Wouter De Vos

Alumnus
(Group member from 2002 until 2003)


+ 32 (0) 9 33 13 822

VIB / Ghent University
Bioinformatics & Systems Biology
Technologiepark 927
B-9052 Gent
BELGIUM

Research

In 1970, Ohno proposed that it would be much easier to create new genes by duplication of existing ones instead of creating them at random from non-coding DNA. These duplicates would play an important role in biological evolution where they could give the chance for organisms to adapt to new environments and to develop new gene-functions. Nowadays, a controversial theory, known as the 2R-hypothesis, implies two rounds of genome duplication during the early vertebrate-evolution. Further, there exist several indications that in the fish-lineage, an additional complete genome-duplication event occurred 300-450 million years ago. Extensive research of fish genomes will make it possible to formulate conclusions about the 2R in early vertebrates and the additional R in the fish-lineage.

Papers

(1) Vandepoele, K., De Vos, W., Taylor, J.S., Meyer, A., Van de Peer, Y. (2004) Major events in the genome evolution of vertebrates: paranome age and size differs considerably between fishes and land vertebrates. Proc. Natl. Acad. Sci. USA 101(6):1638-43.











Contact:
VIB / UGent
Bioinformatics & Evolutionary Genomics
Technologiepark 927
B-9052 Gent
BELGIUM
+32 (0) 9 33 13807 (phone)
+32 (0) 9 33 13809 (fax)

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