hfAIM: a reliable bioinformatics approach for in silico genome-wide identification of autophagy-associated atg8-interacting motifs in various organisms
Achieving reliability and/or fidelity of the prediction of such AIMs on a genome-wide scale represents a major challenge. Here, we present a bioinformatics approach, high fidelity AIM (hfAIM), which uses additional sequence requirements – the presence of acidic amino acids and the absence of positively charged amino acids in certain positions - to reliably identify AIMs in proteins.
Xie, Qingjun, Tzfadia, O., Levy, M., Weithorn, E., Peled-Zehavi, H., Van Parys, T., Van de Peer, Y., et al. (2016). hfAIM: a reliable bioinformatics approach for in silico genome-wide identification of autophagy-associated Atg8-interacting motifs in various organisms. AUTOPHAGY, 12(5), 876–887