Many scientists believe that there were two large-scale gene duplications at the origin of the vertebrates (2R hypothesis) which made the success of this group possible. About 320 million years ago, the fishes underwent an additional large-scale gene duplication (3R). The goal of my study is to investigate the consequences of this fish-specific large-scale gene duplication. This study is meant to bring more clarity in vertebrate genome evolution and in the mechanisms that cause gene loss and the development of novel gene functions.
Papers(2) Van Hellemont, R., Blomme, T., Van de Peer, Y., Marchal, K. (2007) Divergence of regulatory sequences in duplicated fish genes. Genome Dyn 3:81-100.
(1) Blomme, T., Vandepoele, K., De Bodt, S., Simillion, C., Maere, S., Van de Peer, Y. (2006) The gain and loss of genes during 600 million years of vertebrate evolution. Genome Biol. 7(5):R43.
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Bioinformatics & Evolutionary Genomics
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