Wouter De Vos

(Group member from 2002 until 2003)

+ 32 (0) 9 33 13 822

VIB / Ghent University
Bioinformatics & Systems Biology
Technologiepark 927
B-9052 Gent


In 1970, Ohno proposed that it would be much easier to create new genes by duplication of existing ones instead of creating them at random from non-coding DNA. These duplicates would play an important role in biological evolution where they could give the chance for organisms to adapt to new environments and to develop new gene-functions. Nowadays, a controversial theory, known as the 2R-hypothesis, implies two rounds of genome duplication during the early vertebrate-evolution. Further, there exist several indications that in the fish-lineage, an additional complete genome-duplication event occurred 300-450 million years ago. Extensive research of fish genomes will make it possible to formulate conclusions about the 2R in early vertebrates and the additional R in the fish-lineage.


(1) Vandepoele, K., De Vos, W., Taylor, J.S., Meyer, A., Van de Peer, Y. (2004) Major events in the genome evolution of vertebrates: paranome age and size differs considerably between fishes and land vertebrates. Proc. Natl. Acad. Sci. USA 101(6):1638-43.

VIB / UGent
Bioinformatics & Evolutionary Genomics
Technologiepark 927
B-9052 Gent
+32 (0) 9 33 13807 (phone)
+32 (0) 9 33 13809 (fax)

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