Current job opening PhD student/ Postdoctoral researcher. Application deadline 31 Dec 2015.
In the framework of applied projects (IWT funded) Bioframe and NEMOA we are very much interested in setting up industrial collaborations to test and validate the applicability of our tools (proof-of-concept studies). We offer expertise in datapreprocessing, dataintegration and advanced computational analysis of omics data. We have expertise with applications in prokaryotes and higher eukaryotes and can rely on previous experiences gained through previous industrial collaborations.
Running Research ConsortiaWe are partner in several larger research projects.
NEMOA:Network-based approaches for the identification and mode of action determination of anti-bacterial agents
is an IWT (SBO) funded research project between the KU LEUVEN and Ghent University. For more information see NEMOA.NEMOA envisages an innovative way of addressing problems related to the increasing cost and complexity of drug development. It offers a platform for drug repurposing by maximally exploiting publicly available knowledge.
- By combining a strategy based on phenotypic characterization with a simultaneous MMOA determination, it combines the advantages of a target-based strategy that starts from the MMOA with the efficacity of a phenotypic screening.
- By providing insight in the MMOA at global cellular level (interference of the drug with signaling and reaction pathways) and not only at a the level of the local interaction between the drug and its target will aid in the design of more complex therapeutics (drug-cocktailing, polypharmacology) that can overcome problems related to multiple resistance.
SYNCELLS: At the interface between systems and synthetic biology: the conceptualization of modularity
SYNCELLS (WOG-FWO) is a scientific research community sponsored by the Fund for Scientific research, Flanders. The goal of the community is to bring together in Europe experts in systems and synthetic biology not only to stay aware of progresses made in either field, but more importantly to discuss how both fields can leverage each other. For more information see SYNCELLS.
NATAR: Natural and Artifical Genetic Variation in Microbes
Is a KULeuven supported Center of Excellence with as goal studying the fundamental and industrial importance of complex genetic interactions in microbial model organisms. The project combines advanced wetlab approaches (bacterial evolution experiments, pooled segregant analysis) with innovative computational analysis procedures (eQTL based approaches) to unveil complex traits underlying ethanol tolerance in yeast and Escherichia coli. Our contribution in this project relates to developing and applying novel data-analysis procedures for advanced genotype-phenotype mapping in microbial organisms. For more information see NATAR.
MRP: N2N from nucleotides to networks
is a Multidisciplinary Research Partnership to spearhead research on Bioinformatics and Systems Biology at Ghent University. Our role in this project is to contribute to the development of novel tools and approaches for systems biology (inferring and modelling biological networks). For more information see N2N.