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hfAIM

hfAIM: a reliable bioinformatics approach for in silico genome-wide identification of autophagy-associated atg8-interacting motifs in various organisms

Achieving reliability and/or fidelity of the prediction of such AIMs on a genome-wide scale represents a major challenge. Here, we present a bioinformatics approach, high fidelity AIM (hfAIM), which uses additional sequence requirements – the presence of acidic amino acids and the absence of positively charged amino acids in certain positions - to reliably identify AIMs in proteins.





Xie, G.-C., Tzfadia, O., Levy, AA., Weithorn, E., Peled-Zehavi, H., Van Parys, T., Van de Peer, Y., Galili, G. (2016) hfAIM: a reliable bioinformatics approach for in silico genome-wide identification of autophagy-associated atg8-interacting motifs in various organisms. Autophagy 12(5):876-87.




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