000000
IPR013784Carbohydrate-binding-like fold1 (0.38%)0100000000
IPR006153Cation/H+ exchanger1 (0.38%)0000000100
IPR001071Cellular retinaldehyde binding/alpha-tocopherol transport1 (0.38%)0000100000
IPR008429Cleft lip and palate transmembrane 11 (0.38%)1000000000
IPR008985Concanavalin A-like lectin/glucanases superfamily1 (0.38%)0000100000
IPR006476Conserved hypothetical protein CHP01589, plant1 (0.38%)0000010000
IPR002403Cytochrome P450, E-class, group IV1 (0.38%)0000100000
IPR003834Cytochrome c assembly protein, transmembrane domain1 (0.38%)0100000000
IPR004146DC11 (0.38%)0000010000
IPR016177DNA-binding domain1 (0.38%)1000000000
IPR009025DNA-directed RNA polymerase, RBP11-like dimerisation domain1 (0.38%)0100000000
IPR011263DNA-directed RNA polymerase, RpoA/D/Rpb3-type1 (0.38%)0100000000
IPR011773DNA-directed RNA polymerase, alpha subunit1 (0.38%)0100000000
IPR011262DNA-directed RNA polymerase, insert domain1 (0.38%)0100000000
IPR015712DNA-directed RNA polymerase, subunit 21 (0.38%)0000001000
IPR007120DNA-directed RNA polymerase, subunit 2, domain 61 (0.38%)0000001000
IPR013562Domain of unknown function DUF17261 (0.38%)0000001000
IPR008166Domain of unknown function DUF231 (0.38%)0000000010
IPR025398Domain of unknown function DUF43711 (0.38%)0000001000
IPR023150Double Clp-N motif1 (0.38%)0000010000
IPR014720Double-stranded RNA-binding domain1 (0.38%)0000010000
IPR015633E2F Family1 (0.38%)0000100000
IPR019542Enhancer of polycomb-like, N-terminal1 (0.38%)0010000000
IPR023278Ethylene insensitive 3-like protein, DNA-binding domain1 (0.38%)1000000000
IPR013112FAD-binding 81 (0.38%)0000000001
IPR008259FMN-dependent alpha-hydroxy acid dehydrogenase, active site1 (0.38%)0000000001
IPR000262FMN-dependent dehydrogenase1 (0.38%)0000000001
IPR017927Ferredoxin reductase-type FAD-binding domain1 (0.38%)0000000001
IPR013130Ferric reductase transmembrane component-like domain1 (0.38%)0000000001
IPR013121Ferric reductase, NAD binding1 (0.38%)0000000001
IPR001519Ferritin1 (0.38%)0000010000
IPR014034Ferritin, conserved site1 (0.38%)0000010000
IPR009040Ferritin- like diiron domain1 (0.38%)0000010000
IPR009078Ferritin-like superfamily1 (0.38%)0000010000
IPR012347Ferritin-related1 (0.38%)0000010000
IPR008331Ferritin/DPS protein domain1 (0.38%)0000010000
IPR026891Fibronectin type III-like domain1 (0.38%)1000000000
IPR000960Flavin monooxygenase FMO1 (0.38%)0000001000
IPR012474Frigida-like1 (0.38%)0100000000
IPR020472G-protein beta WD-40 repeat1 (0.38%)0010000000
IPR000182GNAT domain1 (0.38%)0000001000
IPR009038GOLD1 (0.38%)0000100000
IPR026892Glycoside hydrolase family 31 (0.38%)1000000000
IPR002772Glycoside hydrolase family 3 C-terminal domain1 (0.38%)1000000000
IPR001764Glycoside hydrolase, family 3, N-terminal1 (0.38%)1000000000
IPR017853Glycoside hydrolase, superfamily1 (0.38%)1000000000
IPR003440Glycosyl transferase, family 481 (0.38%)0000000001
IPR002495Glycosyl transferase, family 81 (0.38%)0000100000
IPR023214HAD-like domain1 (0.38%)0000000100
IPR006383HAD-superfamily hydrolase, subfamily IB, PSPase-like1 (0.38%)0000000100
IPR008906HAT dimerisation domain, C-terminal1 (0.38%)0000001000
IPR007807Helicase domain1 (0.38%)0000001000
IPR000047Helix-turn-helix motif1 (0.38%)0000010000
IPR000558Histone H2B1 (0.38%)1000000000
IPR005819Histone H51 (0.38%)0100000000
IPR007125Histone core1 (0.38%)1000000000
IPR009072Histone-fold1 (0.38%)1000000000
IPR008422Homeobox KN domain1 (0.38%)0000100000
IPR017970Homeobox, conserved site1 (0.38%)0000010000
IPR023282Hydroxymethylglutaryl-CoA reductase, N-terminal1 (0.38%)1000000000
IPR002202Hydroxymethylglutaryl-CoA reductase, class I/II1 (0.38%)1000000000
IPR009023Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding1 (0.38%)1000000000
IPR023074Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain1 (0.38%)1000000000
IPR023076Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site1 (0.38%)1000000000
IPR009029Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding1 (0.38%)1000000000
IPR004554Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type1 (0.38%)1000000000
IPR004883Lateral organ boundaries, LOB1 (0.38%)0000000010
IPR001220Legume lectin domain1 (0.38%)0000100000
IPR025875Leucine rich repeat 41 (0.38%)0000001000
IPR003106Leucine zipper, homeobox-associated1 (0.38%)0000010000
IPR003591Leucine-rich repeat, typical subtype1 (0.38%)0000001000
IPR005818Linker histone H1/H5, domain H151 (0.38%)0100000000
IPR002921Lipase, class 31 (0.38%)0000000010
IPR008976Lipase/lipooxygenase, PLAT/LH21 (0.38%)1000000000
IPR025756MYB-CC type transcription factor, LHEQLE-containing domain1 (0.38%)1000000000
IPR024948Major latex protein domain1 (0.38%)0100000000
IPR007145Microtubule-associated protein, MAP65/Ase1/PRC11 (0.38%)0000100000
IPR005301Mob1/phocein1 (0.38%)1000000000
IPR009036Molybdenum cofactor biosynthesis, MoeB1 (0.38%)0000010000
IPR001117Multicopper oxidase, type 11 (0.38%)0100000000
IPR011706Multicopper oxidase, type 21 (0.38%)0100000000
IPR011707Multicopper oxidase, type 31 (0.38%)0100000000
IPR011598Myc-type, basic helix-loop-helix (bHLH) domain1 (0.38%)0000010000
IPR003441NAC domain1 (0.38%)0000001000
IPR016040NAD(P)-binding domain1 (0.38%)0000010000
IPR026057PC-Esterase1 (0.38%)0100000000
IPR001024PLAT/LH2 domain1 (0.38%)1000000000
IPR025846PMR5 N-terminal domain1 (0.38%)0100000000
IPR006563POX domain1 (0.38%)0000100000
IPR012334Pectin lyase fold1 (0.38%)0000010000
IPR011050Pectin lyase fold/virulence factor1 (0.38%)0000010000
IPR018040Pectinesterase, active site1 (0.38%)0000010000
IPR000070Pectinesterase, catalytic1 (0.38%)0000010000
IPR001096Peptidase C13, legumain1 (0.38%)0100000000
IPR023566Peptidyl-prolyl cis-trans isomerase, FKBP-type1 (0.38%)0001000000
IPR001179Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain1 (0.38%)0001000000
IPR004469Phosphoserine phosphatase SerB1 (0.38%)0000000100
IPR023190Phosphoserine phosphatase, domain 21 (0.38%)0000000100
IPR002114Phosphotransferase system, HPr serine phosphorylation site1 (0.38%)0000000100
IPR000528Plant lipid transfer protein/Par allergen1 (0.38%)0000100000
IPR003245Plastocyanin-like1 (0.38%)0000010000
IPR027992Possible tRNA binding domain1 (0.38%)0000001000
IPR023333Proteasome B-type subunit1 (0.38%)0000010000
IPR016050Proteasome beta-type subunit, conserved site1 (0.38%)0000010000
IPR000717Proteasome component (PCI) domain1 (0.38%)0000000001
IPR001353Proteasome, subunit alpha/beta1 (0.38%)0000010000
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol binding1 (0.38%)0000010000
IPR004963Protein notum homologue1 (0.38%)0100000000
IPR009606Protein of unknown function DUF12181 (0.38%)0000000100
IPR019438Protein of unknown function DUF24191 (0.38%)0000010000
IPR021775Protein of unknown function DUF33391 (0.38%)0100000000
IPR022203Protein of unknown function DUF37271 (0.38%)0000000010
IPR022212Protein of unknown function DUF37411 (0.38%)1000000000
IPR000222Protein phosphatase 2C, manganese/magnesium aspartate binding site1 (0.38%)0000010000
IPR002192Pyruvate phosphate dikinase, PEP/pyruvate-binding1 (0.38%)0100000000
IPR014724RNA polymerase Rpb2, OB-fold1 (0.38%)0000001000
IPR007645RNA polymerase Rpb2, domain 31 (0.38%)0000001000
IPR007646RNA polymerase Rpb2, domain 41 (0.38%)0000001000
IPR007647RNA polymerase Rpb2, domain 51 (0.38%)0000001000
IPR007641RNA polymerase Rpb2, domain 71 (0.38%)0000001000
IPR011260RNA polymerase, alpha subunit, C-terminal1 (0.38%)0100000000
IPR007121RNA polymerase, beta subunit, conserved site1 (0.38%)0000001000
IPR003954RNA recognition motif domain, eukaryote1 (0.38%)0000010000
IPR018102Ribosomal S11, conserved site1 (0.38%)0100000000
IPR001515Ribosomal protein L32e1 (0.38%)0000000001
IPR001971Ribosomal protein S111 (0.38%)0100000000
IPR000851Ribosomal protein S51 (0.38%)0000010000
IPR020568Ribosomal protein S5 domain 2-type fold1 (0.38%)0000010000
IPR014721Ribosomal protein S5 domain 2-type fold, subgroup1 (0.38%)0000010000
IPR005324Ribosomal protein S5, C-terminal1 (0.38%)0000010000
IPR013810Ribosomal protein S5, N-terminal1 (0.38%)0000010000
IPR018192Ribosomal protein S5, N-terminal, conserved site1 (0.38%)0000010000
IPR005711Ribosomal protein S5, eukaryotic/archaeal1 (0.38%)0000010000
IPR017444Ribulose bisphosphate carboxylase, large subunit, N-terminal1 (0.38%)0000010000
IPR017443Ribulose bisphosphate carboxylase, large subunit, ferrodoxin-like N-terminal1 (0.38%)0000010000
IPR014729Rossmann-like alpha/beta/alpha sandwich fold1 (0.38%)0000000100
IPR001232SKP1 component1 (0.38%)0100000000
IPR016072SKP1 component, dimerisation1 (0.38%)0100000000
IPR023393START-like domain1 (0.38%)0100000000
IPR011042Six-bladed beta-propeller, TolB-like1 (0.38%)1000000000
IPR001045Spermidine/spermine synthases family1 (0.38%)0000000010
IPR006509Splicing factor, CC1-like1 (0.38%)0000001000
IPR018119Strictosidine synthase, conserved region1 (0.38%)1000000000
IPR001938Thaumatin1 (0.38%)0000100000
IPR017949Thaumatin, conserved site1 (0.38%)0000100000
IPR006683Thioesterase superfamily1 (0.38%)0000000001
IPR003316Transcription factor E2F/dimerisation partner (TDP)1 (0.38%)0000100000
IPR002999Tudor domain1 (0.38%)0010000000
IPR000594UBA/THIF-type NAD/FAD binding fold1 (0.38%)0000010000
IPR002213UDP-glucuronosyl/UDP-glucosyltransferase1 (0.38%)1000000000
IPR019572Ubiquitin-activating enzyme1 (0.38%)0000010000
IPR000127Ubiquitin-activating enzyme repeat1 (0.38%)0000010000
IPR023313Ubiquitin-conjugating enzyme, active site1 (0.38%)0000100000
IPR023280Ubiquitin-like 1 activating enzyme, catalytic cysteine domain1 (0.38%)0000010000
IPR028077Ubiquitin/SUMO-activating enzyme ubiquitin-like domain1 (0.38%)0000010000
IPR019775WD40 repeat, conserved site1 (0.38%)0000100000
IPR013990Water stress and hypersensitive response domain1 (0.38%)0000001000
IPR013087Zinc finger C2H2-type/integrase DNA-binding domain1 (0.38%)0000000100
IPR000315Zinc finger, B-box1 (0.38%)0000000001
IPR001965Zinc finger, PHD-type1 (0.38%)0000010000
IPR018022tRNA delta(2)-isopentenylpyrophosphate transferase1 (0.38%)0000001000
IPR002627tRNA isopentenyltransferase1 (0.38%)0000001000