Gene duplication and biased functional retention of paralogs in bacterial genomes.
Gene duplication is considered an important prerequisite
for gene innovation that can facilitate adaptation to
changing environments. The analysis of 106 bacterial
genome sequences has revealed the existence of a significant
number of paralogs. Analysis of the functional
classification of these paralogs reveals a preferential
enrichment in functional classes that are involved in
transcription, metabolism and defense mechanisms.
From the organization of paralogs in the genome we
can conclude that duplicated genes in bacteria appear
to have been mainly created by small-scale duplication
events, such as tandem and operon duplications.
Gevers, D., Vandepoele, K., Simillion, C., Van de Peer, Y. (2004) Gene duplication and biased functional retention of paralogs in bacterial genomes. Trends Microbiol. 12(4):148-54. |
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